RNA Therapeutics

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Dec 302018

Medicinal chemistry is both science and art. The science of medicinal chemistry offers mankind one of its best hopes for improving the quality of life. The art of medicinal chemistry continues to challenge its practitioners with the need for both intuition and experience to discover new drugs. Hence sharing the experience of drug research is uniquely beneficial to the field of medicinal chemistry. Drug research requires interdisciplinary team-work at the interface between chemistry, biology and medicine. Therefore, the topic-related series Topics in Medicinal Chemistry covers all relevant aspects of drug research, e.g. pathobiochemistry of diseases, identification and validation of (emerging) drug targets, structural biology, drugability of targets, drug design approaches, chemogenomics, synthetic chemistry including combinatorial methods, bioorganic chemistry, natural compounds, high-throughput screening, pharmacological in vitro and in vivo investigations, drug-receptor interactions on the molecular level, structure-activity relationships, drug absorption, distribution, metabolism, elimination, toxicology and pharmacogenomics. In general, special volumes are edited by well known guest editors.
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Atlas of Human Body Ultrasound Scanning: Methods and Diagnostic Applications

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Dec 132018

This atlas describes the diagnosis practice and cases of human body ultrasound. It includes anatomic section, standard scan ultrasonogram of every organ, scanning methods and key points, measurement methods, normal value ranges, and clinical significances of every sections. Providing basic information and fundamental principles of ultrasonic diagnosis, it discusses ultrasound scanning of 14 organs in individual chapters. Each section sonography is accompanied by the scanning method, section structure, measuring method and clinical application. The uniform structure and detailed instructions make this atlas an easy-to-use resource for residents to refer to when they encounter specific ultrasound diagnostic problems.





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MicroRNA Regulatory Network: Structure and Function

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Dec 132018

This book discusses topics related to the topological structure and biological function of gene networks regulated by microRNAs. It focuses on analyzing the relation between topological structure and biological function, applying these theoretical results to gene networks involving microRNA, illustrating their biological mechanisms, and identifying the roles of microRNA in controlling various phenomena emerging from the networks. In addition, the book explains how to control the complex biological phenomena using mathematical tools and offers a new perspective on studying microRNA. It is a useful resource for graduate students and researchers who are working on or interested in microRNAs and gene network.





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Otolaryngology Cases: The University of Cincinnati Clinical Portfolio, Second Edition

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Nov 262018

In the tradition of the acclaimed first edition, experts from the University of Cincinnati’s Department of Otolaryngology-Head and Neck Surgery present new case reviews. Every chapter presents patient-based scenarios to prepare practitioners for ENT cases they will encounter during rounds, rotations, and patient exams. By establishing a uniform algorithm in obtaining and utilizing discreet points of data, the authors encourage a disciplined approach to patient assessment and management options.

Sections organized by anatomy and subspecialty enhance the ability to learn and retain knowledge. For example, benign and malignant pathologies are systematically detailed in anatomical sections dedicated to the neurovascular structures, oral cavity and pharynx, larynx, thyroid, salivary gland, and skin. The text covers the full age continuum – including congenital, acquired, benign, and malignant disorders such as pediatric subglottic stenosis and facial, head, and neck cancers that primarily affect adults.

Key Highlights

Presentation of 100 practical cases including history, differential diagnoses, test interpretations, definitive diagnoses, medical and surgical management, rehabilitation, and follow-up.
Up-to-date coverage of every major ENT specialty: otology and neurotology, the skull base, rhinology, laryngology, head and neck cancer, sleep disorders, pediatric otolaryngology, trauma, and facial plastic and reconstructive surgery.
Nearly 150 meticulous color photographs and graphics elucidate disease characteristics and clinical findings
Chapter bibliographies with current literature sources augment case reviews.
Multiple-choice questions serve as a robust study tool, optimizing knowledge acquisition and retention.
This must-have resource enables otolaryngology residents and practitioners to learn from case studies and incorporate state-of-the-art techniques into daily practice, thereby optimizing patient care.





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Current Developments in Stroke, Volume 1 : New Concepts in Stroke Diagnosis and Therapy

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Nov 262018

This volume presents a summary of recent research and debates on old and new aspects in stroke medicine. The volume covers topics such as causative factors of stroke such as hypertension, the immune system, genetic factors and the neurovegetative system, to the role of new imaging techniques in improving diagnosis and treatment, from preventive therapy and recanalization to the important and intriguing effects of neuroprotection, neuroregeneration and post stroke rehabilitation. Readers will be able to understand perspectives from stroke medicine researchers about the relationship between the nervous system and other physiological systems in the body and their role in the onset and treatment of stroke. The volume is intended as a resource for neurologists and medical professionals involved in other specialties such as cardiology, internal medicine, rehabilitation and physiology.





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Endoscopic Sinonasal Dissection Guide: Including Orbit and Skull Base, Second Edition

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Nov 262018

This remarkable manual encompasses the author’s 30 years of experience and unique perspectives teaching endoscopic sinonasal surgery to residents and fellows. It also reflects a wealth of surgical pearls from rhinology and endoscopic skull base surgery experts on how to safely navigate through the nose, sinuses, orbit, and skull base.

