Research Ethics in the Arab Region (Research Ethics Forum)

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Feb 142018
 

This book addresses the pressing issues involved with the ethical conduct of research in one developing world region – the Arab Region. Clinical research has soared in the developing world -as pharmaceutical companies continue their search for regions with large, treatment naive populations – including the Arab region, and has profound implications for the health and the economies for the area. The ethical issues involved with the conduct of such research, however, have so far not been adequately addressed. This volume presents the issues regarding research ethics and research governance that have relevance for health authorities, regulators, industry, and academia. As a multi-authored volume it includes both international and local experts on ethical issues in research, representing all stakeholders, thus presenting a balanced view on this timely topic.
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Interventional Treatment of Wounds: A Modern Approach for Better Outcomes

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Feb 142018
 

Our aging population, combined with an increase incidence of both diabetes and obesity, has fueled the need for better care of acute and chronic wounds associated with these diseases. Interventional Wound Healing focuses on what modern surgery can do to accelerate the healing of such wounds. Utilizing case studies alongside background and in-depth analysis for each technique with color images and videos, this book is intended to guide the reader in surgical and non-surgical procedures to assist with wound closure.

Edited by the medical director of the Brigham and Women’s Hospital Wound Care Center, Interventional Wound Healing takes the plastic surgeon’s point of view on wound care and various surgical and non-surgical interventional treatments. Where the typical wound care book addresses bandaging and dressing of various surface wounds, Interventional Wound Healing delves into the surgical and interventional procedures that can effectively treat both acute and chronic wounds. Written for wound care professional including physicians, podiatrists, nurses, residents and students this book features three distinct sections covering surgical methods and techniques, amputation, and interventional techniques, paying special attention to skin grafts, flaps, and substitutions, as well as arterial and venous interventions.

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Matrix Metalloproteinases In Health And Disease

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Feb 132018
 

The biochemistry and cell biology of Matrix Metalloproteinases (MMPs) are not necessarily straightforward, but basic information on the history of these enzymes, their various functions that extend far beyond the cleaving of the extracellular matrix, and the complex mechanisms that control their expression are valuable to both scientists and clinicians. This volume summarizes the salient features and functions of MMPs and applies this information in a practical manner in order to understand how they contribute to normal physiology and pathology of selected diseases. Chapters by noted clinicians Jean-Michel Dayer, MD in rheumatology, Jian Cao, MD in oncology, and Peter Libby, MD in cardiology, represent important practical and clinically-oriented contributions

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Network Meta-Analysis for Decision-Making

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Feb 122018
 

A practical guide to network meta-analysis with examples and code

In the evaluation of healthcare, rigorous methods of quantitative assessment are necessary to establish which interventions are effective and cost-effective. Often a single study will not provide the answers and it is desirable to synthesise evidence from multiple sources, usually randomised controlled trials. This book takes an approach to evidence synthesis that is specifically intended for decision making when there are two or more treatment alternatives being evaluated, and assumes that the purpose of every synthesis is to answer the question “for this pre-identified population of patients, which treatment is ‘best’?”

A comprehensive, coherent framework for network meta-analysis (mixed treatment comparisons) is adopted and estimated using Bayesian Markov Chain Monte Carlo methods implemented in the freely available software WinBUGS. Each chapter contains worked examples, exercises, solutions and code that may be adapted by readers to apply to their own analyses.

This book can be used as an introduction to evidence synthesis and network meta-analysis, its key properties and policy implications. Examples and advanced methods are also presented for the more experienced reader.

Methods used throughout this book can be applied consistently: model critique and checking for evidence consistency are emphasised.
Methods are based on technical support documents produced for NICE Decision Support Unit, which support the NICE Methods of Technology Appraisal.
Code presented is also the basis for the code used by the ISPOR Task Force on Indirect Comparisons.
Includes extensive carefully worked examples, with thorough explanations of how to set out data for use in WinBUGS and how to interpret the output.
Network Meta-Analysis for Decision Making will be of interest to decision makers, medical statisticians, health economists, and anyone involved in Health Technology Assessment including the pharmaceutical industry.

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http://nitroflare.com/view/297818815D4D126/9781118951651_Underaglassmoon.pdf

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Moral Distress in the Health Professions

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Feb 112018
 

 

This is the first book on the market or within academia dedicated solely to moral distress among health professionals. It aims to bring conceptual clarity about moral distress and distinguish it from related concepts. Explicit attention is given to the voices and experiences of health care professionals from multiple disciplines and many parts of the world. Contributors explain the evolution of the concept of moral distress, sources of moral distress including those that arise at the unit/team and organization/system level, and possible solutions to address moral distress at every level. A liberal use of case studies will make the phenomenon palpable to readers.
This volume provides information not only for academia and educational initiatives, but also for practitioners and the research community, and will serve as a professional resource for courses in health professional schools, bioethics, and business, as well as in the hospital wards, intensive care units, long-term care facilities, hospice, and ambulatory practice sites in which moral distress originates.

