Cellular and Molecular Toxicology of Nanoparticles

 Toxicology  Comments Off on Cellular and Molecular Toxicology of Nanoparticles
Mar 202018
 

This edited book is a compilation of findings on the molecular and cellular toxicity of nanoparticles (NPs) in animal cell, human cells, invertebrates. The varied selection of test models will provide better understanding about the horizon of NPs toxicity. Interaction of NPs with cells and its organelles can induce toxicological consequences, including transcriptional and translational alterations, DNA damage, cytotoxicity, oxidative stress, mitochondrial dysfunction and cell death. NPs can get internalized in cells through phagocytosis, macropinocytosis, receptor-mediated endocytosis and passive penetration, which can affect varied cell types.
Readers will be benefited with the compilations on basic and molecular facet of NPs toxicity. The chapters will provide a comprehensive information on the state-of-the-art methodologies. The application of toxicogenomic approaches, which is already established in nanotoxicology, has been given special consideration to unravel the toxicodynamics of nanomaterials. Among these approaches, the high-throughput RNA sequencing (RNA-Seq), which is able to build a complete map of transcriptome across different cell types and perturbations upon NPs exposure has been included. The readers are also introduced to the less studied topic on the adsorption of biomolecules (mainly proteins) on the NPs surface, constituting the so-called “biomolecular corona”.

The book has been designed for scientists engaged in NPs toxicity research. Nonetheless, it should be of interest to a variety of scientific disciplines including marine biology, environmental pollution, genetics, pharmacology, medicine, drug and food material sciences, consumer products. Also, the compilations will be of interest to the environmental watchdogs, federal regulators, risk assessors and the policy makers.

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Bone Toxicology (Molecular and Integrative Toxicology)

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Mar 132018
 

The content of this book is intended to provide the toxicologist in drug development in the pharmaceutical and biotechnology industries with a broad understanding of bone and its interactions with other organ systems in safety assessments. The book is divided into three parts. The first part describes our current understanding of bone biology and its primary regulatory pathways. Additional chapters address regulatory and study design considerations for incorporating bone end points in toxicology studies, with special consideration being given to juvenile toxicology studies. This is intended to address recent regulatory requirements to evaluate skeletal development for drugs in development for pediatric populations. The second part of the book describes the principal techniques and methods used in bone research; understanding how these end-points are derived is fundamental to their appropriate application. These first two parts of the book provide the background and the means to develop the concepts in part three which describes bone and its interaction with other organ systems. The unique series of chapters in part three, contributed to by key leaders in their respective fields and in bone research, provides a comprehensive collective work. Although constantly evolving, the crosstalk and interaction of the skeleton with several organ systems is now recognized and well documented, such as for the reproductive system, muscle and kidney, while our understanding of the interaction with other organ systems, such as the immune system and CNS, is in its infancy. Recent work highlights the key role of the skeleton in the regulation of energy metabolism and the impact this has on research in metabolic diseases such as obesity and diabetes. The hope is that this book will enlighten many and encourage more to explore the impact of new compounds on the skeleton in the development of effective and safe drugs.
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Thyroid Toxicity

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Mar 082018
 

Thyroid hormones are involved in numerous physiological processes as regulators of metabolism, bone remodeling, cardiac function and mental status. Moreover, thyroid hormones are of special importance in fetal development, more particularly, in the development of the brain. Thus, maintenance of normal thyroid functioning is essential for psychological, biochemical, immunological, endocrine and physiological well being of the body as well as normal growth and development. Understanding how the thyroid gland is affected by adverse factors can help clinicians to handle emergency situations or apply preventive care measures to patients. Thyroid Toxicity is a comprehensive monograph on thyroid toxicology. It gathers all information about the toxic effects of different kinds of factors (hormonal, radiation and chemical) that affect the thyroid system. The ebook gives a brief introduction to the thyroid system and answers several important questions about the topic such as the biochemical mechanisms through which various compounds (for example, pesticides, food additives, etc.) induce toxicity on the thyroid gland, how endocrine disruption alters the physiology of the human body and brain as well as how radiation harms the thyroid gland. Thyroid Toxicity is the definitive reference for any medical officer, endocrinologist, or toxicologist seeking knowledge on thyroid gland toxicology.

