Percutaneous Penetration Enhancers Chemical Methods in Penetration Enhancement: Modification of the Stratum Corneum

 Pharmacology  Comments Off on Percutaneous Penetration Enhancers Chemical Methods in Penetration Enhancement: Modification of the Stratum Corneum
Feb 132018
 

 

Percutaneous Penetration Enhancers in a mini-series format comprising five volumes, represents the most comprehensive reference on enhancement methods – both well established and recently introduced – in the field of dermal/transdermal drug delivery. In detail the broad range of both chemical and physical methods used to enhance the skin delivery of drugs is described. All aspects of drug delivery and measurement of penetration are covered and the latest findings are provided on skin structure and function, mathematics in skin permeation and modern analytical techniques adapted to assess and measure penetration. In offering a detailed description of the methods currently in use for penetration enhancement, this book will be of value for researchers, pharmaceutical scientists, practitioners and also students.

 

GET IT FREE HERE

 

http://nitroflare.com/view/DD6525548F940CF/3662470381.pdf

Share Button

Drugs and Social Context: Social Perspectives on the Use of Alcohol and Other Drugs

 Pharmacology  Comments Off on Drugs and Social Context: Social Perspectives on the Use of Alcohol and Other Drugs
Feb 112018
 

 

This book goes beyond the traditional approaches to drug use and discusses the issue from a societal perspective, integrating contributions from different disciplines such as psychology, public health, anthropology, law, public policies and sociology to address specifically the social aspects of the phenomenon.
Given its complexity, drug use demands a multidisciplinary approach from many different perspectives, but despite the vast literature about the topic, the majority of the books are restricted either to a purely medical perspective (focused mainly on treatment techniques) or to a criminological perspective (focused mainly on drug trafficking and organized crime).

The social approach adopted in this volume challenges this dichotomy and analyzes both the social contexts to which drug use is related and the social and political consequences of the attitudes and policies adopted by governments and other social groups towards drug users, addressing topics such as:
Drugs and poverty
Drugs and gender
Drugs and race
Drugs and territory
Stigmatization of drug use
Prohibitionism
Given its broad and innovative approach, Drugs and Social Context – Social Perspectives on the Use of Alcohol and Other Drugs will be of interest for researchers, clinicians and other health professionals, since the study of the social aspects of drug use is central to everyone who deals with the issue.

 

GET IT FREE HERE

 

http://nitroflare.com/view/1011AF6D20CB1CD/3319724452.epub

 

http://nitroflare.com/view/94E651421DAE6F4/3319724452.pdf

Share Button

cGMP: Generators, Effectors and Therapeutic Implications

 Pharmacology  Comments Off on cGMP: Generators, Effectors and Therapeutic Implications
Feb 082018
 

 

After the discovery of endogenous NO formation in the late ’80s and the 1998 Nobel Prize in Physiology or Medicine, many researchers and physicians again became interested in the NO/sGC interaction and cGMP-dependent signaling. This book is an enthusiastic celebration of cyclic guanosine monophosphate (cGMP) and amply illustrates the importance of this field of science to patients and the way in which the field has evolved. It is exclusively devoted to this exciting and important signaling molecule, addressing all recent advances in understanding guanylate cyclase regulation, NO/sGC interactions, cGMP effector mechanisms and their pathophysiological and pharmacological implications. Particular attention will also be given to clinical applications of the novel cGMP-elevating drugs which are on the horizon, thus spanning the continuum from basic science to clinic.

