Negative Symptom and Cognitive Deficit Treatment Response in Schizophrenia

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Jul 022018

For the first time in a single volume, distinguished experts address the complex issues – issues rarely confronted in empirical studies of patients with schizophrenia – and controversial research surrounding the assessment of negative symptoms and cognitive deficits in patients with schizophrenia.
Despite recent advances in our understanding of schizophrenia, still notably absent is consensus in assessing negative symptom treatment response. What is the most effective assessment method – given the varying methodologies and contradictory results to date? What constitutes an adequate response? Which medication – none is specifically indicated and licensed for negative symptom treatment – yields the best results? What are the indications for use of this medication? Which instrument best measures negative symptom treatment response (eight rating scales are analyzed here)? Reaching consensus among clinicians and researchers alike is even more difficult because assessment is often thwarted by extrapyramidal side effects of medications, similarities to depressive symptoms, and secondary effects of psychotic experiences.
In addition to clarifying these pressing issues, Negative Symptom and Cognitive Deficit Treatment Response in Schizophrenia also discusses The importance of measuring the experience of emotion versus the more traditional objectively measured symptoms in patients with schizophrenia, and how deficits in emotional experience may resist treatment – even in treatment-responsive patients.
The family as an often overlooked source of information about negative symptom improvement or worsening, and the impact of negative symptoms on patients’ relatives.
How treatment affects social functioning and subjective experience of “quality of life,” and the importance of neurocognitive dysfunction in the social deficits of schizophrenia, which often persist despite significant amelioration of other symptoms.
Specific guidelines for assessing neurocognitive treatment response. Cognitive enhancement is a major factor in improving the quality of patients’ lives.
The latest research on the neurobiology of negative symptoms, including the role of various neurotransmitter systems and brain regions in mediating negative symptom pathology. Also discussed is single vs. multiple pathophysiological processes and single treatment modality vs. distinct treatments for different aspects of negative symptoms.
How to distinguish “pure” negative symptoms from deficit symptoms (i.e., those that persist for at least 1 year and are not secondary to factors such as depression, medication side effects, anxiety, delusions, and hallucinations), and which treatment is indicated for each.
Highlighted by patient vignettes, this in-depth guide will be welcomed by all clinicians who treat patients with schizophrenia and want to know and document whether their interventions ameliorate negative symptoms and cognitive dysfunction, and by all researchers who study schizophrenia, particularly those interested in clinical issues and treatment studies.


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3D Bioprinting in Regenerative Engineering:: Principles and Applications

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Jun 232018

This book is comprehensive in nature with contributions by leading world experts in 3D bioprinting related to regenerative engineering. It includes history, incorporating the process and methods used in bioprinting. Significant sections will be reserved for the applications of the types of tissues generated by using bioprinting, along with an overview of different technologies used in bioprinting. In addition to equipment, the book also describes the different biomaterials and cells used in these approaches. Overall this is a book that includes both entry-level knowledge and advanced methods and techniques. Applications will emphasize engineering and clinical principles.


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Poised for Peak Performance in Healthcare: A Practical Approach to Execute Expense Reduction and Revenue Enhancement Initiative

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Jun 222018

The current healthcare system is under attack by market, government, and consumer forces. To stay solvent, organizations must be performing at the top of their game. This book provides detailed instructions to bring organizations to the next level of performance by teaching all the secrets straight from the healthcare consultant’s playbook in less than 100 days.

This book defines the coming challenges in the healthcare environment and provides a 10-step solution to develop the infrastructure for peak performance. These solutions include detailed implementation plans, software, reports, metrics, and the top projects that yield the highest financial rewards.

This is the first book of its kind to not just discuss the top strategies, but also provide step-by-step instructions to achieve results. The book defines the strategy, the tactics, the infrastructure, the targets, the solutions, the barriers, and the leadership required to achieve a high performing organization. With these simple instructions, any organization with the will to achieve a brighter future can be poised for success in the next decade in less than 100 days.


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Physical Medicine and Rehabilitation Q&A Review, Second Edition

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Jun 132018

Now with a free mobile & web app with print purchase!

Revised, expanded, and updated new edition of the first and only Q&A review for physical medicine and rehabilitation. Question and answer format remains one of the most effective methods for self-study and exam preparation. Physical Medicine and Rehabilitation QA Review, Second Edition is a comprehensive, active self-assessment tool for medical students, residents, and attending physicians. Configured to help professionals quickly and efficiently review core topics, the book covers in detail the breadth and scope of physical medicine & rehabilitation (PM&R) knowledge and practice.

Now with 16 sections addressing key concepts and including emerging high-value content areas, the expanded second edition contains over 1,850 multiple-choice questions with answers and explanations. The must-know information in the PM&R curriculum for learning, individual self-assessment, and board review is at your fingertips.

