Cancer Screening in the Developing World

 Oncology  Comments Off on Cancer Screening in the Developing World
Jul 222018
 

Worldwide, cancer is responsible for one in eight deaths—more than AIDS, tuberculosis, and malaria combined. This global burden starkly illustrates the inequality between the developed and the developing world. While the majority of people living in developed countries receive timely treatment, those living in developing countries are not as fortunate and their survival rates are much lower—not only due to delays in diagnosis, but also to a lack of personnel, a paucity of treatment facilities, and the unavailability of many medications. Routine screening—a mainstay in the developed world—could greatly increase the likelihood of identifying individuals with early stage cancers and thus reduce the number of people who present with advanced disease.

This book represents a critical addition to the literature of global health studies. Focusing on cervical, breast, and oral cancers, these case studies highlight innovative strategies in cancer screening in a diverse array of developing countries. The authors discuss common issues and share how obstacles—medical, economic, legal, social, and psychological—were addressed or overcome in specific settings. Each chapter offers an empirical discussion of the nature and scope of a screening program, the methodology used, and its findings, along with a candid discussion of challenges and limitations and suggestions for future efforts

Review
“A welcome addition to an under-researched subject. Important topics, including the need for awareness, vaccination, lifestyle changes, appropriate point of care diagnostics, and infrastructure for treatment, are well covered with illustrative examples. Screening helps in down-staging disease and improving survival of patients diagnosed with malignancy in the low- and middle-income countries―a desperate need.” (Ravi Mehrotra, director, National Institute of Cancer Prevention and Research, Indian Council of Medical Research)

About the Author
MADELON L. FINKEL, PHD, is professor of healthcare policy and research and director of the Office of Global Health Education at Weill Cornell Medicine, the medical school of Cornell University. She is an epidemiologist who for many years has been engaged in cervical cancer screening in developing countries

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Not Quite a Cancer Vaccine : Selling HPV and Cervical Cancer

 Oncology  Comments Off on Not Quite a Cancer Vaccine : Selling HPV and Cervical Cancer
Jul 182018
 

In Not Quite a Cancer Vaccine, medical anthropologist S.D. Gottlieb explores how the vaccine Gardasil—developed against the most common sexually-transmitted infection, human papillomavirus (HPV)—was marketed primarily as a cervical cancer vaccine. Gardasil quickly became implicated in two pre-existing debates—about adolescent sexuality and pediatric vaccinations more generally.

Prior to its market debut, Gardasil seemed to offer female empowerment, touting protection against HPV and its potential for cervical cancer. Gottlieb questions the marketing pitch’s vaunted promise and asks why vaccine marketing unnecessarily gendered the vaccine’s utility, undermining Gardasil’s benefit for men and women alike. This book demonstrates why in the ten years since Gardasil’s U.S. launch its low rates of public acceptance have their origins in the early days of the vaccine dissemination. Not Quite a Cancer Vaccine addresses the on-going expansion in U.S. healthcare of patients-as-consumers and the ubiquitous, and sometimes insidious, health marketing of large pharma.

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Targeting the DNA Damage Response for Anti-Cancer Therapy

 Oncology  Comments Off on Targeting the DNA Damage Response for Anti-Cancer Therapy
Jul 162018
 

Over the past decade a complex role for DNA damage response (DDR) in tumorigenesis has emerged. A proficient DDR has been shown to be a primary cause for cellular resistance to the very many DNA damaging drugs, and IR, that are widely used as standard-of-care across multiple cancer types. It has also been shown that defects in this network, predominantly within the ATM mediated signaling pathway, are commonly observed in cancers and may be a primary event during tumorigenesis.
Such defects may promote a genomically unstable environment, facilitating the persistence of mutations, any of which may provide a growth or survival advantage to the developing tumor. In addition, these somatic defects provide opportunities to exploit a reliance on remaining repair pathways for survival, a process which has been termed synthetic lethality. As a result of all these observations there has been a great interest in targeting the DDR to provide anti-cancer agents that may have benefit as monotherapy in cancers with high background DNA damage levels or as a means to increase the efficacy of DNA damaging drugs and IR.

