Jul 072016
 

Cracking the Code


By (author): Stephen Damiani, Sally Damiani, Leah Kaminsky

A family doctor shares a mother and father’s determination to save their son. This story of a father’s search to find a diagnosis and ultimately a cure for his son’s mystery disease is an inspiration that has set the world of genetic medicine and research abuzz with the possibilities for the future.

After Cracking the Code screened on Australian Story, Stephen Damiani and his extraordinary ordinary family have been inundated with messages of support for Mission Massimo.

Stephen has a background in construction economics and risk management. He teamed with geneticist Ryan Taft to map his family’s genome in an attempt to discover the cause of his son’s illness and in the process developed a diagnostic tool that will revolutionise diagnoses and treatments of diseases as complex and rare as Massimo’s leukodystrophy to widespread diseases, such as diabetes and cardiovascular disease.

Previously, trying to find a specific gene mutation that might be responsible for a disease was a million times harder than finding a needle in a haystack. Stephen’s suggestion that Ryan align the genomes, or DNA blueprints, of himself; his wife, Sally; as well as Massimo to find any unique variations and thereby create a smaller haystack was previously untried. Stephen convinced Massimo’s neurologist, Dr Rick Leventer at Melbourne’s RCH, that it was just a case of technology, statistics, data, and money, but it could be done.

Once Taft was able to locate and isolate the specific genetic mutation of Massimo’s DARS gene, the hunt was on to find other children with the same genetic mutation so that the diagnoses could be confirmed.

With the help of Dr Adeline Vanderver at the Children’s National Hospital in Washington DC, along with Prof. Marjo van der Knaap and Dr Nicole Wolf in Amsterdam, they were able to locate several other children with DARS mutations and have now moved on to the next phase of Mission Massimo: finding a cure.

Crac…

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Jul 062016
 

Advances in Mathematical Modeling, Optimization and Optimal Control (Springer Optimization and Its Applications)


This book contains extended, in-depth presentations of the plenary talks from the 16th French-German-Polish Conference on Optimization, held in Kraków, Poland in 2013. Each chapter in this book exhibits a comprehensive look at new theoretical and/or application-oriented results in mathematical modeling, optimization, and optimal control. Students and researchers involved in image processing, partial differential inclusions, shape optimization, or optimal control theory and its applications to medical and rehabilitation technology, will find this book valuable.

The first chapter by Martin Burger provides an overview of recent developments related to Bregman distances, which is an important tool in inverse problems and image processing. The chapter by Piotr Kalita studies the operator version of a first order in time partial differential inclusion and its time discretization. In the chapter by Günter Leugering, Jan Soko?owski and Antoni ?ochowski, nonsmooth shape optimization problems for variational inequalities are considered. The next chapter, by Katja Mombaur is devoted to applications of optimal control and inverse optimal control in the field of medical and rehabilitation technology, in particular in human movement analysis, therapy and improvement by means of medical devices. The final chapter, by Nikolai Osmolovskii and Helmut Maurer provides a survey on no-gap second order optimality conditions in the calculus of variations and optimal control, and a discussion of their further development.

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Jul 062016
 

Computational Diffusion MRI: MICCAI Workshop, Munich, Germany, October 9th, 2015 (Mathematics and Visualization)


These Proceedings of the 2015 MICCAI Workshop “Computational Diffusion MRI” offer a snapshot of the current state of the art on a broad range of topics within the highly active and growing field of diffusion MRI. The topics vary from fundamental theoretical work on mathematical modeling, to the development and evaluation of robust algorithms, new computational methods applied to diffusion magnetic resonance imaging data, and applications in neuroscientific studies and clinical practice.

Over the last decade interest in diffusion MRI has exploded. The technique provides unique insights into the microstructure of living tissue and enables in-vivo connectivity mapping of the brain. Computational techniques are key to the continued success and development of diffusion MRI and to its widespread transfer into clinical practice. New processing methods are essential for addressing issues at each stage of the diffusion MRI pipeline: acquisition, reconstruction, modeling and model fitting, image processing, fiber tracking, connectivity mapping, visualization, group studies and inference.

