The Cancer Chronicles: Unlocking Medicine’s Deepest Mystery

 Oncology  Comments Off on The Cancer Chronicles: Unlocking Medicine’s Deepest Mystery
May 232019
 

When the woman he loved was diagnosed with a metastatic cancer, science writer George Johnson embarked on a journey to learn everything he could about the disease and the people who dedicate their lives to understanding and combating it. What he discovered is a revolution under way—an explosion of new ideas about what cancer really is and where it comes from. In a provocative and intellectually vibrant exploration, he takes us on an adventure through the history and recent advances of cancer research that will challenge everything you thought you knew about the disease.

Deftly excavating and illuminating decades of investigation and analysis, he reveals what we know and don’t know about cancer, showing why a cure remains such a slippery concept. We follow him as he combs through the realms of epidemiology, clinical trials, laboratory experiments, and scientific hypotheses—rooted in every discipline from evolutionary biology to game theory and physics. Cogently extracting fact from a towering canon of myth and hype, he describes tumors that evolve like alien creatures inside the body, paleo-oncologists who uncover petrified tumors clinging to the skeletons of dinosaurs and ancient human ancestors, and the surprising reversals in science’s comprehension of the causes of cancer, with the foods we eat and environmental toxins playing a lesser role. Perhaps most fascinating of all is how cancer borrows natural processes involved in the healing of a wound or the unfolding of a human embryo and turns them, jujitsu-like, against the body.

Throughout his pursuit, Johnson clarifies the human experience of cancer with elegiac grace, bearing witness to the punishing gauntlet of consultations, surgeries, targeted therapies, and other treatments. He finds compassion, solace, and community among a vast network of patients and professionals committed to the fight and wrestles to comprehend the cruel randomness cancer metes out in his own family. For anyone whose life has been affected by cancer and has found themselves asking why?, this book provides a new understanding. In good company with the works of Atul Gawande, Siddhartha Mukherjee, and Abraham Verghese, The Cancer Chronicles is endlessly surprising and as radiant in its prose as it is authoritative in its eye-opening science.

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Precision Radiation Oncology

 Oncology, Radiology  Comments Off on Precision Radiation Oncology
May 232019
 

by Bruce G. Haffty (Author), Sharad Goyal (Author)

Precision medicine is a rapidly-evolving field in the management of cancer. The use of novel molecular or genetic signatures in local-regional management is still in its infancy. Precision Radiation Oncology demystifies this state-of-the-art research and technology.

By describing current existing clinical and pathologic features, and focusing on the ability to improve outcomes in cancer using radiation therapy, this book discusses incorporating novel genomic- or biology-based biomarkers in the treatment of patients moving radiation oncology into precision/personalized medicine. Precision Radiation Oncology provides readers with an overview of the new developments of precision medicine in radiation oncology, further advancing the integration of new research findings into individualized radiation therapy and its clinical applications

About the Author
BRUCE HAFFTY, M.D. is an international expert in breast radiation oncology. He is a professor and chairman in the Department of Radiation Oncology at Rutgers Robert Wood Johnson Medical School, Rutgers New Jersey Medical School, and Rutgers Cancer Institute of New Jersey. He also serves as Chief of Staff of the Rutgers Cancer Institute.

SHARAD GOYAL, M.D. is a professor and division chief of Radiation Oncology in the Department of Radiology at the George Washington University School of Medicine and Health Sciences. He is a board-certified radiation oncologist whose clinical practice is primarily focused on breast and brain cancers.

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Multiscale modeling of cancer : an integrated experimental and mathematical modeling approach

 Oncology  Comments Off on Multiscale modeling of cancer : an integrated experimental and mathematical modeling approach
May 082019
 

The correct functioning of the mammalian brain depends on the integrated activity of myriad neuronal and non-neuronal cells. Discrete areas serve discrete functions, and dispersed or distributed communities of cells serve others. Throughout, these networks of activity are under the control of neuromodulatory systems. One goal of current neuroscientific research is to elucidate the precise methods by which these systems operate, especially during normal conscious behaviours and processes. Mircea Steriade and Denis Paré describe the neuronal properties and networks that exist within and between the cortex and two important sub-cortical structures: the thalamus and amygdala. The authors explore the changes in these properties, covering topics including morphology, electrophysiology, architecture and gating; and comparing regions and systems in both normal and diseased states. Aimed at graduates and postdoctoral researchers in neuroscience “Mathematical modeling, analysis and simulation are set to play crucial roles in explaining tumor behavior, and the uncontrolled growth of cancer cells over multiple time and spatial scales. This book, the first to integrate state-of-the-art numerical techniques with experimental data, provides an in-depth assessment of tumor cell modeling at multiple scales. The first part of the text presents a detailed biological background with an examination of single-phase and multi-phase continuum tumor modeling, discrete cell modeling, and hybrid continuum-discrete modeling. In the final two chapters, the authors guide the reader through problem-based illustrations and case studies of brain and breast cancer, to demonstrate the future potential of modeling in cancer research. This book has wide interdisciplinary appeal and is a valuable resource for mathematical biologists, biomedical engineers and clinical cancer research communities wishing to understand this emerging field”–Provided by publisher. Machine generated contents note: Part I. Theory: 1. Introduction; 2. Biological background; 3. Continuum tumor modeling: single phase; 4. Analysis and calibration of single-phase continuum tumor models; 5. Continuum tumor modeling: multiphase; 6. Discrete cell modeling; 7. Hybrid continuum-discrete models; 8. Numerical schemes; Part II. Applications: 9. Continuum tumor modeling: a multidisciplinary approach; 10. Agent-based cell modeling: application to breast cancer
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Imaging in Pediatric Oncology

