Predictive Toxicology: From Vision to Reality

 Toxicology  Comments Off on Predictive Toxicology: From Vision to Reality
Feb 212019
 

Tailored to the needs of drug developers, this one–stop reference for medicinal chemists covers all the latest developments in the field of predictive toxicology and its applications in safety assessment. With a keen emphasis on novel approaches, the topics have been tackled by selected expert scientists, who are familiar with the theoretical scientific background as well as with the practical application of current methods. Emerging technologies in toxicity assessment are introduced and evaluated in terms of their predictive power, with separate sections on computer predictions and simulation methods, novel in vitro systems including those employing stem cells, toxicogenomics and novel biomarkers. In each case, the most promising methods are discussed and compared to classical in vitro and in vivo toxicology assays. Finally, an outlook section discusses such forward–looking topics as immunotoxicology assessment and novel regulatory requirements. With its wealth of methodological knowledge and its critical evaluation of modern approaches, this is a valuable guide for toxicologists working in pharmaceutical development, as well as in safety assessment and the regulation of drugs and chemicals.

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Fundamentals of Analytical Toxicology

 Toxicology  Comments Off on Fundamentals of Analytical Toxicology
Feb 192019
 

The analytical toxicologist may be required to detect, identify, and in many cases measure a wide variety of compounds in samples from almost any part of the body or in related materials such as residues in syringes or in soil. This book gives principles and practical information on the analysis of drugs and poisons in biological specimens, particularly clinical and forensic specimens.
After providing some background information the book covers aspects of sample collection, transport, storage and disposal, and sample preparation. Analytical techniques – colour tests and spectrophotometry, chromatography and electro­phoresis, mass spectrometry, and immunoassay – are covered in depth, and a chapter is devoted to the analysis of trace elements and toxic metals. General aspects of method implementation/validation and laboratory operation are detailed, as is the role of the toxicology laboratory in validating and monitoring the performance of point of care testing (POCT) devices. The book concludes with reviews of xenobiotic absorption, distribution and metabolism, pharmacokinetics, and general aspects of the interpretation of analytical toxicology results.

  • A clearly written, practical, integrated approach to the basics of analytical toxicology.
  • Focuses on analytical, statistical and pharmacokinetic principles rather than detailed applications.
  • Assumes only a basic knowledge of analytical chemistry.
  • An accompanying website provides additional material and links to related sites.

Written by an experienced team of authors,Fundamentals of Analytical Toxicology is an invaluable resource for those starting out in a career in analytical toxicology across a wide range of disciplines including clinical and forensic science, food safety, and pharmaceutical development.
Praise from the reviews:

“This is an ambitious effort to describe in detail the many and varied aspects of the science of toxicological analysis. The 17 chapters cover every foreseeable aspect, from specimen collection through analytical techniques and quality control to pharmacological principles and interpretation of results. The authors bring together a great deal of experience in the field and have succeeded admirably in achieving their goal: “to give principles and practical information on the analysis of drugs, poisons and other relevant analytes in biological specimens…”. The book is very readable and quite up-to-date, and contains many illustrative figures, charts and tables. Both the student and the practicing professional would do well to study this material carefully, as there is something here for every conceivable level of interest.”   Review from Randall Baselt
“This text comes highly recommended for any analytical toxicology trainee.” The Bulletin of the Royal College of Pathologists
“Overall, this book provides a comprehensive, thorough, clear, up to date and practical treatment of analytical toxicology at a high standard.  Understanding of the text is enhanced by the use of many illustrations.  Specifications, guidelines, and methods are highlighted in grey background “Boxes”.  The many and up to date literature references in each chapter demonstrate the authors’ thorough work and permit easy access to deeper information.  Therefore this book can be highly recommended as a valuable source of knowledge in analytical toxicology both as an introduction and for the advanced reader.”  GTFCh Bulletin “Toxichem + Krimtech”, May 2008 (translated, original review in German)
“Many toxicologists will add this important reference to their libraries because it competently fills a need …”International Journal of Toxicology
“The book is very well illustrated, easy to understand and pleasant to read, and contains a wealth of dedicated information.” International Journal of Environmental Analytical Chemistry

