Analgesics: From Chemistry and Pharmacology to Clinical Application

 Pharmacology  Comments Off on Analgesics: From Chemistry and Pharmacology to Clinical Application
Feb 222018

Classified by their mode of action, all important classes of analgesics are presented here, including recent developments that have not yet been introduced to the market. Altogether, more than 300 compounds are described. A carefully designed layout presents the most relevant information at a glance, including compound structure, physical properties, synthesis schemes and clinical uses. Trade names for different countries are also given, allowing quick reference to compounds currently on the market.
In addition to proven pain relievers, novel approaches to pain treatment are discussed and drug candidates for future therapies are presented.
With its broad scope and extensive compound listings, this is a premier reference source for pain treatment by pharmacological means. A valuable resource for clinicians, drug developers and pain researchers.


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Endocannabinoids : Molecular, Pharmacological, Behavioral and Clinical Features

 Behavioral Sciences, Pharmacology  Comments Off on Endocannabinoids : Molecular, Pharmacological, Behavioral and Clinical Features
Feb 212018

The endocannabinoid system comprises at least two G-protein-coupled receptors (the cannabinoid CB1 and CB2 receptors) activated by marijuana’s psychoactive principle ^9-tetrahydrocannabinol (THC) and the endogenous ligands known as endocannabinoids. The apex of endocannabinoid research seems to have been reached with the clinical development, and also in some cases, the marketing, of synthetic or natural pharmaceuticals targeting this signalling system, which followed the understanding of the physiological and pathological role of endocannabinoids in several conditions, a role that was investigated first in rodent experimental models and then in humans.

Endocannabinoids: Molecular, Pharmacological, Behavioral and Clinical Features is a monograph that presents interesting manuscripts selected by the editor on the subject. Chapters in this book include original research or reviews which report the relevance of the endocannabinoid system by describing the results of experimental evidence about the neurobiological role of the endocannabinoid system. The main topics include, but are not limited to:

* The genetics of cannabinoid CB1 and CB2 receptors and their tissue distribution, their splicing variants and polymorphisms, and the possible implications of all this in determining different behaviours as well as various pathological conditions and the addiction to substances of abuse.

* Pharmacological approaches describing the potential use in the central nervous system disorders of endocannabinoid-based drugs, such as cannabinoid receptor agonists and antagonists, inhibitors of endocannabinoid inactivation processes, and even plant cannabinoids other than THC and with a molecular mechanism of action.

* The role of the endocannabinoid system in several neurological and neuropsychiatric conditions, such as epilepsy.

The volume would be a great interest to neuropharmacologists, physiologists and biochemists who aim to learn about the endocannabinoid system in detail.


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Handbook of Research on Medicinal Chemistry: Innovations and Methodologies

 Pharmacology  Comments Off on Handbook of Research on Medicinal Chemistry: Innovations and Methodologies
Feb 192018

This valuable new book, Handbook of Research on Medicinal Chemistry: Innovations and Methodologies, presents some of the latest advancements in the various fields of combinatorial chemistry, drug discovery, biochemical aspects, pharmacology of medicinal agents, current practical problems, and nutraceuticals.

The editors keep the drug molecule as the central component of the volume and aim to explain the associated features essential to exhibiting pharmacological activity. With a unique combination of chapters in biology, clinical aspects, biochemistry, synthetic chemistry, medicine and technology, the volume provides broad exposure to the essential aspect of pharmaceuticals.

The volume many important aspects of medicinal chemistry, including

techniques in drug discovery
pharmacological aspects of natural products
chemical mediators: druggable targets
advances in medicinal chemistry

The field of medicinal chemistry is growing at an unprecedented pace, and this volume takes an interdisciplinary approach, covering a range of new research and new practices in the field. The volume takes into account the latest therapeutic guidelines put forward by the World Health Organization and the U.S Food and Drug Administration..





