New Trends in Cancer for the 21st Century: Proceedings of the International Symposium on Cancer: New Trends in Cancer for the 2

 Oncology  Comments Off on New Trends in Cancer for the 21st Century: Proceedings of the International Symposium on Cancer: New Trends in Cancer for the 2
Jan 122019
 

Given the latest advances in cancer research, which includes basic research and its derived diagnostic, clinical, and therapeutic applications, the book New Trends in Cancer for the 21st Century is written by individuals such as molecular biologists, whose tasks are to decipher, after sequencing the human genome, those new genes and pathways involved in the carcinogenesis process; clinical and molecular pathologists, who apply these discoveries for the molecular diagnosis and characterization of the tumor; and clinical oncologists, who treat patients. Pharmacogenetics introduces new perspectives in the translational fields with the design of drugs against specific targets, which at this moment are in clinical trials phases. This book achieves a state of the art in every field of cancer research and discusses the new perspectives that will open the future for cancer treatment (basic research, new technologies, new drugs, therapies…). For this reason, the book is intended for pathologists, clinicians, and biologists, as well as fellows and students of physiology and medicine.
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Histological Typing of Cancer and Precancer of the Oral Mucosa

 Histology, Oncology  Comments Off on Histological Typing of Cancer and Precancer of the Oral Mucosa
Jan 012019
 

There are two major differences in concept between this volume and others in the International Histological Classification of Tu­ mours series. The first of these is the inclusion of more clinical aspects than has usually been the case and the second is a con­ centration on a more limited range of conditions. There are sev­ eral reasons for adopting this approach. With regard to both cancer and pre cancer of the oral mucosa, we believe it is impor­ tant that general pathologists, in whose interests this volume has primarily been written, should be informed of the significance of the clinical features of the various lesions under discussion as they may on the whole be unfamiliar with them. Also, we con­ sider it necessary to draw attention to those conditions particu­ lar to the oral tissues that may give rise to appearances which are important in differential diagnosis but can be misleading to the pathologist who does not have detailed knowledge of these tissues. On the other hand, many of the benign and malignant tumours that affect the oral tissues have been dealt with in other volumes in the series and we believe that little or no advantage would be gained by repeating them here.
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Retinoids in Oncology

 Oncology  Comments Off on Retinoids in Oncology
Dec 312018
 

Recent developments with respect to the biology and clinical use of retinoids in cancer therapy and prevention are comprehensively covered by experts in this new field. Newer aspects of molecular mechanisms of retinoid effects, the cellular biology and the developmental effects of these compounds are presented together with a comprehensive description of the latest findings of retinoid pharmacology, toxicology and clinical effects in a wide range of hematological and solid malignancies.
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Applications of Biotechnology in Oncology

 Oncology  Comments Off on Applications of Biotechnology in Oncology
Dec 312018
 

Applications of Biotechnology in Oncology collects key writings by Kewal K. Jain on the most important contributions of biotechnology to cancer research, particularly to the molecular diagnosis of cancer and drug delivery in cancer for personalized management of patients. Basics of various “omics” technologies and their application in oncology are described as oncogenomics and oncoproteomics. This detailed volume also explores molecular diagnostics, nanobiotechnology, cell and gene therapies, as well as personalized oncology. With approximately one thousand selected references from recent literature on this topic and numerous tables and figures, Applications of Biotechnology in Oncology serves as an ideal reference for oncologists, scientists involved in research on cancer biology, and physicians in various specialties who deal with cancer.

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Isolated Liver Perfusion for Hepatic Tumors

 Oncology  Comments Off on Isolated Liver Perfusion for Hepatic Tumors
Dec 312018
 

The contributions in this book were originally presented at the workshop “Research and Clinical Application of Isolated Liver Perfusion for Hepatic Tumors” held on 28 February to 1 March 1997 in Hanover, Germany. The workshop was planned to bring together groups working with isolated liver perfusion techniques worldwide. Experts from various countries were invited to pre­ sent and discuss their experimental data and clinical results. USA par­ Groups from Japan, The Netherlands, Sweden and the ticipated. At the beginning, oncologists, surgeons and patholo­ gists presented possible indications and the oncological back­ ground for therapeutic isolated liver perfusion from their points of view. Based on data from previous studies about loco regional chemotherapy and based on the pathology of metastasis, it could be concluded that there is a place for isolated liver perfusion in the therapy of liver cancer. Second, different surgical techniques of isolated liver perfusion were presented. These techniques var­ ied from a percutaneous approach with extracorporeal chemofil­ tration to extended open abdominal surgery. Perfusion of the liv­ er without a considerable amount of drug reaching the systemic circulation proved to be possible. The complex procedure with complicated extracorporeal perfusion technique represented a disadvantage of the methods presented. Further studies should simplify the technical and surgical aspects. Intraoperative and postoperative management of . patients undergoing isolated liver perfusion were also discussed. Coagulopathy was one important aspect which can occur during isolated liver perfusion. The per­ centage of leakage determined systemic side effects.
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Progress in Diagnostics and Therapy of Prostatic Cancer

 Oncology  Comments Off on Progress in Diagnostics and Therapy of Prostatic Cancer
Dec 302018
 

