Sepsis and Organ Dysfunction: Epidemiology and Scoring Systems Pathophysiology and Therapy

 Epidemiology, Pathology, Physiology  Comments Off on Sepsis and Organ Dysfunction: Epidemiology and Scoring Systems Pathophysiology and Therapy
Jan 212019
 

Sepsis is a syndrome or sometimes it is a clinical condition evoked by uncontrolled endotoxin-reactions. These pathophysiological alterations can disturb the organism’s homeostasis leading ultimately to a condition of severe organ dysfunction which in itself means a bad prognosis for patient survival. In the last decades researchers and clinicians have been involved in process directed to a better understanding of the basic mechanisms of sepsis and MODS. The best goal will be the achievement of preventive measures and optimization of management in patients suffering severe infections and critical conditions. This objective represents a true challenge at the dawn of the XXI century.
ALTERNATIVE LINK
Share Button

Left Ventricular Hypertrophy: Physiology versus Pathology

 Pathology, Physiology  Comments Off on Left Ventricular Hypertrophy: Physiology versus Pathology
Jan 142019
 

The importance of left ventricular hypertrophy in cardiovascular disease has gained wide recognition. Left ventricular hypertrophy is a highly important risk factor associated with major cardiovascular events, including symptomatic heart failure, particularly in patients with systemic hypertension. Over the past years much has been learned about the genetics, molecular background, prevalence, incidence and prognosis of left ventricular hypertrophy. A variety of noninvasive methods has emerged for detecting left ventricular hypertrophy and the assessment of reversal of hypertrophy. Yet, a lot of controversy remains about the connotations and clinical implications of left ventricular hypertrophy. For instance, in the athlete’s heart left ventricular hypertrophy may constitute a physiological adaptation to pressure overload, which normalizes following discontinuation of strenuous physical activity. On the other hand, in particular in patients with hypertension, left ventricular hypertrophy denotes a serious prognosis in the course of hypertension. In these patients left ventricular hypertrophy should be regarded as a grave prognostic sign rather than an innocent compensatory phenomenon. The distinction between physiologic and pathophysiologic left ventricular hypertrophy has been the basis for this book.
GET IT FREE HERE
ALTERNATIVE LINK
Share Button

Pathophysiology of Heart Failure

 Cardiovascular, Pathology, Physiology  Comments Off on Pathophysiology of Heart Failure
Jan 132019
 

Pathophysiology of Heart Failure brings together leading basic scientists and clinicians, presenting new approaches to this complex problem, involving cardiomyopathic processes and ischemia perfusion injury. The result is a synthesis of state-of-the-art information on molecular biology, cellular physiology and structure-function relationships in the cardiovascular system. The role which excess intracellular calcium plays in the genesis of cardiac dysfunction is described as a fundamental mechanism underlying heart failure; one which may lead to improved prevention and treatment. Audience: Clinical and experimental cardiologists will find the book a helpful source of ideas and inspiration.
GET IT FREE HERE
ALTERNATIVE LINK
Share Button

Alagille Syndrome: Pathogenesis and Clinical Management

 Pathology  Comments Off on Alagille Syndrome: Pathogenesis and Clinical Management
Jan 082019
 

This text provides a concise yet comprehensive overview of Alagille syndrome. The book reviews the pathophysiology and genetics of the disorder, discusses recent molecular advances and its impact on diagnostics, and describes management challenges and strategies. The text also touches upon future treatment options.
Written by experts in the field, Alagille Syndrome: Pathogenesis and Clinical Management is a valuable resource for physicians and researchers dealing with this disorder, one that will help guide patient management and stimulate investigative efforts.

GET IT FREE HERE

http://nitroflare.com/view/3718987DA1586D9/331994570X.epub

http://nitroflare.com/view/E3AED2F34686B74/331994570X.pdf

ALTERNATIVE LINK

https://filejoker.net/dvn42uzm5sy3

https://filejoker.net/mkektuxd5xra

Share Button

Alpha 1 – Antitrypsin Deficiency: Biology-Pathogenesis-Clinical Manifestations-Therapy

 Pathology  Comments Off on Alpha 1 – Antitrypsin Deficiency: Biology-Pathogenesis-Clinical Manifestations-Therapy
Jan 042019
 

Providing a broad overview of basic and clinical aspects of alpha 1-antitrypsin (a 1AT) deficiency, this up-to-date reference discusses the complex pathobiological processes underlying the pathogenesis of a1AT deficiency, describes the a1AT gene and its promoter, and details specific therapies to prevent the major clinical manifestations of the disorder.
GET IT FREE HERE
ALTERNATIVE LINK
Share Button

Immunopathogenesis of HIV Infection

 Immunology, Infectious Diseases, Pathology  Comments Off on Immunopathogenesis of HIV Infection
Jan 022019
 

During the last 5 years, major advances have been made in our understanding of the pathogenesis of human immunodeficiency virus (HIV) disease and in the development of new potent antiviral agents. With regard to HIV pathogenesis, several recent observations have not only changed our perspectives of HIV disease, but have been critical for the design of therapeutic strategies. These oberservations include: 1. The delineation of the virologic and immunologic events associated with primary HIV infection. 2. The development of highly sensitive molecular techniques including polymerase chain reaction (PCR) assays for the determination of HIV RNA in plasma, together with the identification of lymphoid tissue as the primary anatomic site for HIV replication and spreading. 3. The characterization of the dynamics of HIV infection. 4. The identification of chemokines with suppressor activity on HIV replication and the discovery of co-receptor molecules for HIV entry.
GET IT FREE HERE
ALTERNATIVE LINK
Share Button