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Kucers’ The Use of Antibiotics, 7th Edition (Three Volume Set)

 Pharmacology  Comments Off on Kucers’ The Use of Antibiotics, 7th Edition (Three Volume Set)
Feb 172018

Kucers’ The Use of Antibiotics is the definitive, internationally-authored reference, providing everything that the infectious diseases specialist and prescriber needs to know about antimicrobials in this vast and rapidly developing field. The much-expanded Seventh Edition comprises 4800 pages in 3 volumes in order to cover all new and existing therapies, and emerging drugs not yet fully licensed. Concentrating on the treatment of infectious diseases, the content is divided into four sections – antibiotics, anti-fungal drugs, anti-parasitic drugs, and anti-viral drugs – and is highly structured for ease of reference.

Each chapter is organized in a consistent format, covering susceptibility, formulations and dosing (adult and pediatric), pharmacokinetics and pharmacodynamics, toxicity, and drug distribution, with detailed discussion regarding clinical uses – a feature unique to this title. Compiled by an expanded team of internationally renowned and respected editors, with expert contributors representing Europe, Africa, Asia, Australia, South America, the US, and Canada, the Seventh Edition adopts a truly global approach. It remains invaluable for anyone using antimicrobial agents in their clinical practice and provides, in a systematic and concise manner, all the information required when prescribing an antimicrobial to treat infection.




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Pharmacogenomics in Latin America: Challenges and Opportunities

 Pharmacology  Comments Off on Pharmacogenomics in Latin America: Challenges and Opportunities
Feb 172018

Worldwide, adverse drug reactions are a major cause of morbidity and mortality in patients, as well as increased healthcare costs. Published data show that there are around 2 million adverse drug reactions, including 100,000 deaths, which are established as the fourth leading cause of mortality. This culminates an estimated cost of 136 billion dollars to the global healthcare system. However, these values are underestimated, because in many parts of the world there are no reliable records of pharmacovigilance. This is the case in Latin America, where the records of adverse reactions are still insufficient, and therefore it is not possible to properly establish the extent of its effects on public health. At the same time, treatment failure due to sub-therapeutic levels of drugs is not evaluated in healthcare systems, especially in Latin America, where the “importation” of dosages and results from clinical trials form the fundamental basis of the application and acquisition of pharmaceutical products. This is due mainly to current protocols, which assume that patients are a single entity; therefore, drugs effective and well-tolerated in some patients are equally effective in the rest. Clinical experience shows that drugs that work well in some patients are ineffective or cause adverse reactions in others, and may even prove fatal to intolerant patients.
The main objective of this book is to catalog the most relevant information concerning healthcare drug effects in Latin America. This could provide a huge benefit for Latin American patients, where it is estimated that there are plenty of side effects and treatment failure due to the “importation” of dosages and therapies regardless of population variability. It should encourage discussion and concern about the implementation and validation of pharmacogenomic testing and clinical guidelines for specific mixed populations of the region. It will also be valuable to demonstrate this research to health professionals (prescribers, insurers and regulators) in the region and the impact of pharmacogenomics on pharmacotherapy cost-effectiveness


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Forensic Pharmacology

 Forensic Medicine, Pharmacology  Comments Off on Forensic Pharmacology
Feb 162018

Forensic Pharmacology describes one aspect of forensic science: forensic pharmacology and toxicology of drugs of abuse. The reader is introduced to the daily work of the scientists, the principles of pharmacology and toxicology, the technical analysis of drugs, and the characteristics of eight major categories of drug abuse. The text is a handy reference source for people of all ages interested in the solving of drug-related crimes.
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Basic and Clinical Pharmacology – 14th Edition (November 2017 Release)

 Pharmacology  Comments Off on Basic and Clinical Pharmacology – 14th Edition (November 2017 Release)
Feb 142018

The most up-to-date, comprehensive, and authoritative pharmacology text in health medicine―enhanced by a new full-color illustrations

Organized to reflect the syllabi in many pharmacology courses and in integrated curricula, Basic & Clinical Pharmacology, Fourteenth Edition covers the important concepts students need to know about the science of pharmacology and its application to clinical practice. Selection of the subject matter and order of its presentation are based on the authors’ many years’ experience in teaching this material to thousands of medical, pharmacy, dental, podiatry, nursing, and other health science students.

