Features a practical approach to the analysis of biomedical data via mathematical methods and provides a MATLAB® toolbox for the collection, visualization, and evaluation of experimental and real-life data
Applied Mathematics for the Analysis of Biomedical Data: Models, Methods, and MATLAB® presents a practical approach to the task that biological scientists face when analyzing data. The primary focus is on the application of mathematical models and scientific computing methods to provide insight into the behavior of biological systems. The author draws upon his experience in academia, industry, and government–sponsored research as well as his expertise in MATLAB to produce a suite of computer programs with applications in epidemiology, machine learning, and biostatistics. These models are derived from real–world data and concerns. Among the topics included are the spread of infectious disease (HIV/AIDS) through a population, statistical pattern recognition methods to determine the presence of disease in a diagnostic sample, and the fundamentals of hypothesis testing.
In addition, the author uses his professional experiences to present unique case studies whose analyses provide detailed insights into biological systems and the problems inherent in their examination. The book contains a well-developed and tested set of MATLAB functions that act as a general toolbox for practitioners of quantitative biology and biostatistics. This combination of MATLAB functions and practical tips amplifies the book’s technical merit and value to industry professionals.
Through numerous examples and sample code blocks, the book provides readers with illustrations of MATLAB programming. Moreover, the associated toolbox permits readers to engage in the process of data analysis without needing to delve deeply into the mathematical theory. This gives an accessible view of the material for readers with varied backgrounds. As a result, the book provides a streamlined framework for the development of mathematical models, algorithms, and the corresponding computer code.
In addition, the book features:
• Real–world computational procedures that can be readily applied to similar problems without the need for keen mathematical acumen
• Clear delineation of topics to accelerate access to data analysis
• Access to a book companion website containing the MATLAB toolbox created for this book, as well as a Solutions Manual with solutions to selected exercises
Applied Mathematics for the Analysis of Biomedical Data: Models, Methods, and MATLAB® is an excellent textbook for students in mathematics, biostatistics, the life and social sciences, and quantitative, computational, and mathematical biology. This book is also an ideal reference for industrial scientists, biostatisticians, product development scientists, and practitioners who use mathematical models of biological systems in biomedical research, medical device development, and pharmaceutical submissions.
PETER J. COSTA, PhD, is Senior Applied Mathematician at Hologic Incorporated in Marlborough, MA. Dr. Costa is the co-creator of MATLAB’s Symbolic Math Toolbox. He has developed mathematical models for the spread of HIV, the outbreak of AIDS, the transmission of an infectious respiratory disease throughout a population, and the diagnosis of cervical cancer. His research interests include scientific computing and mathematical biology. He received a PhD in Applied Mathematics from the University of Massachusetts at Amherst.
This book provides the reader with the best available evidence on the most pressing issues relating to reconstruction of the anterior cruciate ligament (ACL) with the goal of supporting surgical reconstruction of the ACL and improving outcomes for patients. Key topics for which evidence-based information is presented include selection of graft material and source, the use of different surgical techniques, graft rupture in relation to surgical technique, and progression to osteoarthritis. The book will aid the surgeon in making decisions with respect to fixation devices and tensioning, the bundles to be reconstructed, and whether to preserve remnants or partial bundle ruptures. An evidence-based stance is taken on evolving topics such as the anatomy of the tibial insertion site of the ACL and the role of the anterolateral capsule and posteromedial corner in high-grade rotatory instability. Furthermore, novel technical developments for measurement of knee laxity and soft tissue navigation are discussed. The reader will also find useful information on general issues concerning physical examination, arthroscopic setup, timing of reconstruction, anesthesia, and anticoagulation.
This text provides a comprehensive, state-of-the art review of complex endovascular aortic techniques. It will serve as a valuable resource for vascular and cardiovascular surgeons, interventionalists, cardiologists, clinicians, bioengineers and researchers with an interest in complex aortic diseases. The book reviews imaging modalities, diagnostic work up and novel endovascular approaches. Technical aspects are provided by experts in the field, with over 600 illustrations and photographs of key steps for each type of procedure. Results of epidemiologic studies and national databases are summarized, as well as large institutional experiences. An evidence-based approach is used for recommendations regarding best therapies. Other highlights of this unique text include: A new, state-of-the-art review on fenestrated, branched and parallel stent-graft techniques from procedure planning to stent design and implantation. A text dedicated to a topic that has been increasingly recognized by vascular specialists as a priority area in aortic management. An updated overview of current designs and future developments. Special attention to technical details of the procedures with use of illustrations. Technical tips on how to get out of problems during these challenging procedures.
Endovascular Aortic Repair: Current Techniques with Fenestrated, Branched and Parallel Stent-Grafts will serve as a very useful resource for physicians and researchers dealing with and interested in complex aortic diseases. It will provide a concise yet comprehensive summary of the current status of the field that will help guide patient management and stimulate investigative efforts. All chapters are written by experts in their fields and include the most up to date scientific and clinical information.
