Analysis of Aggregates and Particles in Protein Pharmaceuticals

 Pharmacology  Comments Off on Analysis of Aggregates and Particles in Protein Pharmaceuticals
Apr 132019
 

This book describes how to address the analysis of aggregates and particles in protein pharmaceuticals, provides a comprehensive overview of current methods and integrated approaches used to quantify and characterize aggregates and particles, and discusses regulatory requirements. Analytical methods covered in the book include separation, light scattering, microscopy, and spectroscopy.

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Generic Drug Product Development: Solid Oral Dosage Forms, Second Edition

 Geriatrics, Pharmacology  Comments Off on Generic Drug Product Development: Solid Oral Dosage Forms, Second Edition
Apr 132019
 



In this era of increased pharmaceutical industry competition, success for generic drug companies is dependent on their ability to manufacture therapeutic-equivalent drug products in an economical and timely manner, while also being cognizant of patent infringement and other legal and regulatory concerns.

Generic Drug Product Development: Solid Oral Dosage Forms, Second Edition presents in-depth discussions from more than 30 noted specialists describing the development of generic drug products—from the raw materials to the development of a therapeutic-equivalent drug product to regulatory approval.

Major topics discussed include:

Active pharmaceutical ingredients
Experimental formulation development, including a new section on Quality by Design (QbD)
Scale-up
Commercial product formulation
Quality control and bioequivalence
Drug product performance
ANDA regulatory process
Post-approval changes
Post-marketing surveillance
Legislative and patent challenges

This second edition also contains a new chapter on the relationship between the FDA and the United States Pharmacopeia and in Chapter 4, using specific examples, the application of Quality by Design (QbD) during formulation development is examined.The book is a thorough guide to the development of solid oral generic dosage formulations. This textbook is ideal for the pharmaceutical industry, graduate programs in pharmaceutical sciences, and health professionals working in the area of generic drug development.

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Molecular Pharmacology: From DNA to Drug Discovery

 Pharmacology  Comments Off on Molecular Pharmacology: From DNA to Drug Discovery
Apr 072019
 

This textbook provides a fresh, comprehensive and accessible introduction to the rapidly expanding field of molecular pharmacology. Adopting a drug target-based, rather than the traditional organ/system based, approach this innovative guide reflects the current advances and research trend towards molecular based drug design, derived from a detailed understanding of chemical responses in the body.

Drugs are then tailored to fit a treatment profile, rather than the traditional method of ‘trial and error’ drug discovery which focuses on testing chemicals on animals or cell cultures and matching their effects to treatments.

Providing an invaluable resource for advanced under-graduate and MSc/PhD students, new researchers to the field and practitioners for continuing professional development, Molecular Pharmacology explores; recent advances and developments in the four major human drug target families (G-protein coupled receptors, ion channels, nuclear receptors and transporters), cloning of drug targets, transgenic animal technology, gene therapy, pharmacogenomics and looks at the role of calcium in the cell.

• Current – focuses on cutting edge techniques and approaches, including new methods to quantify biological activities in different systems and ways to interpret and understand pharmacological data.
• Cutting Edge – highlights advances in pharmacogenomics and explores how an individual’s genetic makeup influences their response to therapeutic drugs and the potential for harmful side effects.
• Applied – includes numerous, real-world examples and a detailed case-study based chapter which looks at current and possible future treatment strategies for cystic fibrosis. This case study considers the relative merits of both drug therapy for specific classes of mutation and gene therapy to correct the underlying defect.
• Accessible – contains a comprehensive glossary, suggestions for further reading at the end of each chapter and an associated website that provides a complete set of figures from within the book.

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Essentials of Human Physiology and Pathophysiology for Pharmacy and Allied Health

 Pathology, Pharmacology, Physiology  Comments Off on Essentials of Human Physiology and Pathophysiology for Pharmacy and Allied Health
Mar 312019
 

Combining two separate textbooks entitled Essentials of Human Physiology for Pharmacy and Essentials of Pathophysiology for Pharmacy into one cohesive volume, this new book seamlessly integrates material related to normal human physiology and pathophysiology into each chapter.

