The Gale Encyclopedia of Cancer: a guide to cancer and its treatments: 3 volume set, 4th edition

 Oncology  Comments Off on The Gale Encyclopedia of Cancer: a guide to cancer and its treatments: 3 volume set, 4th edition
Jul 262019
 

This edition of the Gale Encyclopedia of Cancer provides a comprehensive survey of cancers, cancer drugs, traditional and alternative treatments, diagnostic procedures, and side effects. Its 620 entries include more than 40 brand new entries and more than 270 updated entries. Information is organized in an easy-to-read format; standard headings within entries include definition, description, demographics, causes and symptoms, diagnosis, clinical staging, treatment, coping with cancer treatment, treatment team, clinical trials, prevention, prognosis, special concerns, and resources. Rubrics for cancer drug entries include: definition, purpose, description, recommended dosage, precautions, side effects, and interactions. Sidebars include Questions to Ask Your Doctor and Key Terms, which help define more complex medical concepts. Appendixes include a glossary; contact information for state-specific National Cancer Institute comprehensive cancer centers; and contact information for national and international support groups, government agencies, and research groups. Other features include anatomical illustrations of the major body systems; a subject index; and approximately 275 additional photographs, illustrations, and statistical tables

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Molecular Exploitation Of Apoptosis Pathways In Prostate Cancer

 Oncology  Comments Off on Molecular Exploitation Of Apoptosis Pathways In Prostate Cancer
Jul 262019
 

This book focuses on the functional significance of targeting apoptosis for the treatment of prostate cancer. New concepts on the challenges relating to the development of resistance by androgen-independent tumors are introduced, in terms of the contribution of anoikis and cross-talk of androgens with key growth factor signaling pathways. This volume also provides insightful discussion on the exploitation of the apoptotic and angiogenic synergism towards complete eradication of prostate tumors. Last but not least, it includes reflections on the drug development challenge based on the analysis of data from existing clinical trials.

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Plants that Fight Cancer, Second Edition

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Jul 242019
 

An increasing amount of cancer research is being directed towards the investigation of plant-derived anticancer compounds, many of which have been used in traditional herbal treatments for centuries. Plants that Fight Cancer is an up-to-date, extensive review of plant genera and species with documented anti-tumor and anti-leukaemic properties. Following an overview of the disease and the diverse methods of therapy and clinical testing, the book provides a detailed examination of the plants whose compounds are currently used in conventional cancer treatment, the species which show the greatest potential as future candidates, and other species with established anticancer properties. The third section explores each of more than 150 terrestrial plant genera and species, with a review of their traditional uses, mythology, botany, active ingredients, and product applications, along with photographs and illustrations and an analysis of expected results and risks. The text closes with a discussion of algal extracts and isolated metabolites with anticancer activity, a summary of published research for each species, and chemical structures of the most important compounds.
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Difficult Decisions in Head and Neck Oncologic Surgery

 Oncology, Surgery  Comments Off on Difficult Decisions in Head and Neck Oncologic Surgery
Jul 212019
 

This book provides a practical guide to decision making in head and neck oncologic surgery. As new technology is introduced, there is increasing knowledge regarding the efficacy of traditional head and neck surgical therapies and how to select among these varied and complex approaches is becoming increasingly difficult. Concise easy to follow chapters are devoted to one or two specific questions or decisions in head and neck oncologic surgery, aiding the reader to develop their decision making skills.
Difficult Decisions in Head and Neck Oncologic Surgery is a timely reference source for practicing surgeons, surgeons in training, and educators on the recommended ideal approaches in selected clinical situations.

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Male Reproductive Cancers: Epidemiology, Pathology and Genetics

 Epidemiology, Genetics, Oncology, Pathology, Reproductive Health  Comments Off on Male Reproductive Cancers: Epidemiology, Pathology and Genetics
Jul 192019
 

Male Reproductive Cancers: Epidemiology, Pathology and Genetics presents a thoughtful, comprehensive and up-to-date overview of the etiology of the prostate gland and the testes, summarizing decades of research in the three most important etiological disciplines: epidemiology, pathology and genetics. This book is comprised of four distinct sections: Epidemiology, Pathology, Molecular Genetics, and Inherited Susceptibility, with each section divided into chapters categorized by disease. Section A reviews the epidemiology of prostate and testicular cancer, with an emphasis on clinical and environmental factors associated with these diseases. Section B begins by describing various pathological features of prostate cancer, followed by descriptions of the wide variety of testicular cancers as well as a brief section on the use of tumor markers for monitoring disease. Section C focuses on somatic genetic changes in prostate and testicular cancers using new technologies such as comparative genomic hybridization and gene expression profiling. Section D concentrates on the progress made toward understanding inherited susceptibility to prostate cancer and to testicular cancer.
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Chemical Carcinogenesis

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Jul 192019
 

This monograph provides a contemporary account of advances in chemical carcinogenesis. It promotes the view that it is alteration of the DNA by endogenous and exogenous carcinogens that ultimately leads to sporadic mutations which are a root cause of many human cancers. It deals with the metabolic activation of common classes of chemical carcinogens (tobacco carcinogens, heterocyclic amines, polycyclic aromatic hydrocarbons) and their detoxication. It describes the DNA-adducts that ensue and their repair mechanisms. It covers advances in structural-biology that provide a glimpse of both the DNA-repair process and the by-pass of DNA-lesions and how this informs the mutational code. It also deals with the concepts of chemoprevention and biomarkers for biomonitoring human exposure. Many contemporary texts on the biology of cancer now focus almost exclusively on the molecular and cell biology of the disease and do not cover the initiating (DNA damaging events) of chemical carcinogenesis in depth. It is with this perceived gap-in knowledge that world experts in their particular fields have contributed to this monograph. This monograph will be an important reference re-source for students in training, postdoctoral scientists, and senior scientists knowledgeable in the field.
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Ocular Oncology

