ISBI 2019 C-NMC Challenge: Classification in Cancer Cell Imaging: Select Proceedings

 Oncology, Radiology  Comments Off on ISBI 2019 C-NMC Challenge: Classification in Cancer Cell Imaging: Select Proceedings
Jan 212020
 

This book comprises select peer-reviewed proceedings of the medical challenge – C-NMC challenge: Classification of normal versus malignant cells in B-ALL white blood cancer microscopic images. The challenge was run as part of the IEEE International Symposium on Biomedical Imaging (IEEE ISBI) 2019 held at Venice, Italy in April 2019. Cell classification via image processing has recently gained interest from the point of view of building computer-assisted diagnostic tools for blood disorders such as leukaemia. In order to arrive at a conclusive decision on disease diagnosis and degree of progression, it is very important to identify malignant cells with high accuracy. Computer-assisted tools can be very helpful in automating the process of cell segmentation and identification because morphologically both cell types appear similar. This particular challenge was run on a curated data set of more than 14000 cell images of very high quality. More than 200 international teams participated in the challenge. This book covers various solutions using machine learning and deep learning approaches. The book will prove useful for academics, researchers, and professionals interested in building low-cost automated diagnostic tools for cancer diagnosis and treatment.
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Squamous Cell Head and Neck Cancer: Recent Clinical Progress and Prospects for the Future

 Oncology  Comments Off on Squamous Cell Head and Neck Cancer: Recent Clinical Progress and Prospects for the Future
Jan 212020
 

Leading expert physicians and investigators from around the world review the state-of-the-art in the management of squamous cell head and neck cancer, with emphasis on coordinating different treatment modalities. The authors address several surgical issues, including laser-based surgery, larynx preservation approaches, salvage surgery, and neck management after non-operative treatment. They also discuss definitive radiation for larynx cancer, brachytherapy, altered fractionation radiation, intensity modulated radiation therapy, and the importance of tumor hypoxia, as well as the role of chemotherapy in sequential, concurrent, and adjuvant multi-modality treatment schedules. Other topics of special interest include targeted and gene therapies, multimodality management of nasopharyngeal cancer, chemoprevention, toxicity modification, quality of life outcomes, symptom palliation, and epidemiology.
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Paediatric Oncology, Third edition

 Oncology, Pediatrics  Comments Off on Paediatric Oncology, Third edition
Jan 182020
 

This comprehensive and established textbook presents an up-to-date overview of all aspects of managing children with cancer and in its third edition has been completely revised and updated to reflect recent developments in the field. Individual malignancies are given comprehensive coverage, including details of clinical presentation, diagnostic investigations, novel imaging techniques and current management with chemotherapy, radiotherapy and surgery.
Current controversies relating to diagnosis and management – a popular feature of previous editions – are presented in boxes for increased emphasis. Content changes to the new edition include a restructured pathology section and new chapters under separate headings of ‘advances in therapy’ and ‘late effects and supportive care’.
Retaining a European flavour, but incorporating information from American and other national studies to give an objective and comprehensive overview, the third edition of Paediatric Oncology remains invaluable reading for trainee and practising paediatric oncologists, and nurse specialists, world-wide.
[contributors mainly UK and European, plus 1 from US and 1 from Australia]

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Chemotherapy Regimens and Cancer Care (Vademecum)

 Oncology, Pharmacology  Comments Off on Chemotherapy Regimens and Cancer Care (Vademecum)
Jan 182020
 

This handbook is a concise, thorough, and portable reference guide to the multitude of complex chemotherapy protocols and other frequently utilized medications in the field of Hematology/Oncology. Its inclusion of commonly used oncology regimens, guidelines for supportive care during administration and sections on pain control, antibiotic use and antiemesis guidelines set it apart from other ?chemotherapy handbooks?. The authors have prepared this book with the intention of improving the care of those suffering from cancer.

