Science and Practice of Pressure Ulcer Management, Second Edition

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Aug 102018
 

This updated volume provides the current knowledge on the diagnosis, treatment, management, and prevention of pressure ulcers. Chapters on the early detection of pressure ulcers, negative pressure therapy, pressure ulcers in pediatric patients, adjunctive therapies, surgical management of pressure ulcers, and innovation in pressure ulcer research and practice are included.
This second edition aims to be the primary reference for pressure ulcers from diagnosis and prevention to management and treatment options.

The book is relevant to dermatology clinicians, vascular surgeons, and dermatology nurses.

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Molecular Mechanisms of Notch Signaling

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Aug 082018
 

This book describes the Notch signaling pathway with a focus on molecular mechanisms. The Notch signaling pathway is a seemingly simple pathway that does not involve any second messenger. Upon ligand binding two consecutive proteolytic cleavages of the NOTCH receptor release the Notch intracellular domain from the membrane. The Notch intracellular domain migrates into the nucleus and activates gene expression.
Recently, new technologies allowed us to better understand this pivotal signaling cascade and revealed new regulatory mechanisms. The different chapters cover many aspects of the Notch signaling focusing on the mechanisms governing the receptor/ligand interaction as well as on the downstream intracellular signaling events. Aspects of both canonical and non-canonical signaling are discussed and the function of Notch signaling in physiological and pathological contexts are elucidated.

This book is not only intended for experts but it should also be a useful resource for young, sprouting scientists or interested scientists from other research areas, who may use this book as a stimulating starting point for further discoveries and developments.

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Nanotechnology and Drug Delivery, Volume One: Nanoplatforms in Drug Delivery

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Aug 062018
 
Pharmacotherapy is often limited by the inefficient activity and severe toxicity of drug molecules. Nanotechnology offers a revolutionary and definitive approach for the efficient delivery of drug molecules to non-healthy tissues and cells. This first volume of a series of two volumes analyzes the basics in the development of drug-loaded nanoplatforms, the so-called nanomedicines. Special attention is given to physicochemical engineering, pharmacokinetics, biocompatibility and biodegradability, representative nanoplatforms (based on lipids, polymers, cyclodextrins, metals, carbon, silica, iron oxides, etc.), and advanced nano-engineering strategies for passive, ligand-mediated, and/or stimuli-sensitive drug delivery and release.
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Methods for Neural Ensemble Recordings, Second Edition

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Aug 042018
 

In the last ten years neural ensemble recording grew into a well-respected and highly data-lucrative science. New experimental paradigms, including the fabrication of high-density microelectrodes, new surgical implantation techniques, multi-channel signal processing, and the establishment of direct real-time brain-machine interfaces, hold promise not just for neurophysiology research, but also for new-generation prosthetic devices aimed at restoring mobility and communication skills in severely disabled patients.
Extensively updated and expanded, Methods for Neural Ensemble Recording, Second Edition distills the current state-of-the-science and provides the nuts and bolts foundation from which to advance the field for the next ten years. With contributions from pioneering researchers, this second edition begins with an overview of microwire array design for chronic neural recordings. Demonstrating the diversity now enjoyed in the field, the book reviews new surgical techniques for chronic implantation of microwire arrays in not just rodents, but primates as well. It explores microelectrode microstimulation of brain tissue, discusses multielectrode recordings in the somatosensory system and during learning, and analyzes neural ensemble recordings from the central gustatory-reward pathways in awake and behaving animals.
An exploration of new strategies for neural ensemble data analysis for Brain-Machine Interface (BMI) applications foreshadows an investigation into employing BMI to restore neurological function. Using multielectrode field potential recordings, contributions define global brain states and propose conceptual and technical approaches to human neural ensemble recordings in the future.

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Coping Effectively With Spinal Cord Injuries: A Group Program Therapist Guide

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Aug 042018
 

For individuals who have suffered a spinal cord injury, it is a struggle to know how to assess and cope with such a life-changing event. The coping strategies that a person employs can have an enormous impact on their mental well-being and long-term health. Approach focused coping, in which the individual accepts and seeks to understand their condition, results in a sense of mastery, self-efficacy, and post traumatic growth. Conversely, avoidance focused coping can lead to anxiety, depression, self neglect, and substance abuse problems. Approximately 50% will meet the diagnostic criteria for depression at 6 months post injury. Research shows that those with depression will have a poorer outcome and shorter life-span. Coping effectiveness training (CET) aims to improve skills for assessing stress, teaching a range of coping skills that can be used to tackle stress, and provide an opportunity for interaction with others who have similar experiences of spinal cord injury. CET includes the identification of effective and ineffective responses to stress, especially those that are particularly unhelpful, such as disengagement, general avoidance, long term denial, and the expression of extreme emotion. By encouraging individuals to think critically about their behaviour in response to stressors, CET helps people avoid unproductive ways of coping. Like all TreatmentsThatWork programs, this treatment is evidence-based. In the author’s clinical studies, CET has proven to successfully reduce levels of depression and anxiety in individuals with spinal cord injury, and also resulted in changes in negative self-perception and improved self-efficiacy. The intervention consists of seven, 60-75 minute sessions run two a week in small groups of six to nine people.
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Cupping Therapy for Muscles and Joints: An Easy-to-Understand Guide for Relieving Pain, Reducing Inflammation and Healing…

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Aug 032018
 

Step-by-Step Guide to Understanding and Using the Ancient Art of Cupping!

