Cytokines in Human Health: Immunotoxicology, Pathology, and Therapeutic Applications

 Immunology, Toxicology  Comments Off on Cytokines in Human Health: Immunotoxicology, Pathology, and Therapeutic Applications
Feb 142019
 

Cytokines in Human Health: Immunotoxicology, Pathology, and Therapeutic Applications explores the role of cytokines in immunotoxicology and human health using a variety of complex methods, from basic research to highly applied therapeutic applications. The first section of the book is devoted to basic concepts of cytokine biology, especially as this relates to the practice of immunotoxicology. Chapters in this section review the ability of external influences to modify the expression, production, and activity of these molecules. The second section provides a broad understanding of the range of cytokine activity in human disease, describing methods for assessing cytokine immunotoxicity. In the third and final section of the book, the increasingly important use of cytokines as therapeutics is explored in detail. This section includes examinations into the effects of cytokines on the immune system and in treating cancer. Timely and comprehensive, Cytokines in Human Health: Immunotoxicology, Pathology, and Therapeutic Applications will serve as both a primer and a starting point for a more detailed investigation of the role these fascinating biological regulators play in human health and disease.
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Persistent, Bioaccumulative, and Toxic Chemicals I. Fate and Exposure

 Toxicology  Comments Off on Persistent, Bioaccumulative, and Toxic Chemicals I. Fate and Exposure
Feb 012019
 

Content: 1. Fate and exposure — 2. Assessment and new chemicals.
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Metal ions in toxicology : effects, interactions, interdependencies

 Toxicology  Comments Off on Metal ions in toxicology : effects, interactions, interdependencies
Jan 312019
 

Content: Understanding combined effects for metal co-exposure in ecotoxicology — Human risk assessment of heavy metals: principles and applications — Mixtures and their risk assessment in toxicology — Metal ions affecting the pulmonary and cardiovascular systems — Metal ions affecting the gastrointestinal system including the liver — Metal ions affecting the kidney — Metal ions affecting the hematological system — Metal ions affecting the immune system — Metal ions affecting the skin and eyes — Metal ions affecting the neurological system — Metal ions affecting reproduction and development — Are cadmium and other heavy metal compounds acting as endocrine disrupters? — Genotoxicity of metal ions: chemical insights — Metal ions in human cancer development
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New horizons in predictive toxicology : current status and application

 Toxicology  Comments Off on New horizons in predictive toxicology : current status and application
Jan 312019
 

The sophistication of modelling and simulation technologies have improved dramatically over the past decade and their applications in toxicity prediction and risk assessment are of critical importance. The integration of predictive toxicology approaches will become increasingly necessary as industrial chemicals advance and as new pharmaceuticals enter the market.In this comprehensive discussion of predictive toxicology and its applications, leading experts express their views on the technologies currently available and the potential for future developments. The book covers a wide range of topics including in silico, in vitro and in vivo approaches that are being used in the safety assessment of chemical substances. It reflects the growing and urgent need to strengthen and improve our ability to predict the safety and risks posed by industrial and pharmaceutical chemicals in humans. The reader will find extensive information on the use of current animal models used for various toxicities and target mediated toxicities. Also discussed are the recent regulatory initiatives to improve the safety assessment of chemicals.The book provides an expert and comprehensive discussion on the current status and future directions of predictive toxicology and its application. The various chapters in the book also reflect the growing need for improvements in our technologies and abilities to predict toxicities of pharmaceutical and industrial chemicals to ensure product safety and protect public health.
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In silico toxicology : principles and applications

 Toxicology  Comments Off on In silico toxicology : principles and applications
Jan 312019
 

Content: Introduction; Section 1: Compiling the Model; Sources of Toxicity Data for In Silico Toxicology; Calculation of Physico-Chemical Properties; Calculation of Theoretical 2-D Descriptors; Calculation of Molecular Orbital Descriptors; QSAR Methods: Receptor Modelling in Toxicology; Evaluating Data Quality; Section 2: Data Integration, Analysis and Utilisation; QSAR Methods: Statistical Methodologies; Characterisation, Evaluation and Possible Validation of a QSAR; Applicability Domain Mechanisms of Toxic Action in In Silico Toxicology; Formation of Categories; Read-Across Endpoint-Based Extrapolation; Role of Exposure in Modelling; Expert Systems Tools for Category Formation and Read-Across; Section 3: Application of In Silico Toxicology to Risk Assessment; Weight of Evidence in Toxicity Prediction; Integrated Testing Strategies; Case Study: Predicting Environmental Toxicity; Case Study: Predicting Human Health; In Silico Toxicology in Risk Assessment
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A Guide to Practical Toxicology: Evaluation, Prediction, and Risk

