Activation of Viruses by Host Proteases (May 2018 Release)

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Jul 102018

This book will give an overview on viruses undergoing proteolytic activation through host proteases. The chapters will be organized in three themed parts, the first part describing respective viruses and their characteristics in detail. In the second part the molecular and cellular biology of the proteases involved as well as their physiological functions will be further explored. The third part will contain a chapter on protease inhibitors that are promising tools for antiviral therapy.
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Basic Applied Bioinformatics

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Jul 052018

An Accessible Guide that Introduces Students in All Areas of Life Sciences to Bioinformatics

Basic Applied Bioinformatics provides practical guidance in bioinformatics and helps students to optimize parameters for data analysis and then to draw accurate conclusions from the results. In addition to parameter optimization, the text will also familiarize students with relevant terminology. Basic Applied Bioinformatics is written as an accessible guide for graduate students studying bioinformatics, biotechnology, and other related sub-disciplines of the life sciences.

This text outlines the basics of bioinformatics, including pertinent information such as downloading molecular sequences (nucleotide and protein) from databases; BLAST analyses; primer designing and its quality checking, multiple sequence alignment (global and local using freely available software); phylogenetic tree construction (using UPGMA, NJ, MP, ME, FM algorithm and MEGA7 suite), prediction of protein structures and genome annotation, RNASeq data analyses and identification of differentially expressed genes and similar advanced bioinformatics analyses. The authors, Chandra Sekhar Mukhopadhyay, Ratan Kumar Choudhary, and Mir Asif Iquebal are noted experts in the field and have come together to provide updated information on bioinformatics.

Salient features of this book include:

Accessible and updated information on bioinformatics tools
A practical step-by-step approach to molecular-data analyses
Information pertinent to study a variety of disciplines including biotechnology, zoology, bioinformatics and other related fields
Worked examples, glossary terms, problems and solutions.

Basic Applied Bioinformatics gives students studying bioinformatics, agricultural biotechnology, animal biotechnology, medical biotechnology, microbial biotechnology, and zoology an updated introduction to the growing field of bioinformatics

About the Authors
Chandra Sekhar Mukhopadhyay is an Assistant Scientist (Senior Scale) at the School of Animal Biotechnology, Guru Angad Dev Veterinary and Animal Sciences University (GADVASU) at Ludhiana, Punjab, India.

Ratan Kumar Choudhary is an Assistant Professor at the School of Animal Biotechnology, Guru Angad Dev Veterinary and Animal Sciences University (GADVASU) at Ludhiana, Punjab, India.

Mir Asif Iquebal is a Scientist at the Centre for Agricultural Bioinformatics, Indian Council of Agricultural Research-Indian Agricultural Statistics and Research Institute (ICAR-IASRI) at Pusa, New Delhi, India.


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Applied Exercise Psychology

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Jul 052018

Applied Exercise Psychology emphasizes the application of evidence-based knowledge drawn from the fields of exercise psychology, health psychology, clinical and counseling psychology, and exercise physiology for physical activity behavior change. The book provides readers with:

theoretical bases for understanding and promoting physical activity behavior;
interventions to use for facilitating physical activity behavior change and the tools for measuring the effectiveness of these interventions;
cross-cultural considerations for practitioners to ensure multicultural competency;
considerations to guide best practices with special populations (e.g., persons with medical conditions and persons with mental health conditions);
overall applied implications and future directions.

The collection builds a bridge between up-to-date research findings, relevant field experiences, and applied implications. This is the first book to cover such breadth of topics in applied exercise psychology, with chapters bringing often overlooked issues to the attention of practitioners to promote not only evidence-based practice but also responsible ethics and referral.