 

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http://nitroflare.com/view/82C62CAE700CC39/3319646257.pdf

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Biomechanics, Muscle Fibers, and How to Interface Experimental Apparatus to a Computer

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Feb 112018
 

 

This book is written to help and enable students in how to observe biological specimens in terms of viscosity, mass, elasticity and work producing elements. The observations are related to underlying chemical reactions by means of strain (fractional length change) sensitivity of the reactions, and a theory is developed how to connect these. Their mathematical derivation is complex when three or more states are involved, but a method is presented here to demonstrate how to simplify this complex problem. Basic mathematical solutions that are useful for this book, are presented (Fourier and Laplace transforms, differential equations, matrix operations) together with Fortran programs in the Appendix.

 

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http://nitroflare.com/view/D5F78D866670016/3319720341.pdf

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Telemanagement of Inflammatory Bowel Disease

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Feb 112018
 

 

This volume provides a comprehensive, state-of-the art review of inflammatory bowel disease and its management through the use of telemedicine applications. The book reviews barriers to successful outcomes in patients with IBD and offers a rationale for how self-management and telemedicine approaches can improve care in chronic illnesses such as IBD. This volume also includes a summary of the burden of telephone encounters in patients with IBD, characteristics of frequent callers to the office, outcomes associated with high telephone use, and strategies to provide education via telephone to patients with IBD. Prior literature on implementation of teleconsultation in research and clinical practice, as well as mobile applications used to track symptoms, quality of life, diet, and medication use in IBD are also explored in the book.

 

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Extracellular RNA

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Feb 112018
 

This volume provides a collection of methods and protocols detailing extracellular RNA and hopes to be a useful resource for those interested in this exciting and emerging field. Chapters are divided into four sections covering an overview of the field, approaches for the isolation of exRNA, protocols for detection and quantitation of exRNA, and approaches that can be useful for studies to evaluate potential therapeutic applications. Written in the highly successful Methods in Molecular Biology series format, chapters include introductions to their respective topics, lists of the necessary materials and reagents, step-by-step, readily reproducible laboratory protocols, and tips on troubleshooting and avoiding known pitfalls.
Authoritative and cutting-edge, Extracellular RNA: Methods and Protocols aims to ensure successful results in the further study of this vital field.

 

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Guide to Evidence-Based Physical Therapist Practice, Fourth Edition

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Feb 102018
 

Guide to Evidence-Based Physical Therapist Practice, Fourth Edition teaches the knowledge and skills to evaluate medical evidence and apply it to the practice of physical therapy. This valuable reference explains the fundamentals of medical research and how to determine which studies are useful in practice. As the leading evidence-based practice text for physical therapy, this is a comprehensive resource no physical therapist or student should be without.

The Fourth Edition has been updated with new clinical scenarios, additional research examples, and more activities to support the application of key concepts. This practical guide empowers readers to learn how to evaluate research designs, appraise evidence, and apply research in clinical practice. Its reader-friendly style facilitates learning and presents the knowledge essential for physical therapist students to develop a strong foundation in research methods and methodologies related to evidence-based medicine.

New to the Fourth Edition
• New Clinical Scenarios at the beginning of each chapter aid in the application of key concepts
• New chapter on appraising qualitative research studies
• Expanded coverage of clinical practice guidelines
• Updated coverage of the most commonly used electronic search engines
• Inclusion of updated terminology from the APTA’s Guide to Physical Therapist Practice 3.0

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http://nitroflare.com/view/930AE54437F3C91/Guide_to_Evidence-Based_Physical_Therapist_Practice.pdf

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Human Dna Polymerases

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Feb 102018
 

Maintenance of the information embedded in the genomic DNA sequence is essential for life. DNA polymerases play pivotal roles in the complex processes that maintain genetic integrity. Besides their tasks in vivo, DNA polymerases are the workhorses in numerous biotechnology applications such as the polymerase chain reaction (PCR), cDNA cloning, next generation sequencing, nucleic acids based diagnostics and in techniques to analyze ancient and otherwise damaged DNA (e.g. for forensic applications). Moreover, some diseases are related to DNA polymerase defects and chemotherapy through inhibition of DNA polymerases is used to fight HIV, Herpes and Hepatitis B and C infections. This book focuses on (i) biology of DNA polymerases, (ii) medical aspects of DNA polymerases and (iii) biotechnological applications of DNA polymerases. It is intended for a wide audience from basic scientists, to diagnostic laboratories, to companies and to clinicians, who seek a better understanding and the practical use of these fascinating enzymes.

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http://nitroflare.com/view/493E038F79A11F5/Human_Dna_Polymerases_Biology%2C_Medicine_And_Biotechnology.pdf

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