 Oncology  Comments Off on Ocular Oncology
Jul 182019
 

This book concentrates on ocular oncology covering the latest advances in both adult and pediatric oncology. The topics covered are: retinoblastoma, melanoma, graft vs. host disease, squamous cell neoplasia, intraocular lymphoma, coats disease, and choroidal hemangioma. Each chapter is written by an expert in the field and covers the most recent developments in management. As part of the series “Current Practices in ophthalmology” this volume is meant for residents, fellows-in-training, generalist ophthalmologists and specialists alike.

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Novel Optical Endoscopes for Early Cancer Diagnosis and Therapy

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Jul 152019
 


This thesis describes the design, development, characterisation and clinical translation of three novel devices for optical endoscopic imaging. Over the past decade, rapid innovation in optics and photonics has led to the availability of low-cost and high-performance optical technologies that can be exploited for biomedical applications, but relatively few have been translated into clinic. The work presented outlines for the first time, a comprehensive analysis of the common barriers and unique challenges associated with the translation of optical imaging techniques. To assist developers streamline translation of optical imaging devices in future, a roadmap to clinical translation is outlined, and key translational characteristics are defined. Guided by these, subsequent development of endoscopic devices resulted in preparation and approval of endoscopes for first in human trials in the oesophagus, for early detection of cancer, and in the brain, for delineation of tumour during surgical resection. The thesis culminates in the presentation of results from the first in human use of a compact multispectral endoscope for imaging endogenous tissue contrast in the oesophagus. With continuation of the work as outlined at the end of this thesis, the novel techniques described have the potential to improve the standard of care in their respective indications.

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Cancer Cytogenetics: Methods and Protocols

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Jul 102019
 

Cytogenetic studies of malignancy have become an essential tool in the clinical management of cancer patients. Cancer Cytogenetics: Methods and Protocols presents eminently practical key cytogenetic and FISH techniques for every stage of diagnostic service. Experts in the field describe detailed cytogenetic analysis methods, fluorescence in situ hybridization and array methods currently being applied to investigate and diagnose different varieties of cancer. Written in the highly successful Methods in Molecular Biology™ series format, chapters contain introductions to their respective topics, lists of the necessary materials and reagents, and step-by-step, readily reproducible laboratory protocols. The authors of the various chapters have also provided extensive notes to guide individuals who are new to these methods through the pitfalls that bedevil all such testing. Authoritative and accessible, Cancer Cytogenetics: Methods and Protocols serves as an ideal guide to scientists of all backgrounds, allowing them to either establish new techniques in their laboratories or find the different variations of standard methods helpful in improving their results.
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The Molecular Biology of Cancer: A Bridge from Bench to Bedside, 2nd Edition

 Oncology  Comments Off on The Molecular Biology of Cancer: A Bridge from Bench to Bedside, 2nd Edition
Jul 102019
 

The Molecular Biology of Cancer, Stella Pelengaris & Michael Khan

This capturing, comprehensive text, extensively revised and updated for its second edition, provides a detailed overview of the molecular mechanisms underpinning the development of cancer and its treatment.

“Bench to Bedside”: A key strength of this book that sets it apart from general cancer biology references is the interweaving of all aspects of cancer biology from the causes, development and diagnosis through to the treatment and care of cancer patients – essential for providing a broader view of cancer and its impact.

The highly readable presentation of a complex field, written by an international panel of researchers, specialists and practitioners, would provide an excellent text for graduate and undergraduate courses in the biology of cancer, medical students and qualified practitioners in the field preparing for higher exams, and for researchers and teachers in the field.

For the teaching of cancer biology, special features have been included to facilitate this use: bullet points at the beginning of each chapter explaining key concepts and controversial areas; each chapter builds on concepts learned in previous chapters, with a list of key outstanding questions remaining in the field, suggestions for further reading, and questions for student review. All chapters contain text boxes that provide additional and relevant information.

Key highlights are listed below:

An overview of the cancer cell and important new concepts.
Selected human cancers: lung, breast, colorectal, prostate, renal, skin, cervix, and hematological malignancies.
Key cellular processes in cancer biology including (a) traditionally important areas such as cell cycle control, growth regulation, oncogenes and tumour suppressors apoptosis, as well as (b) more highly topical areas of apoptosis, telomeres, DNA damage and repair, cell adhesion, angiogenesis, immunity, epigenetics, and the proteasome.
Clinical oncology: In-depth coverage of important concepts such as screening, risk of cancer and prevention, diagnoses, managing cancer patients from start to palliative care and end-of-life pathways.

Chapters highlighting the direct links between cancer research and clinical applications.
New coverage on how cancer drugs are actually used in specific cancer patients, and how therapies are developed and tested.
Systems Biology and cutting edge research areas covered such as RNA interference (RNAi).
Each chapter includes key points, chapter summaries, text boxes, and topical references for added comprehension and review.
Quotations have been used in each chapter to introduce basic concepts in an entertaining way.

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