“Applied Exercise Psychology is an exceptional contribution to the field. Razon and Sachs focus on the immense challenges associated with increasing exercise participation rates. This thought-provoking compendium includes a diverse array of 32 chapters that focus on theoretical foundations and applied suggestions for exercise adoption and adherence by respected researchers in the field.” – Bonnie G. Berger, Bowling Green State University, USA

“Razon and Sachs, along with nearly 60 international scholars, seek to narrow the gap between people’s good intentions toward living healthy, active lifestyles and their achievement of these goals. Their book uniquely links theory, research, and practice together in relatable, relevant, and nuanced ways – ways that can truly make a difference!” – Bradley J. Cardinal, Oregon State University, USA

“This book provides a timely and important integration of research and application and will be essential reading for anyone interested in the field of applied exercise psychology. It breaks new ground regarding best practice, compiling contributions from world-leading scholars and highlighting important cross-cultural and demographic considerations. I can recommend it to students, researchers, and practitioners alike.” – Chris Wagstaff, University of Portsmouth, UK

About the Author
Selen Razon is an assistant professor in the Department of Kinesiology, College of Health Sciences, West Chester University.

Michael L. Sachs is a professor in the Department of Kinesiology, College of Public Health, Temple University.


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Fluency Plus

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Jul 042018

Fluency disorders such as stuttering, cluttering, and atypical disfluency are often accompanied by concomitant speech and language disorders, as well as other disorders impacting and interacting with fluency. Despite this common presentation, there is little training for speech-language pathologists to confidently treat fluency disorders and concomitant disorders together. Fluency Plus: Managing Fluency Disorders in Individuals with Multiple Diagnoses fills this much-needed gap, providing a strong research base along with practical strategies and treatment activities to guide speech-language pathologists in managing clients with fluency and concomitant disorders.

Dr. Kathleen Scaler Scott brings her years of clinical experience and her research in the areas of stuttering, cluttering and atypical disfluencies to Fluency Plus, designing it to act as both a textbook for students and a practical guide for the clinician. The comprehensive review of current definitions of fluency disorders and the evidence base for treatments will be of great help to students, while clinicians will appreciate the specific guidelines, strategies, and activities for managing fluency in concomitant disorders.

After reviewing general principles and covering how executive functions relate to the management of these multiple concerns, the text addresses seven concomitant disorder areas the speech-language pathologist may encounter in practice. For each disorder category, an overview of potential fluency problems is provided, myths regarding treatment of fluency disorders in each population are debunked, and effective treatment activities are recommended.
Some Concomitant Disorders Covered:
Intellectual Disability
Speech Sound Disorders (apraxia, phonological, articulation disorders)
Learning Disabilities, Auditory Processing and Language Disorders
Attention Deficit Hyperactivity Disorder
Autism Spectrum Disorder
Selective Mutism

Fluency Plus: Managing Fluency Disorders in Individuals with Multiple Diagnoses helps close an education and training gap for students and clinicians alike by increasing their confidence, knowledge, and skills when dealing with fluency disorders and complex combinations of concomitant disorders

About the Author
Kathleen Scaler Scott, PhD, CCC-SLP, BCS-F, is a practicing speech-language pathologist, board-certified specialist in fluency disorders, and associate professor of speech-language pathology at Misericordia University in Dallas, Pennsylvania. She has been a practicing clinician for over 25 years in school, hospital, and private practice settings. Her clinical and research work has included focus on the impact of executive functions on daily speech and communication. Dr. Scaler Scott’s research interests are largely in cluttering, atypical disfluency, and clinician training and treatment effectiveness. She is the co-editor of Cluttering: A Handbook of Research, Intervention, and Education (2011) and co-author of Managing Cluttering: A Comprehensive Guidebook of Activities (2013), both with Dr. David Ward. Dr. Scaler Scott has spoken nationally and internationally on the topics of fluency and social pragmatic disorders. She is a certified special education and elementary education teacher and was the first coordinator of the International Cluttering Association.


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The Surgeon’s Guide to SMILE

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Jul 042018

Corneal refractive surgeons are likely already familiar with the theory behind small incision lenticule extraction (SMILE) and the excellent postoperative outcomes it can achieve, but they were left without a thorough and comprehensive guide to performing the procedure, until now. The Surgeon’s Guide to SMILE: Small Incision Lenticule Extraction is designed to provide surgeons who are interested in starting or are already performing SMILE with a detailed description of the preoperative assessment, surgical technique, and postoperative management of SMILE treatments.

This book by Professor Dan Z. Reinstein, Mr. Timothy J. Archer, and Dr. Glenn I. Carp is designed as a surgical video-fellowship, focusing on the granular details of every aspect of patient preparation and management with special attention to how to perform a perfect routine SMILE procedure. The protocols and methods are sourced in both the published scientific evidence and the extensive experience and expertise of the authors. It also includes tips and tricks of how to manage the full range of possible scenarios and complications that can occur during and after a SMILE surgery. Each process described in the book is accompanied by at least one, and in many cases numerous, narrated video examples.

