Cancer Therapy with Radiolabeled Antibodies

 Oncology, Radiology  Comments Off on Cancer Therapy with Radiolabeled Antibodies
Sep 052018
 

Cancer Therapy with Radiolabeled Antibodies explores the most current experimental and clinical advances in the newly emerging field of cancer radioimmunotherapy (RAIT). Providing a multidisciplinary and international context, some of the world’s leading experts examine the problems and prospects of RAIT from radiation, immunological, chemical, physical, physiological, and clinical perspectives with both overviews and original research.
Discussions cover the up-to-date clinical results in the RAIT of ovarian, breast, colorectal, and brain cancers, as well as the current status of RAIT in the management of B cell lymphomas. Radiobiology, dosimetry, radiochemistry, targeting biology in experimental models, clinical experiences in hematopoietic and solid tumors, and new approaches to improve cancer radioimmunotherapy are also discussed. In addition, new dosimetry concepts, new labeling methods, new concepts of antibody pharmacokinetics, and new methods to enhance selective cancer radioimmunotherapy are included.

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Molecular Determinants of Head and Neck Cancer, Second Edition

 Oncology  Comments Off on Molecular Determinants of Head and Neck Cancer, Second Edition
Sep 012018
 

Squamous cell cancers of the head and neck (SCCHN), also known as head and neck cancers (HNC) encompass malignancies of the oral cavity, larynx, nasopharynx and pharynx, and are diagnosed in over 500,000 patients worldwide each year, accounting for 5% of all malignancies. It is estimated that approximately 50,000 patients develop head and neck cancer annually in the United States, of whom approximately 50% succumb to this cancer. For most cases of SCCHN, treatment is multimodal, often combining surgery or irradiation with chemotherapy; even successfully treated patients frequently experience durable and severe side effects.
Improving cure rates and reducing chronic morbidity are urgent clinical needs for head and neck cancer. However, in contrast to cancer types such as breast or prostate that have been much studied and have well-defined biology, until recently, relatively few researchers investigated the molecular basis of HNC, making it difficult to design targeted treatments with better efficacy and less debilitating side effects.

This volume will provide an overview of the factors contributing to disease pathogenesis, including the recognition of discrete molecular subtypes with distinct etiology, prognosis, and treatment response. This volume will familiarize the reader with the critical signaling pathways and oncogenic drivers for HNC. It will outline the differences between HPV-positive and HPV-negative disease, and how these differences affect treatment choice and outcome. The book will emphasize developments in the past five years, including the growing understanding of the genomic and epigenomic features of the disease based on analysis of next generation sequencing (NGS) data, and timely topics such as the analysis of HNC stem cell populations, non-coding mRNAs, and inflammatory response. It will address exciting new therapeutic approaches such as the use of immunotherapies to treat HNC patients. Overall, the book will provide the reader with current understanding of the biology and treatment of the disease, and describe timely questions that will guide future research aimed at controlling and curing this disease.

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Treating Urothelial Bladder Cancer

 Oncology  Comments Off on Treating Urothelial Bladder Cancer
Aug 282018
 


This book aims to bring together the current research and discussions surrounding bladder cancer management. New technologies and therapeutic agents have become increasingly effective at treating urothelial bladder cancer and have created a range of opportunities to change the ways in which the disease is treated. Chapters cover the changes in adjuvant treatment, confocal laser endomicroscopy, and the roles of oncologists, pathologists, and radiotherapists in managing bladder cancer.
Treating Urothelial Bladder Cancer is particularly relevant to urologists, oncologists, and radiotherapists, but is also applicable to practitioners, geriatricians, and public health managers due to its multidisciplinary approach to bladder cancer management.

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Androgen Deprivation Therapy: An Essential Guide for Prostate Cancer Patients and Their Loved Ones, 2nd Edition

 Oncology  Comments Off on Androgen Deprivation Therapy: An Essential Guide for Prostate Cancer Patients and Their Loved Ones, 2nd Edition
Aug 272018
 

This expanded new edition of Androgen Deprivation Therapy remains the only guide written exclusively about the side effects of hormone therapy. This is a comprehensive workbook for prostate cancer patients and their loved ones, filled with practical advice from experts in the field. The book covers a wealth of strategies to help men cope with ADT and maintain a good quality of life while on this treatment. It is not only an informational manual, but a guide for both patients and partners about ways to make changes in their own lives that can keep them healthy and positive when the patient is on ADT.

