Pathogenesis of Idiopathic Scoliosis

 Pathology  Comments Off on Pathogenesis of Idiopathic Scoliosis
Mar 252018
 


This book provides comprehensive coverage of current topics in idiopathic scoliosis (IS). A three-dimensional deformity of the spine, the condition is characterized by lateral curvature combined with vertebral rotation. The primary lesion, however, lies in the median sagittal plane, taking the form of a lordosis. Although the clinical manifestations of scoliosis have been well documented, its cause and pathogenesis have not yet been determined.
Research into what causes IS has focused on the structural elements of the spine, spinal musculature, collagenous structures, the endocrine system, the central nervous system, and genetics. Results of these studies have brought about a new perception of IS epiphenomena, but the main cause of IS remains unknown. Recently, several investigators have produced new hypotheses regarding the cause of IS using the developing techniques of genetics, biochemistry, and neurology. This book is a review of the various causative factors thus far proposed for IS and an introduction to the directions in which research is heading to determine the primary cause of IS.

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Pulmonary Pathology: Neoplastic and Non-Neoplastic (Encyclopedia of Pathology)

 Pathology, Respiratory Medicine  Comments Off on Pulmonary Pathology: Neoplastic and Non-Neoplastic (Encyclopedia of Pathology)
Mar 202018
 

This book covers the complete field of pulmonary pathology – neoplastic and non-neoplastic – from Acinic cell tumor in the lung to Wegener`s Granulomatosis. The alphabetically arranged entries, each of which provides a detailed description of a specific pathological disease pattern, allow readers to quickly and easily find the information they need.

 

 

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Precision Molecular Pathology of Prostate Cancer

 Oncology, Pathology  Comments Off on Precision Molecular Pathology of Prostate Cancer
Mar 162018
 


This volume focuses on our current understanding of the molecular underpinnings of prostate cancer and their potential application for precision medicine approaches. The emergence and applications of new technologies has allowed for a rapid expansion of our understanding of the molecular basis of prostate cancer and has revealed a remarkable genetic heterogeneity that may underlie the clinically variable behavior of the disease.
The book consists of five sections which provide insight about the following: (1) General principles; (2) Molecular signatures of primary prostate cancer; (3) Molecular signatures of advanced prostate cancer; (4) Key molecular pathways in prostate cancer development and progression; (5) and Precision medicine approach: Diagnosis, treatment, prognosis. Precision Molecular Pathology of Prostate Cancer is an important resource for the practicing oncologist, urologist, and pathologist, and will also be useful for researchers in the prostate cancer community.

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Developmental Neuropathology, 2nd edition

 Neurology/Neurosurgery, Pathology  Comments Off on Developmental Neuropathology, 2nd edition
Mar 112018
 

A definitive, clinically oriented guide to the pathology of genetics of developmental neuropathology

Developmental neuropathology relates to the wide range of disorders affecting the developing brain or pre– and post–natal life, with emphasis on the genetic and molecular mechanisms involved. This book provides a practical guide to diagnosing and understanding these disorders affecting this vulnerable population and potentially stimulates further advances in this exciting area. It also addresses the controversies in inflicted head injury in infants.

The fourth major title to be approved by the International Society of Neuropathology (ISN), Developmental Neuropathology offers in–depth chapter coverage of brain development; chromosomal changes; malformations; secondary malformations and destructive pathologies; developmental vascular disorders; acquired metabolic and exogenous toxins; metabolic disorders; Rett syndrome and autism; and infectious diseases. The text provides:

Clinical, disease–oriented approach to the pathology and genetics developmental neuropathology
Fuses classical and contemporary investigative approaches
Includes genetic and molecular biological pathogeneses
Fully illustrated
Approved and endorsed by International Society of Neuropathology
Developmental Neuropathology is the perfect book for practicing neuropathologists, pediatric pathologists, general pathologists, neurologists, and geneticists in deciphering the pathology and pathogenesis of these complex disorders affecting the nervous system of the embryo, fetus, and child.

 

 

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Pathology in Practice

 Pathology  Comments Off on Pathology in Practice
Mar 052018
 

Post-mortems may have become a staple of our TV viewing, but the long history of this practice is still little known. This book provides a fresh account of the dissections that took place across early modern Europe on those who had died of a disease or in unclear circumstances. Drawing on different approaches and on sources as varied as notes taken at the dissection table, legal records and learned publications, the chapters explore how autopsies informed the understanding of pathology of all those involved. With a broad geography, including Rome, Amsterdam and Geneva, the book recaptures the lost worlds of physicians, surgeons, patients, families and civic authorities as they used corpses to understand diseases and make sense of suffering. The evidence from post-mortems was not straightforward, but between 1500 and 1750 medical practitioners rose to the challenge, proposing various solutions to the difficulties they encountered and creating a remarkable body of knowledge. The book shows the scope and diversity of this tradition and how laypeople contributed their knowledge and expectations to the wide-ranging exchanges stimulated by the opening of bodies.

About the Author
Silvia De Renzi teaches history of medicine at the Open University, UK.

Marco Bresadola teaches history of science at the University of Ferrara, Italy, where he is director of the MA in science communication.

Maria Conforti teaches history of medicine at Sapienza, University of Rome, Italy.