This dynamic learning tool is supplemented by the SMILE video library containing over 16 hours of surgical videos and tutorials.

The succinct and demonstrative style of The Surgeon’s Guide to SMILE: Small Incision Lenticule Extraction will help novice and experienced SMILE surgeons alike learn important techniques and improve their outcomes.

From the Foreword:
“The reader is in for a treat, receiving authoritative technical information from seasoned leaders in the field of refractive surgery, who have attained tremendous experience in excimer laser ablation and who have also been on the forefront of scientific evaluation of the new femtosecond only surgical approach that is SMILE.”
-J. Bradley Randleman, MD, University of Southern California, Los Angeles, CA

About the Author
Dan Z. Reinstein, MD, MA(Cantab), FRCSC, DABO, FRCOphth, FEBO is the Medical Director of London Vision Clinic, London, UK, Adjunct Professor of Ophthalmology at Columbia University Medical Center, New York, Visiting Professor at Ulster University, Coleraine, UK, and Professeur Associe en Ophtalmologie at the Centre Hospitalier National d’Ophthalmologie des Quinzes Vingts, Paris, France.

Professor Reinstein received his undergraduate degree from Cambridge University, Cambridge, UK, and his postgraduate degree in medicine from the University of Cambridge School of Clinical Medicine. He conducted his internship in medicine at the University College London School of Medicine, University of London, UK. He spent several years at the Weill Medical College of Cornell University in New York as a Bioengineering Fellow, developing very high-frequency (VHF) digital ultrasound technology (Artemis Insight 100) for studying the micro-anatomical structure of the cornea in vivo. His residency in ophthalmology was at the Icahn School of Medicine at Mount Sinai, New York, and his Fellowship training in refractive surgery, cornea, and external diseases of the eye was completed at the University of British Columbia, Vancouver, British Columbia, Canada. He is US board-certified and a Diplomat of the American Board of Ophthalmology, Fellow of the Royal College of Physicians and Surgeons (Canada), Fellow of the Royal College of Ophthalmologists (UK), and Fellow of the European Board of Ophthalmology.

Professor Reinstein’s research focuses on applications of VHF digital ultrasound technology to improve corneal and phakic intraocular refractive surgery with a particular focus on measurement and analysis of corneal epithelial changes for applications such as keratoconus screening and therapeutic corneal refractive surgery. He has held the position of lead consultant to Carl Zeiss Meditec for 17 years, developing their presbyopic excimer laser application (PRESBYOND Laser Blended Vision) and has contributed to the development of SMILE: a flapless keyhole intrastromal method of performing keratomileusis. His research has led to more than 145 peer-reviewed publications, 35 book chapters and 550 international presentations and lectures. He was awarded the Waring Medal in 2006 and received the Kritzinger Award in 2013. He holds more than 10 patents in the field of corneal laser refractive surgery, ultrasound diagnostic imaging and signal processing.
In 2015, Professor Reinstein was appointed Visiting Professor at Ulster University, in order to join the faculty of the Post-Graduate Diploma in Cataract and Refractive Surgery—one of the few formal training courses in refractive surgery. Together with his colleagues at the London Vision Clinic, he provided a total 34 lectures to update the corneal laser refractive surgery half of the course.

Concurrently with his medical career Professor Reinstein has been playing the saxophone for over 40 years including 2 years as performance scholar at the Berklee College of Music, Boston, Massachusetts, and he continues to play jazz on a regular basis.
Glenn I. Carp, MBBCh, FC Ophth (SA) is a distinguished and skilled ophthalmic surgeon, who has undergone one of the most extensive training programs of any laser eye surgeon in the UK. He is one of the very few full-time consultant Ophthalmic Surgeons in the UK to dedicate his entire professional career to corneal laser refractive surgery.

