Recombinant Antibodies for Cancer Therapy: Methods and Protocols

 Oncology  Comments Off on Recombinant Antibodies for Cancer Therapy: Methods and Protocols
May 022018

Many antibodies recently developed as therapeutic agents have been tailored by the powerful new recombinant antibody technology, and already their clinical data show highly encouraging results. In Recombinant Antibodies for Cancer Therapy: Methods and Protocols, Martin Welschof and Jürgen Krauss present a collection of carefully selected protocols for the design, construction, and characterization of those novel anticancer therapeutics.
Written by seasoned investigators who have successfully verified the particular method described, these readily reproducible methods include coverage of hybridoma-derived recombinant antibodies, recombinant antibody fragments from phagemid-displayed antibody repertoires, antibody fragments with additional properties, and large-scale production of recombinant antibodies for clinical applications. The main focus is on providing detailed protocols that describe these procedures step-by-step, accompanied by a troubleshooting guide discussing possible problems and offering many tips for their potential solutions. Concise review articles also survey the current status of recombinant antibodies in cancer therapy, as well as the generation of antibody molecules through antibody engineering.
Up-to-date and highly practical, Recombinant Antibodies for Cancer Therapy: Methods and Protocols surveys the current status of engineered antibodies and describes in rich detail many readily reproducible methods of generating the novel and promising antibody-based reagents of today’s cancer therapy.



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Devita, Hellman, and Rosenberg’s Cancer: Principles and Practice of Oncology Review

 Oncology  Comments Off on Devita, Hellman, and Rosenberg’s Cancer: Principles and Practice of Oncology Review
May 012018

Ace the oncology boards with the field’s most comprehensive self-paced review! Based on DeVita, Lawrence, and Rosenberg’s Cancer: Principles & Practice of Oncology, Ninth Edition, this in-depth question-and-answer review and workbook covers the entire specialty of oncology and provides thorough preparation for oncology boards.
Inside, readers will discover hundreds of multiple-choice and case-based questions covering the principles of surgical oncology, radiation oncology, medical oncology, and hematology/oncology and the biology, diagnosis, staging, and multimodality treatment of cancers at every anatomic site. Included are state-of-the-art chapters on molecular techniques, targeted therapies, and current approaches to cancer prevention.
Detailed answers and explanations follow the questions to help readers grasp the ‘how and ‘why’ behind each correct response. The ideal way to maximize exam scores for today’s student and residents.
Learning and review features include…
• Hundreds of multiple-choice and case-based questions to build comprehension and improve retention.
• All topics cross-referenced to the latest edition of DeVita, Hellman, and Rosenberg’s CANCER: Principles & Practice of Oncology, Ninth Edition
• Material on all aspects of oncology, including medical, radiation and surgical oncology, as well as hematology/oncology issues
• FREE interactive online question bank, featuring multiple-choice and case-based questions, lets readers learn at their own pace and convenience from any computer—perfect for individual self-assessment!



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TNM Classification of Malignant Tumours, Eighth Edition

 Oncology  Comments Off on TNM Classification of Malignant Tumours, Eighth Edition
Apr 302018

 TNM Classification of Malignant Tumours eighth edition provides the latest, internationally agreed-upon standards to describe and categorize cancer stage.

– Published in affiliation with the Union for International Cancer Control (UICC)
– Arranged by anatomical region, this authoritative pocket sized guide contains many important updated organ-specific classifications
– There are new classifications for p16 positive oropharyngeal carcinomas, carcinomas of the thymus, neuroendocrine tumours of the pancreas, and sarcomas
– To facilitate the collection of stage data for cancer surveillance in low and middle income countries there are new sections on Essential TNM and Paediatric Cancer Stage
– New colour presentation

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Methods and Biostatistics in Oncology: Understanding Clinical Research as an Applied Tool

 Oncology  Comments Off on Methods and Biostatistics in Oncology: Understanding Clinical Research as an Applied Tool
Apr 262018