 Toxicology  Comments Off on A Guide to Practical Toxicology: Evaluation, Prediction, and Risk
Jan 042019
 

Toxicology is a means to an important end: safety. The effective toxicologist begins with this in mind, and uses a clear understanding of safety as a relative concept, together with a rational view of the current safety evaluation paradigm to direct their work. Too often this approach is ignored or discouraged by traditional practice.This lucid, readable book encourages both experienced toxicologists and those in training to place toxicological investigation in such a framework. It looks at the importance of toxicological normality, reviews toxicity testing methods, and explores new and ‘alternative’ methods of safety evaluation. The interpretation of toxicity findings in individual studies and data packages and the prediction of human-relevant hazards are reviewed, followed by an introduction to risk and how we perceive and assess risk in the light of known hazards and the probability of their occurrence. The final stage of the toxicological process, risk assessment and management, is reviewed with particular reference to the work-place.A Guide to Practical Toxicology uses text boxes to give background information on specific subjects or to act as simple guides to toxicological method or process; this is supported by tables and case-studies intended to illustrate method, study design and interpretation. These features mean the book works at different levels, suitable for professional and student toxicologists as well as those from outside the field who require some knowledge of toxicological method and interpretation, for instance in occupational hygiene or medicine and veterinary surgery.
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Analytical toxicology for clinical, forensic, and pharmaceutical chemists

 Pharmacology, Toxicology  Comments Off on Analytical toxicology for clinical, forensic, and pharmaceutical chemists
Dec 092018
 

Aimed at toxicologists and pharmacists involved in analytical work, this text provides critical evaluations of analytical possibilities to help with the choice of methods.
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Reviews of Environmental Contamination and Toxicology (Vol.215)

 Toxicology  Comments Off on Reviews of Environmental Contamination and Toxicology (Vol.215)
Nov 022018
 

Reviews of Environmental Contamination and Toxicology attempts to provide concise, critical reviews of timely advances, philosophy and significant areas of accomplished or needed endeavor in the total field of xenobiotics, in any segment of the environment, as well as toxicological implications.

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Environmental Chemistry and Toxicology of Mercury

 Toxicology  Comments Off on Environmental Chemistry and Toxicology of Mercury
Oct 072018
 

The book that looks at mercury’s impact on the planet today
Recent research by the EPA has concluded that one in six women of childbearing age have unsafe levels of mercury in their bodies, which puts 630,000 newborn babies each year at risk of neurological impairment.

Mercury poses severe risks to the health of animals and ecosystems around the world, and this book provides the essential information that anyone interested in environmental sciences should know about the fundamentals of the entire mercury cycle.

Comprised of four parts that present an overview of mercury in the environment, mercury transformations, transport, and bioaccumulation and toxicology, each chapter of Environmental Chemistry and Toxicology of Mercury includes the basic concepts of the targeted subject, a critical review of that subject, and the future research needs.

This book explains the environmental behavior and toxicological effects of mercury on humans and other organisms, and provides a baseline for what is known and what uncertainties remain in respect to mercury cycling. The chapters focus on the fundamental science underlying the environmental chemistry and fate of mercury. This work will be invaluable to a wide range of policy experts, environmental scientists, and other people requiring a comprehensive source for the state of the science in this field.

http://nitroflare.com/view/7336A131C074CC6/0470578726.pdf

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Ecotoxicology: Perspectives on Key Issues

 Toxicology  Comments Off on Ecotoxicology: Perspectives on Key Issues
Sep 252018
 

This book presents an integrated discussion on ecotoxicology, containing both general concepts and specific ecotoxicological issues of major biological groups, extending beyond conventional systems. It explores worldwide, regional, and biocompartmentalized topics, bringing forth new points of view on global issues and addressing the increasing diversity and complexity of the ecotoxicological field. It also contains novel information on emerging contaminants, presents bioaccumulation effects on different levels of ecological organization and risk analyses, and discusses novel fields of methodological applications, including key aspects in ecotoxicological and environmental monitoring studies.
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