Macrolides: Properties, Synthesis and Applications

 Pharmacology  Comments Off on Macrolides: Properties, Synthesis and Applications
Jun 092018
 

Macrolide antibiotics represent a class of natural macrocyclic products, one of the most clinically important antibiotics. Unfortunately, the production and development of new macrolide antibiotics are not represented enough in the pharmaceutical industry today. The intention of the book is therefore not only to be a teaching tool for students and experts, but also to draw the attention of the general public to this extremely useful, cheap and relatively unharmful effective anti-macrobials, and potential anti-malarials. The authors introduce the different classes of macrolides and their derivatives, principles of their biological activity, their structure and interactions with biological targets as well as synthetic methods to produce new macrolide antibiotics of similar or improved properties. Special emphasis was put on conjugates of macrolides with nucleobases or nucleosides with numerous applications; among them the most important remains the attempt to overcome bacterial resistance

About the Author
Biljana Arsic, University of Nis, Nis, Republic of Serbia.

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Pharmacology and Therapeutics of Asthma and COPD (Handbook of Experimental Pharmacology)

 Pharmacology  Comments Off on Pharmacology and Therapeutics of Asthma and COPD (Handbook of Experimental Pharmacology)
Jun 032018
 

The present volume is supposed to be a major reference resource for chest physicians and those involved in the development of novel pharmaceutical entities for these diseases. Internationally recognized authorities review the most important new information on the advances in our understanding of the pathogenesis and treatment of these diseases, including the substantial advances in the topical delivery of inhaled medicines. Each chapter is extensively referenced, generously illustrated with clear diagrams and photographs, and represents a state-of-the-art review of this important area of respiratory medicine.
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Best Choices from the People’s Pharmacy: What You Need to Know Before Your Next Visit to the Doctor or Drugstore

 Pharmacology  Comments Off on Best Choices from the People’s Pharmacy: What You Need to Know Before Your Next Visit to the Doctor or Drugstore
May 292018
 

From the trusted authors of the “People’s Pharmacy” syndicated newspaper column comes Best Choices from the People’s Pharmacy, an essential reference that empowers readers to make intelligent, informed choices from among the array of treatment options—home remedies, herbal and nutritional supplements, and prescription and over-the-counter drugs—available today

We can read the newspaper for candid restaurant or movie reviews or consult Consumer Reports for an impartial analysis of the best buys on toasters or automobiles. But where can we find objective evaluations of popular treatments for conditions like arthritis, high cholesterol, and migraines?

Joe and Teresa Graedon, the best-selling authors of The People’s Pharmacy, will fill the void with a comprehensive new reference that presents all the information readers need to become savvy health-care consumers. The book offers:

• best-choice treatments for 50 medical conditions—from allergies, asthma, and heartburn to high blood pressure and osteoporosis
• a remedy ratings guide to compare the effectiveness and affordability of various treatment options
• compelling new information on the potential dangers of generic drugs

Featuring a list of the authors’ must-have remedies and organized alphabetically by condition for fast, easy access, this trustworthy, practical guide should find a sizable and grateful audience.

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Clinical Psychopharmacology for Neurologists: A Practical Guide

 Neurology/Neurosurgery, Pharmacology, Psychiatry  Comments Off on Clinical Psychopharmacology for Neurologists: A Practical Guide
May 262018
 

This book provides neurologists with a basic knowledge of psychiatric medications. It begins with general principles of psychopharmacology and the frequency of psychiatric illness in neurology patients. It goes on to cover psychoactive drugs in the elderly and treating behavioral symptoms of dementia. There is a special emphasis on drug-drug and drug-diet interactions that may be seen in clinical practice. Neurologists, residents, neuropsychiatrists, neuropsychologists and psychiatrists in training will find this practical guide invaluable in numerous clinical settings.
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Targeting Trafficking in Drug Development (Handbook of Experimental Pharmacology)

 Pharmacology  Comments Off on Targeting Trafficking in Drug Development (Handbook of Experimental Pharmacology)
May 262018
 

Cellular trafficking is only recently identified as a site for therapeutic intervention. This book provides up to date information on the mechanism for exploiting this area for drug development as well as a clear understanding of the individual components of cellular trafficking. The authors are experts in their areas and the book features tables and figures that enable comparison and clear understanding.
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Reviews of Physiology, Biochemistry and Pharmacology Vol. 174

 Pharmacology, Physiology  Comments Off on Reviews of Physiology, Biochemistry and Pharmacology Vol. 174
May 252018
 

Leading researchers are specially invited to provide a complete understanding of a key topic within the multidisciplinary fields of physiology, biochemistry and pharmacology. In a form immediately useful to scientists, this periodical aims to filter, highlight and review the latest developments in these rapidly advancing fields.