The progress made in the diagnosis of prostate carcinoma with the introduction of transrectal ultrasound (TRUS), PSA determination, and ultrasound-guided prostate biopsy as well as improved operating techniques have led to a considerable increase in the number of radical prostate operations being performed and thus increased the chances of success of curative treatment in many patients. The use of neoadjuvant endocrine therapy before radical prostatectomy is still a matter of debate. It will certainly only be possible to make a final judgement on the basis of long-term observations. This book takes into account that only an international exchange of new findings can create the necessary conditions for improved treatment.
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Pediatric Hematology-Oncology in Countries with Limited Resources: A Practical Manual

 Hematology, Oncology, Pediatrics  Comments Off on Pediatric Hematology-Oncology in Countries with Limited Resources: A Practical Manual
Dec 292018
 

Typically, manuals of pediatric hematology-oncology are written by specialists from high-income countries, and usually target an audience with a sub-specialist level of training, often assisted by cutting-edge diagnostic and treatment facilities. However, approximately 80% of new cases of cancer in children appear in mid- and low-income countries. Almost invariably, general practitioners or general pediatricians without special training in oncology will look after children with malignancies who enter the health care system in these countries. The diagnostic facilities are usually limited, as are the treatment options. The survival figures in these conditions are somewhere below 20%, while in high-income countries they are in the range of 80% for many childhood cancers. Pediatric Hematology-Oncology in Countries with Limited Resources is the only book of its kind to provide specific guidance applicable to limited resource settings and builds up from the foundation of general practitioner or general pediatrician competence. Written and edited by leaders in the field, this manual educates physicians on the essential components of the discipline, filtered through the experience of specialists from developing countries, with immediate applicability in the specific healthcare environment in these countries.​
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Eicosanoids and Other Bioactive Lipids in Cancer, Inflammation, and Radiation Injury, 4

 Oncology, Radiology  Comments Off on Eicosanoids and Other Bioactive Lipids in Cancer, Inflammation, and Radiation Injury, 4
Dec 292018
 

Since their discovery over sixty years ago, eicosanoids have come to represent a diverse family of bioactive lipid modulators, including prostaglandins, thromboxanes, leukotrienes, lipoxins, isoprostanes, hepoxilins, hydroxy acids, epoxy and hydroxy fatty acids. This book contains conference presentations regarding the regulation of eicosanoid enzymes and, in particular, cyclooxygenases, lipoxygenases, and phospholipases. In addition, recent evidence over the last seven years has led to the identification of a number of receptors for these bioactive lipids. The new field of isoprostanes is also represented. It has become increasingly evident that eicosanoids play a critical role in signal transduction, both in normal cells and in pathological processes. These aspects are discussed in relation to cellular events, such as apoptosis, angiogenesis, and cancer prevention and treatment.
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Targeted Cancer Treatment in Silico: Small Molecule Inhibitors and Oncolytic Viruses

 Oncology  Comments Off on Targeted Cancer Treatment in Silico: Small Molecule Inhibitors and Oncolytic Viruses
Dec 292018
 

Countless medical researchers over the past century have been occupied by the search for a cure of cancer. So far, they have developed and implemented a wide range of treatment techniques, including surgery, chemo- and radiotherapy, antiangiogenic drugs, small molecule inhibitors, and oncolytic viruses. However, patterns of these treatments’ effectiveness remain largely unclear, and a better understanding of how cancer therapies work has become a key research goal. Cancer Treatment in Silico provides the first in-depth study of approaching this understanding by modeling cancer treatments, both mathematically and through computer simulations.The main goal of this book is to help expose students and researchers to in silico methods of studying cancer. It is intended for both the applied mathematics and experimental oncology communities, as mathematical models are playing an increasingly important role to supplement laboratory biology in the fight against cancer. Written at a level that generally requires little technical background, the work will be a valuable resource for scientists and students alike.
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Hypoxia and Cancer: Biological Implications and Therapeutic Opportunities

 Oncology  Comments Off on Hypoxia and Cancer: Biological Implications and Therapeutic Opportunities
Dec 292018
 

​​​The imbalance between rapidly proliferating tumor cells and inadequate and inefficient tumor vasculature leads to a decrease in oxygen levels (hypoxia and/or anoxia) in tumor tissues. Intra-tumor hypoxia profoundly affects the biological behavior of cancer cells, which become resistant to conventional therapies and acquire a more invasive and metastatic phenotype. Hypoxia is a hallmark of the malignant phenotype and a key feature of the tumor microenvironment. Hypoxia Inducible Factor 1 (HIF-1) is a master regulator of the transcriptional response to oxygen deprivation. HIF triggers the expression of genes whose products induce angiogenesis, decrease oxygen consumption, switch metabolism to glycolysis, maintain a stem cell phenotype and select for more invasive and metastatic cells. Therapeutic approaches targeting HIF, directly or downstream mediators of its transcriptional activity, are being developed. Intra-tumor hypoxia is a topic has been gaining scientific interest over the last few years for its wide involvement in many physiological and pathological processes. This volume will cover the latest research and translational aspects associated with intra-tumor hypoxia, along with opportunities for drug development offered by this unique feature of the tumor microenvironment. The ongoing efforts to translate our understanding of the biology underlying intra-tumor hypoxia in viable therapeutic options face many challenges, but this book will provide an opportunity for an in-depth analysis of the fundamental mechanisms implicated in the adaption to low oxygen levels and will scrutinize the potential for opportunities that are being pursued in both research and the drug development industry.
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