Born and educated in South Africa, he qualified as a doctor in 1996 in Johannesburg. He began his career in ophthalmology as an Ophthalmic Senior House Officer, followed by a year spent as a Clinical Research Officer, and followed this with his residency training in the Department of Ophthalmology at the University of the Witwatersrand in South Africa. On completion of his training he was awarded the Elie Dahan Opthalmic Surgery Prize for outstanding performance.

On emigrating to the UK, Mr. Carp was selected for a prestigious 1-year fellowship in Cornea and Anterior Segment Pathology and Surgery at the Western Eye Hospital, London. He subsequently undertook an 18-month fellowship in Laser Refractive Surgery at the London Vision Clinic under Professor Dan Reinstein and has now, in turn, supervised the training of 6 fellows at the London Vision Clinic. Mr. Carp is a regular attendee both at national and international congresses around the world, delivering more than 200 lectures at professional meetings on 5 continents. In addition, he has published more than 25 articles in peer-reviewed medical journals and in the Ophthalmic press. He is also a Carl Zeiss Meditec-appointed expert and speaker both for congress symposia and training courses. Mr. Carp’s teaching experience also extends to being a supervisor and contributor to a number of lectures on the Ulster University Post-Graduate Diploma in Cataract and Refractive Surgery. He has himself achieved a distinction for this Diploma and was awarded the Certificate in Laser Refractive Surgery from the Royal College of Ophthalmologists in the UK in 2009.

Mr. Carp had his own laser eye surgery with Professor Reinstein in 2006, and recently returned the favor in April 2016.

Timothy J. Archer, MA(Oxon), DipCompSci(Cantab) has been the research manager at the London Vision Clinic since 2003. He arrived at the clinic having studied mathematics at Oxford University followed by computer science at Cambridge University. His numerical background has enabled him to form an efficient partnership with Professor Reinstein and Mr. Carp by combining analytical skills and mindset with their surgical and clinical knowledge.
Over the last 14 years, Mr. Archer has built up the London Vision Clinic research output to produce more than 1 peer-reviewed publication each month, as well as overseeing the preparation of more than 100 presentations at international conferences and training courses each year. He was instrumental in preparing the lecture materials for the Ulster University Post-Graduate Diploma Cataract and Refractive Surgery and is currently completing a PhD under the supervision of Professor Tara Moore at Ulster University. He is responsible for running the biannual training courses in PRESBYOND Laser Blended Vision and SMILE, also participating as a lecturer in treatment planning and nomogram development.

Mr. Archer has also applied his computer science background to build and implement various software solutions to maximize the efficiency of data analysis at London Vision Clinic. These have included building the PIQASO II database to automate the analysis of refractive surgery outcomes, as well as managing the project to transition from paper charts to electronic medical records. His expertise in refractive surgery outcomes analysis has led to his contributions to the series of editorials in the Journal of Refractive Surgery expanding and updating the Standard Graphs for Reporting Refractive Surgery. As part of this process, he built a publicly available template spreadsheet for plotting these graphs according to the published format.


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Negative Symptom and Cognitive Deficit Treatment Response in Schizophrenia

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Jul 022018

For the first time in a single volume, distinguished experts address the complex issues – issues rarely confronted in empirical studies of patients with schizophrenia – and controversial research surrounding the assessment of negative symptoms and cognitive deficits in patients with schizophrenia.
Despite recent advances in our understanding of schizophrenia, still notably absent is consensus in assessing negative symptom treatment response. What is the most effective assessment method – given the varying methodologies and contradictory results to date? What constitutes an adequate response? Which medication – none is specifically indicated and licensed for negative symptom treatment – yields the best results? What are the indications for use of this medication? Which instrument best measures negative symptom treatment response (eight rating scales are analyzed here)? Reaching consensus among clinicians and researchers alike is even more difficult because assessment is often thwarted by extrapyramidal side effects of medications, similarities to depressive symptoms, and secondary effects of psychotic experiences.
In addition to clarifying these pressing issues, Negative Symptom and Cognitive Deficit Treatment Response in Schizophrenia also discusses The importance of measuring the experience of emotion versus the more traditional objectively measured symptoms in patients with schizophrenia, and how deficits in emotional experience may resist treatment – even in treatment-responsive patients.
The family as an often overlooked source of information about negative symptom improvement or worsening, and the impact of negative symptoms on patients’ relatives.
How treatment affects social functioning and subjective experience of “quality of life,” and the importance of neurocognitive dysfunction in the social deficits of schizophrenia, which often persist despite significant amelioration of other symptoms.
Specific guidelines for assessing neurocognitive treatment response. Cognitive enhancement is a major factor in improving the quality of patients’ lives.
The latest research on the neurobiology of negative symptoms, including the role of various neurotransmitter systems and brain regions in mediating negative symptom pathology. Also discussed is single vs. multiple pathophysiological processes and single treatment modality vs. distinct treatments for different aspects of negative symptoms.
How to distinguish “pure” negative symptoms from deficit symptoms (i.e., those that persist for at least 1 year and are not secondary to factors such as depression, medication side effects, anxiety, delusions, and hallucinations), and which treatment is indicated for each.
Highlighted by patient vignettes, this in-depth guide will be welcomed by all clinicians who treat patients with schizophrenia and want to know and document whether their interventions ameliorate negative symptoms and cognitive dysfunction, and by all researchers who study schizophrenia, particularly those interested in clinical issues and treatment studies.