This book introduces and discusses the most important aspects of clinical research methods and biostatistics for oncologists, pursuing a tailor-made and practical approach. Evidence-based medicine (EBM) has been in vogue in the last few decades, particularly in rapidly advancing fields such as oncology. This approach has been used to support decision-making processes worldwide, sparking new clinical research and guidelines on clinical and surgical oncology.
Clinical oncology research has many peculiarities, including specific study endpoints, a special focus on survival analyses, and a unique perspective on EBM. However, during medical studies and in general practice, these topics are barely taught. Moreover, even when EBM and clinical cancer research are discussed, they are presented in a theoretical fashion, mostly focused on formulas and numbers, rather than on clinical application for a proper literature appraisal. Addressing that gap, this book discusses more practical aspects of clinical research and biostatistics in oncology, instead of relying only on mathematical formulas and theoretical considerations. Methods and Biostatistics in Oncology will help readers develop the skills they need to understand the use of research on everyday oncology clinical practice for study design and interpretation, as well to demystify the use of EBM in oncology.


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Bioactive Components, Diet and Medical Treatment in Cancer Prevention

 Oncology  Comments Off on Bioactive Components, Diet and Medical Treatment in Cancer Prevention
Apr 222018

The high rate of urbanization and a steady increase in per capita income has improved the socio-economic status of people all over the world. This has resulted in drastic changes in their lifestyle and food consumption patterns, where traditional foods are being replaced with more ready-made junk foods with few servings of fresh vegetables and fruits. It has been postulated that industrialization has caused change in food choice, dietary pattern modification and resulted in a sedentary lifestyle. In addition, contaminated foods with unsafe microbes and chemical hazards are increasing. All of these events have resulted in an increased risk of cancer, the leading cause of mortality and morbidity worldwide.
This book will provide a basic understanding of cancer, its risk factors, preventive measures, and possible treatments currently available, as well as identifying the different dietary factors that might synergize with a sedentary lifestyle in the etiology of cancer, and its prevention measure.


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Partial Breast Reconstruction

 Oncology  Comments Off on Partial Breast Reconstruction
Apr 222018

FOUR STARS from Doody’s Star Ratings™

…both an excellent primer for the uninitiated and a superb resource for providers…Superb photographs, color illustrations, key concepts, and didactic charts adorn the chapters. The videos, on an accompanying website, take readers into the operative theatre to view various partial breast reconstructive surgeries. The authors and contributors are to be commended.–Doody’s Reviews (Score: 94)

This second edition of Partial Breast Reconstruction: Techniques in Oncoplastic Surgery builds on and expands the authoritative procedures presented in the first edition, adding and updating the content with up-to-the-minute concepts, techniques, and innovations in oncoplastic breast surgery, all elucidated with hundreds of color images and illustrations.

This edition offers readers the following:

A breadth of topics presented by internationally recognized experts from a range of disciplines from the U.S., Europe, United Kingdom, and South America
A systematic chapter structure that provides patient presentation, workup, surgical techniques, and follow-up for each approach
Emphasis on the essential contributions of all members of the multidisciplinary team
Extensive coverage of oncologic principles, indications, psychological considerations/body image, the challenges of radiotherapy, and postoperative surveillance
Prevention and correction of BCT deformities
Exploration of the risks and benefits of delayed versus immediate reconstruction
Reduction and mastopexy techniques with parenchyma autoaugmentation, central defect reconstruction, fat grafting, and local and perforator flap reconstruction techniques
Outcomes presented as the ultimate proof of the validity of each technique, with long-term follow-up
Treatment of complications
Provided in both printed and e-book formats, with multiple videos of techniques

As the oncoplastic approach to partial breast reconstruction continues to grow exponentially in popularity as a reliable treatment option, the updated information provided in this comprehensive new edition is absolutely essential to every surgeon performing partial breast reconstruction for women with breast cancer.


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2018 Oncology Nursing Drug Handbook

 Nursing, Oncology  Comments Off on 2018 Oncology Nursing Drug Handbook
Apr 212018

Written especially for nurses caring for patients with cancer, the 2018 Oncology Nursing Drug Handbook uniquely expresses drug therapy in terms of the nursing process: nursing diagnoses, etiologies of toxicities, and key points for nursing assessment, intervention, and evaluation. Updated annually, this essential reference provides valuable information on effective symptom management, patient education, and chemotherapy administration.

Completely revised and updated, the 2018 Oncology Nursing Drug Handbook includes separate chapters on molecular and immunologic/biologic targeted therapies. These chapters provide fundamental reviews to assist nurses in understanding the cellular communication pathways disrupted by cancer. It also offers simplified content, attention to understanding the immune checkpoint inhibitors, new information about immunotherapy, new drugs and their indications, and updated indications and side effects for recently FDA approved drugs.