This volume, which includes both careful mathematical derivations and a wealth of rich, full-color visualizations and biologically or clinically relevant results, offers a valuable starting point for anyone interested in learning about computational diffusion MRI and mathematical methods for mapping brain connectivity, as well as new perspectives and insights on current research challenges for those currently working in the field. It will be of interest to researchers and practitioners in the fields of computer science, MR physics, and applied mathematics.?

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Jul 062016
 

An Introduction to Male Reproductive Medicine


An Introduction to Male Reproductive Medicine is written specifically for readers seeking entry into this fast-moving, complex specialty with a solid understanding of the subject. The first chapters cover the anatomy and physiology, clinical evaluation, surgery, medicine, genetics and laboratory testing involved in the current evaluation and treatment of the infertile male, and the final chapter describes the interaction of the field with female reproductive medicine. Throughout the book, references are directly made to the fourth edition of the major text in the specialty, Infertility in the Male, edited by Larry Lipshultz, Stuart Howards and Craig Niederberger, allowing readers to expand their understanding of specific areas where desired. Each chapter is written by a well-renowned expert in an easy to follow, informal style, making the text ideal for students, residents and general physicians who are seeking to increase their general knowledge of the field.
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Jul 042016
 

Applying Lean in Healthcare: A Collection of International Case Studies


Typically entrenched and systemic, healthcare problems require the sort of comprehensive solutions that can only be addressed by a change in culture and a shift in thinking.Applying Lean in Healthcare: A Collection of International Case Studies demonstrates how honest appraisal, intelligent planning, and vigilant follow-up have led to dramatic improvements in a variety of healthcare settings across the world. It teaches us how innovative organizations can find sustainable solutions to seemingly intractable problems by following a path guided by Lean Thinking. Lean methods may not solve every healthcare problem, but as these cases prove, changing a culture rather than personnel results in more effective sustainable change.

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Jul 042016
 

Posterior Capsular Rupture: A Practical Guide to Prevention and Management


By (author): Amar Agarwal MS FRCS FRCOphth

Posterior Capsular Rupture: A Practical Guide to Prevention and Management addresses a nightmare of every cataract surgeon: a posterior capsular rupture. The book details each aspect of the process, from prevention of a posterior capsular rupture to management and IOL placement.

Dr. Amar Agarwal and his contributors, leading international ophthalmic surgeons, discuss the latest techniques in easy-to-understand text and format and include more than 250 high-quality photographs that enhance reader comprehension.

Posterior Capsular Rupture: A Practical Guide to Prevention and Management presents a variety of complicated cases and complications such as posterior polar cataracts, IOL scaffold & glued IOL, sutured IOLs, management of dislocated IOLs, and corneal damage & posterior capsule rupture, to name a few.

Additionally, a video website accompanies Posterior Capsular Rupture: A Practical Guide to Prevention and Management and allows readers to gain a better understanding of the subject. As a bonus, readers will be able to submit questions and receive clinical answers from Dr. Agarwal through the video website.

Practicing ophthalmologists, residents, and post-graduate students alike will benefit from this book’s clear portrayal of this difficult medical issue.




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Jul 042016
 

National Health Insurance in the United States and Canada: Race, Territory, and the Roots of Difference (American Government and Public Policy)


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By (author): Gerard W. Boychuk

After World War II, the United States and Canada, two countries that were very similar in many ways, struck out on radically divergent paths to public health insurance. Canada developed a universal single-payer system of national health care, while the United States opted for a dual system that combines public health insurance for low-income and senior residents with private, primarily employer-provided health insurance?or no insurance?for everyone else. In National Health Insurance in the United States and Canada, Gerard W. Boychuk probes the historical development of health care in each country, honing in on the most distinctive social and political aspects of each country?the politics of race in the U.S. and territorial politics in Canada, especially the tensions between the national government and the province of Quebec.