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Gold Nanoparticles in Biomedical Applications

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Feb 172018
 

This book discusses fabrication of functionalized gold nanoparticles (GNPs) and multifunctional nanocomposites, their optical properties, and applications in biological studies. This is the very first book of its kind to comprehensively discuss published data on in vitro and in vivo biodistribution, toxicity, and uptake of GNP by mammalian cells providing a systematization of data over the GNP types and parameters, their surface functionalization, animal and cell models. As distinct from other related books, Gold Nanoparticles in Biomedical Applications discusses the immunological properties of GNPs and summarizes their applications as an antigen carrier and adjuvant in immunization for the preparation of antibodies in vivo. Although the potential of GNPs in nanobiotechnology has been recognized for the past decade, new insights into the unique properties of multifunctional nanostructures have recently emerged. With these developments in mind, this book unites ground breaking experimental data with a discussion of hybrid nanoparticle systems that combine different nanomaterials to create multifunctional structures. These novel hybrids constitute the material basis of theranostics, bringing together the advanced properties of functionalized GNPs and composites into a single multifunctional nanostructure with simultaneous diagnostic and therapeutic functions. Such nanohybrids can be physically and chemically tailored for a particular organ, disease, and patient thus making personalized medicine available.

 

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The Toxicologist’s Pocket Handbook, Third Edition

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Feb 152018
 

 

This scaled-down version of the best-selling CRC Handbook of Toxicology provides the most frequently used toxicology reference information in a convenient pocket-sized format allowing quick access to vital information, especially when traveling outside the lab or office.

 

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Food Forensics and Toxicology

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Feb 132018
 

 

A comprehensive guide, offering a toxicological approach to food forensics, that reviews the legal, economic, and biological issues of food fraud

Food Forensics and Toxicology offers an introduction and examination of forensics as applied to food and foodstuffs. The author puts the focus on food adulteration and food fraud investigation. The text combines the legal/economic issues of food fraud with the biological and health impacts of consuming adulterated food. Comprehensive in scope, the book covers a wide-range of topics including food adulteration/fraud, food “fingerprinting” and traceability, food toxicants in the body, and the accidental or deliberate introduction of toxicants into food products.

In addition, the author includes information on the myriad types of toxicants from a range of food sources and explores the measures used to identify and quantify their toxicity. This book is designed to be a valuable reference source for laboratories, food companies, regulatory bodies, and researchers who are dealing with food adulteration, food fraud, foodborne illness, micro-organisms, and related topics. Food Forensics and Toxicology is the must-have guide that:

Takes a comprehensive toxicological approach to food forensics
Combines the legal/economic issue of food fraud with the biological/health impacts of consuming adulterated food in one volume
Discusses a wide range of toxicants (from foods based on plants, animals, aquatic and other sources)
Provides an analytical approach that details a number of approaches and the optimum means of measuring toxicity in foodstuffs
Food Forensics and Toxicology gives professionals in the field a comprehensive resource that joins information on the legal/economic issues of food fraud with the biological and health implications of adulterated food.

 

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Toxicology Recall

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Feb 022018
 

Written primarily for third and fourth year medical students, Toxicology Recall is a complete, concise review of clinical toxicology. The book is written in the rapid-fire question-and-answer format of the Recall Series, with the question appearing on the left side of the page and the answer appearing on the right. Mnemonics and reference charts further aid in rapid review. Major sections cover evaluation of the poisoned patient, medications, drugs of abuse, environmental and industrial toxins, heavy metals, pesticides, chemical agents of terrorism, natural toxins, therapies, and visual diagnosis in medical toxicology.
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Case Studies in Medical Toxicology: From the American College of Medical Toxicology

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Jan 172018
 

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Preclinical Development Handbook: Toxicology

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Jan 162018
 

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Trichloroethylene: Toxicity and Health Risks

 Toxicology  Comments Off on Trichloroethylene: Toxicity and Health Risks
Jan 022018
 

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