Jul 172017

Cellular Rhythms and Networks: Implications for Systems Medicine (SpringerBriefs in Cell Biology)

By (author): Qing Yan

?This book provides an overview of circadian rhythms and cellular networks in their relation to biological systems and dynamical medicine. Six concise chapters explore circadian cell rhythms and biomarkers in inflammation, cardiovascular disease, cancer, depression, and more in causing and treating these ailments. The final chapter discusses optimization of drug delivery and individualized treatment systems using chronotherapy and chronobiology-based biomarkers as a general system of medicine. Succinct yet comprehensive, Cellular Rhythms and Networks, part of SpringerBriefs in Cell Biology presents a novel framework for clinical applications in personalized and systems medicine. It is invaluable reading for researchers and clinicians in cell biology, mood disorders, and systems medicine.
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Jul 162017

Shoulder Pain? The Solution & Prevention, Revised & Expanded

By (author): John M. Kirsch M.D.

This is a self-help book written by John M. Kirsch, M.D., an Orthopedic Surgeon for the public. It is the result of 25 years of research into a new and simple shoulder exercise program to treat and prevent rotator cuff tears, the impingement syndrome, and the ”frozen shoulder.” Testimonials and research CT scan images are included, as well as images of the exercises performed by models and patients.
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Jul 162017

HypnoBirthing, Fourth Edition: The natural approach to safer, easier, more comfortable birthing – The Mongan Method, 4th Edition

Features: Health Communications
By (author): Marie Mongan

HypnoBirthing® has gained momentum around the globe as a positive and empowering method of childbirth. Here’s why: HypnoBirthing helps women to become empowered by developing an awareness of the instinctive birthing capability of their bodies. It greatly reduces the pain of labor and childbirth; frequently eliminates the need for drugs; reduces the need for caesarian surgery or other doctor-controlled birth interventions; and it also shortens birthing and recovery time, allowing for better and earlier bonding with the baby, which has been proven to be vital to the mother-child bond.  What’s more, parents report that their infants sleep better and feed more easily when they haven’t experienced birth trauma. 

HypnoBirthing founder Marie Mongan knows from her own four births that it is not necessary for childbirth to be a terribly painful experience.  In this book she shows women how the Mongan Method works and how parents they can take control of the greatest and most important event of their lives.

So, why is birth such a traumatic event for so many women? And why do more than 40% of births now end in caesarian section, the highest percentage in history? The answer is simple: because our culture teaches women to fear birth as a painful and unsettling experience. Fear causes three physical reactions in the body?tightening of the muscles, reduced blood flow to the birthing muscles, and the release of certain hormones?which increase the pain and discomfort of childbirth. This is not hocus-pocus this is science.

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Jul 162017

Transforming the Legacy: Couple Therapy with Survivors of Childhood Trauma

By (author): Kathryn Karusaitis Basham, Dennis Miehls

To serve the increasing numbers of individuals who have survived interpersonal and domestic violence, or as refugees, have sought asylum from political violence, armed conflict, or torture, Transforming the Legacy presents an innovative relationship-based and culturally informed couple therapy practice model that is grounded in a synthesis of psychological and social theories. This unique couple therapy model encompasses three phases of clinical practice: Phase I entails a process of establishing safety, stabilization, and a context for changing legacies of emotional, sexual, and/or physical abuse. Phase II guides reflection on the trauma narrative. The goal of phase III is to consolidate new perspectives, attitudes, and behaviors.

Within these phases, the model?illustrated with rich case studies?focuses on specific issues, including: intersubjectivity between the client and clinician (such as transference and countertransference, vicarious traumatization, and racial identity development); intrapersonal, interactional, and institutional factors; the role of the “victim-victimizer-bystander” dynamic in the couple and therapeutic relationships; preserving a locus of control with clients; flexibility in decisionmaking regarding clinical processes; and specific practice themes, such as the composition of a couple, the role of violence, parenting, sexuality, affairs, dual diagnoses, and dissociation.

A dramatic departure from formulaic therapeutic approaches, this biopsychosocial model emphasizes the crafting of specific treatment plans and specific clinical interventions to show how couple therapy can transform the legacies of childhood traumatic events for a wide range of populations, including military couples and families, gay lesbian/bisexual/transgendered couples and families, and immigrant and refugee couples and families. This thorough attention to issues of cultural diversity distinguish Transforming the Legacy from the current literature and make it an invaluable resource for clinicians in a wide range of professional disciplines.

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Jul 152017

Angiogenesis and Vascularisation: Cellular and Molecular Mechanisms in Health and Diseases

The book presents the overview of the current knowledge in some fields of vascular biology, addressing cellular and molecular aspects of blood-vessel formation and their role in health and disease. The major factors involved in the formation of blood vessels are presented by scientists actively involved in this area of research. Special emphasis is put on the presentation of various molecular mechanisms not addressed in similar works to date. The book is divided into three parts. The first part describes the cells and mediators in angiogenesis. The significance of various populations of potential endothelial progenitors is particularly highlighted. The chapters of the second part focus on molecular mechanisms, with special emphasis on the role of hypoxia, gasotransmitters and reactive oxygen species as well as microRNAs in regulation of angiogenic processes. In the third part, the pathological aspects of disturbed – aggravated or impaired – vascularization are discussed and new modalities for potential therapies are presented. The book is intended for scientists and PhD students in the fields of vascular biology and cancer research. It may be of interest for medical professionals in the fields of cardiovascular disease, diabetes, oncology and rheumatoid arthritis.

