This monograph deals with the pathophysiology of atherosclerosis with emphasis on epigenetics, metabolomics, inflammation, molecular and cellular mechanisms involved in cardiovascular disease development. This book has been written with the intention of providing new concepts about coronary artery disease pathogenesis that may link various aspects of the disease, going beyond the traditional risk factors.
Contents
Preface
Part 1 Pathogenesis
1 Gene Polymorphism and Coronary Heart Disease
2 Lipoprotein(a) Oxidation, Autoimmune and Atherosclerosis
3 ICAM-1: Contribution to Vascular Inflammation and Early Atherosclerosis
4 Molecular and Cellular Aspects of Atherosclerosis: Emerging Roles of TRPC Channels
5 Hypoxia-Regulated Pro- and Anti-Angiogenesis in the Heart
6 Paraoxonase 1 (PON 1) Activity, Polymorphisms and Coronary Artery Disease
Part 2 Acute Coronary Syndrome
7 Acute Coronary Syndrome: Pathological Findings by Means of Electron Microscopy, Advance Imaging in Cardiology
8 Shortened Activated Partial Thromboplastin Time (APTT): A Simple but Important Marker of Hypercoagulable State During Acute Coronary Event
Part 3 Cardiovascular Prevention
9 Individualized Cardiovascular Risk Assessment
10 Metabolomics in Cardiovascular Disease: Towards Clinical Application
11 Novel Regulators of Low-Density Lipoprotein Receptor and Circulating LDL-C for the Prevention and Treatment of Coronary Artery Disease
12 Serum Choline Plasmalogen is a Reliable Biomarker for Atherogenic Status
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