To be as clinically relevant as possible, the book includes sections that specifically address the clinical choice and use of drugs in patients and the monitoring of their effects, and case studies that introduce clinical problems in many chapters. Presented in full color and enhanced by more than three hundred illustrations (many new to this edition), Basic & Clinical Pharmacology features numerous summary tables and diagrams that encapsulate important information.

• Student-acclaimed summary tables conclude each chapter
• Everything students need to know about the science of pharmacology and its application to clinical practice
• Strong emphasis on drug groups and prototypes
• NEW! 100 new drug tables
• Includes 330 full-color illustrations, case studies, and chapter-ending summary tables
• Organized to reflect the syllabi of pharmacology courses
• Descriptions of important new drugs


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Percutaneous Penetration Enhancers Chemical Methods in Penetration Enhancement: Modification of the Stratum Corneum

 Pharmacology  Comments Off on Percutaneous Penetration Enhancers Chemical Methods in Penetration Enhancement: Modification of the Stratum Corneum
Feb 132018


Percutaneous Penetration Enhancers in a mini-series format comprising five volumes, represents the most comprehensive reference on enhancement methods – both well established and recently introduced – in the field of dermal/transdermal drug delivery. In detail the broad range of both chemical and physical methods used to enhance the skin delivery of drugs is described. All aspects of drug delivery and measurement of penetration are covered and the latest findings are provided on skin structure and function, mathematics in skin permeation and modern analytical techniques adapted to assess and measure penetration. In offering a detailed description of the methods currently in use for penetration enhancement, this book will be of value for researchers, pharmaceutical scientists, practitioners and also students.



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Drugs and Social Context: Social Perspectives on the Use of Alcohol and Other Drugs

 Pharmacology  Comments Off on Drugs and Social Context: Social Perspectives on the Use of Alcohol and Other Drugs
Feb 112018


This book goes beyond the traditional approaches to drug use and discusses the issue from a societal perspective, integrating contributions from different disciplines such as psychology, public health, anthropology, law, public policies and sociology to address specifically the social aspects of the phenomenon.
Given its complexity, drug use demands a multidisciplinary approach from many different perspectives, but despite the vast literature about the topic, the majority of the books are restricted either to a purely medical perspective (focused mainly on treatment techniques) or to a criminological perspective (focused mainly on drug trafficking and organized crime).

The social approach adopted in this volume challenges this dichotomy and analyzes both the social contexts to which drug use is related and the social and political consequences of the attitudes and policies adopted by governments and other social groups towards drug users, addressing topics such as:
Drugs and poverty
Drugs and gender
Drugs and race
Drugs and territory
Stigmatization of drug use
Given its broad and innovative approach, Drugs and Social Context – Social Perspectives on the Use of Alcohol and Other Drugs will be of interest for researchers, clinicians and other health professionals, since the study of the social aspects of drug use is central to everyone who deals with the issue.



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cGMP: Generators, Effectors and Therapeutic Implications

 Pharmacology  Comments Off on cGMP: Generators, Effectors and Therapeutic Implications
Feb 082018


After the discovery of endogenous NO formation in the late ’80s and the 1998 Nobel Prize in Physiology or Medicine, many researchers and physicians again became interested in the NO/sGC interaction and cGMP-dependent signaling. This book is an enthusiastic celebration of cyclic guanosine monophosphate (cGMP) and amply illustrates the importance of this field of science to patients and the way in which the field has evolved. It is exclusively devoted to this exciting and important signaling molecule, addressing all recent advances in understanding guanylate cyclase regulation, NO/sGC interactions, cGMP effector mechanisms and their pathophysiological and pharmacological implications. Particular attention will also be given to clinical applications of the novel cGMP-elevating drugs which are on the horizon, thus spanning the continuum from basic science to clinic.



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