In this book we will review a series of important topics that are of great interest to a broad range of academic, industrial and clinical researchers, including the basic science of the DDR, its role in tumorigenesis and in dictating response to DNA damaging drugs and IR. Additionally, we will focus on the several proteins that have been targeted in attempts to provide drug candidates, each of which appear to have quite distinct profiles and could represent very different opportunities to provide patient benefit.

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Sex and Cancer : Intimacy, Romance, and Love After Diagnosis and Treatment

 Oncology  Comments Off on Sex and Cancer : Intimacy, Romance, and Love After Diagnosis and Treatment
Jul 142018
 


An intimate partnership has physical and psychological components, both of which often take a hit when cancer enters the union. The prospect, and then the process, of treatments tend to alter the way the two people relate to each other. When the diagnosis is one of gynecologic or reproductive cancer for a woman, questions of sexual intimacy and function often color relationships, confuse partners, and raise concerns that other cancers might not.

With an estimated 83,000 women a year added to the roles of those battling gynecologic cancers and 300,000 women a year added to roles of those battling breast cancer, Sex and Cancer focuses on surviving and thriving—more than 70 percent of women with gynecologic cancers now survive!—and helps readers mitigate outcomes and overcome challenges of sexual dysfunction after a cancer diagnosis; reassess the priorities in an intimate relationship to support the patient’s struggle, healing, and libido; and learn to interact with the professionals tasked with saving lives and enhancing those areas affected by cancer diagnosis and treatment. Sex and Cancer features stories that illuminate insights about the impact of gynecologic and reproductive cancers on relationships. The stories give life to guidance that’s critical in shaping the effect that gynecologic cancer has on intimate relationships. And readers will find insight, comfort, and suggestions for addresses the questions about intimacy and sexual function that are often left unexpressed.

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Anticancer plants: Properties and Application: Volume 1

 Oncology  Comments Off on Anticancer plants: Properties and Application: Volume 1
Jul 142018
 

CanceCancer is one of the leading death cause of human population increasingly seen in recent times. Plants have been used for medicinal purposes since immemorial times. Though, several synthetic medicines are useful in treating cancer, they are inefficient and unsafe. However, plants have proved to be useful in cancer cure. Moreover, natural compounds from plants and their derivatives are safe and effective in treatment and management of several cancer types.
The anticancer plants such as Catharanthus roseus, Podophyllum peltatum, Taxus brevifolia, Camptotheca acuminate, Andrographis paniculata, Crateva nurvala, Croton tonkinensis, Oplopanax horridus etc., are important source of chemotherapeutic compounds. These plants have proven their significance in the treatment of cancer and various other infectious diseases. Nowadays, several well-known anticancer compounds such as taxol, podophyllotoxins, camptothecin, vinblastine, vincristine, homoharringtonine etc. have been isolated and purified from these medicinal plants. Many of them are used effectively to combat cancer and other related diseases. The herbal medicine and their products are the most suitable and safe to be used as an alternative medicine. Based on their traditional uses and experimental evidences, the anticancer products or compounds are isolated or extracted from the medicinally important plants. Many of these anticancer plants have become endangered due to ruthless harvesting in nature. Hence, there is a need to conserve these species and to propagate them in large scale using plant tissue culture. Alternatively, plant cell tissue and organ culture biotechnology can be adopted to produce these anticancer compounds without cultivation. The proper knowledge and exploration of these isolated molecules or products could provide an alternative source to reduce cancer risk, anti-tumorigenic properties, and suppression of carcinogen activities.

Anticancer plants: Volume 1, Properties and Application is a very timely effort in this direction. Discussing the various types of anticancer plants as a source of curative agent, their pharmacological and neutraceutical properties, cryo-preservations and recent trends to understand the basic cause and consequences involved in the diseases diagnosis.