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Advances in Male Mediated Developmental Toxicity

 Toxicology  Comments Off on Advances in Male Mediated Developmental Toxicity
Feb 162019
 

This volume highlights major contributions that identify new developments and directions in the field over the past decade, as well as challenges for the foreseeable future. An integration of information from laboratory and epidemiological studies, male reproduction and teratology can be found throughout the volume. The range of topics include parental legacies and genomics, lifestyle, occupational and therapeutic paternal exposures and effects; effects on the gamete-packaging of human sperm; role of DNA repair and germ cell apoptosis; stem cells, epigenetics and closing; model systems and implications to clinicians and general counselors.
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Computational Toxicology: Volume I

 Toxicology  Comments Off on Computational Toxicology: Volume I
Feb 152019
 

Rapid advances in computer science, biology, chemistry, and other disciplines are enabling powerful new computational tools and models for toxicology and pharmacology. These computational tools hold tremendous promise for advancing science, from streamlining drug efficacy and safety testing, to increasing the efficiency and effectiveness of risk assessment for environmental chemicals. Computational Toxicology provides biomedical and quantitative scientists with essential background, context, examples, useful tips, and an overview of current developments in the field. Divided into four sections, Volume I covers a wide array of methodologies and topics. Opening with an introduction to the field of computational toxicology and its current and potential applications, the volume continues with ’best practices’ in mathematical and computational modeling, followed by chemoinformatics and the use of computational techniques and databases to predict chemical properties and toxicity, as well as an overview of molecular dynamics. The final section is a compilation of the key elements and main approaches used in pharmacokinetic and pharmacodynamic modeling, including the modeling of absorption, compartment and non-compartmental modeling, physiologically based pharmacokinetic modeling, interspecies extrapolation, and population effects. Written in the successful Methods in Molecular Biology™ series format where possible, chapters include introductions to their respective topics, lists of the materials and software tools used, methods, and notes on troubleshooting.Authoritative and easily accessible, Computational Toxicology will allow motivated readers to participate in this exciting field and undertake a diversity of realistic problems of interest.
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Computational Toxicology: Volume II

 Toxicology  Comments Off on Computational Toxicology: Volume II
Feb 142019
 

Rapid advances in computer science, biology, chemistry, and other disciplines are enabling powerful new computational tools and models for toxicology and pharmacology. These computational tools hold tremendous promise for advancing applied and basic science, from streamlining drug efficacy and safety testing, to increasing the efficiency and effectiveness of risk assessment for environmental chemicals. Computational Toxicology was conceived to provide both experienced and new biomedical and quantitative scientists with essential background, context, examples, useful tips, and an overview of current developments in the field. This two-volume set serves as a resource to help introduce and guide readers in the development and practice of these tools to solve problems and perform analyses in this area.Divided into six sections, Volume II covers a wide array of methodologies and topics. The volume begins by exploring the critical area of predicting toxicological and pharmacological endpoints, as well as approaches used in the analysis of gene, signaling, regulatory, and metabolic networks. The next section focuses on diagnostic and prognostic molecular indicators (biomarkers), followed by the application of modeling in the context of government regulatory agencies. Systems toxicology approaches are also introduced. The volume closes with primers and background on some of the key mathematical and statistical methods covered earlier, as well as a list of other resources. Written in a format consistent with the successful Methods in Molecular Biology™ series where possible, chapters include introductions to their respective topics, lists of the necessary materials and software tools used, methods, and notes on troubleshooting and avoiding known pitfalls.Authoritative and easily accessible, Computational Toxicology will allow motivated readers to participate in this exciting field and undertake a diversity of realistic problems of interest.
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Cytokines in Human Health: Immunotoxicology, Pathology, and Therapeutic Applications

 Immunology, Toxicology  Comments Off on Cytokines in Human Health: Immunotoxicology, Pathology, and Therapeutic Applications
Feb 142019
 

