Functional Imaging in Oncology: Biophysical Basis and Technical Approaches – Volume 1

 Oncology, Radiology  Comments Off on Functional Imaging in Oncology: Biophysical Basis and Technical Approaches – Volume 1
Feb 102019
 

In the new era of functional and molecular imaging, both currently available imaging biomarkers and biomarkers under development are expected to lead to major changes in the management of oncological patients. This well-illustrated two-volume book is a practical manual on the various imaging techniques capable of delivering functional information on cancer, including preclinical and clinical imaging techniques, based on US, CT, MRI, PET and hybrid modalities. This first volume explains the biophysical basis for these functional imaging techniques and describes the techniques themselves. Detailed information is provided on the imaging of cancer hallmarks, including angiogenesis, tumor metabolism, and hypoxia. The techniques and their roles are then discussed individually, covering the full range of modalities in clinical use as well as new molecular and functional techniques. The value of a multiparametric approach is also carefully considered.
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Handbook of Pediatric Hematology and Oncology: Children’s Hospital & Research Center Oakland, Second edition

 Hematology, Oncology, Pediatrics  Comments Off on Handbook of Pediatric Hematology and Oncology: Children’s Hospital & Research Center Oakland, Second edition
Feb 102019
 

This new edition of Handbook of Pediatric Hematology and Oncology: Children’s Hospital & Research Center Oakland features practical guidance on how to handle common inpatient and outpatient challenges seen in pediatric hematology and oncology. Designed as a rapid reference to the latest diagnostic and therapeutic protocols, the text is short and didactic and supplemented with practical algorithms and case studies throughout. Completely revised and updated, there are brand-new chapters on subjects including bone marrow transplantation, pain management and palliative care. Comprehensive, yet concise, the handbook presents essential guidelines on the diagnosis and management of the most common pediatric blood disorders and malignancies, in addition to chemotherapeutic drug information and transfusion protocols. Designed for medical students, residents, and fellows, this user-friendly portable reference is also the perfect companion on the ward for pediatric hematology and oncology nurses.Content: Chapter 1 Approach to the Anemic Child (pages 1–9): Chapter 2 Hemolytic Anemia (pages 10–17): Chapter 3 Sickle Cell Disease (pages 18–35): Chapter 4 Thalassemia (pages 36–43): Chapter 5 Transfusion Medicine (pages 44–56): Chapter 6 Chelation Therapy (pages 57–61): Chapter 7 Approach to the Bleeding Child (pages 62–70): Chapter 8 Von Willebrand Disease (pages 71–78): Chapter 9 Hemophilia (pages 79–84): Chapter 10 The Child with Thrombosis (pages 85–91): Chapter 11 The Neutropenic Child (pages 92–102): Chapter 12 Thrombocytopenia (pages 103–121): Chapter 13 Evaluation of the Child with a Suspected Malignancy (pages 122–132): Chapter 14 Oncologic Emergencies (pages 133–143): Chapter 15 Acute Leukemias (pages 144–156): Chapter 16 Central Nervous System Tumors (pages 157–165): Chapter 17 Hodgkin and Non?Hodgkin Lymphoma (pages 166–173): Chapter 18 Wilms Tumor (pages 174–177): Chapter 19 Neuroblastoma (pages 178–182): Chapter 20 Sarcomas of the Soft Tissues and Bone (pages 183–192): Chapter 21 Germ Cell Tumors (pages 193–199): Chapter 22 Rare Tumors of Childhood (pages 200–206): Chapter 23 Histiocytic Disorders (pages 207–211): Chapter 24 Hematopoietic Stem Cell Transplantation (pages 212–225): Chapter 25 Supportive Care of the Child with Cancer (pages 226–234): Chapter 26 Central Venous Catheters (pages 235–243): Chapter 27 Management of Fever in the Child with Cancer (pages 244–255): Chapter 28 Acute Pain Management in the Inpatient Setting (pages 256–263): Chapter 29 Palliative Care (pages 264–280): Chapter 30 Chemotherapy Basics (pages 281–290): Chapter 31 Guide to Procedures (pages 291–299): Chapter 32 Treatment of Chemotherapy Extravasations (pages 300–303):
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Functional Foods & Nutraceuticals in Cancer Prevention

 Nutrition, Oncology  Comments Off on Functional Foods & Nutraceuticals in Cancer Prevention
Feb 102019
 