Providing a sound definition and review of the pertinent treatment goals for the management of adult lumbar scoliosis, this practical and comprehensive guide covers everything from pre-operative evaluation and radiography to post-operative management and complications. Both non-operative and operative strategies are presented, including minimally invasive techniques, decompression, anterior release, spinal osteotomy, and proximal and distal fixation, with an emphasis on clinical guidelines and management outcomes. The impact and prevention of complications following treatment are also discussed, including the prevention of proximal junctional kyphosis. Concluding with an examination of future directions for research and clinical treatment strategies, the comprehensive approach of this book provides the orthopedic surgeon, neurosurgeon and spinal practitioner with the most current evidence and expert thought about the evaluation and management of adult lumbar scoliosis.
This book provides a comprehensive, state-of-the-art review of this evaluation of voiding disorders and will serve as a valuable resource for clinicians and surgeons. The book reviews the basic indications for urodynamics as well as the interpretation of basic and advanced studies with the use of clinical vignettes. In addition to step-by-step description in text, the textbook provides illustrations/photographs and tracings of different urodynamics scenarios. This atlas of urodynamics will serve as an extremely useful resource for physicians dealing with and interested in the evaluation of pelvic floor disorders and voiding dysfunction. It will provide a concise and comprehensive review of all the different types of urodynamics scenarios, while instructing its readers on how to accurately and consistently interpret these studies. All chapters are written by experts in the fields of pelvic floor disorders and voiding dysfunction.
The fifth edition of this practical textbook on transfusion medicine has been thoroughly revised with the latest in scientific and technological developments and edited by a leading team of international expert haematologists, including new co-editor Mark H. Yazer MD.
A succinct and user-friendly resource of transfusion medicine for clinicians, scientists and trainees with key points, charts and algorithms
Discusses practice in blood centres and hospitals including regulatory aspects, transfusion safety, production and storage, donor care, and blood transfusion in a global context
Coverage of cellular and tissue therapies and organ transplantation including stem cell collection and haematopoietic stem cell processing and storage
Review of the development of the evidence-base for transfusion medicine
Content on the clinical practice for transfusion and alternatives to transfusion
Applications which use wireless sensors are increasing in number. The emergence of wireless sensor networks has also motivated the integration of a large number of small and lightweight nodes which integrate sensors, processors, and wireless transceivers. Existing books on wireless sensor networks mainly focus on protocols and networks and pay little attention to the sensors themselves which the author believes is the main focus. Without adequate knowledge of sensors as well as how they can be designed, realized and used, books on wireless sensor networks become too theoretical and irrelevant. The purpose of this book is to intimately acquaint readers with the technique of sensing (resistive, capacitive, inductive, magnetic, inertial, etc.) and existing sensor technologies. It also discusses how the sensors are used in a wide application domain and how new sensors can be designed and used in a novel way.
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How did Singapore’s health care system transform itself into one of the best in the world? It not only provides easy access, but its standards of health care, not only in curative medicine but also in prevention, are exemplary. Fifty years ago, the infant mortality rate (Imr) was 26 per thousand live births; today the Imr is 2. Life expectancy was 64 years then; today, it is 83. The Singapore Medicine brand is trusted internationally, and patients are drawn to Singapore from all over the world. And while many countries struggle to finance their health care, Singapore has developed a health care financing framework that makes health care affordable for its people and gives sustainability to the health care system. Reliability is provided by a professional workforce that seeks to continually learn, improve and become ever more proficient with cutting edge technology while emphasizing the relational aspects of health care by nurturing compassion and maintaining high standards of integrity. Convenience and safety are enhanced by a unifying It system that enables the portability of medical records across health care institutions. All these have been achieved not by chance but by careful planning, strong leadership and dedicated people who are prepared to learn from Singapore’s own experience while adapting best practices from around the world. But the system is not without challenges – not least those of an aging population, and an increasing market influence. This book provides a fascinating insight into the development of Singapore’s health care system from the early days of fighting infections and providing nutrition supplementation for school children, to today’s management of lifestyle diseases and high-end tertiary care. It also discusses how the system must adapt to help Singaporeans continue to “live well, live long, and with peace of mind.”
This in-depth survey of salutogenesis shows the breadth and strengths of this innovative perspective on health promotion, health care, and wellness. Background and historical chapters trace the development of the salutogenic model of health, and flesh out the central concepts, most notably generalized resistance resources and the sense of coherence, that differentiate it from pathogenesis. From there, experts describe a range of real-world applications within and outside health contexts, from positive psychology to geriatrics, from small towns to corrections facilities, and from school and workplace to professional training. Perspectives from scholars publishing in languages other than English show the global relevance of the field.
Among the topics in the Handbook:
· Emerging ideas relevant to the salutogenic model of health
· Specific resistance resources in the salutogenic model of health
· The sense of coherence and its measurement
· The application of salutogenesis in communities and neighborhoods
· The application of salutogenesis to health development in youth with chronic conditions
· The application of salutogenesis in mental health care settings
The Handbook of Salutogenesis summarizes an increasingly salient field for graduate and professional students of public health, nursing, psychology, and medicine, and for their instructors. It will also appeal to health-related academicians and professionals who wish to have a thorough grounding in the topic.