Key Features

Comprehensive coverage of the knowledge base and clinical practice areas necessary for success
More questions! Over 350 new questions on pain medications and conversion equivalents, gait patterns and analysis, spinal cord injury, and much more
Completely new chapter on Ultrasound and Regenerative Medicine
All questions and explanations reviewed and updated for currency and comprehensiveness; new illustrations added to enhance understanding


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Evaluation and Management of Autonomic Disorders: A Case-Based Practical Guide

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Jun 122018

This book approaches the basic features of autonomic dysfunction in a practical way, complemented by an examination of unique and didactic case reports. Unlike other books on autonomic disorders, its goal is to provide a brief, practical and ready to use resource for physicians faced with patients’ autonomic complaints. Autonomic dysfunctions are specific disorders that affect or are related to the autonomic nervous system.
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Arthritis Research: Methods and Protocols

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Jun 112018

Arthritis Research: Methods and Protocols, Second Edition expands upon the first edition to present new and current techniques for the research of arthritis and related conditions.


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Music and Public Health: A Nordic Perspective

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Jun 072018

From the Nordic countries (Denmark, Norway, Sweden and Finland) comes an exciting source of theoretical approaches, epidemiological findings, and real-life examples regarding the therapeutic and health-enhancing effects of music. Experts across fields including psychology, neurology, music therapy, medicine, and public health review research on the benefits of music in relieving physiological, psychological, and socioemotional dysfunction. Chapters link musical experiences (listening and performing, as well as involvement in movement, dance, and theatre) to a wide range of clinical and non-clinical objectives such as preventing isolation, regulating mood, reducing stress and its symptoms, and treating dementia.
And the book’s section on innovative music-based interventions illustrates opportunities for incorporating musical activities into public health programs.

Among the topics covered are:

· Associations between the use of music, cultural participation and health-related outcomes in adult Scandinavian populations

· Music practice and emotion handling

· How music translates itself biologically in the body

· Music as a forum for social-emotional health

· Participation and partnership as core concepts in music and public health

· Music therapy as health promotion for mothers and children at a public health clinic

Music and Public Health will gain interested readers among researchers, teachers, students, and clinicians in the fields of music education and therapy, as well as researchers and students of public health who are interested in the influence of culture and the arts. The book also will be relevant to administrators in public health services.


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The Hair Fibre: Proteins, Structure and Development

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Jun 062018

Hair is a sophisticated bio-based material, whether it is on a human head or part of a mammalian coat. In particular, the role of the proteins in the follicle, integral to hair development, are not well understood. This new book seeks to integrate the latest research in proteomic and morphological studies into a coherent description of fibre development from the follicle to its final mature, keratinized form.
To achieve this the book has been divided into three sections. The first describes the keratins, their associated proteins and how they assemble into intermediate filaments in the fibre. The second covers the latest information on the morphological changes that occur from the base of the follicle, through the keratinization process to the mature fibre and the role that proteins play in this. The final section delves into fundamental fibre properties such as crosslinking, thermal and oxidative modifications and how these affect the mature fibre.
The editors of this book are internationally recognised for their work in the area of mammalian hair, Jeffrey Plowman for his knowledge of the proteomics of the fibre, Santanu Deb-Choudhury for his work in the area of crosslinking in the fibre and Duane Harland for his understanding of the morphological development of the fibre. Together they have collected material from other international experts: Leopold Eckhart and Florian Ehrlich for their knowledge of the evolution of keratins; Dong Dong Wu and David Irwin for their studies on keratin associated protein evolution; David Parry and Bruce Fraser for their work on keratin and keratin associated protein structure and assembly; John McKinnon for his studies on macrofibril formation; Crisan Popescu for the thermodynamics of keratins; and Jolon Dyer for his oxidative modification studies of keratins.

This book provides a comprehensive introduction, and useful reference guide to hair biology and will be of interest to both scientists and technologists.


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Engineering Stem Cells For Tissue Regeneration

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Jun 062018

Tissue engineering integrates knowledge and tools from biological sciences and engineering for tissue regeneration. A challenge for tissue engineering is to identify appropriate cell sources. The recent advancement of stem cell biology provides enormous opportunities to engineer stem cells for tissue engineering. The impact of stem cell technology on tissue engineering will be revolutionary.

This book covers state-of-the-art knowledge on the potential of stem cells for the regeneration of a wide range of tissues and organs, including cardiovascular, musculoskeletal, neurological and skin tissues. The technology platforms for studying and engineering stem cells, such as hydrogel and biomaterials development, microfluidics system and microscale patterning, are also illustrated. Regulatory challenges and quality control for clinical translation are also detailed. This book provides an comprehensive update on the advancement in the field of stem cells and regenerative medicine, and serves as a valuable resource for both researchers and students.


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Copper and the Skin

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Jun 032018

Copper is increasingly recognized for its possible role in the prevention and moderation of disease, as well as the treatment of a number of conditions including skin irritation, sensitization, rheumatoid arthritis, and other inflammatory conditions. This source reviews general principles of percutaneous penetration to clarify the mechanisms controlling anti-inflammatory activity, dermal sensitivity, and the absorption of copper compounds in the human body and the effects of these functions on healthy skin and human health.


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