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Dermal Absorption Models in Toxicology and Pharmacology

 Pharmacology, Toxicology  Comments Off on Dermal Absorption Models in Toxicology and Pharmacology
May 212018
 

Many experimental methods and mathematical modeling approaches rooted in disciplines outside of toxicology can be effectively applied to estimating dermal absorption. Dermal Absorption Models in Toxicology and Pharmacology explores current approaches and techniques that can be used to quantify dermal absorption with endpoints useful in both toxicology and pharmacology.
The book begins with a review of basic principles and the in vitro and in vivo experimental approaches available for assessing dermal absorption of drugs and chemicals. This is followed by coverage of mathematical or in silico models for quantitating percutaneous absorption and the applications of these techniques to the risk assessment process. The remainder of the book explores scenarios where the unique properties of the chemicals being studied or the matrix in which they are exposed must be considered and then wraps up with a comparative analysis of chemical permeability in human and animal skin.
Many of the books covering this subject are just too comprehensive and serve primarily as reference works. This book takes a different approach. Jim Riviere’s editorial guidance ensures that the information is readable, accessible, authoritative, and concise, making it the perfect resource for familiarizing new researchers and students to the field and updating established scientists.

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Integrin Targeting Systems for Tumor Diagnosis and Therapy

 Pharmacology, Toxicology  Comments Off on Integrin Targeting Systems for Tumor Diagnosis and Therapy
May 212018
 


This volume collects a variety of techniques and methodologies developed to facilitate research on integrin biology and to identify ideal targets and approaches for the treatment of multiple organ diseases, with a focus on cancer in particular. The chapters consecutively describe the tools for structural analysis, identification and detection of integrins as biomarkers, and include thorough laboratory and clinically-related methods on different strategies for generation, synthesis and evaluation of probes, carriers, peptides or small particles for integrin targeting, imaging, and drug delivery. As part of the Methods in Pharmacology and Toxicology series, this book contains the practical details that are invaluable in the laboratory.
Authoritative and advantageous, Integrin Targeting Systems for Tumor Diagnosis and Therapy serves readers from a wide spectrum, including researchers and students seeking an overview of existing developments, as well as leading professionals aiming to become more familiar with integrin-related innovative technologies in cancer research.

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The Addiction Solution: Treating Our Dependence on Opioids and Other Drugs

 Pharmacology  Comments Off on The Addiction Solution: Treating Our Dependence on Opioids and Other Drugs
May 202018
 

A groundbreaking examination of addiction from a psychiatrist and public health doctor, offering practical, proven solutions for individuals, families, and communities dealing with substance use and abuse.

Written with warmth, accessibility, and vast authority, The Addiction Solution is a practical guide through the world of drug use and abuse and addiction treatment. Here, Lloyd I. Sederer, MD, brings together scientific and clinical knowledge, policy suggestions, and case studies to describe our current drug crisis and establish a clear path forward to recovery and health. In a time when so many people are affected by the addiction epidemic, when 142 people die of overdoses every day in the United States, principally from opioids, Sederer’s decades of wisdom and clinical experience are needed more than ever before.

With a timely focus on opioids, Sederer takes us through the proven essentials of addiction treatment and explains why so many of our current policies, like the lingering remnants of the War on Drugs, fail to help drug users, their families, and their wider communities. He identifies a key insight, often overlooked in popular and professional writing about addiction and its treatment: namely, that people who use drugs do so to meet specific needs, and that drugs may be the best solution those people currently have. Writing with generosity and empathy about the many Americans who use illicit and prescribed substances, Sederer lays out specific, evidence-based, researched solutions to the prevention and problems of drug use, including exercise, medications, therapy, recovery programs, and community services. In this challenging time, The Addiction Solution provides practical help, comfort, and hope.

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Chemotherapy in Neonates and Infants: Pharmacological Oncology for Children Under 1 Year Old

 Oncology, Pediatrics, Pharmacology  Comments Off on Chemotherapy in Neonates and Infants: Pharmacological Oncology for Children Under 1 Year Old
May 112018
 


This book provides a comprehensive overview of pediatric oncology, discussing drug therapy and treatment in children under the age of 1 year. It is the first volume to focus on chemotherapy in newborns and infants, especially the daily clinical practice and treatment protocols.

Intended as a practical manual, it addresses all the major topics related to pediatric oncology in an accessible and easy-to-use format. It examines topics in pediatric oncology therapeutics, including drug metabolism, excretion, toxicity, drugs that can be used for each week or month of the patient’s life, dose adjustment and treatment protocols.
Chemotherapy in Neonates and Infants focuses on the safe treatment of children in the first year of life, and is aimed at pediatric oncology/hematology institutions, clinics and departments. It is particularly valuable for researchers, pediatric oncology physicians, pediatric and neonatology physicians, oncology pharmacists and the other healthcare professionals directly involved in the chemotherapy of neonates and infants.

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