Reviews of Physiology, Biochemistry and Pharmacology Vol. 174

 Pharmacology, Physiology  Comments Off on Reviews of Physiology, Biochemistry and Pharmacology Vol. 174
May 252018
 

Leading researchers are specially invited to provide a complete understanding of a key topic within the multidisciplinary fields of physiology, biochemistry and pharmacology. In a form immediately useful to scientists, this periodical aims to filter, highlight and review the latest developments in these rapidly advancing fields.

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Dermal Absorption Models in Toxicology and Pharmacology

 Pharmacology, Toxicology  Comments Off on Dermal Absorption Models in Toxicology and Pharmacology
May 212018
 

Many experimental methods and mathematical modeling approaches rooted in disciplines outside of toxicology can be effectively applied to estimating dermal absorption. Dermal Absorption Models in Toxicology and Pharmacology explores current approaches and techniques that can be used to quantify dermal absorption with endpoints useful in both toxicology and pharmacology.
The book begins with a review of basic principles and the in vitro and in vivo experimental approaches available for assessing dermal absorption of drugs and chemicals. This is followed by coverage of mathematical or in silico models for quantitating percutaneous absorption and the applications of these techniques to the risk assessment process. The remainder of the book explores scenarios where the unique properties of the chemicals being studied or the matrix in which they are exposed must be considered and then wraps up with a comparative analysis of chemical permeability in human and animal skin.
Many of the books covering this subject are just too comprehensive and serve primarily as reference works. This book takes a different approach. Jim Riviere’s editorial guidance ensures that the information is readable, accessible, authoritative, and concise, making it the perfect resource for familiarizing new researchers and students to the field and updating established scientists.

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Integrin Targeting Systems for Tumor Diagnosis and Therapy

 Pharmacology, Toxicology  Comments Off on Integrin Targeting Systems for Tumor Diagnosis and Therapy
May 212018
 


This volume collects a variety of techniques and methodologies developed to facilitate research on integrin biology and to identify ideal targets and approaches for the treatment of multiple organ diseases, with a focus on cancer in particular. The chapters consecutively describe the tools for structural analysis, identification and detection of integrins as biomarkers, and include thorough laboratory and clinically-related methods on different strategies for generation, synthesis and evaluation of probes, carriers, peptides or small particles for integrin targeting, imaging, and drug delivery. As part of the Methods in Pharmacology and Toxicology series, this book contains the practical details that are invaluable in the laboratory.
Authoritative and advantageous, Integrin Targeting Systems for Tumor Diagnosis and Therapy serves readers from a wide spectrum, including researchers and students seeking an overview of existing developments, as well as leading professionals aiming to become more familiar with integrin-related innovative technologies in cancer research.

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The Addiction Solution: Treating Our Dependence on Opioids and Other Drugs

 Pharmacology  Comments Off on The Addiction Solution: Treating Our Dependence on Opioids and Other Drugs
May 202018
 

A groundbreaking examination of addiction from a psychiatrist and public health doctor, offering practical, proven solutions for individuals, families, and communities dealing with substance use and abuse.

Written with warmth, accessibility, and vast authority, The Addiction Solution is a practical guide through the world of drug use and abuse and addiction treatment. Here, Lloyd I. Sederer, MD, brings together scientific and clinical knowledge, policy suggestions, and case studies to describe our current drug crisis and establish a clear path forward to recovery and health. In a time when so many people are affected by the addiction epidemic, when 142 people die of overdoses every day in the United States, principally from opioids, Sederer’s decades of wisdom and clinical experience are needed more than ever before.

With a timely focus on opioids, Sederer takes us through the proven essentials of addiction treatment and explains why so many of our current policies, like the lingering remnants of the War on Drugs, fail to help drug users, their families, and their wider communities. He identifies a key insight, often overlooked in popular and professional writing about addiction and its treatment: namely, that people who use drugs do so to meet specific needs, and that drugs may be the best solution those people currently have. Writing with generosity and empathy about the many Americans who use illicit and prescribed substances, Sederer lays out specific, evidence-based, researched solutions to the prevention and problems of drug use, including exercise, medications, therapy, recovery programs, and community services. In this challenging time, The Addiction Solution provides practical help, comfort, and hope.

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Chemotherapy in Neonates and Infants: Pharmacological Oncology for Children Under 1 Year Old

 Oncology, Pediatrics, Pharmacology  Comments Off on Chemotherapy in Neonates and Infants: Pharmacological Oncology for Children Under 1 Year Old
May 112018
 


This book provides a comprehensive overview of pediatric oncology, discussing drug therapy and treatment in children under the age of 1 year. It is the first volume to focus on chemotherapy in newborns and infants, especially the daily clinical practice and treatment protocols.

Intended as a practical manual, it addresses all the major topics related to pediatric oncology in an accessible and easy-to-use format. It examines topics in pediatric oncology therapeutics, including drug metabolism, excretion, toxicity, drugs that can be used for each week or month of the patient’s life, dose adjustment and treatment protocols.
Chemotherapy in Neonates and Infants focuses on the safe treatment of children in the first year of life, and is aimed at pediatric oncology/hematology institutions, clinics and departments. It is particularly valuable for researchers, pediatric oncology physicians, pediatric and neonatology physicians, oncology pharmacists and the other healthcare professionals directly involved in the chemotherapy of neonates and infants.