 

 

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Clinical Management of Speech Sound Disorders

 Pathology  Comments Off on Clinical Management of Speech Sound Disorders
Mar 052018
 

Clinical Management of Speech Sound Disorders: A Case-Based Approach begins with a review of the application and significance of case-based or problem-cased learning in the field of speech-language pathology. This comprehensive resource is organized by intervention approach and includes helpful case studies and videos.

Designed for the speech sound disorders course, Clinical Management of Speech Sound Disorders: A Case-Based Approach combines foundational knowledge, clinical theory and
principles, evidence-based practice, and practical insight into clinical management strategies. Case-based learning serves as a cornerstone of this resource, facilitating critical
thinking and problem solving in a clinical context through the use of clinical vignettes and applications. Accompanying video segments highlight assessment and intervention
strategies and are designed to be utilized to support and enhance instruction and student learning.

 

 

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Principles of Exercise Testing and Interpretation: Including Pathophysiology and Clinical Applications

 Pathology, Physiology  Comments Off on Principles of Exercise Testing and Interpretation: Including Pathophysiology and Clinical Applications
Feb 222018
 

Discover what exercise testing can reveal about cardiopulmonary, vascular, and muscular health. Now in its Fifth Edition, Principles of Exercise Testing and Interpretation continues to deliver timely information on the physiology and pathophysiology of exercise and their relevance to clinical medicine.
The text begins by explaining the processes by which cells receive oxygen and dispose of carbon dioxide produced as a byproduct of exercise and metabolism. By measuring gas exchange, we can better evaluate cardiovascular and cardiopulmonary functioning, as well as cellular respiration. Detailed discussions explore various types of exercise intolerance, their effects on test results, and clinical diagnoses. Using real-world cases, the text illustrates how cardiopulmonary exercise testing can evaluate the functional competency of each component in the coupling of cellular to external respiration, including the cardiovascular system. Expert authors’ comments, analysis, and conclusions for each case, help to improve readers’ interpretive and diagnostic skills.
This in-depth resource provides…
• Updated content and new graphics present the most current information in a reader-friendly format.
• Updated flow charts detail clinical presentations and differential diagnosis
• More than 80 case presentations improve diagnostic accuracy.
• Normal test values for a wide range of patient groups provide a basis for comparison and help to identify abnormalities.
• Companion website includes the complete text, PLUS 30 additional case presentations.

 

 

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Metallothioneins in Biochemistry and Pathology

 Pathology  Comments Off on Metallothioneins in Biochemistry and Pathology
Feb 202018
 

Metallothioneins (MTs) represent a large family of proteins characterized by high heavy metal content (mainly CuII and ZnII) and by an unusual cysteine abundance. They have a powerful protective function in all animal tissues, due most likely to their properties as free radical scavengers protecting against oxidative damage. Moreover, the presence and overexpression of MTs in various pathological conditions, such as metal dyshomeostasis, cell proliferation, neurological disorders, and chemotherapy and radiotherapy resistance, could be used as an important prognostic marker, as a histopathological diagnostic tool, and to follow specific pharmacological treatments.
This important book explores the role of MTs in the field of neurological disorders (brain inflammation, Alzheimer’s and prion diseases, autism, ALS, etc.), cardiology (cardiomyopathy, atherosclerosis), and oncology (melanoma, prostate and breast cancer), through authoritative contributions and a description of basic biochemical information and paradigmatic pathological events.
Contents: Metallothionein in Neurological Disorders; Metallothionein in Oncology; Metallothionein in Cardiopathy; Metallothionein in Hepatology.

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Scleroderma: From Pathogenesis to Comprehensive Management

 Pathology  Comments Off on Scleroderma: From Pathogenesis to Comprehensive Management
Feb 172018
 

Comprised of the authoritative work of international experts, this fully-updated second edition of Scleroderma builds upon the well-regarded approach in the first edition to provide integrated, concise, and up-to-date synthesis of current concepts of pathogenesis and modern approaches to management of systemic sclerosis (scleroderma). With a multidisciplinary approach to comprehensive care, this book is easily accessible for health care professionals in many fields. The new edition includes extensive updated material based on major developments in the field, with new chapters on personalized medicine, cancer complications, global perspectives on scleroderma, and more. It presents a succinct and thoughtful synthesis of current pathomechanistic concepts, providing a valuable reference tool for basic and translational investigators working in the field. Scleroderma: From Pathogenesis to Comprehensive Management serves as an essential, all-inclusive resource for rheumatologists, pulmonologists, cardiologists, gastroenterologists, nephrologists and all those involved in the care of scleroderma patients.
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Pathophysiology of Oral Diseases

 Pathology  Comments Off on Pathophysiology of Oral Diseases
Feb 112018
 

 

Teaching a large number of ever-inspiring students for the past few years was the motivation for the author to compile this book. This book would not have seen the light of the day if it were not for them.
Knowledge of the pathogenesis of the various diseases affecting the oral cavity offers a great help in understanding its clinical features, its radiographic features, and histological features as well as the treatment for the diseases. These are the reasons for the necessity to compile various pathophysiological causes of the diseases. Some of the diseases are still being explained by their old pathogeneses; however, some others are being attributed to new causes following the advent of new and innovative technologies, which identify genes and new knowledge about stem cell culturing. This book simplifies the subject of Oral Pathology by understanding the underlying causes of the various diseases.

 

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