We acknowledge the publisher, Springer for their continuous inspiration and valuable suggestions to improvise the content of this book. We further extend our heartfelt gratitude to all our book contributors for their support, and assistance to complete this assignment. I am sure that these books will benefit the scientific communities including academics, pharmaceuticals, nutraceuticals and medical practitioners.r is one of the leading death cause of human population increasingly seen in recent times. Plants have been used for medicinal purposes since immemorial times. Though, several synthetic medicines are useful in treating cancer, they are inefficient and unsafe. However, plants have proved to be useful in cancer cure. Moreover, natural compounds from plants and their derivatives are safe and effective in treatment and management of several cancer types.
The anticancer plants such as Catharanthus roseus, Podophyllum peltatum, Taxus brevifolia, Camptotheca acuminate, Andrographis paniculata, Crateva nurvala, Croton tonkinensis, Oplopanax horridus etc., are important source of chemotherapeutic compounds. These plants have proven their significance in the treatment of cancer and various other infectious diseases. Nowadays, several well-known anticancer compounds such as taxol, podophyllotoxins, camptothecin, vinblastine, vincristine, homoharringtonine etc. have been isolated and purified from these medicinal plants. Many of them are used effectively to combat cancer and other related diseases. The herbal medicine and their products are the most suitable and safe to be used as an alternative medicine. Based on their traditional uses and experimental evidences, the anticancer products or compounds are isolated or extracted from the medicinally important plants. Many of these anticancer plants have become endangered due to ruthless harvesting in nature. Hence, there is a need to conserve these species and to propagate them in large scale using plant tissue culture. Alternatively, plant cell tissue and organ culture biotechnology can be adopted to produce these anticancer compounds without cultivation. The proper knowledge and exploration of these isolated molecules or products could provide an alternative source to reduce cancer risk, anti-tumorigenic properties, and suppression of carcinogen activities.

Anticancer plants: Volume 1, Properties and Application is a very timely effort in this direction. Discussing the various types of anticancer plants as a source of curative agent, their pharmacological and neutraceutical properties, cryo-preservations and recent trends to understand the basic cause and consequences involved in the diseases diagnosis.

We acknowledge the publisher, Springer for their continuous inspiration and valuable suggestions to improvise the content of this book. We further extend our heartfelt gratitude to all our book contributors for their support, and assistance to complete this assignment. I am sure that these books will benefit the scientific communities including academics, pharmaceuticals, nutraceuticals and medical practitioners.

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http://nitroflare.com/view/D13423C184B4AF9/9811085471.epub

http://nitroflare.com/view/F5F834E6F611240/9811085471.pdf

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The Heterogeneity of Cancer Metabolism

 Endocrinology/Metabolism/Diabetes Mellitus, Oncology  Comments Off on The Heterogeneity of Cancer Metabolism
Jul 122018
 

Genetic alterations in cancer, in addition to being the fundamental drivers of tumorigenesis, can give rise to a variety of metabolic adaptations that allow cancer cells to survive and proliferate in diverse tumor microenvironments. This metabolic flexibility is different from normal cellular metabolic processes and leads to heterogeneity in cancer metabolism within the same cancer type or even within the same tumor.
In this book, we delve into the complexity and diversity of cancer metabolism, and highlight how understanding the heterogeneity of cancer metabolism is fundamental to the development of effective metabolism-based therapeutic strategies. Deciphering how cancer cells utilize various nutrient resources will enable clinicians and researchers to pair specific chemotherapeutic agents with patients who are most likely to respond with positive outcomes, allowing for more cost-effective and personalized cancer therapeutic strategies.

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Gynaecological Oncology for the MRCOG

 Ob/Gynae, Oncology  Comments Off on Gynaecological Oncology for the MRCOG
Jul 122018
 

Written with the MRCOG examination requirements at its core, this book offers an extensive and up-to-date review of the full range of gynaecological cancers. The principles of epidemiology, imaging and treatment modalities are presented in a succinct and clinically focused manner. Each gynaecological cancer features in a stand-alone chapter, incorporating information on clinical issues, staging and principles of management. Genetic conditions and surgical principles are analysed, as well as topics such as palliative care, holistic approaches and communication. RCOG guidelines and Scientific Advisory Committee advice feature throughout the book. While authoritative and factual, the text is concise and clear. Flow-charts and diagrams support the assimilation of complex information, while practical tips, management algorithms, and clinical images enhance each chapter. Essential for those preparing for the MRCOG examination, this book is a comprehensive resource for health professionals working with gynaecological cancers, and those who want to further understand gynaecological oncology.
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The MD Anderson Surgical Oncology Handbook, 6th edition