An important part of Traditional Chinese Medicine for thousands of years, cupping has recently gained widespread acclaim for its many benefits. It may look like some kind of torture and temporarily leave strange circles on your skin, but it’s so effective that everyone from professional athletes to famous celebrities is using it to improve their health and well being.

In this book, you will discover what cupping is, how it works, and which cupping techniques would be best for you. You will learn the science behind the suction and the many conditions and ailments it can alleviate, including:

• Lower Back Strain
• Tennis Elbow
• Wrist and Forearm Pain
• Neck and Shoulder Injuries
• Sore Hamstrings
• Knee Pain
• Allergies
• Insomnia
• Anxiety and Stress
• Constipation
• Eczema
• Menstruation

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Chemistry and Medicines: An Introductory Text

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Aug 012018
 

Medicinal chemistry incorporates bio-organic chemistry, organic synthetic methods, physical organic chemistry and organic reaction mechanisms. These areas of chemistry are crucial to the design and synthesis of new drugs, both in academia and the pharmaceutical industry. Chemistry and Medicines: An Introductory Text provides a general introduction to this fascinating subject. The first chapters contain a brief historical introduction followed by a description of the chemical features involved in the adsorption, distribution, metabolism and excretion of a drug. The remaining chapters describe the chemistry underlying the design and synthesis of some of the key drugs used to combat some major diseases of the peripheral and central nervous system, infectious diseases and cancers. A glossary and suggestions for further reading complete this textbook. The book is aimed at those studying advanced undergraduate and postgraduate courses in medicinal chemistry.

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Aplastic Anemia and Other Bone Marrow Failure Syndromes

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Jul 312018
 

During the past decade, there have been numerous direct and indirect scientific contributions to both the etiology and therapy of aplastic anemia and related bone marrow failure syndromes. Clinical observations, such as autologous bone marrow recovery after conditioning with immunosup­ pressive agents for bone marrow transplantation; failure to achieve en­ graftment in some identical twins without prior immunosuppressive ther­ apy; and hematologic response to immunosuppressive agents, have led to the concept of immune-mediated etiology of acquired aplastic anemia.
Such a concept was further strengthened by laboratory findings, implicat­ ing the role of activated cytotoxic T lymphocytes and abnormal produc­ tion of inhibitory lymphokines. The immunologic mechanisms may also apply to the idiosyncratic bone marrow aplasias associated with drugs, toxic chemicals, and viruses. These agents may alter normal cellular recog­ nition sites by interacting with cellular components and result in loss of self tolerance. Immunologic mechanisms have long been advocated in many other organ failures, and the hemopoietic organ is no exception. It is of interest that parallel clinical and laboratory investigations in juvenile diabetes mellitus type I and in rodent models of this disease have yielded results compatible with the same pathogenic mechanisms. The infiltration of pancreatic islets by activated T lymphocytes, functional and morphological alterations of islet cells upon incubation with lymphokines such as gamma interferon and tumor necrosis factor, and clinical response to cyclosporine are a few examples.

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Coronary Graft Failure: State of the Art

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Jul 302018
 

Presents the current knowledge on coronary grafting and graft disease
Details the mechanism of coronary graft failure, its pathology and diagnosis
Describes the new-generation drug-eluting stents and other treatment options​

Coronary artery bypass surgery has been developed since 1960s to overcome proximal coronary artery disease. Worldwide, the number of patients that are undergoing coronary artery bypass surgery is steadily increasing. Depending on diverse risk factors, one fifth of grafts are occluded at 1 year. For the remaining, graft patency last usually 8–15 years. This book brings together the main specialists in the field to review the current evidence on epidemiology, pathophysiology, diagnostic, new imaging techniques and specific therapeutic modalities. This volume aims to update a complex subject represented by coronary graft failure. The authors of this monograph are interventional cardiologists, cardiovascular surgeons and research scientists, who will be creating four parts and 71 chapters that are divided in order to give a uniform interpretation of this condition including all aspects of coronary graft failure This book not only provides the most up-to-dated scientific evidence in the field but in a two-step manner. Each chapter is divided into a at a glance part that reflects the basic evidence on the topic, and a “full picture” part that brings all what the advanced reader should be brought with.

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Celebrating the Wounded Healer Psychotherapist: Pain, Post-Traumatic Growth and Self-Disclosure

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Jul 262018
 

Why would someone decide to become a psychotherapist? It is well-known within the field that psychoanalysts and psychotherapists are often drawn to their future professions as a result of early traumatic experiences and being helped by their own psychoanalytic treatment. While dedicating their lives to relieving emotional suffering without being judgmental, they fear compromising their reputations if they publicly acknowledge such suffering in themselves. This phenomenon is nearly universal among those in the helping professions, yet there are few books dedicated to the issue.
In this innovative book, Farber and a distinguished range of contributors examine how the role of the ‘wounded healer’ was instrumental in the formulation of psychoanalysis, and how using their own woundedness can help clinicians work more effectively with their patients, and advance theory in a more informed manner.

Celebrating the Wounded Healer Psychotherapist will be of interest to psychoanalysts and psychoanalytic psychotherapists, graduate students in clinical disciplines including psychology, social work, ministry/chaplaincy and nursing, as well as the general public.

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