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The Breakthrough: Immunotherapy and the Race to Cure Cancer

 Immunology, Oncology  Comments Off on The Breakthrough: Immunotherapy and the Race to Cure Cancer
Jan 182020
 

For thousands of years, physicians observed cases of “spontaneous remissions” from cancer. These sudden and dramatic cancer cures were chalked up to magic or miracle. In fact it was the immune system, mysteriously unleashed.
Now scientists have learned to recreate that miracle with medicines so new that cancer patients- and even many doctors- don’t realize they exist.
From the New York Times bestselling author of The Good Nurse comes an empowering and accessible story of the discoveries of the tricks cancer uses to avoid the immune system, and the important new cancer immunotherapies already unleashing the immune system to fight – and beat – the disease.
Four years in the writing, THE BREAKTHROUGH is an “exciting read” about the discoveries which received the 2018 Nobel Prize winning discoveries in October, and a dramatic and exciting turning point in our relationship with a disease that has for too long defined us.
For decades, scientists have puzzled over one of medicine’s most confounding mysteries: Why doesn’t our immune system recognize and fight cancer the way it does other diseases, like the common cold?
As it turns out, the answer to that question can be traced to a series of tricks that cancer has developed to turn off normal immune responses-tricks that scientists have only recently discovered and learned to defeat. The result is what many are calling cancer’s “penicillin moment,” a revolutionary discovery in our understanding of cancer and how to beat it.
In THE BREAKTHROUGH, Graeber guides us through the surprisingly recent scientific discoveries that change the way we will treat- and maybe even beat- cancer in the years to come.
Amazingly, many patients, and even many doctors, are not fully aware of what many are calling our “penicillin moment” with cancer. With literally thousands of new therapies that harness the power of the immune system to recognize and fight cancer in clinical trials, it’s never been more important for patients to understand their choices, and empowered to ask better questions. In the new war against cancer, information is now a crucial weapon.
Groundbreaking, riveting, and expertly told, THE BREAKTHROUGH is a scientific mystery story about the quest to unleash our natural ability to recognize and defeat cancer, told through the experiences of the patients, physicians, and cancer immunotherapy researchers who are on the front lines. This is the incredible true story of the race to find a cure, a dispatch from the life-changing world of modern oncological science, and a brave new chapter in medical history.

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Cancer Prevention and Management through Exercise and Weight Control (Nutrition and Disease Prevention)

 Oncology  Comments Off on Cancer Prevention and Management through Exercise and Weight Control (Nutrition and Disease Prevention)
Jan 172020
 

“..it is increasingly clear that cancer is also a disease of inertia. In this book, a broadly multidisciplinary group presents the evidence and provides the recommendations. … The antidote to diseases of inertia is movement — let’s move!” John Potter, M.D.,Ph.D., from the Foreword The American Cancer Society estimates that a third of all cancer deaths could be prevented through avoidance of obesity and the rejection of sedentary lifestyles. The World Health Organization also supports this claim. Additionally, these and other organizations now recognize the role that activity can play in improving the quality of life for cancer patients. Cancer Prevention and Management through Exercise and Weight Control provides us with the support necessary to make a call to action. Itbrings together the contributions of world-class researchers to lay out the evidence and a plan of attack for coping with this crisis. The text begins by focusing on the research methods used in assessing the complex associations between activity, energy balance, and risk and prognosis. In comprehensive literature reviews, the authors consider the role of physical activity in the incidence of individual cancers, then explore the mechanisms that might explain this connection. They continue with a look at the relation between weight and cancer incidence, including a consideration of genetics. Research is also provided linking physical activity and weight control to a cancer patient’s quality of life and prognosis. The work concludes with ideas on how a plan of action might be implemented at the individual, clinical, and public health levels. It also provides guidance on incorporating exercise and diet recommendations into clinical oncology practice.

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Cancer Regional Therapy: HAI, HIPEC, HILP, ILI, PIPAC and Beyond

 Oncology  Comments Off on Cancer Regional Therapy: HAI, HIPEC, HILP, ILI, PIPAC and Beyond
Jan 152020
 

This book is a state-of-the-art overview of cancer regional therapy (CRT) for the surgeons and interventional radiologists active in CRT development and research. The goals of this book are 1) to review the theory and practice of cancer regional therapies including pharmacology, devices, techniques, and workflow, 2) illustrate the most common procedures performed in the interventional and operating rooms, and 3) discuss data supporting use of CRT. This is meant to be a definitive text on the theory and practice of CRT. It begins with a summary of the history, technical principles that underlie regional therapy. The following parts discuss current data and practice in peritoneal, liver, limb, pleural and other sites. Included in the practice are considerations of workflow and financial issues revolving around CRT. Novel techniques and therapies under investigation are presented to inform the direction of the field.
Cancer Regional Therapy summarizes the history, current technology, common procedures, and future prospects in this field and includes procedures from many surgical and interventional radiologic disciplines.