Chapters include:

– Study objectives at the beginning of each chapter;
– Summary tables, flow charts, diagrams, and key definitions;
– Real life case studies to emphasize clinical application and stimulate student critical thinking;
– An emphasis on the rationale for drug therapy;
– Simple, straightforward language.

Written by authors with extensive teaching experience in the areas, Essentials of Human Physiology and Pathophysiology for Pharmacy and Allied Health is a concise learning instrument that will guide students in pharmacy and allied health programs.

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Pharmacotherapy Principles and Practice, Second Edition

 Pharmacology  Comments Off on Pharmacotherapy Principles and Practice, Second Edition
Mar 312019
 

Learn the Essential Principles of Pharmacotherapy and Understand Their Clinical Application
Now in full color!
Pharmacotherapy Principles and Practices utilizes a solid, evidence-based approach that supports the optimal pharmacotherapy of disease. In order to be as clinically relevant as possible, the disease states and treatments discussed focus on disorders most often seen in practice.

98 diseaes-based chapters review etiology, epidemiology, pathophysiology, and clinical presentation, followed by clear therapeutic recommendations for drug selection, dosing, and patient monitoring. All chapters have been written by content experts and reviewed by authorities in their fields.

Features:
NEW full-color format
NEW chapters on pediatrics, geriatrics, and palliative care
Valuable learning aids, including
Structured learning objects
Key concepts
Patient care and monitoring guidelines
Up-to-date literature citations
Tables, figures, text boxes, and algorithms
A glossary of terms
An online learning center that includes self-assessment questions and answers
Laboratory values expressed as both conventional units and SI units
Appendices that include conversion factors and anthropometrics, common laboratory tests and their reference ranges, and common medical abbreviations
Patient encounter vignettes to develop critical-thinking skills and make the text more applicable to everyday patient care

5 STAR DOODY’S REVIEW!
“This book covers more than 100 disease states using an easy-to-use format that includes structured learning objectives, key concepts, patient care and monitoring guidelines, up-to-date literature citations, tables, figures, text boxes, algorithms, a glossary of terms, and an online learning center….Although primarily for students, the book offers a concise review for general practitioners. There are more than 160 authors and 140 reviewers that contributed to this book and they represent the highest authority in the field.”–Doody’s Review Service

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Integrated Pharmaceutics: Applied Preformulation, Product Design, and Regulatory Science

 Pharmacology  Comments Off on Integrated Pharmaceutics: Applied Preformulation, Product Design, and Regulatory Science
Mar 302019
 

Focusing on the application of physical pharmacy, drug design, and drug regulations as they relate to produce effective dosage forms for drug delivery, Integrated Pharmaceutics provides a comprehensive picture of pharmaceutical product design, describing the science and art behind the concepts of dosage form development. Combining physical pharmacy, product design, and regulatory affairs issues in a single book, the authors address topics governing drug regulations of United States, European, and Japanese agencies and detail new regulatory guidelines, including quality by design, design space analysis, and blend sample uniformity.

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Neuropsychopharmacology and Therapeutics

 Neurology/Neurosurgery, Pharmacology  Comments Off on Neuropsychopharmacology and Therapeutics
Mar 182019
 

Neuropsychopharmacology is a relatively new subject area in the neurosciences. It is a field of study that describes the effects of drugs from the molecular to the behavioural level and requires integration and synthesis of knowledge from various disciplines including neuroanatomy, physiology, molecular biology, pharmacology and the behavioural sciences. The principal aims of this book are to provide students with a clear understanding of CNS disorders, and an appreciation of how basic and clinical research findings can be translated into therapeutics.