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Drug Delivery and Targeting: For Pharmacists and Pharmaceutical Scientists

 Pharmacology  Comments Off on Drug Delivery and Targeting: For Pharmacists and Pharmaceutical Scientists
May 082018
 

The advances in biotechnology and molecular biology over recent years have resulted in a large number of novel molecules with the potential to revolutionize the treatment and prevention of disease. However, such potential is severely compromised by significant obstacles to delivery of these drugs in vivo. These obstacles are often so great that effective drug delivery and targeting is now recognized as the key to effective development of many therapeutics. Advanced drug delivery and targeting can offer significant advantages to conventional drugs, such as increased efficiency, convenience, and the potential for line extensions and market expansion. An accessible and easy-to-read textbook, Drug Delivery and Targeting for Pharmacists and Pharmaceutical Scientists is the first book to provide a comprehensive introduction to the principles of advanced drug delivery and targeting, their current applications and potential future developments, including:
*Methods to optimize therapeutic efficacy, and the related commercial implications
*Difficulties with drug absorption, unwanted distribution and premature inactivation / elimination
*Attempts to minimize toxicity or alter immunogenicity
*Methods to achieve rate-controlled drug release and effective drug targeting
*Novel and established routes of delivery
*Use of new generation technologies such as biosensors, microchips, stimuli-sensitive hydrogels and plasmid-based gene therapy
This volume is indispensable for pharmac Jeutical students, scientists and researchers.

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Computer Applications in Pharmaceutical Research and Development (Wiley Series in Drug Discovery & Development)

 Pharmacology  Comments Off on Computer Applications in Pharmaceutical Research and Development (Wiley Series in Drug Discovery & Development)
May 012018
 

A unique, holistic approach covering all functions and phases of pharmaceutical research and development While there are a number of texts dedicated to individual aspects of pharmaceutical research and development, this unique contributed work takes a holistic and integrative approach to the use of computers in all phases of drug discovery, development, and marketing. It explains how applications are used at various stages, including bioinformatics, data mining, predicting human response to drugs, and high-throughput screening. By providing a comprehensive view, the book offers readers a unique framework and systems perspective from which they can devise strategies to thoroughly exploit the use of computers in their organizations during all phases of the discovery and development process. Chapters are organized into the following sections: Computers in pharmaceutical research and development: a general overview Understanding diseases: mining complex systems for knowledge Scientific information handling and enhancing productivity Computers in drug discovery Computers in preclinical development Computers in development decision making, economics, and market analysis Computers in clinical development Future applications and future development Each chapter is written by one or more leading experts in the field and carefully edited to ensure a consistent structure and approach throughout the book. Figures are used extensively to illustrate complex concepts and multifaceted processes. References are provided in each chapter to enable readers to continue investigating a particular topic in depth. Finally, tables of software resources are provided in many of the chapters. This is essential reading for IT professionals and scientists in the pharmaceutical industry as well as researchers involved in informatics and ADMET, drug discovery, and technology development. The book’s cross-functional, all-phases approach provides a unique opportunity for a holistic analysis and assessment of computer applications in pharmaceutics.

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Math For Pharmacy Technicians

 Pharmacology  Comments Off on Math For Pharmacy Technicians
Apr 302018
 

Math for Pharmacy Technicians is an introductory text covering the key math skills needed for Pharmacy Technicians. This text is an essential resource for both Pharmacy Technician students and practicing Pharmacy Technicians. Presented in a simple and clear manner, students will find numerous solved problems and a step-by-step format that allows for quick comprehension. Key features include practice problems with answers, written procedures, boxes with tips, exercises, and chapter quizzes to reinforce student learning. Instructor Resources: PowerPoints and Pre and Post Test Answers Student Resources: Companion Website
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Computer Applications in Pharmaceutical Research and Development (Wiley Series in Drug Discovery & Development)

 Pharmacology  Comments Off on Computer Applications in Pharmaceutical Research and Development (Wiley Series in Drug Discovery & Development)
Apr 302018
 

A unique, holistic approach covering all functions and phases of pharmaceutical research and development While there are a number of texts dedicated to individual aspects of pharmaceutical research and development, this unique contributed work takes a holistic and integrative approach to the use of computers in all phases of drug discovery, development, and marketing. It explains how applications are used at various stages, including bioinformatics, data mining, predicting human response to drugs, and high-throughput screening. By providing a comprehensive view, the book offers readers a unique framework and systems perspective from which they can devise strategies to thoroughly exploit the use of computers in their organizations during all phases of the discovery and development process. Chapters are organized into the following sections: Computers in pharmaceutical research and development: a general overview Understanding diseases: mining complex systems for knowledge Scientific information handling and enhancing productivity Computers in drug discovery Computers in preclinical development Computers in development decision making, economics, and market analysis Computers in clinical development Future applications and future development Each chapter is written by one or more leading experts in the field and carefully edited to ensure a consistent structure and approach throughout the book. Figures are used extensively to illustrate complex concepts and multifaceted processes. References are provided in each chapter to enable readers to continue investigating a particular topic in depth. Finally, tables of software resources are provided in many of the chapters. This is essential reading for IT professionals and scientists in the pharmaceutical industry as well as researchers involved in informatics and ADMET, drug discovery, and technology development. The book’s cross-functional, all-phases approach provides a unique opportunity for a holistic analysis and assessment of computer applications in pharmaceutics.

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Psychopharmacology: An Introduction, 4th Edition

 Pharmacology, Psychiatry  Comments Off on Psychopharmacology: An Introduction, 4th Edition
Apr 302018
 

Describes the latest advances in psychopharmacology – one of the most rapidly developing fields in modern science. This latest edition has been updated to cover new developments in drug therapy and research including newly introduced antipsychotics, antidepressants and antidementia drugs. Sections on the treatment of depression and dementia have been revised to include new developments in treatment strategies. It will be welcomed for its essentially clinical and psychological approach to modern pharmaceuticals, their therapeutic uses and limitations, adverse reactions and future directions for research.
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