Cancer is a leading cause of death among adults but research shows that the chances of developing cancer can be reduced by lifestyle changes. Increasing numbers of people use dietary vegetables, medicinal herbs, and plant extracts to prevent or treat cancer. Their availability as “over the counter” supplements has contributed to an explosion in the use of herbal extracts and related compounds for health enhancement. This vital resource brings together the worlds leading experts’ research, their conclusions and recommendations on functional foods and nutraceuticals in the prevention and treatment of cancer. Research professionals, academics, hospital-based dietitians, nutritionists, oncology physicians, cancer researchers, marketers and food and drug officials are just a few of the key people who need this book.Content: Chapter 1 Antioxidants as Cancer Therapies (pages 1–26): T. Bermejo Vicedo and F. J. Hidalgo CorreasChapter 2 Cancer and Nutrition (pages 27–36): Danine FisherChapter 3 Vitamin E in Cancer Prevention and Treatment (pages 37–54): Ester Du, Jin Zhang, Bailin Liang and Ronald R. WatsonChapter 4 Chemical Versus Food Forms of Selenium in Cancer Prevention (pages 55–86): Cindy D. Davis and John W. FinleyChapter 5 Nutrients to Stimulate Cellular Immunity: Role in Cancer Prevention and Therapy (pages 87–104): Satoru Moriguchi, Satoe Yamashita and Eiji ShimizuChapter 6 Nutrition and Skin Cancer Risk Prevention (pages 105–120): Steven Pratt, Hubert T. Greenway and Craig NaugleChapter 7 Nutritional Strategies for the Prevention of Cervical Cancer (pages 121–130): Paula Inserra and Brent P. MahoneyChapter 8 Tomato and Cancer (pages 131–152): Patrizia Riso, Antonella Brusamolino and Marisa PorriniChapter 9 The Role of Dietary Fiber in Colon Cancer Prevention (pages 153–172): Nancy J. EmenakerChapter 10 Soy Food and Breast Cancer (pages 173–178): Debra HickmanChapter 11 Preventive and Therapeutic Effects of Dietary Phytochemicals on Cancer Development (pages 179–198): Ali Reza Waladkhani and Michael R. ClemensChapter 12 Phytomedicines and Cancer Prevention (pages 199–212): Piergiorgio PiettaChapter 13 Phytoestrogens and Cancer (pages 213–236): Ruth S. MacDonald, Ju?Yuan Guo, Mary Sharl Sakla, Nader Shenouda and Dennis B. LubahnChapter 14 Herbals and Cancer Prevention (pages 237–262): Michael J. Wargovich, Destiny M. Hollis and Mary E. S. ZanderChapter 15 Cruciferous Vegetables and Cancer Prevention (pages 263–288): Cynthia A. Thomson and Tina L. GreenChapter 16 Breast Cancer Prevention (pages 289–296): Brent P. Mahoney and Paula Inserra
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Dynamic Adaptive Radiotherapy for Prostate Cancer

 Oncology  Comments Off on Dynamic Adaptive Radiotherapy for Prostate Cancer
Feb 072019
 

This booklet provides a comprehensive overview of Dynamic Adaptive Radiotherapy (DART), the most advanced radiation therapy for the treatment of prostate cancer, utilizing all available technologies associated with 4 Dimensional Image-Guided Intensity Modulated Radiation Therapy (4D IG-IMRT). This title is part of the Prostate Cancer Essentials For Survival Series sponsored by the Dattoli Cancer Foundation.

Michael J. Dattoli, M.D. is an internationally renowned radiation oncologist and brachytherapist. As a leading specialist in the treatment of prostate cancer, Dr. Dattoli has published numerous peer-reviewed research studies and has reported the most successful long term cure rate in the world using DART and palladium brachytherapy.

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Radiation Safety and Prostate Cancer: Need You Be Concerned?

 Oncology  Comments Off on Radiation Safety and Prostate Cancer: Need You Be Concerned?
Feb 072019
 

This booklet provides a comprehensive overview of the issues of radiation safety for the diagnosis and treatment of prostate cancer, as related to the most advanced from of radiation therapy, Dynamic Adaptive Radiotherapy (DART).