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Jul 152017

JIMD Reports, Volume 34

JIMD Reports publishes case and short research reports in the area of inherited metabolic disorders. Case reports highlight some unusual or previously unrecorded feature relevant to the disorder, or serve as an important reminder of clinical or biochemical features of a Mendelian disorder.
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Jul 152017

Proteases in Human Diseases

This book bridges the gap between fundamental research and biomedical and pharmacological applications on proteases. It represents a comprehensive overview of the multifaceted field of proteases in cellular environment and highlights the recently elucidated functions of complex proteolytic systems in different diseases. Several established investigators have elucidated the crucial role of proteases in biological processes, including how proteolytic function and regulation can be combined to develop new strategies of therapeutic interventions.

Proteases form one of the largest and most diverse families of enzymes known. It is now clear that proteases are involved in every aspect of life functions of an organism. Under physiological conditions, proteases are regulated by their endogenous inhibitors; however, when the activity of proteases is not regulated appropriately, disease processes can result in. So, there is absolute need for a stringent control of proteolytic activities in cells and tissues.

Dysregulation of proteases may cause derangement of cellular signalling network resulting in different pathophysiological conditions such as vascular remodelling, atherosclerotic plaque progression, ulcer and rheumatoid arthritis, Alzheimer disease, cancer metastasis, tumor progression and inflammation. Additionally, many infective microorganisms require proteases for replication or use proteases as virulence factors, which have facilitated the development of protease-targeted therapies for a variety of parasitic diseases.

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Jul 152017

Gene Therapy for HIV: From Inception to a Possible Cure (SpringerBriefs in Biochemistry and Molecular Biology)

By (author): Gerhard Bauer, Joseph S. Anderson

This Brief describes the concept and realization of gene therapy for HIV from the unique historic perspective and insight of two pioneers of the clinical applications of stem cell gene therapy for HIV.

Gerhard Bauer applied ribozyme-anti-HIV and other vectors to manufacture clinical grade, HIV-resistant hematopoietic stem cells for the first patients that received stem cell gene therapy for HIV, including the first child in the world and the first fully marrow-ablated HIV infected patient. Joseph Anderson developed the most recent and most potent combination anti-HIV lentiviral vectors and pluripotent stem cell applications for HIV gene therapy and tested these in the appropriate in vitro and vivo models, paving the way for novel HIV gene therapy approaches to possibly cure patients.

In Gene Therapy for HIV, Bauer and Anderson discuss the unique aspects of this therapy, including its limitations and proper safety precautions and outline a path for a possible functional cure for HIV using stem cell gene therapy based on a cure already achieved with a bone marrow stem cell transplantation performed in Germany using donor stem cells with a naturally arising CCR5 mutation. In addition, the Brief provides a thorough and methodical explanation of the basics of gene therapy, gene therapy vector development, in vitro and in vivo models for HIV gene therapy and clinical applications of HIV gene therapy, including Good Manufacturing Practices.

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Jul 152017

Thyroid Disorders: Basic Science and Clinical Practice

This book provides comprehensive knowledge about thyroid gland and highlights the recent trends in the management of thyroid dysfunctions.

Thyroid disorders are amongst the most prevalent of medical conditions possibly after diabetes. The prevalence of thyroid dysfunction in adults in the general population ranges from 1 to 10 percent, and is even higher in selected groups. In the United Kingdom, 1–2% of the adult population is found to have thyroid dysfunction. It is interesting to note that thyroxin is the sixth most commonly dispensed drug in Scotland. Virtually all studies report higher prevalence rates for hypothyroidism in women and with advancing age. 

Abnormal thyroid functions have important public health consequences. Suppressed TSH levels have been associated with decreased bone density and with an increased risk of atrial fibrillation and premature atrial beat. It has been known for decades that overt hypothyroidism contributes to elevated serum cholesterol levels and cardiovascular risk and recent studies suggest this may also be true with subclinical hypothyroidism?.
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Jul 152017

Disorders of the Patellofemoral Joint

Features: Used Book in Good Condition
By (author): John P. Fulkerson MD

The classic text by the leading expert on patellofemoral joint disorders is now in its thoroughly updated Fourth Edition, presenting comprehensive, current guidelines on the diagnosis and nonoperative and operative treatment of these common and controversial disorders. Highlights of this edition include revised chapters on imaging and arthroscopy of the patellofemoral joint and expanded coverage of nonarthritic anterior knee pain, patellar subluxation, patellar dislocation, articular cartilage lesions in patellofemoral pain patients, and surgical treatment of patellofemoral chondrosis and arthrosis. The concise and readable text is enhanced by more than 400 illustrations.

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