 Oncology, Pediatrics, Radiology  Comments Off on Imaging in Pediatric Oncology
Apr 302019
 


This book, co-authored by an internationally acclaimed team of experts in the field of pediatric oncologic imaging, provides a comprehensive update on new advances in diagnostic imaging as they relate to pediatric oncology. In contrast to other oncologic imaging texts focusing on the radiology of specific tumors, this book emphasizes the important fundamentals of imaging that every child with a new or treated malignancy receives. Guidance is provided on the selection and use of appropriate imaging techniques, with individual chapters devoted to each of the major cross-sectional imaging modalities used in the detection and follow-up of pediatric cancers, including PET-CT, PET-MRI, whole-body MRI, and diffusion-weighted MRI. Additional nuclear medicine techniques are addressed, and detailed attention is paid to more advanced areas of practice such as contrast-enhanced ultrasound, pediatric interventional radiology techniques, radiation treatment planning, and radiation dose considerations (ALARA). Other areas covered include screening of children with cancer predisposition syndromes, treatment related complications, potential pitfalls during neuro-oncologic imaging, and the risks and benefits inherent in post-therapy surveillance imaging.

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Mammographies: The Cultural Discourses of Breast Cancer Narratives

 Oncology  Comments Off on Mammographies: The Cultural Discourses of Breast Cancer Narratives
Apr 272019
 

While breast cancer continues to affect the lives of millions, contemporary writers and artists have responded to the ravages of the disease in creative expression. Mary K. DeShazer’s book looks specifically at breast cancer memoirs and photographic narratives, a category she refers to as mammographies, signifying both the imaging technology by which most Western women discover they have this disease and the documentary imperatives that drive their written and visual accounts of it. Mammographies argues that breast cancer narratives of the past ten years differ from their predecessors in their bold address of previously neglected topics such as the link between cancer and environmental carcinogens, the ethics and efficacy of genetic testing and prophylactic mastectomy, and the shifting politics of prosthesis and reconstruction.

Mammographies is distinctive among studies of contemporary illness narratives in its exclusive focus on breast cancer, its analysis of both memoirs and photographic texts, its attention to hybrid and collaborative narratives, and its emphasis on ecological, genetic, transnational, queer, and anti-pink discourses. DeShazer’s methodology—best characterized as literary critical, feminist, and interdisciplinary—includes detailed interpretation of the narrative strategies, thematic contours, and visual imagery of a wide range of contemporary breast cancer memoirs and photographic anthologies. The author explores the ways in which the narratives constitute a distinctive testimonial and memorial tradition, a claim supported by close readings and theoretical analysis that demonstrates how these narratives question hegemonic cultural discourses, empower reader-viewers as empathic witnesses, and provide communal sites for mourning, resisting, and remembering

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An Energetic Approach to Oncology

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Apr 262019
 

The information contained within the Chinese Medical Qigong Therapy: A Comprehensive Clinical Text has currently been tripled, and formatted into five exciting new textbooks. The five new Medical Qigong textbooks are composed of both modern and ancient knowledge, graphics and expanded techniques guaranteed to fascinate and intrigue the reader. Never before in the history of Chinese Medicine has a textbook series been made available to the public that includes such comprehensive and thorough understandings on ancient Chinese energetic healing techniques. Written by an internationally recognized Grand Master of Martial, Medical, and Spiritual Qigong training, this five textbook series (often referred to as the “Medical Qigong Encyclopedia”) provides the first complete explanation of ancient Chinese esoteric theory that has for centuries eluded and confounded the West. This fifth textbook includes a thorough understanding of the Medical Qigong treatment protocols and prescription homework used successfully in both China and the U.S. for the treatment of various types of cancer. The featured highlights of this clinical textbook include: – History of Medical Qigong and Oncology – Introduction to Clinical Protocol – Medical Qigong Therapy for Radiation – Medical Qigong Therapy for Chemotherapy – Medical Qigong Therapy for Surgery – Medical Qigong with Herbs and Nutrition – Social Oncology for Cancer Treatment – Medical Qigong Cancer Prescription Meditations – Medical Qigong Cancer Prescription Exercises – Clinical Protocol for the following types of cancer: – Brain Cancer – Esophageal Cancer – Breast Cancer – Lung Cancer – Stomach Cancer – Pancreatic Cancer – Liver Cancer – Ovarian Cancer – Uterine Cancer – Cervical Cancer – Prostate Cancer – Colorectal Cancer – Bone Cancer – Multiple Myeloma – Leukemia – Malignant Lymphoma – Skin Cancer
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Toxicities of Radiation Treatment for Breast Cancer: Risks and Management Strategies

