Molecular Pathology of the Prions (Methods in Molecular Medicine)

 Pathology  Comments Off on Molecular Pathology of the Prions (Methods in Molecular Medicine)
May 252018
 

Internationally recognized investigators review the latest developments in, and novel approaches to, understanding the prion protein and prion diseases at the molecular level. Utilizing a variety of cutting-edge techniques, these distinguished scientists seek to define the normal function of a prion protein, to detect and measure the early immune response to prion disease, and to discover possible therapeutic targets. They also use transgenic mice and new electrophysiological investigations to elucidate the pathogenetic mechanisms involved in prion diseases. State-of-the-art and richly insightful, Molecular Pathology of the Prions captures for basic and clinical neuropathologists the latest developments and approaches to understanding the pathogenesis of prion diseases, and by analogy suggests possible research techniques for the more common proteinopthies, such as Alzheimer’s and Parkinson’s diseases.
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Trichothecene Mycotoxicosis: Pathophysiologic Effects: Volume I

 Pathology, Physiology  Comments Off on Trichothecene Mycotoxicosis: Pathophysiologic Effects: Volume I
May 232018
 

There are instances of unresolved differences of opinion , as in the case of underlying biochemical mechanisms of action. It has been particularly challenging to interpret the diversity of effects induced by several trichothecenes when studied in various cells, tissues, and concentrations, and at dissimilar intervals. In the hope of shortening the time needed to overcome these difficulties, the authors have sought to discuss a range of observations delineating both areas of agreement and aspects remaining to be clarified.

The final chapter of the volumes is comprised of an effort to integrate the various observations detailed throughout the book. With the continued efforts of not only the many dedicated scientists who served as contributors to these volumes, but from the many other authors cited herein and those to follow, out understanding of these interesting compounds will continue to expand. We have already learned enough to greatly reduce the adverse effects of the trichothecene mycotoxins on humans and other animals.

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Bronchial Vascular Remodeling in Asthma and COPD

 Pathology, Physiology  Comments Off on Bronchial Vascular Remodeling in Asthma and COPD
May 232018
 

Responding to the growth of research in the field over the past decade, this book brings together leading investigators with expertise in pulmonology, pathology, and developmental biology to clarify the mechanisms that regulate the development of bronchial vascular remodeling in asthma and COPD, as well as explore the pathophysiological processes that may impact the formulation of new therapeutic strategies for these conditions.

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Cytologic Detection of Urothelial Lesions

 Histology, Pathology  Comments Off on Cytologic Detection of Urothelial Lesions
May 182018
 

• Second volume to be published in the Essentials in Cytopathology series

• 125 full-color images

• User-friendly and concise guide

• Convenient format: Fits in lab coat pocket

• 2,000 of the 22,000 practicing pathologists in the US are cytopathologists

• 66,000 laboratory technicians deal with urine samples and are potential buyers

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Greenfield’s Neuropathology, Ninth Edition (Two Volume Set)

 Neurology/Neurosurgery, Pathology  Comments Off on Greenfield’s Neuropathology, Ninth Edition (Two Volume Set)
May 132018
 

Greenfield’s Neuropathology, the world’s leading neuropathology reference, provides a comprehensive account of the pathological findings in neurological disease, their biological basis, and their clinical manifestations.

The book’s detailed advice on pathological assessment and interpretation is based on clear descriptions of molecular and cellular processes and reactions that are relevant to the development of the nervous system, as well as its normal and abnormal functioning. The information is presented in an accessible way to readers working within a range of disciplines in the clinical neurosciences, and neuropathological findings are placed within the context of a broader diagnostic process.

New for the Ninth Edition:

Features online and downloadable digital formats with rapid search functions, annotation and bookmarking facilities, image collections, and live reference links
Contains many color illustrations and high-quality clinical photographs to help with interpretation and understanding
Includes more than 1000 new photographs and drawings
Incorporates new design elements, such as alternate colour coding of chapters for easier navigation
Known for its thorough yet practical approach, Greenfield’s continues to provide trusted information to all neuropathologists and those in related specialties, including neurologists, neurosurgeons, general pathologists, neuroradiologists, and clinical neuroscientists.

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Dermatopathology

 Dermatology, Pathology  Comments Off on Dermatopathology
May 072018
 

Arch Dermatology Intended for use as a practical manual, the information in this book has been presented so as to yield a differential diagnosis for each histological finding. With some 500 entities described, the contents of this handbook are quite inclusive. It serves not only as a primer in dermatopathology directed at residents of pathology and dermatology, but also as a useful reference for practicing dermatologists, general pathologists and primary care physicians who routinely evaluate skin lesions and biopsies in their practice.
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Resistant Hypertension: Epidemiology, Pathophysiology, Diagnosis and Treatment

 Epidemiology, Pathology, Physiology  Comments Off on Resistant Hypertension: Epidemiology, Pathophysiology, Diagnosis and Treatment
May 032018
 

A growing number of people suffer from so-called resistant hypertension, that is to say, high blood pressure that does not respond to treatment. This disorder is of great current interest and importance for public health, being a common clinical problem faced by both primary care clinicians and specialists.