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Cancer and Inflammation: Novartis Foundation Symposium 256

 Oncology  Comments Off on Cancer and Inflammation: Novartis Foundation Symposium 256
Feb 052019
 

Chronic inflammation predisposes to some forms of cancer and the host response to malignant disease shows several parallels with inflammation and wound healing. The cells involved in inflammation are detected in a range of common cancers, together with the inflammatory cytokines and members of the chemokine ligand/receptor systems. Neutralization or deletion of the gene for some inflammatory cytokines confers resistance to tumour induction and experimental metastasis. Over-expression of such cytokines in tumour cells may enhance malignant potential. Certain chemokines are likely to subvert antitumour immunity by favouring development of ineffective Type 2 responses. Tumour cells may even utilize chemokine receptors in homing to lymph nodes and other organs. Thus, the cells, cytokines and chemokines found in tumours are more likely to contribute to tumour growth, progression and immunosuppression than they are to mount an effective host antitumour response. This book draws together contributions from an international group of scientists and clinicians from diverse disciplines, ranging from epidemiology to immunology, cell biology, molecular oncology, molecular medicine and pharmacology to debate these and related issues. Topics covered include the epidemiological links between cancer and inflammation, the parallels between inflammation and cancer, the role of inflammation in cancer, inflammatory genes as risk factors for cancer initiation and progression, inflammation and cancer angiogenesis, and preventative and therapeutic strategies. Related Novartis Foundation symposia: 252 Generation and Effector Functions of Regulatory Lymphocytes Chair: Jean-Fran?s Bach 254 Immunoinformatics: Bioinformatic Strategies for Better Understanding of Immune Function Chair: Hans-Georg RammenseeContent:
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Mindfulness-Based Cognitive Therapy for Cancer: Gently Turning Towards

 Oncology  Comments Off on Mindfulness-Based Cognitive Therapy for Cancer: Gently Turning Towards
Feb 052019
 

Mindfulness-based Cognitive Therapy for Cancer presents an eight-week course for MBCT which has been tried and tested over ten years of clinical use, and is targeted specifically for people with cancer. There is growing evidence of mindfulness as a successful and cost-effective intervention for reducing the negative psychological impact of cancer and treatment  Content: Chapter One Mindfulness and Cancer (pages 11–22): Chapter Two Cancer – The Psychological Implications (pages 23–32): Stirling Moorey and Ursula BatesChapter Three Cancer – The Medical Implications (pages 33–42): Nicholas S. A. StuartChapter Four The First Circle – Cancer and the Circle of Suffering (pages 43–47): Chapter Five Starting out (pages 55–66): Chapter Six The Eight Week Course (pages 72–242): Chapter Seven The Second Circle: Mindful Awareness and the Circle of Practice (pages 243–249): Chapter Eight The Practices (pages 254–283): Chapter Nine Mindfulness in Palliative Care (pages 289–302): Ursula BatesChapter Ten After the Eight Week Course (pages 303–309): Chapter Eleven The Third Circle – Being and the Circle of Presence (pages 310–317): Chapter Twelve Introducing the Teacher (pages 321–327): Chapter 13 Embodying The Practice (pages 328–339): Chapter Fourteen Facilitating the Learning (pages 340–353): Chapter Fifteen The Three Circle Model: A Formulation of MBCT for Cancer (MBCT?Ca) (pages 354–363): Trish Bartley and Ursula Bates
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Molecular Cancer Therapeutics: Strategies for Drug Discovery and Development

 Oncology  Comments Off on Molecular Cancer Therapeutics: Strategies for Drug Discovery and Development
Feb 042019
 

