Jan 182017
 

Drug Target miRNA: Methods and Protocols (Methods in Molecular Biology)


This volume provides a concise and technical discussion of recently developed approaches to overcome challenges, such as pharmacodynamics and pharmacokinetics difficulties, in miRNA drug discovery. These strategies cover anti-sense agents targeting miRNA that are applied in advanced formulations or are chemically optimized to increase delivery; small molecule miRNA modulators to overcome anti-sense agents’ limitations; general enhancers of miRNA maturation; and Argonaute 2 protein and its pharmacokinetic parameters. Written in the highly successful Methods in Molecular Biology series format, chapters include introductions to their respective topics, lists of the necessary materials and reagents, step-by-step, readily reproducible laboratory protocols, and tips on troubleshooting and avoiding known pitfalls.

Cutting-edge and thorough, Drug Target miRNA: Methods and Protocols is a valuable resource for anyone interested in the ever-evolving field of miRNA drug discovery.

 

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Jan 172017
 

Antibiotics: Methods and Protocols (Methods in Molecular Biology)


This volume provides state-of-the-art and novel methods on antibiotic isolation and purification, identification of antimicrobial killing mechanisms, and methods for the analysis and detection of microbial adaptation strategies.  Antibiotics: Methods and Protocols guides readers through chapters on production and design, mode of action, and response and susceptibility. Written in the highly successful Methods in Molecular Biology series format, chapters include introductions to their respective topics, lists of the necessary materials and reagents, step-by-step, readily reproducible laboratory protocols, and tips on troubleshooting and avoiding known pitfalls.

Authoritative and cutting-edge, Antibiotics: Methods and Protocols aims to inspire scientific work in the exciting field of antibiotic research.

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Jan 122017
 

Safe at Home with Assistive Technology (Springerbriefs in Applied Sciences and Technology)


This book describes how assistive technology can help handicapped, elderly and acutely sick people to manage their daily lives better and stay safe in the home. It discusses how safety is understood from an ethical, technical and social perspective, and offers examples of the problems that users, their helpers and professional carers have with assistive technology in everyday situations.

The book provides insights from user-centred research and uses photographs to illustrate the main topic: how users and technology can work together to ensure safety. User-focused and combining experience with research, the book will interest users of these kinds of technology, health professionals who might introduce and/or prescribe them, engineers who develop and sell assistive technological gadgets, and architects who build safe homes – as well as researchers and students who work in these fields. It provides an overview of the existing technology, examines ways to test its effectiveness from the point of view of users, health professionals and researchers from different fields (architecture, education, engineering, facility management, medicine, nursing, occupational therapy, rehabilitative medicine, physiotherapy, social science and speech therapy), and lists useful addresses, websites and literature

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Jan 122017
 

Synopsis of Sleep Medicine


Here is a unique resource that provides a comprehensive and highly readable summary of the basic concepts and clinical applications in sleep medicine, written for all professionals involved in health care.

Sleep medicine encompasses an unusually board spectrum of contributions from biology, technology, and medicine. This volume summarizes the considerable mass of knowledge that has been accumulated in the field and imparts its major findings in a manner that is comprehensive yet not overwhelming. Edited by an eminent sleep researcher and with contributions from leading experts in the field, the volume provides a basic grounding in sleep medicine and covers the fascinating complexity of the field. It separates figure from ground for those who are newcomers to the field and who are seeking guideposts for further research.

Sleep problems are frequently co-morbid with other medical conditions, and clinicians need to be alert to this interconnectedness and to recognize which difficulties are primary and which are not. Synoposis of Sleep Medicine will be a valuable tool for clinicians in many specialties for addressing diagnostic problems in sleep medicine.

The volume is the first of its kind, rich yet comprehensive and focused and one that is sure to meet the needs of both basic and clinical research for some years to come.

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Jan 122017
 

A Microscopic Submarine in My Blood: Science Based on Fantastic Voyage


By (author): Sylvain Martel

This book describes at the introductory level how modern technology has made the scenario of the classic science-fiction movie Fantastic Voyage a reality. The movie is about a submarine and its crew members being shrunk to microscopic size and ventured into the body. Exactly 50 years following the release of the film, such reality takes the form of a medical interventional room capable of mimicking this scenario. Based on 15 years of intensive research and development by the world-leading team in this specific field, the book goes through the scenes of the movie while explaining how it is implemented in this first-of-a-kind interventional facility.

This is the first book that explains the fundamentals of navigation of therapeutic agents in the vascular network. The scope of the book is twofold: (1) to initiate readers into various technologies, including, but not limited to, nanotechnology, robotics, and biochemistry (more importantly, it shows how critical the integration of all these disciplines is to solving problems that indeed require a multidisciplinary environment); (2) to inspire the younger generation by showing that science and technology can bring one everywhere with the power to transform fiction to reality that can help humankind.

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Jan 122017
 

Regulatory Disorders in Infants: Assessment, Diagnosis, and Treatment


This innovative book discusses current findings on regulatory disorders in infants and offers practical guidelines for diagnosis and intervention. Focusing on core infant and toddler concerns including crying, sleeping, feeding, clinginess, and aggression, it presents a developmental continuum from normal to disturbed behavior regulation and examines science-based strategies for halting this trajectory. Case examples and widely used tools illustrate diverse approaches to assessment and diagnosis, emphasizing nuances of parent-infant interactions and parents‘ reactions that may fail to answer, or may even exacerbate, the child’s distress. And chapters outline counseling and therapy options for infants and parents, so that persistent problems do not become entrenched in children’s future behavior or lead to long-term family dysfunction.
Among the topics covered:
  • Approaches to diagnosing regulatory disorders in infants.
  • Feeding disorders in infants and young children.
  • Developmentally appropriate vs. persistent defiant and aggressive behavior.
  • Treatment approaches for regulatory disorders.
  • Video and video feedback in counseling and therapy.
Regulatory Disorders in Infants is an essential resource for clinicians and practitioners as well as researchers and graduate students in clinical child and school psychology, pediatrics, social work, psychiatry, and family studies. 
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Jan 122017
 