 

GET IT FREE HERE

 

http://nitroflare.com/view/6BC7899130D9D67/cGMP_Generators%2C_Effectors_and_Therapeutic_Implications.pdf

Share Button

Translating Molecules into Medicines: Cross-Functional Integration at the Drug Discovery-Development Interface

 Pharmacology  Comments Off on Translating Molecules into Medicines: Cross-Functional Integration at the Drug Discovery-Development Interface
Feb 082018
 

 

Tackling translational medicine with a focus on the drug discovery development-interface, this book integrates approaches and tactics from multiple disciplines, rather than just the pharmaceutical aspect of the field. The authors of each chapter address the paradox between the molecular understanding of diseases, drug discovery, and drug development. Laying out the detailed trends from various fields, different chapters are dedicated to target engagement, toxicological safety assessments, and the compelling relationship of optimizing early clinical studies with design strategies. The book also highlights the importance of balancing the three pillars: sufficient efficacy, acceptable safety and appropriate pharmacokinetics, all of which are crucial to successful efforts in discovery and development. With discussions regarding the combined approaches of molecular research, personalized medicine, pre-clinical and clinical development, as well as targeted therapies―this compendium is a flexible fit, perfect for professionals in the pharmaceutical industry and related academic fields.
GET IT FREE HERE
Share Button

Social Work Practice and Psychopharmacology

 Pharmacology, Psychiatry  Comments Off on Social Work Practice and Psychopharmacology
Feb 082018
 

 

This book documents the major medications used to treat mental health conditions and offers guidelines for how to use various medications in practice. This text serves as a supportive guide for social workers and mental health practitioners that assists in providing the best care for patients.

GET IT FREE HERE

 

 

http://nitroflare.com/view/EE9AAF7552A3787/0826102174.pdf

Share Button

Handbook of Stability Testing in Pharmaceutical Development: Regulations, Methodologies, and Best Practices

 Pharmacology  Comments Off on Handbook of Stability Testing in Pharmaceutical Development: Regulations, Methodologies, and Best Practices
Feb 062018
 

 

This handbook is the first to cover all aspects of stability testing in pharmaceutical development. Written by a group of international experts, the book presents a scientific understanding of regulations and balances methodologies and best practices.

 

GET IT FREE HERE

 

http://nitroflare.com/view/10324D52774E4F2/Handbook_of_Stability_Testing_in_Pharmaceutical_Development.pdf

Share Button

Roach’s Introductory Clinical Pharmacology (10th edition)

 Pharmacology  Comments Off on Roach’s Introductory Clinical Pharmacology (10th edition)
Feb 042018
 

You can prepare for your future career and success on the NCLEX with the only pharmacology textbook truly written for the LPN/LVN student, Roach’s Introductory Clinical Pharmacology. This proven book will help you every step of the way to master one of the most challenging content areas in the LPN/LVN curriculum. Organized by body system, the book provides a clear, concise introduction to pharmacology, focusing on basic principles and the nurse’s responsibility in drug administration. You can focus your reading and enhance your mastery of course concepts through chapter-opening Learning Objectives, Key Terms, and Drug Class lists that identify potential errors and safety concerns. You can learn drug contraindications, precautions, and interactions through The Nursing Process framework that presents care of the patient as it relates to the drug and drug regimen, as well as Checklists of Relevant Nursing Diagnoses. You can master important patient care concepts with Pharmacology in Practice case studies that focus on assessment, administration, or teaching issues that have an impact on a real-life patient. Chapter-ending Think Critically questions return to the patient in the case study and ask you to explore options and make clinical judgments related to the administration of drugs. You can get a sense of real world practice through Patient Case Study scenarios threaded through each chapter that offer a “simulation-focus.” Quickly identify urgent nursing actions that may be required when managing a patient receiving a specific drug or drug category through Nursing Alerts.

GET IT FREE HERE

http://nitroflare.com/view/FB69BBCCFC055BC/1451186711_Roach%27s.epub

Share Button

Top Drugs: History, Pharmacology, Syntheses

 Pharmacology  Comments Off on Top Drugs: History, Pharmacology, Syntheses
Feb 042018
 