Molecular Cancer Therapeutics covers state-of-the-art strategies to identify and develop cancer drug target molecules and lead inhibitors for clinical testing. It provides a thorough treatment of drug target discovery, validation, and development. The introductory chapters provide an overview of pathways to discovery and development of molecular cancer therapeutics. Subsequent chapters progress from initial stages of drug target discovery to drug discovery, development, and testing in preclinical and clinical models. Topics include drug lead screening, drug-to-lead development, proof-of-concept studies, medicinal chemistry issues, intellectual property concerns, and clinical development. This invaluable reference promotes understanding of steps involved in developing drug leads for industrial partnering and development. It provides an overview of the strategies for discovery and validation of drug target molecules, and discusses cell- and molecule-based drug screening strategies, as well as mouse models for cancer. Coverage also includes how to refine drug leads for suitability in clinical testing, the special issues of clinical testing of molecular-targeted drugs, and intellectual property concerns.Content: Chapter 1 Introduction (pages 1–5): George C. PrendergastChapter 2 Molecular Cancer Therapeutics: Will the Promise be Fulfilled? (pages 7–40): Beverly A. TeicherChapter 3 Cancer Genetics and Drug Target Selection (pages 41–53): Guo?Jun Zhang and William G. KaelinChapter 4 RNA Interference in Mammals: Journey to the Center of Human Disease (pages 55–72): Patrick J. Paddison and Gregory J. HannonChapter 5 Applications and Issues for Tissue Arrays in Target and Drug Discovery (pages 73–90): Eric Jonasch, Kim?Anh Do, Christopher Logothetis and Timothy J. McDonnellChapter 6 Protein Transduction Strategies for Target and Mechanism Validation (pages 91–118): Sergei A. Ezhevsky and Steven F. DowdyChapter 7 Drug Screening: Assay Development Issues (pages 119–140): Steven S. Carroll, James Inglese, Shi?Shan Mao and David B. OlsenChapter 8 Gene Microarray Technologies for Cancer Drug Discovery and Development (pages 141–186): Robert H. te Poele, Paul A. Clarke and Paul WorkmanChapter 9 Transgenic Mouse Models of Cancer (pages 187–202): T. J. Bowen and A. Wynshaw?BorisChapter 10 Transgenic Versus Xenograft Mouse Models of Cancer: Utility and Issues (pages 203–226): Ming Liu, W. Robert Bishop, Yaolin Wang and Paul KirschmeierChapter 11 Pharmacodynamic Assays in Cancer Drug Discovery: From Preclinical Validation to Clinical Trial Monitoring (pages 227–254): Robert B. Lobell, Nancy E. Kohl and Laura Sepp?LorenzinoChapter 12 Pharmacokinetic and Toxicology Issues in Cancer Drug Discovery and Development (pages 255–286): Pamela A. Benfield and Bruce D. CarChapter 13 Clinical Development Issues (pages 287–306): Steven D. Averbuch, Michael K. Wolf, Basil F. El?Rayes and Patricia M. LoRussoChapter 14 Intellectual Property and Commercialization Issues in Drug Discovery (pages 307–327): Lisa Gail Malseed
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Targeting Notch in Cancer: From the Fruit Fly to the Clinic

 Oncology  Comments Off on Targeting Notch in Cancer: From the Fruit Fly to the Clinic
Feb 012019
 


The serendipitously discovered link between developmental biology and cancer, touched of an explosion of discoveries on the role of Notch in human malignancies, including every aspect of cancer biology, from control of differentiation, proliferation and apoptosis in transformed cells to angiogenesis, tumor-stroma interaction and anti-cancer immune responses. A number of observations have revealed that Notch even plays a role in the renewal of cancer stem cells and tumor initiating cells, which are thought to be a major cause of resistance to treatment. Targeting Notch in Cancer will provide researchers, oncologists, pharmacologists and students with a detailed understanding of the intricate cross-talk between Notch and other pathways of therapeutic interest so to better design rational drug combinations for specific diseases and disease subsets.

Divided into two parts, Part I describes in detail what we know about the genetics, molecular biology, biochemistry and structural biology of Notch, as well as the role of Notch in such processes as angiogenesis and immune surveillance. Without insights gained from these basic studies, rational targeting of Notch in human disease would be impossible. Part II describes the role of Notch and ongoing experimental therapeutic efforts in the most important subtypes of human cancers, organized in a clinically oriented fashion by organs and systems affected.

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Uterine Cervical Cancer: Clinical and Therapeutic Perspectives

 Oncology  Comments Off on Uterine Cervical Cancer: Clinical and Therapeutic Perspectives
Feb 012019
 

This volume provides a broad background of the basic sciences, clinical and therapeutic aspects, and management of uterine cervical cancer. It offers state-of-the-art information on the molecular genetics, biology, and clinical aspects of premalignant lesions of the uterine cervix, and provides a better understanding of the molecular and cellular events that underlie uterine cervical cancer. Uterine Cervical Cancer: Clinical and Therapeutic Perspectives contains extensive, updated information on the promising new developments in the diagnosis and management of uterine cervical cancer. It will serve as an invaluable resource for all clinicians and basic medical scientists caring for women with uterine cervical cancer, including attending surgeons, physicians, clinical fellows, and residents in the disciplines of gynecologic oncology, medical oncology, and surgical oncology.
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