Thyroid Pathology

 Pathology  Comments Off on Thyroid Pathology
Jan 012019
 

In recent years, a series of excellent textbooks have been published dealing with pathology of the thyroid gland. The present volume of CURRENT TOPICS IN PATHOLOGY provides further information for both pathologists and clinicians interested in the thyroid gland. The contributions deal with surgical pathology of the thyroid as well as with basic aspects of thyroid metabolism, hormone transport, and growth factors in thyroid cells. The topics covered in this book should mainly be considered as adjuncts to common textbooks on thyroid pathology. The contributions should help pathologists in their routine diagnosis and should stimulate further thyroid research.
GET IT FREE HERE
ALTERNATIVE LINK
Share Button

Severe Head Injuries: Pathology, Diagnosis and Treatment

 Pathology  Comments Off on Severe Head Injuries: Pathology, Diagnosis and Treatment
Jan 012019
 

Severe head injuries are a frequent occurrence in the life of every emergency care specialist, traumatologist, neurosurgeon, and rehabilitation specialist. For example, between 30.000 to 40.000 severe head injuries occur in Germany each year. OVer 75.000 Americans die each year after having suffered a severe head injury. Nevertheless, treatment is not always optimal. Survival and longterm outcome depends not only on the type of injury but also on timely and appropriate diagnosis and treatment. Thus, all physicians involved must be aware of the current procedures in the management of severe head injuries. This reference book, based on the experience of international experts, provides an up to date and practical guideline.
GET IT FREE HERE
ALTERNATIVE LINK
Share Button

Epithelial Tumors of the Thymus: Pathology, Biology, Treatment

 Pathology  Comments Off on Epithelial Tumors of the Thymus: Pathology, Biology, Treatment
Dec 292018
 

Histological and Immunological Characterization of Thymic EpithelialTumors and Their Differential Diagnoses. Classification of Thymic Epithelial Neoplasms; L. Harris. Thymic Carcinoma; Y. Shiosato.Altered T Cell Functions in Thymic Epithelial Tumors. T Cell Development in the Human Thymus; B. Vandekerkhove. Intrathymic Autoantigens and Their Role in Shaping of the Autoimmune T Lymphocyte Repertoire; H. Weberle.Paraneoplastic Autoimmunity. Thymoma and Autoimmune Neurological Disorders: A Search for Missing Links in Pathogenesis; A. Vincent. t-Cell Derived Mechanisms in the Pathogenesis of Myasthenia Gravis; A. Lefvert.Diagnosis and Therapyof Thymic Epithelial Tumors. Clinical Immunology of Thymic Tumors in Patients with Myasthenia Gravis; A. Aarli. 1 Myasthenia Gravis with Thymoma; H.J.G.H. Oosterhuis.Management of Thymectomized Patients. Aspects of Clinical Preparation of Thymectomy in Myasthenic Cases with or without Thymoma and the Clinico-biological Follow-Up of the Thymectomized Patients; F. Cornelio. Longterm Prognosis of Patients with Thymoma-Associated Myasthenia Gravis; B.C.G. Schalke. 40 Additional Articles. Index.
GET IT FREE HERE
ALTERNATIVE LINK
Share Button

Molecular Diagnostics in Cytopathology: A Practical Handbook for the Practicing Pathologist

 Pathology  Comments Off on Molecular Diagnostics in Cytopathology: A Practical Handbook for the Practicing Pathologist
Dec 272018
 

Molecular diagnostics are increasingly used to help guide targeted therapy in solid organ tumors and hematologic malignancies. A large proportion of molecular testing is performed on limited-volume samples obtained via minimally invasive techniques, such as fine needle aspiration. Increasingly, cytopathologists play an essential role in this process, both in the triage of specimens during rapid on-site evaluation and in the evaluation of archival samples to determine suitability for ancillary testing. Therefore, it is imperative that practicing cytopathologists stay abreast of up-to-date diagnostic, prognostic, and predictive ancillary tests that can be used on limited cytologic material. This is a challenge since the landscape of known genomic alterations is constantly evolving and the subsequent set of testing options is ever expanding.
The proposed text will provide a user-friendly quick-reference handbook to serve as a useful resource for practicing pathologists and laboratory personnel dealing with, and interested in, this evolving field of molecular cytopathology. Essential components to be presented include: 1) pre-analytic factors that affect sample selection and evaluation; 2) specimen preparation to maximize confidence in results; 3) interpretation of results; 4) potential limitations; and 5) workflow algorithms. In addition, specific disease specific molecular testing details will be outlined to provide the reader with resources for quick reference. All chapters will be written by experts in their fields and will include the most up-to-date scientific and clinical information.
Molecular Diagnostics in Cytopathology will be of value to Cytopathologists, Cytotechnologists, Cytotechnology students, Cytopathology fellows, Surgical pathologists, Pathology residents and fellows, Molecular Pathologists, Molecular pathology fellows, Molecular technologists, as well as Translational researchers with an interest in molecular cytopathology.

GET IT FREE HERE

http://nitroflare.com/view/C8D988651A246E5/3319973967.pdf

ALTERNATIVE LINK

https://filejoker.net/wkvux5njcdfe

Share Button