After an introduction to the subject area, the remaining chapters are focused on reviewing the main psychiatric and neurological disorders that are covered in most courses. They are discussed in terms of their clinical symptoms, epidemiology, pathology, aetiology, underlying neurobiological and neurochemical mechanisms, pharmacotherapy, adjunctive non–pharmacological treatments, and clinical outcomes. Each chapter of the book is a stand–alone chapter and is written in a clear, accessible style.

Written by an author with many years teaching and research experience, this textbook will prove invaluable for students of pharmacology, pharmacy and the medical sciences needing a truly integrated introduction to this exciting field.

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Intelligent Data Analysis in Medicine and Pharmacology

 Pharmacology  Comments Off on Intelligent Data Analysis in Medicine and Pharmacology
Mar 132019
 

Intelligent data analysis, data mining and knowledge discovery in databases have recently gained the attention of a large number of researchers and practitioners. This is witnessed by the rapidly increasing number of submissions and participants at related conferences and workshops, by the emergence of new journals in this area (e.g., Data Mining and Knowledge Discovery, Intelligent Data Analysis, etc.), and by the increasing number of new applications in this field. In our view, the awareness of these challenging research fields and emerging technologies has been much larger in industry than in medicine and pharmacology. The main purpose of this book is to present the various techniques and methods that are available for intelligent data analysis in medicine and pharmacology, and to present case studies of their application. Intelligent Data Analysis in Medicine and Pharmacology consists of selected (and thoroughly revised) papers presented at the First International Workshop on Intelligent Data Analysis in Medicine and Pharmacology (IDAMAP-96) held in Budapest in August 1996 as part of the 12th European Conference on Artificial Intelligence (ECAI-96), IDAMAP-96 was organized with the motivation to gather scientists and practitioners interested in computational data analysis methods applied to medicine and pharmacology, aimed at narrowing the increasing gap between excessive amounts of data stored in medical and pharmacological databases on the one hand, and the interpretation, understanding and effective use of stored data on the other hand. Besides the revised Workshop papers, the book contains a selection of contributions by invited authors. The expected readership of the book is researchers and practitioners interested in intelligent data analysis, data mining, and knowledge discovery in databases, particularly those who are interested in using these technologies in medicine and pharmacology. Researchers and students in artificial intelligence and statistics should find this book of interest as well. Finally, much of the presented material will be interesting to physicians and pharmacologists challenged by new computational technologies, or simply in need of effectively utilizing the overwhelming volumes of data collected as a result of improved computer support in their daily professional practice.
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Molecular Pharmacology and Pathology of Strokes

 Pathology, Pharmacology  Comments Off on Molecular Pharmacology and Pathology of Strokes
Mar 072019
 

Stroke, an important neurological disease, is becoming an increasingly non-communicable ailment and is the second leading cause of death after coronary heart disease in developed countries . Present treatment options for stroke are adapting lifestyle practice, diabetes treatment, drugs, and other factors management, but no cure is yet available, despite new insights into the molecular and therapeutic targets.

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Practical Manual of Dispensing Pharmacy

 Pharmacology  Comments Off on Practical Manual of Dispensing Pharmacy
Mar 062019
 

Pharmaceutical Science is one such realm of novel thoughts translating into technologies to improve the quality of life. In the vicinity of Pharmaceutical Science, preparation and dispensing of pharmaceutical products has occupied a vast space. Hence, attempt has been made to delve further into the subject of dispensing pharmacy with certain products of significance to the undergraduate students of pharmacy. This book may also be a helping hand for the postgraduate students and other readers. This book consists of 60 numbers of practicals. Every single practical is designed and represented such a way so that the student’s fraternity can understand the real objective behind the practical. The detailed theory of practicals will enlighten the students with facts and the science behind it. The book contains compendia and extemporaneous products dispensing with suitable labeling, packaging and storage instructions. The book also contains the precaution that need to be exercised during compounding of such products. This book is supported by appendices containing commonly used Latin terms used in prescriptions, dosage calculation and containers & labeling instructions. At the end of every practical few important questions are provided for student’s ready reference.

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