Drugs like Lipitor, Plavix, Taxol, and Zoloft are integral in today’s medicinal world. These widely used products save lives and improve the quality of lives, playing a crucial role in everything from cholesterol management to cancer treatment. These advances in medicine were brought into existence after nuanced process of creation, featuring a wide range of chemical and pharmacological experimentation and discovery.
Top Drugs: Their History, Pharmacology, and Synthesis provides an in-depth study on ten prominent drugs, outlining the chemistry behind each one’s creation. Jie Jack Li, a medicinal chemist and an expert on drug discovery, offers a thorough analysis of the landscape of current drug development. The comprehensive text is divided by health issues, including cardiovascular, cancer, metabolic diseases, and infectious diseases. Each section features individual chapters on significant drugs, outlining the chemistry and history of the drug’s discovery. Li begins each chapter with the product’s history, providing necessary context. Li then proceeds to describe the mechanism of action, structure-activity relationship (SAR), bioavailability, metabolism, toxicology, the discovery route, and the process route. Top Drugs: Their History, Pharmacology, and Synthesis will acclimate students, scientists, and interested laypersons to the world of chemistry and drug discovery.

GET IT FREE HERE

http://nitroflare.com/view/48FE48535156647/Top_Drugs_History%2C_Pharmacology%2C_Syntheses.epub

Share Button

Introduction to Statistics in Pharmaceutical Clinical Trials

 Pharmacology, Statistics  Comments Off on Introduction to Statistics in Pharmaceutical Clinical Trials
Feb 022018
 

This book is a self-contained introduction to Statistics, presented in the context of clinical trials and pharmaceutical drug development. It focuses on the statistical analyses most commonly used in drug development and is therefore an ideal introduction to pharmaceutical statistics. Instead of introducing a series of statistical techniques, the book’s organizational structure follows the order in which numerical information and statistical analyses are used in trials and new drug development.All students taking classes in pharmaceutical sciences and clinical research need a solid knowledge and understanding of the nature, methods, application and importance of Statistics. They need to understand:why, and how data are collected in clinical trials; how these data are summarized and analyzed; what the results mean in the context of the clinical research question; and, how the results are communicated to regulatory agencies and to scientific and medical communities.This title therefore adopts a unique approach and concept in organization of the content. It begins with an introduction to statistical theory, analysis and interpretation. This is followed by a discussion of t-tests and confidence intervals. Readers are then taken through the whole process of new drug development (using one specific example throughout) that is meaningful in the context of their broader studies. Throughout this process, statistical techniques and analyses are introduced in the order in which they are employed during the process.The book’s realistic scientific and progressive organization from pre-clinical trials to clinical pharmacology through clinical trials is novel, meaningful and educationally powerful. The book emphasises the importance of descriptive statistics as well as inferential statistics, something that is rarely done.Supplementary material is included for this text on the PharmPress website in the form of PowerPoint lecture notes on Statistics (based on content of this book) that can be downloaded by lecturers.
GET IT FREE HERE
Share Button

Textbook of Receptor Pharmacology (3rd Edition)

 Pharmacology  Comments Off on Textbook of Receptor Pharmacology (3rd Edition)
Feb 022018
 

For the past four decades, University College London has offered a renowned course on receptor pharmacology. Originating from this course, the perennially bestselling Textbook of Receptor Pharmacology has presented in-depth coverage of this rapidly expanding area of research. This third edition continues to combine current understanding of classical quantitative pharmacology and drug-receptor interactions with the basics of receptor structure and signal transduction mechanisms, providing an integrated analysis of the mechanisms of drug action at membrane receptors. Maintaining the second edition’s focus on cell membrane receptors and the immediate signal transduction events at the membrane, this edition includes updated chapters on receptor structure and signal transduction by G-proteins and tyrosine kinases as well as enhancements to the quantitative treatment of drug-receptor interactions. Several chapters contain problems and worked-out solutions, giving students the ability to test their comprehension of the material. Hundreds of diagrams and figures further enhance the text. A time-saving resource and comprehensive learning tool, Textbook of Receptor Pharmacology, Third Edition carries on the tradition of providing in-depth, up-to-date coverage of this critical area that is both fundamental to the science of pharmacology and on the cutting edge of new drug development.
GET IT FREE HERE
Share Button