Furthermore, as older age and obesity are among the strongest risk factors for uncontrolled hypertension, the incidence of resistant hypertension will likely increase as the population becomes more elderly and heavier. While the prognosis of resistant hypertension is unknown, cardiovascular risk is undoubtedly increased since patients often have a history of long-standing, severe hypertension complicated by multiple other cardiovascular risk factors.

This volume, compiled by a panel of world-renowned experts, offers a comprehensive exploration of resistant hypertension, covering epidemiology, complex diagnostic aspects, and the therapeutic options currently available, with due attention to overall treatment strategies. New therapeutic agents and procedures, such as renal denervation and baroreceptor stimulation, are also described. In addition, the book addresses the economic aspects of resistant hypertension and the role of the different professional figures, from GPs to hypertension specialists, in dealing with it.

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Hemodynamic Rounds: Interpretation of Cardiac Pathophysiology from Pressure Waveform Analysis

 Cardiovascular, Pathology, Physiology  Comments Off on Hemodynamic Rounds: Interpretation of Cardiac Pathophysiology from Pressure Waveform Analysis
May 022018
 

The essential resource on cardiac hemodynamics now in a new edition

Hemodynamic Rounds, Fourth Edition is intended to help cardiologists, cardiovascular fellowship trainees, residents and other members of the medical community enhance their understanding of cardiac physiology and its associated hemodynamic presentations in health and disease. This includes the basic principles of flow and pressure measurements, systemic as well as coronary hemodynamics in normal and diseased states, and changes in hemodynamics following interventional procedures ranging from TAVI and valvuloplasty to stent placement.

Like its popular predecessors, this new edition draws on case studies to illustrate characteristic cardiac hemodynamic findings and discusses the essential methods used in interpreting pressure waveforms as a diagnostic and monitoring tool.

The text is organized into chapters on specific areas of the heart, common cardiac pathophysiologic conditions, and hemodynamic situations resulting from different therapeutic procedures. It includes discussions of both normal and abnormal pressure waveforms. This new edition has been revised throughout to include brand new content on aortic and mitral valve stenosis and regurgitation as well as TAVI and mitral clip hemodynamics. Highlights include:

Essential and easy to understand resource for those required to interpret cardiac blood flow and blood pressure tracings
Covers hemodynamic assessment by cardiac disorder, plus the bedside applications of hemodynamics
Revised throughout and includes brand new content on valve stenosis and regurgitation and TAVI and mitral clip hemodynamics
Hemodynamic Rounds: Interpretation of Cardiac Pathophysiology from Pressure Waveform Analysis, Fourth Edition is an indispensable tool for all physicians, nurses, and students responsible for measuring and interpreting cardiac waveforms in cardiac diagnosis and monitoring.

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Rubin’s Pathology: Clinicopathologic Foundations of Medicine, 7th Edition

 Pathology  Comments Off on Rubin’s Pathology: Clinicopathologic Foundations of Medicine, 7th Edition
Apr 302018
 

Succeed in your course and on the boards with Rubin’s Pathology, 7th Edition. This acclaimed text provides streamlined coverage of the essential information you need to know. In addition, clinical applications of chapter concepts and hundreds of full-color graphic illustrations, line drawings, gross pathology photos, and micrographs help you master key content.
Expert coverage of common conditions, including heart disease, diabetes, common cancers, acne, and (specifically for dental students) oral diseases, prepare you for the types of conditions you are likely to encounter in practice.
A suite of exciting online tools, including 140 interactive case studies, 1500 audio review questions, and summary podcast lectures, help you master the concepts of the course.
Straightforward coverage of the topics most commonly encountered on the USMLE Step 1, COMLEX, and other exams prepares you for success on the boards.
A chapter on forensic pathology that has been described as “CSI” in a textbook introduces you to key content in a fascinating manner.
A stand-alone online case history section accessible online gives you an opportunity to apply concepts and develop your clinical reasoning skills.

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BSAVA Manual of Canine and Feline Clinical Pathology, Third Edition

 Pathology  Comments Off on BSAVA Manual of Canine and Feline Clinical Pathology, Third Edition
Apr 302018
 

The BSAVA Manual of Canine and Feline Clinical Pathology is an indispensable practical resource for clinical pathologists, clinicians and veterinary students. Features case studies to allow readers to consider how they would approach common problems.

The new edition of this popular manual has been extensively updated to reflect advances in this field, while readers will also find new chapters on inherited and cardiac disease.

Clinical case studies have been retained, allowing readers to consider how they might approach common problems and see for themselves how test selection and interpretation are applied. Body systems are dealt with in their own discrete chapters, as are urinalysis, blood cells and proteins.

Full-colour photographs and illustrations can be found throughout, which will prove indispensable to clinical pathologists, clinicians and veterinary students keen to get grips with a rapidly expanding subject.

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