New drugs include: avelumab (Bavencio), brigatinib (Alunbrig), durvalumab (Imfinzi), enasidenib (Idhifa), metronidazole hydrochloride (Flagyl), midostaurin (Rydapt), neratinib (Nerlynx), niraparib (Zejula), olaratumab (Lartruvo), ribociclib (Kisqali), rituximab and hyaluronidase human injection (Rituxan Hycela injection), rucaparib (Rubraca), telotristat ethyl (Xermelo), and tisagenlecleucel (Kymriah).


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Breast Cancer: Diagnostic Imaging and Therapeutic Guidance

 Oncology  Comments Off on Breast Cancer: Diagnostic Imaging and Therapeutic Guidance
Apr 212018

Breast Cancer: Diagnostic Imaging and Therapeutic Guidance provides a concise, practical, and practice-based source of up-to-date diagnostic and therapeutic information for the general radiologist. In the diagnostic phase of evaluating breast disorders, the overriding consideration in the examination and assessment is to reduce false diagnoses to the absolute minimum-a principle wholly in the interests of the patient. The particular diagnostic pathway chosen will depend on the highly variable individual presentations and the associated findings. A major focus of the book is the comparative value of the various diagnostic imaging modalities. As well as discussing conventional mammography and adjunct modalities such as breast ultrasound and galactography, the text also showcases the superior utility of contrast-enhanced magnetic resonance imaging in providing the highest rate of detection of cancers at any stage. As well as radiological diagnosis, sections written by top specialists cover the interventional procedures for obtaining biopsies and also the surgical and medical therapy of breast carcinoma.

Key Features:
Combined authors’ experience of more than 100 years provides this work with great depth and expertise.
Richly illustrated with almost 600 images, including full color histology, patient photographs, and hundreds of radiological studies.
BI-RADS classification for mammography, breast ultrasound, and breast MRI.
Adjunct topics covered include screening and staging; lymph nodes; breast reconstruction; chemotherapy, also with respect to endocrine-active tumors; radiation therapy; tumors of the male breast; logistics in the breast care center; and psychosocial care.

Breast Cancer: Diagnostic Imaging and Therapeutic Guidance is certain to prove an invaluable tool for all general radiologists involved in the evaluation and treatment of patients with breast cancer


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Molecular Pathogenesis and Treatment of Chronic Myelogenous Leukemia

 Oncology  Comments Off on Molecular Pathogenesis and Treatment of Chronic Myelogenous Leukemia
Apr 172018

Covering the history of breast cancer, theory of radiofrequency ablation (RFA), resection of carcinoma, imaging before and after non-surgical ablation therapy and quality of life, this book focuses on extensive breast-conserving treatment for the preservation of a cosmetically acceptable breast. It investigates the feasibility of percutaneous, minimally invasive techniques to ablate breast tumors and several modalities such as cryosurgery, laser ablation, thermoablation and high-intensity focused ultrasound. Non-surgical Ablation Therapy for Early-stage Breast Cancer centers on RFA and provides insights into cryoablation and focused ultrasound surgery.

RFA has been shown to be effective for treating tumors in many types of tissue, including liver, bone, brain, kidney, pancreas and prostate. As such this book is a valuable resource for breast and general surgeons, radiation oncologists and medical oncologists in all areas. The extensive discussions enable scholars to gain radiological expertise and a basic understanding of molecular biology, leading to better surgery without scalpels.




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Resistance of Targeted Therapies Excluding Antibodies for Lymphomas

 Oncology  Comments Off on Resistance of Targeted Therapies Excluding Antibodies for Lymphomas
Apr 172018

In the last decade, the literature on molecular mechanisms and activated pathways in the different lymphoma categories increased exponentially, which was followed by a more diffuse and successful use of targeted therapies. In this book, expert authors revisit the most relevant aspects of these therapies, with special emphasis on molecular mechanisms and clinical effects of resistance. The knowledge of the underlying mechanisms involved in tumor resistance to target therapies is of paramount importance because they will result in a better selection of patients with sensitive disease and the establishment of suitable combinations of drugs that target different molecules and could overcome the established resistance.
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