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https://nitroflare.com/view/B6AC4DD55377E4C/3030288900.pdf

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Deoxynucleoside Analogs In Cancer Therapy

 Oncology, Pharmacology  Comments Off on Deoxynucleoside Analogs In Cancer Therapy
Jan 042020
 

Successful cancer chemotherapy relies heavily on the application of various deoxynucleoside analogs. Since the very beginning of modern cancer chemotherapy, a number of antimetabolites have been introduced into the clinic and subsequently applied widely for the treatment of many malignancies, both solid tumors and hematological disorders. In the latter diseases, cytarabine has been the mainstay of treatment of acute myeloid leukemia. Although many novel compounds were synthesized in the 1980s and 1990s, no real improvement was made. However, novel technology is now capable of elucidating the molecular basis of several inborn errors as well as some specific malignancies. This has enabled the synthesis of several deoxynucleoside analogs that could be applied for specific malignancies, such as pentostatin and subsequently chlorodeoxyadenosine (cladribine) for the treatment of hairy cell leukemia. Already in the early stage of deoxynucleoside analog development, it was recognized that several of these compounds were very effective in the treatment of various viral infections, such as for the treatment of herpes infections. This formed the basis initially for the design of azidothymidine and subsequently many other analogs, which are currently successfully used for the treatment of HIV infections. As a spin-off of these research lines, some compounds not eligible for development as antiviral agents appeared to be very potent anticancer agents. The classical example is gemcitabine, now one of the most widely applied deoxynucleoside analogs, used for the (combination) treatment of non-small cell lung cancer, pancreatic cancer, bladder cancer, and ovarian cancer.
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Atlas of Differential Diagnosis in Neoplastic Hematopathology

 Hematology, Medical Atlas, Oncology, Pathology  Comments Off on Atlas of Differential Diagnosis in Neoplastic Hematopathology
Jan 042020
 

Management of tumor patients now relies on new individualized approaches to treatment, requiring extensive knowledge of the molecular makeup of tumors. Updated and expanded, the third edition of Atlas of Differential Diagnosis in Neoplastic Hematopathology examines not only the differential diagnosis but also the detailed morphologic, immunophenotypic, and especially genetic characteristics of the majority of hematolymphoid malignancies.

Featuring a new structure and including new chapters, the third edition updates all content and presents considerable expansion on many topics, including:

– Metaphase cytogenetic and FISH

– Flow cytometry (overview and detailed analysis of specific tumors)

– Acute myeloid leukemia and new classification schemes

– MDS, AML, and B- and T-cell lymphoproliferations

– Abnormal patterns in the lymph node and bone marrow with detail differential diagnosis based on histologic features and cellular composition

– Detailed differential diagnosis based on the expression of broad list of antigenic markers (flow cytometry and immunohistochemistry)

– Extranodal lymphomas

– Diagnosis of MDS and myeloproliferative neoplasm and their differential diagnosis based on the morphologic, flow cytometric, and chromosomal features

The book also provides expanded differential diagnosis of the most common as well as most difficult and rare entities, including morphologic, immunophenotypic, and karyotypic/molecular features. This edition includes updated algorithms for most common diagnoses as well as several new algorithms. The majority of figures have been revised and are in full color.

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Endometrial Cancer : Risk Factors, Management and Prognosis

 Ob/Gynae, Oncology  Comments Off on Endometrial Cancer : Risk Factors, Management and Prognosis
Dec 292019
 

Endometrial cancer is the most common gynecological cancer and the sixth cause of cancer in developed countries. The findings that EC is a heterogeneous group of tumors with distinct risk factors and histopathological features, together with our improved understanding of its molecular mechanism has paved the way to the investigation of new surgical and medical therapies. The aim of this book is to give a complete overview on risk factors, pre-operative methods and management of endometrial cancer. The authors hope that this book will be a useful tool for any health provider involved in gynecological cancer care.

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