New to this Edition:
• Updates to every chapter, including an extensive update on the various drugs used for androgen deprivation
• Suggestions for managing the physical side effects of ADT, such as hot flashes, weight gain, muscle loss, and fatigue
• Strategies to handle the emotional side effects, including coping with mood swings and depression
• Advice on how to maintain intimacy despite reduced libido and difficulties with erections
• A new chapter on the psychological and relational impact of ADT on gay men
• Exercises, activities, worksheets, and other tools to promote discussion and inspire sustainable behavioral changes that can reduce the burden of ADT

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Drug Delivery in Oncology, 3 Volume Set: From Basic Research to Cancer Therapy

 Oncology  Comments Off on Drug Delivery in Oncology, 3 Volume Set: From Basic Research to Cancer Therapy
Aug 262018
 

In this first authoritative overview on modern cancer chemotherapy 121 international specialists have contributed their experience and recent data for what is likely to become the gold standard in the field.
The authors summarize knowledge gained over the past decade, from basic concepts to successful applications in the clinic, covering active and passive targeting strategies as well as tissue-specific approaches. All current and future targeted delivery systems are discussed, from ligand-based to antibody-based polymer-based systems, right up to micro- and nanoparticulate systems. A special section covers the delivery of nucleic acid therapeutics, such as siRNA, miRNA and antisense nucleotides. In each case, a description of the basic technique is followed by a discussion of the latest preclinical and clinical developments in the field.
By virtue of its clear and didactic structure, rich illustrative material and summary chapters, this handbook and ready reference enables the efficient transfer of knowledge between different disciplines, from basic research to the clinician and vice versa. It is equally well suited for professionals, researchers and students in medical oncology and cancer biology, and is also excellent for teaching medical students the foundations of 21st century cancer chemotherapy.

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ESMO Handbook of Cancer Prevention

 Oncology  Comments Off on ESMO Handbook of Cancer Prevention
Aug 262018
 

This handbook summarizes the fast-moving world of research into prevention of cancer. An international selection of experts here present the points of most relevance for oncologists and those involved professionally with prevention and screening programmes.

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International Agency for Research on Cancer Biennial Report 2006-2007

 Oncology  Comments Off on International Agency for Research on Cancer Biennial Report 2006-2007
Aug 262018
 

A wide range of projects are described in the latest Biennial Report of the International Agency for Research on Cancer (IARC), the cancer research branch of the World Health Organization. Most of these projects involve collaborations with scientists in institutes throughout the world, covering topics ranging from descriptive epidemiology and biostatistics, cancer registration and analysis of data on cancer occurrence, to basic research on genetic and molecular aspects of cancer development to pathogenesis and prevention studies. Profusely illustrated, the Report also contains details of the personnel and organization of IARC and its activities, as well as a complete list of over 500 publications and articles authored by its scientists and thhttpseir collaborators during the biennium.

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Anticancer Plants: Natural Products and Biotechnological Implements: Volume 2

 Oncology  Comments Off on Anticancer Plants: Natural Products and Biotechnological Implements: Volume 2
Aug 232018
 

This volume provides summarized scientific evidence of the different classes of plant-derived phytocompounds, their sources, chemical structures, anticancer properties, mechanisms of action, methods of extraction, and their applications in cancer therapy. It also discusses endophyte-derived compounds as chemopreventives to treat various cancer types.
In addition, it provides detailed information on the enhanced production of therapeutically valuable anticancer metabolites using biotechnological interventions such as plant cell and tissue culture approaches, including in vitro-, hairy root- and cell-suspension culture; and metabolic engineering of biosynthetic pathways. Anticancer Plants: Natural Products and Biotechnological Implements – Volume 2” explores the natural bioactive compounds isolated from plants as well as fungal endophytes, their chemistry, and preventive effects to reduce the risk of cancer. Moreover, it highlights the genomics/proteomics approaches and biotechnological implementations. Providing solutions to deal with the challenges involved in cancer therapy, the book benefits a wide range of readers including academics, students, and industrial experts working in the area of natural products, medicinal plant chemistry, pharmacology, and biotechnology.

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DeVita, Hellman, and Rosenberg’s Cancer: Principles & Practice of Oncology, Tenth edition

 Oncology  Comments Off on DeVita, Hellman, and Rosenberg’s Cancer: Principles & Practice of Oncology, Tenth edition
Aug 182018
 

Select references are available in the print book. ALL REFERENCES FOR DeVita, Hellman, and Rosenberg’s Cancer: Principles & Practice of Oncology, 10th edition ARE AVAILABLE ONLINE AT LWWHealthLibrary.com/oncology.
DeVita, Hellman, and Rosenberg’s Cancer: Principles & Practice of Oncology, 10th edition has garnered universal acclaim as the world’s definitive, standard-setting oncology reference. More than 400 respected luminaries explore today’s most effective strategies for managing every type of cancer by stage of presentation – discussing the role of all appropriate therapeutic modalities as well as combined-modality treatments. This multidisciplinary approach will help your cancer team collaboratively face the toughest clinical challenges and provide the best possible care for every cancer patient.

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Nanomaterials for Cancer Diagnosis

 Oncology  Comments Off on Nanomaterials for Cancer Diagnosis
Aug 162018
 

This first in–depth overview to cover all important types of nanostructures being explored for cancer detection brings together the diagnostic side of oncology and nanotechnology. It presents imaging techniques as well as magnetic, metallic and non–metallic particle–based detection systems, showing combination strategies for both diagnosis and treatment. The result is a single source, collecting the valuable information published in specialized journals and thus often difficult to locate for members of the other disciplines involved.
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