 Oncology, Surgery  Comments Off on The MD Anderson Surgical Oncology Handbook, 6th edition
Jul 102018
 

The sixth edition of the MD Anderson Surgical Oncology Handbook focuses on multidisciplinary, cooperative approaches to issues confronting the surgical oncologist. Organized by disease and in full color for the first time, this volume is comprehensive yet concise, and takes into account all of the oncologic issues you need to consider in order to fully understand each disease and its relevant treatments.
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Handbook of Geriatric Oncology : Practical Guide to Caring for the Older Cancer Patient

 Geriatrics, Oncology  Comments Off on Handbook of Geriatric Oncology : Practical Guide to Caring for the Older Cancer Patient
Jul 092018
 

Handbook of Geriatric Oncology is a practical resource for oncologists and related clinicians who want to provide comprehensive, patient-centered care to the elderly cancer patient. Divided into nine succinct sections, it includes topics spanning an Overview of Geriatric Oncology and Aging, Geriatric Syndromes, Geriatric Assessment, Select Cancers Commonly Diagnosed in the Elderly, Communication with the Older Cancer Patient, the Nursing Home Patient with Cancer, Models of Care and Survivorship, Palliative Care, and Integrative Medicine. Complex issues such as the physiologic changes of aging and their effect on cancer, corresponding social and psychological aspects that accompany aging and a cancer diagnosis, assessment of frailty, managing comorbid conditions and diseases, effective communication among healthcare providers, the patient and caregivers, as well as the risks and benefits of cancer screening, are made simpler with helpful clinical guidance and clinical pearls.

Spearheaded by world experts in geriatric oncology from Memorial Sloan Kettering Cancer Center in New York, this book is the definitive resource for oncologists and related clinicians to meet the demands of clinical management along the continuum of geriatric cancer care.

Key Features:

– Provides best practices for evaluating geriatric syndromes such as functional dependency, falls, cognitive impairment and dementia, delirium, depression and anxiety, social isolation as well as syndromes related to nutrition, comorbid conditions, and polypharmacy.
– Includes practical guidance on when to treat and when not to treat cancer in older patients
– Discusses unique factors associated with breast cancer, prostate cancer, colorectal cancer, lung cancer, ovarian cancer, bladder cancer, pancreatic cancer, head and neck cancers, and myelodysplastic syndromes in the elderly that impact care plans and treatment.

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In My Hands: Compelling Stories from a Surgeon and His Patients Fighting Cancer

 Oncology  Comments Off on In My Hands: Compelling Stories from a Surgeon and His Patients Fighting Cancer
Jul 032018
 

In IN MY HANDS, surgical oncologist Dr. Steven Curley shares the empowering lessons he’s learned over 25 years from his cancer patients’ unique stories of struggle, perseverance, and triumph.

As Chief of Surgical Oncology at Baylor College of Medicine, Dr. Steven Curley has worked with cancer patients for over two decades. While his life’s work has been to help his patients live longer lives, he found that they helped him in ways he never could have expected.

IN MY HANDS is a rare, often emotional look at some of Dr. Curley’s real patients and real situations in modern cancer care. These stories of resilience, hope, and determination changed and inspired Dr. Curley, and he uses these same stories to encourage patients dealing with the fear and uncertainty coupled with a diagnosis of cancer.

Every story in the book has a theme inspired by his patients: Hope, Courage, Strength, Determination, Wonder, Cooperation, Creativity, Diligence, Service, Perseverance, Wisdom, Grace, Consideration, Gratitude, Discernment, Reverence, Resourcefulness, Faith, Beauty, Acceptance, and Empathy. Some are positive messages, reminding us of the importance of maintaining balance between family, work, and leisure activities. Others are examples of the remarkable resilience of the human spirit when facing the reality of and the surgical risks that accompany a cancer diagnosis. Realistically, despite remarkable advances in multidisciplinary cancer care, some remind us cancer is still a potentially lethal and destructive disease affecting patients and the family and friends supporting them.

While many people are told that there is no hope in their situation, Dr. Curley’s patients taught him to always provide hope, to push the envelope and give people a chance, and that hope is a critical component of treatment and care. IN MY HANDS is medical narrative at its finest, and provides insight into medicine and patient care along with fascinating details about one of our most feared diseases.

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