Cold Cases: Evaluation Models with Follow-up Strategies for Investigators, Second Edition (Advances in Police Theory and Practice)


By (author): James M. Adcock, Sarah L. Stein

Because the investigation of cold cases is usually an arduous and time-consuming task, most law enforcement agencies in the United States are not able to dedicate the resources necessary to support the cold case investigation process. However, when those cases are fully pursued and prosecuted, they often result in convictions and lengthy prison terms. Cold Cases: Evaluation Models with Follow-up Strategies for Investigators, Second Edition saves law enforcement time by providing detailed guidelines for determining if a cold case is solvable, and if so, how to organize, manage, and evaluate the investigation. It also provides techniques for developing investigative strategies to complement the evaluation process and resolve the crime.

This second edition featuresa new revised model and methodology for investigating cold cases suitable for all police and public safety agencies?large or small, domestic or international. This new model is more expeditious and convenient for departments that have less manpower and experience in dealing with cold cases. It emphasizes the prioritization of cold cases based on the availability of physical evidence and the chances of deriving matches from said evidence and an identified person of interest.

Additional topics covered in the second edition include:

  • How cases go cold
  • Strategies for creating a cold case unit
  • Cold case investigations in a Dutch educational environment?a chapter written by members of the Dutch Police Academy
  • New forensic science technologies, including DNA, CODIS, and AFIS
  • Case studies demonstrating advances in suspectology
  • Strategies for effective investigative interviewing
  • Challenges posed by staged crime scenes in cold cases
  • How to craft a cold case evaluation report

The expert authors of this book maintain The Center for the Resolution of Unresolved Crimes and conduct training and consulting worldwide. Their practical book is designed to help law enforcement agencies resurrect long-forgotten cases, bringing closure to victims and holding accountable those who are responsible.

This book is part of the Advances in Police Theory and Practice series

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Jan 122017
 

Stem Cells in Regenerative Medicine: Science, Regulation and Business Strategies


This book is a unique guide to emerging stem cell technologies and the opportunities for their commercialisation. It provides in-depth analyses of the science, business, legal, and financing fundamentals of stem cell technologies, offering a holistic assessment of this emerging and dynamic segment of the field of regenerative medicine.

• Reviews the very latest advances in the technology and business of stem cells used for therapy, research, and diagnostics

• Identifies key challenges to the commercialisation of stem cell technology and avenues to overcome problems in the pipeline

• Written by an expert team with extensive experience in the business, basic and applied science of stem cell research

This comprehensive volume is essential reading for researchers in cell biology, biotechnology, regenerative medicine, and tissue engineering, including scientists and professionals, looking to enter commercial biotechnology fields.

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Jan 122017
 

Pain : The Science and Culture of Why We Hurt


By (author): Marni Jackson

Pain. Everyone experiences it, yet we have trouble talking about it and science has only recently begun to understand how it works. Pain: The Fifth Vital Sign is a groundbreaking inquiry into the nature, treatment, and definition of modern pain.

In the United States, there has been a recent campaign to treat pain as the fifth vital sign. Just as temperature, respiration, pulse, and blood pressure, the four traditional vital signs, must be charted, hospitals are now obliged to assess pain in their patients, too. If this indeed happens, it will be nothing less than groundbreaking—making pain far more visible.

But how has it come about that we spend $24 billion a year in North America on Tylenol, Advil, and the rest, and yet chronic pain is on the rise? Why is it that medicine can master intrauterine surgery but it can’t help people with bad backs or migraines? Pain is the number one reason why people go to the doctor’s office, and the number one reason they come away disappointed.

For a long time, pain has been a dark continent, both in the body and in our culture.

However, medicine is finally learning to evaluate pain as something more than a symptom—a main focus rather than a frustrating side issue for doctors. In the questing and narrative manner of an Oliver Sacks “neurological novel” or Sherwin Nuland’s inquiry into dying, Pain: The Fifth Vital Sign maps this largely unexplored territory through the stories of people who live with pain—from fibromyalgia to phantom limb pain—as well as the words of pioneers of pain research, and the professional experiences of doctors, scientists, and nurses.

Above all, Pain: The Fifth Vital Sign makes an elusive subject vivid and readable. We all know what pain is. Now it has a voice.

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Jan 122017
 

The Finest Traditions of My Calling: One Physician’s Search for the Renewal of Medicine


By (author): Abraham M. Nussbaum

Patients and doctors alike are keenly aware that the medical world is in the midst of great change. We live in an era of continuous healthcare reforms, many of which focus on high volume, efficiency, and cost-effectiveness. This compelling, thoughtful book is the response of a practicing physician who explains how population-based reforms have diminished the relationship between doctors and patients, to the detriment of both. As an antidote to failed reforms and an alternative to stubbornly held traditions, Dr. Abraham M. Nussbaum suggests ways that doctors and patients can learn what it means to be ill and to seek medical assistance.
 
Using a variety of riveting stories from his own and others’ experiences, the author develops a series of metaphors to explore a doctor’s role in different healthcare reform scenarios: scientist, technician, author, gardener, teacher, servant, and witness. Each role influences what a physician sees when examining a person as a patient. Dr. Nussbaum cautions that true healthcare reform can happen only when those who practice medicine can see, and be seen by, their patients as fellow creatures. His memoir makes a hopeful appeal for change, and his insights reveal the direction that change must take.
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