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3D Bioprinting in Regenerative Engineering:: Principles and Applications

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Jun 232018

This book is comprehensive in nature with contributions by leading world experts in 3D bioprinting related to regenerative engineering. It includes history, incorporating the process and methods used in bioprinting. Significant sections will be reserved for the applications of the types of tissues generated by using bioprinting, along with an overview of different technologies used in bioprinting. In addition to equipment, the book also describes the different biomaterials and cells used in these approaches. Overall this is a book that includes both entry-level knowledge and advanced methods and techniques. Applications will emphasize engineering and clinical principles.


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Poised for Peak Performance in Healthcare: A Practical Approach to Execute Expense Reduction and Revenue Enhancement Initiative

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Jun 222018

The current healthcare system is under attack by market, government, and consumer forces. To stay solvent, organizations must be performing at the top of their game. This book provides detailed instructions to bring organizations to the next level of performance by teaching all the secrets straight from the healthcare consultant’s playbook in less than 100 days.

This book defines the coming challenges in the healthcare environment and provides a 10-step solution to develop the infrastructure for peak performance. These solutions include detailed implementation plans, software, reports, metrics, and the top projects that yield the highest financial rewards.

This is the first book of its kind to not just discuss the top strategies, but also provide step-by-step instructions to achieve results. The book defines the strategy, the tactics, the infrastructure, the targets, the solutions, the barriers, and the leadership required to achieve a high performing organization. With these simple instructions, any organization with the will to achieve a brighter future can be poised for success in the next decade in less than 100 days.


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Physical Medicine and Rehabilitation Q&A Review, Second Edition

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Jun 132018

Now with a free mobile & web app with print purchase!

Revised, expanded, and updated new edition of the first and only Q&A review for physical medicine and rehabilitation. Question and answer format remains one of the most effective methods for self-study and exam preparation. Physical Medicine and Rehabilitation QA Review, Second Edition is a comprehensive, active self-assessment tool for medical students, residents, and attending physicians. Configured to help professionals quickly and efficiently review core topics, the book covers in detail the breadth and scope of physical medicine & rehabilitation (PM&R) knowledge and practice.

Now with 16 sections addressing key concepts and including emerging high-value content areas, the expanded second edition contains over 1,850 multiple-choice questions with answers and explanations. The must-know information in the PM&R curriculum for learning, individual self-assessment, and board review is at your fingertips.

Key Features

Comprehensive coverage of the knowledge base and clinical practice areas necessary for success
More questions! Over 350 new questions on pain medications and conversion equivalents, gait patterns and analysis, spinal cord injury, and much more
Completely new chapter on Ultrasound and Regenerative Medicine
All questions and explanations reviewed and updated for currency and comprehensiveness; new illustrations added to enhance understanding


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Evaluation and Management of Autonomic Disorders: A Case-Based Practical Guide

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Jun 122018

This book approaches the basic features of autonomic dysfunction in a practical way, complemented by an examination of unique and didactic case reports. Unlike other books on autonomic disorders, its goal is to provide a brief, practical and ready to use resource for physicians faced with patients’ autonomic complaints. Autonomic dysfunctions are specific disorders that affect or are related to the autonomic nervous system.
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