 Oncology, Radiology, Toxicology  Comments Off on Toxicities of Radiation Treatment for Breast Cancer: Risks and Management Strategies
Apr 252019
 


This book is a comprehensive guide to breast toxicity. Adjuvant radiation remains standard for a majority of women who undergo breast-conserving surgery for breast cancer, and indications for post-mastectomy and regional lymph node irradiation have also broadened with recent publications. At the same time, locoregional recurrence has declined and survival has improved in recent decades. In the current era of excellent breast cancer outcomes, then, considering the balance between toxicity and outcomes becomes paramount. Several recent editorials recommend considering toxicity against the potential benefit of adjuvant radiation in tailoring radiation decisions for individual patients. Thus, a clear understanding of the potential toxicities of adjuvant radiation for breast cancer is critical to optimizing outcomes in modern breast cancer management. Here, authors have collected recent data focused on toxicity of treatment that provide an opportunity for improving this optimization. Chapters cover both acute and late toxicity of radiation for breast cancer, including tailored risk assessment for each of these potential toxicities, considerations for including risk of toxicity in management decisions, and toxicity management strategies. This is an ideal guide for radiation oncologists, residents, and oncologists seeking to optimize care for their patients.
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Psycho-Oncology for the Clinician: The Patient Behind the Disease

 Oncology  Comments Off on Psycho-Oncology for the Clinician: The Patient Behind the Disease
Apr 242019
 


This volume strives to give oncologists and other medical practitioners a thorough picture of the oncology patient. It’s designed to show that psychological needs of the patient are an important aspect that should be considered for optimizing the effects of cancer treatment, no less than genetic, immunological, physiological and other medical features that are often considered as necessary components of personalized medicine. Using evidence-based information, the book describes the different ways cancer touches upon a person’s life, including emotional, physical, and social changes, important decisions, and support structure. It also details the phases every cancer patient encounters along the way, from getting tested and waiting for the diagnosis, to treatments, survival, and confronting one’s mortality.

Psycho-oncology for the Clinician will serve to contribute to the further scientific development of psycho-oncology, expand its use as a treatment modality, strengthen its status as an essential component of cancer care, and promote the acceptance of psycho-oncology as the new evidence-based constituent of personalized medicine in oncology.

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Molecular Diagnostics in Cancer Patients

 Oncology  Comments Off on Molecular Diagnostics in Cancer Patients
Apr 232019
 


This book aims to bring together a broad variety of examples of the role of pharmacogenomics in current drug development, uncovering dynamic concentration-dependent drug responses on biological systems to understand pharmacodynamics responses in human cancer where genetic lesions serve as tumor markers and provide a basis for cancer diagnosis.

The book describes methods and protocols applied in molecular diagnostics. It offers pathologists and researchers providing molecular diagnostic services an array of the most recent and readily accessible reference to compare methods and techniques.

Highlights include the molecular diagnosis of genetic aberrations by quantitative polymerase reaction (qPCR), sequence-specific oligonucleotide arrays, next-generation sequencing (NGS), CGH arrays-and methodologies directed at the detection of epigenetic events, high-throughput nucleic acid and protein arrays, direct sequencing and FISH-based methodologies, currently used in the diagnosis of solid tumors. The book also includes an innovative line of treatment in relation to the molecular prognosis, diagnosis and pharmacogenomics in the actual practice of clinical findings at molecular levels. The book covers the applications of numerous genetic testing methodologies; in approximately the chronological order of discovery and high-throughput diagnosis using advanced genomic approaches to identify such genes, in the search for novel drug targets and/or key determinants of drug reactions. It also promotes a wider understanding of molecular diagnostics among physicians, medical students, and scientists in academics, industry and corporate world.

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Immune-based Cancer Treatment: The T Iymphocyte Response

 Immunology, Oncology  Comments Off on Immune-based Cancer Treatment: The T Iymphocyte Response
Apr 192019
 


The culmination of 30 years of research and experience in T-cell-based cancer, this book highlights and evaluates new treatments that harness the power of the T cell to attack and kill all cancer cells in our bodies.

It describes how the T cell immune system can be manipulated and redirected to kill resistant cancer cells by understanding and influencing the interaction of many different immune cells in the body. Citing current experimental trials, it examines the role and pathology of T-cells and suggests additional experimental approaches to the problem.

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