Category Archives: Reproductive Health

Reproductive Ecology and Human Evolution (Evolutionary Foundations of Human Behavior)

Reproductive ecology is one of the most exciting and fastest-growing subareas of evolutionary anthropology. Thanks to recently developed, noninvasive techniques for monitoring key aspects of reproductive physiology, new investigations into the interactions between reproduction and a broad array of ecological, behavioral, and constitutional variables can now be carried out under the full range of cultural and ecological conditions that characterize human beings and wild primates. Not only do these studies dramatically expand our understanding of human and primate physiology, but they shed fresh light on central issues in human evolution as well. In Reproductive Ecology and Human Evolution, Dr. Ellison, one of the pioneers in this new field, brings together thirty-one of the most active and influential scientists investigating the evolutionary ecology of primate and human reproduction. The resulting volume both captures the current state of the field and charts the research agenda that will guide its future. The volume’s eighteen chapters are grouped into four sections that reflect the central focus of the contributions: Physiological Context; Ecological Context; Developmental Context; and Comparative Context,. The lively nature of the field is echoed in the resonance that extends to many of the individual chapters, wherein areas of controversy and disagreement are presented along with areas of consolidation and consensus. Students and researchers in the fields of biological anthropology, human biology, and primatology, as well as those from adjacent disciplines such as demography, medicine, social anthropology, and public health, will find Reproductive Ecology and Human Evolution an indispensable guide to the frontiers of this exciting terrain
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Metals, Fertility, and Reproductive Toxicity

Environmental endocrine disruptors have been at the heart of discussions about chemicals and their effects on fertility, but the focus has been on organic compounds and the role of metals has been largely overlooked – until now. Taking an organ-system-based approach, Metals, Fertility, and Reproductive Toxicity examines the effects of metals found in the everyday environment on fertility rates in humans and animal populations. This volume summarizes and evaluates the literature in the area of metal effects on fertility and reproduction in humans, laboratory animals, and wildlife. International experts have contributed chapters that explore how the ovary, testes, uterine system, and neuroendocrine system, among others, respond to metal exposure. Reviewing both current knowledge and cutting edge data, the chapters focus on either a particular metal or a particular population. A massive amount of data on this subject has been generated, summarized, and reviewed over the years. While there are many books available on metals toxicity and on reproductive toxicity, no current book explores both in the same volume. Culling information from throughout the literature, Metals, Fertility, and Reproductive Toxicity supplies an in-depth look at the role of metals in endocrine disruption and the spectrum of mechanisms involving metals that can influence reproduction.
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In-Vitro Fertilization 4 Edition

This extensively updated new edition provides an indispensable account of modern in-vitro fertilization practice, building upon the popularity of previous editions. The authors initially give a comprehensive review of the biology of human gametes and embryos, before outlining basic to advanced IVF techniques. New developments in practical techniques and understanding are discussed, including in-vitro maturation, vitrification, preservation of fertility for cancer patients, stem cell technology, preimplantation genetic testing, and the role of epigenetics and imprinting. The revised introduction also incorporates a ‘refresher’ study review of fundamental principles of cell and molecular biology, now updated with current knowledge of meiosis in human oocytes, embryo metabolism and basic principles of genome editing. With high-quality illustrations and extensive, up-to-date reading lists, it is a must-have textbook for trainee and practising embryologists, as well as clinicians who are interested in the scientific principles that underpin successful IVF.

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Ultrasonography in Reproductive Medicine and Infertility

Nowhere has the impact of ultrasonography been more dramatic than in reproductive medicine, particularly in the diagnosis of female and male infertility, the management of assisted reproductive procedures and the monitoring of early pregnancy. This authoritative textbook encompasses the complete role of ultrasonography in the evaluation of infertility and assisted reproduction. Covering every indication for ultrasonography in assisted reproductive technology, this will prove an invaluable resource in the evaluation of the infertile patient and optimization of the outcome of treatment. The interpretation of images to improve fertility and reproductive success is emphasized throughout. Ultrasonography in Reproductive Medicine and Infertility is essential reading for clinicians working both in IVF clinics and in office practice. It will be particularly useful to gynecologists, infertility specialists, ultrasonographers and radiologists working in reproductive endocrinology and infertility, assisted reproductive technology, ultrasonography and radiology.
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Uterus Transplantation (2020 Edition)

This book discusses all aspects of the uterus transplantation procedure in women who are childless because of a dysfunctional or missing uterus, from initial pre-operative investigations to follow-up after the uterine graft has been removed. All the international experts who are engaged in clinical activities and/or research in this field have contributed one or more of the book’s chapters.

Since the first live birth following uterus transplantation was reported in Sweden in September 2014, the field has been rapidly evolving around the globe: the first cases in USA, Germany, China, Brazil, and Czech Republic were performed in 2016 and several other centres are preparing for clinical trials of uterus transplantation.

Uterus transplantation is a subject that attracts the attention of many bioethicists, and like all other major procedures in transplantation surgery and assisted reproduction techniques, it is a complex process that requires a multidisciplinary team if it is to be successful. As such the book is a valuable resource not only for clinicians from many disciplines, but also for nurses, ethicists, psychologists and researchers.