Cytokines in Human Health: Immunotoxicology, Pathology, and Therapeutic Applications explores the role of cytokines in immunotoxicology and human health using a variety of complex methods, from basic research to highly applied therapeutic applications. The first section of the book is devoted to basic concepts of cytokine biology, especially as this relates to the practice of immunotoxicology. Chapters in this section review the ability of external influences to modify the expression, production, and activity of these molecules. The second section provides a broad understanding of the range of cytokine activity in human disease, describing methods for assessing cytokine immunotoxicity. In the third and final section of the book, the increasingly important use of cytokines as therapeutics is explored in detail. This section includes examinations into the effects of cytokines on the immune system and in treating cancer. Timely and comprehensive, Cytokines in Human Health: Immunotoxicology, Pathology, and Therapeutic Applications will serve as both a primer and a starting point for a more detailed investigation of the role these fascinating biological regulators play in human health and disease.
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Persistent, Bioaccumulative, and Toxic Chemicals I. Fate and Exposure

 Toxicology  Comments Off on Persistent, Bioaccumulative, and Toxic Chemicals I. Fate and Exposure
Feb 012019
 

Content: 1. Fate and exposure — 2. Assessment and new chemicals.
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Metal ions in toxicology : effects, interactions, interdependencies

 Toxicology  Comments Off on Metal ions in toxicology : effects, interactions, interdependencies
Jan 312019
 

Content: Understanding combined effects for metal co-exposure in ecotoxicology — Human risk assessment of heavy metals: principles and applications — Mixtures and their risk assessment in toxicology — Metal ions affecting the pulmonary and cardiovascular systems — Metal ions affecting the gastrointestinal system including the liver — Metal ions affecting the kidney — Metal ions affecting the hematological system — Metal ions affecting the immune system — Metal ions affecting the skin and eyes — Metal ions affecting the neurological system — Metal ions affecting reproduction and development — Are cadmium and other heavy metal compounds acting as endocrine disrupters? — Genotoxicity of metal ions: chemical insights — Metal ions in human cancer development
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New horizons in predictive toxicology : current status and application

 Toxicology  Comments Off on New horizons in predictive toxicology : current status and application
Jan 312019
 

The sophistication of modelling and simulation technologies have improved dramatically over the past decade and their applications in toxicity prediction and risk assessment are of critical importance. The integration of predictive toxicology approaches will become increasingly necessary as industrial chemicals advance and as new pharmaceuticals enter the market.In this comprehensive discussion of predictive toxicology and its applications, leading experts express their views on the technologies currently available and the potential for future developments. The book covers a wide range of topics including in silico, in vitro and in vivo approaches that are being used in the safety assessment of chemical substances. It reflects the growing and urgent need to strengthen and improve our ability to predict the safety and risks posed by industrial and pharmaceutical chemicals in humans. The reader will find extensive information on the use of current animal models used for various toxicities and target mediated toxicities. Also discussed are the recent regulatory initiatives to improve the safety assessment of chemicals.The book provides an expert and comprehensive discussion on the current status and future directions of predictive toxicology and its application. The various chapters in the book also reflect the growing need for improvements in our technologies and abilities to predict toxicities of pharmaceutical and industrial chemicals to ensure product safety and protect public health.
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In silico toxicology : principles and applications

 Toxicology  Comments Off on In silico toxicology : principles and applications
Jan 312019
 

Content: Introduction; Section 1: Compiling the Model; Sources of Toxicity Data for In Silico Toxicology; Calculation of Physico-Chemical Properties; Calculation of Theoretical 2-D Descriptors; Calculation of Molecular Orbital Descriptors; QSAR Methods: Receptor Modelling in Toxicology; Evaluating Data Quality; Section 2: Data Integration, Analysis and Utilisation; QSAR Methods: Statistical Methodologies; Characterisation, Evaluation and Possible Validation of a QSAR; Applicability Domain Mechanisms of Toxic Action in In Silico Toxicology; Formation of Categories; Read-Across Endpoint-Based Extrapolation; Role of Exposure in Modelling; Expert Systems Tools for Category Formation and Read-Across; Section 3: Application of In Silico Toxicology to Risk Assessment; Weight of Evidence in Toxicity Prediction; Integrated Testing Strategies; Case Study: Predicting Environmental Toxicity; Case Study: Predicting Human Health; In Silico Toxicology in Risk Assessment
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