Following a stepwise approach designed to mirror a resident’s progression in the cadaver lab, this user-friendly manual includes the most pertinent information on instrumentation, anteroposterior approaches, and postero-anterior approaches. Starting with the philosophy and history of sinus surgery, the reader is introduced to basic anatomical and surgical concepts – progressing to complete sphenoethmoidectomy and frontal sinusotomy. Subsequent chapters delineate advanced dissection techniques including dacryocystorhinostomy, orbital decompression, anterior skull base resection, infratemporal fossa approach, nasopharyngectomy, and skull base repair techniques utilizing grafts and local/regional flaps. Complementary external approaches to the frontal and maxillary sinuses are also illustrated.

Key Features

Videos available online.
Exquisitely detailed full-color diagrams sequentially illustrate the appearance of the surgical cavity before and after resection, reinforcing the stepwise progression.
Key concepts expertly elucidated through extensive illustrations, endoscopic views, and CT/MRI scans.
Easy-to-follow anatomical landmarks pinpoint safe surgical sinus entry zones, respective of paranasal sinuses and mucociliary pathways.
Minimally invasive approaches to restore sinus ventilation and normal nasal functioning, as well as orbital and skull base procedures and approaches described in depth.
This visually-rich manual is ideal for residents in otolaryngology-head and neck surgery, as well as rhinology and endoscopic skull base fellows. It will also benefit otolaryngologists, ophthalmologists, and neurosurgeons who wish to brush up on specific endoscopic dissection techniques relative to their individual practice needs








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Stickmen’s Guide to Your Mighty Muscles and Bones

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Nov 212018

Muscles help you run, jump, play sports, and even sit still long enough to read this book. Your bony skeleton holds you up and keeps everything in its place. Let the Stickmen give you a tour of your incredible body! Find out why muscles are strong and how they get even stronger, how many bones make up your skeleton, and how your body twists, bends, and moves. Along the way, you’ll discover the world’s oldest skeleton, the longest and strongest muscle, and more. Colorful illustrations and fascinating facts reveal the inner workings of your muscles and bones

John Farndon is Royal Literary Fellow at Anglia Ruskin University in Cambridge, UK, and the author of a huge number of books for adults and children on science, technology, and nature





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First Aid for the COMLEX: An Osteopathic Manipulative Medicine Reveiw (First Aid Series)

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Nov 202018

Your Secret Weapon for Acing the COMLEX
The only step-by-step guide written by OMT fellows who aced the boards . .
Database of high-yield facts covering the latest board-tested OMM techniques and osteopathic considerations for each core clerkship. .

End-of-chapter questions and answers reinforce topic mastery and for exam-day practice. .
Crystal-clear illustrations clarify OMM concepts and anatomy. .
Primer on what to expect on the COMLEX PE exam, Part 1, and Part 2. .
Use with First Aid for the USMLE Step 1 and First Aid for the USMLE Step 2 CK for the ultimate board review!

“This is an easy to follow guide for a student who may not be sure of the preparatory process required to ensure their success in technique examinations. It is comprehensive and well organized, and would be a useful resource to draw together theory and technique to prepare for practice. 3 Stars.”–Doody’s Review Service.




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Stress Response Mechanisms in Fungi: Theoretical and Practical Aspects

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Nov 162018

This book covers both the molecular basics of fungal stress response strategies as well as biotechnological applications thereof. The complex regulatory mechanisms of stress response pathways are presented in a concise and well-readable manner. Also, light will be shed on the interconnection of pathways responding to different types of stress. Profound knowledge of stress responses in yeast and filamentous fungi is crucial for further optimization of industrial processes.
Applications are manifold, for example in fungicide development, for improving the resistance of crop plants to fungal pathogens, but also in medicine to help curing fungal infections.

The book targets researchers from academia and industry, as well as graduate students interested in microbiology, mycology and biomedicine.







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The Massachusetts General Hospital Guide to Depression: New Treatment Insights and Options

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Nov 162018

Major Depressive Disorder (MDD) is one of the most prevalent psychiatric disorders, with a lifetime prevalence rate of roughly 20%. MDD is a leading cause of disability and premature death worldwide, leads to greater impairment in work functioning than other chronic medical conditions, and has an estimated annual cost of $210 billion in the US.
The proposed text is designed for mental health professionals and will present state-of-the-art treatment options that are used in the Depression Clinical and Research Program (DCRP) at the Massachusetts General Hospital. The text provides different treatment options so that providers can ‘think outside the box’ of conventional interventions. The introductory sections discuss general themes about diagnosing and treating depression. The major body of the book, however, consists of chapters organized under the topics of new medication, new psychotherapy, alternative treatments, and consideration of specific populations and how to modify interventions to best treat these patients. Each chapter begins with a case vignette to illustrate key characteristics of the disorder process or treatment and reviews the history, research support, and new advances of these topics. In addition, the chapters include a description of how to apply this topic in treatment and frequently asked questions and answers.

This book will be a unique contribution to the field. Existing guides focus on individual treatments of Depression, or include brief descriptions of interventions as a whole. The DCRP has consistently been a forerunner of clinical treatments for depression and often treats challenging cases of this disorder. This book will provide a practical and useful resource with wide applicability.







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