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IVF Children: The First Generation: Assisted Reproduction and Child Development

In the last decade alone, advances in assisted reproduction have increased dramatically. The miracle of babies born through in vitro fertilization no longer seems so miraculous. However, information about the continued emotional and physical development of IVF children is hard to find, and once found, can be difficult to interpret.
IVF Children: The First Generation: Assisted Reproduction and Child Development comprehensively reviews the current knowledge about the physical and mental outcomes of children conceived through IVF techniques. The author examines all of the studies relevant to the development and well being of IVF children and discusses the results and implications of these studies from every angle. More importantly for the busy staff of fertility clinics, Dr. Sutcliffe explores how to interpret what is known from these studies to qualify the studies’ validity and use their results.
In contrast to many other books devoted to techniques involved in ART, this book addresses what is known about the ultimate outcome of the children born after employing the various ART methods for conception. The author draws together the available data and provides an in-depth analysis of the results. He expertly blends scientific theory and clinical outcomes to provide a handbook also useful for counselling families. IVF Children: The First Generation: Assisted Reproduction and Child Development provides guidance to professionals and parents/prospective parents alike in selecting the fertility treatment that best meets their needs.
About the author: Dr. Alastair Sutcliffe is an academic pediatrician with clinical practice in the Royal Free Hospital Campus of University College London and was awarded his Doctorate in 2000. He was the first person to study children who were cryopreserved as embryos and for the past five years, has been studying a group of ICSI conceived children throughout the UK. These children are currently being assessed in the biggest developmental study in the field. His work is now recognized worldwide as having made an important contribution to assessing outcomes of new types of in vitro fertilization.

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Posttranslational Protein Modifications in the Reproductive System

This book’s aim is to increase the awareness of a great variety of posttranslational modifications in the male and female reproductive system. Some of the most intriguing reproductive strategies, mechanisms, and pathways involving PTM are discussed, with an added angle of evolutionary conservation and diversity. The book also chapters on sperm-egg binding, as well as on histone modification in both the embryo and sperm. Chapters are also devoted to protein ubiquitination, the regulation of sperm function during fertilization in mammals and tubulin modifications in gametes and embryos. There are no other current books on posttranslational protein modifications as they relate to reproduction, making this contribution unique in the field. It is useful for both researchers and graduate students alike.
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Male Infertility in Reproductive Medicine : Diagnosis and Management

This useful illustrated text summarizes for an audience of clinicians in Reproductive Medicine the practical essentials of what they need to know about diagnosis and management of the infertile male patient, whether they need to instruct or liaise with a colleague or undertake the procedures themselves.

Botros Rizk, MD, FRCOG, FRCS, HCLD, FACOG, FACS, is Professor and Head of Reproductive Endocrinology and Infertility, Medical and Scientific Director of In Vitro Fertilization and Assisted Reproduction, University of South Alabama, Mobile, Albama, USA; Distinguished Adjunct Scientific Director, IVF Michigan, Rochester Hills, Michigan, USA; and President Elect, Middle East Fertility Society. Ashok Agarwal, PhD is Director of the Andrology Center, Director of Research at the American Center for Reproductive Medicine at Cleveland Clinic, and Professor at the Cleveland Clinic Lerner College of Medicine of Case Western Reserve University, USA. Edmund S Sabanegh, Jr, MD, is Chairman of the Department of Urology and Director of the Center for Male Fertility, Cleveland Clinic, USA.

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Endometrial Gene Expression: An Emerging Paradigm for Reproductive Disorders

The endometrium goes through cyclical changes under the influence of hormones, and immune effectors in the endometrium change their populations cyclically as well. Dynamic changes in immune effectors determine endometrial cytokine and chemokine milieus and, consequently, the endometrial immune response. Endometrial immune responses have been shown to be important for trophoblast invasion and early pregnancy. Indeed, dysregulated endometrial inflammatory immune responses are associated with reproductive failures, such as recurrent pregnancy losses, repeated implantation failure, and gynecological diseases with oncogenic potential. Hence, the investigation of endometrial gene expression may predict infertility, gynecological and oncological conditions.

This book presents the state of the art in endometrial gene expression as well as recent developmental findings relating to reproduction and reproductive disorders. It begins with a review of the genetic regulation of urogenital tract formation and molecular mechanism underlying the physiology of menstrual cycle before moving on to the current and emerging technological advances in molecular biology. Endometrial gene expressions of immune inflammatory conditions, viral infection, metabolic and nutritional conditions, and reproductive disorders are then presented in following chapters. Examples of the use and interpretation of gene expression in clinical scenarios including recurrent pregnancy losses, infertility and multiple implantation failures are presented with currently available endometrial gene analysis.

Utilizing the latest evidence and clinical guidelines, Endometrial Gene Expression will be a cutting-edge resource for gynecologist, reproductive immunologist, reproductive endocrinologists, obstetrician, maternal fetal medicine specialist and other health care providers in the field of reproductive medicine.

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Screening the Single Euploid Embryo: Molecular Genetics in Reproductive Medicine

Intended for readers with a background in fertility medicine as well as those less familiar with IVF, this comprehensive work presents an update on preimplantation genetic testing to enable single embryo transfer (SET). An international cast of contributors explains the treatment sequence―from ovulation induction to luteal support―aiming to transfer only one euploid embryo. Applications of molecular techniques for gamete and embryo assessment are fully detailed, with a focus on the strengths and limitations of each. In addition, expert commentary is shared across a range of regulatory challenges associated with embryo screening and cryopreservation. As access to advanced reproductive technology increases against a sharper background of healthcare reform, clinicians, economists, bioethicists and legislators alike will find this new volume relevant and highly accessible.

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