In addition to the politics of race and territory, Boychuk sifts through the numerous factors shaping health policy, including national values, political culture and institutions, the power of special interests, and the impact of strategic choices made at critical junctures. Drawing on historical archives, oral histories, and public opinion data, he presents a nuanced and thoughtful analysis of the evolution of the two systems, compares them as they exist today, and reflects on how each is poised to meet the challenges of the future.

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Jul 012016
 

Resolving Ethical Dilemmas: A Guide for Clinicians


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By (author): Bernard Lo MD

Resolving Ethical Dilemmas: A Guide for Clinicians, Fifth Edition

 

Now in its Fifth Edition, this respected reference helps readers tackle the common and often challenging ethical issues that affect patient care. The book begins with a concise discussion of clinical ethics that provides the background information essential to understanding key ethical issues. Readers then explore a wide range of real-world ethical dilemmas, each accompanied by expert guidance on salient issues and how to approach them. The book’s two-color design improves retention of material for visual learners. An accompanying website lets readers access the full text, along with features designed to reinforce understanding and test knowledge.

 

New to the Fifth Edition:
This edition includes new discussions of ethical issues as they relate to clinical practice guidelines and evidence-based medicine, electronic medical records, genetic testing, and opioid prescription. The book also includes an increased focus on ethical issues in ambulatory care. Readers will also find more detailed analysis of cases, more examples of ethical reasoning, more highlight pages relating clinical ethics to emergency medicine, oncology, palliative care, and family medicine. Also new are discussions of quality improvement and use of advance care planning rather than advance directives.

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Jul 012016
 

Adolescent Identities: A Collection of Readings (Relational Perspectives Book Series)


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Adolescent Identities draws the reader into the inner world of the adolescent to examine the process of identity formation through the various lenses of history, anthropology, sociology, psychology, and psychoanalysis.

The volume reveals there is no single “normal” adolescent, nor is there a singular adolescent experience. Editor Deborah L. Browning illustrates that in the course of development, each individual must integrate one’s unique biologically-given constitution and temperament, personal life history, and  the influence of the social and cultural milieu.

The book consists of six sections, arranged by concentric circles of influence, from the most exterior, identifiable, and potentially overt and conscious, to the most internal, private, and potentially unconscious concerns. Opening papers are drawn from sociology, European history, and cross-cultural anthropology, and address the question of whether and how adolescence can be considered a stage in development.

The second section explores how visible or potentially knowable minority statuses are experienced, and how these interact with individual identity processes. Moving closer to the adolescent’s interpersonal world, the third section presents papers about intimate relationships between adolescents and about the conscious preoccupations of adolescents when they are alone.

Extensive excerpts of Erikson’s most important contributions on identity formation and adolescence are offered in the fourth section. Papers on the most internal, private, and potentially unconscious conflicts comprise the fifth section. The book concludes with a section of papers on “failed solutions” to the challenge of adolescent identity consolidation: homelessness, drug abuse, eating disorders, and suicide.

Adolescent Identities provides mental health practitioners, teachers, and graduate students in both fields with a variety of perspectives on the internal experience of adolescents.

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Jul 012016
 

Clinician’s Guide to Bipolar Disorder: Integrating Pharmacology and Psychotherapy (100 Cases)


By (author): David J. Miklowitz PhD, Michael J. Gitlin MD

This much-needed volume gives clinicians essential strategies for managing the complexities of bipolar disorder and tailoring treatment to each patient’s changing needs. Highly readable, accessible, and pragmatic, the book provides expert guidance on critically important treatment questions. It addresses which medications to try and at what dosages, what psychosocial interventions are most helpful at different phases of the illness, how to continually monitor and fine-tune treatment to keep patients functioning well, and how to involve family members productively. The authors draw on state-of-the-art research as well as extensive clinical experience as a psychotherapist and a psychopharmacologist. Vivid case material is included throughout. Reproducible questionnaires and forms can be downloaded and printed in a convenient 8 1/2″ x 11″ size.

Winner (First Place)–American Journal of Nursing Book of the Year Award, Psychiatric and Mental Health Nursing Category
 
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