Resistance to Anti-Cancer Therapeutics Targeting Receptor Tyrosine Kinases and Downstream Pathways

 Oncology  Comments Off on Resistance to Anti-Cancer Therapeutics Targeting Receptor Tyrosine Kinases and Downstream Pathways
Mar 302018
 

This volume comprehensively covers the multiplicity and diversity of mechanisms underlying patient resistance to currently approved anti-cancer drugs, including tyrosine kinase inhibitors and monoclonal antibodies, blockers of growth factor receptors and their downstream pathways, which play essential functions in cancer progression. Each chapter will cover a specific group of targets and the cognate drugs, along with molecular modes of innate and evolving resistance.

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PET/CT in Oesophageal and Gastric Cancer

 Oncology  Comments Off on PET/CT in Oesophageal and Gastric Cancer
Mar 292018
 

Explains the scientific principles, radiotracers, clinical applications, imaging features, pitfalls, and limitations of PET/CT in imaging of gynecological cancers
Describes pathology and management, and the use of conventional radiological imaging
Aims to develop best practice consensus regarding patient selection, protocols, and techniques

This book is a pocket guide to the science and practice of PET/CT imaging of esophageal and gastric malignancies. The scientific principles of PET/CT, the radiopharmaceuticals used in this context, the role of PET/CT, the characteristic PET/CT findings, and limitations and pitfalls are all clearly described. In addition, information is provided on epidemiology, clinical presentation, diagnosis, staging, pathology, management, and radiological imaging. The book is published within the Springer series Clinicians’ Guides to Hybrid Imaging, which is aimed at referring clinicians, nuclear medicine/radiology physicians, radiographers/technologists, and nurses who routinely work in nuclear medicine and participate in multidisciplinary meetings. Compiled under the auspices of the British Nuclear Medicine Society, the series is the joint work of many colleagues and professionals worldwide who share a common vision and purpose in promoting and supporting nuclear medicine as an important imaging specialty for the diagnosis and management of oncological and non-oncological conditions.

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Next Generation Sequencing in Cancer Research, Volume 2: From Basepairs to Bedsides

 Oncology  Comments Off on Next Generation Sequencing in Cancer Research, Volume 2: From Basepairs to Bedsides
Mar 282018
 

Next Generation Sequencing in Cancer Research, Volume 2: From Basepairs to Bedsides, the second in the series “Next Generation Sequencing Technology in Cancer Research―From Basepairs to Bedsides,” is designed to fill the gap between cancer genome research and clinical management of the individual cancer patient. The volume presents the principles of next generation sequencing (NGS) technologies and massively parallel DNA sequencing and their application of the whole genome sequences (WGS), whole exome-seq (WES), RNA-seq, miRNA-seq, and ChIP-seq in cancer research programs and to apply the newly discovered driver genetic alterations for prevention, early diagnosis and genome-oriented precision cancer treatment.

Next Generation Sequencing in Cancer Research, Volume 2: From Basepairs to Bedsides brings together the implementation of a wide range of NGS technologies, including single-cell sequencing, in the clinical setting: discovery and validation of cancer biomarkers; standardization of NGS data production; NGS data reporting systems for clinicians; novel anti-cancer therapies development from NGS data; conducting of clinical trials of newly investigated cancer drugs. It provides compelling evidence to signal a new future for health care and a new standard for cancer care.

 

 

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Managing Cancer during Pregnancy

 Ob/Gynae, Oncology  Comments Off on Managing Cancer during Pregnancy
Mar 282018
 

Provides hands-on information how to manage pregnant cancer patients in clinical practice
Written by experts in the field from a multidisciplinary perspective
Unique resource citing key literature on the topic

This book provides hands-on information on how to manage pregnant cancer patients in clinical practice. In this context a multidisciplinary perspective is essential, and contributions are accordingly presented from experts in surgical management, medical oncology, radiotherapy, pharmacokinetics, obstetric care, psychological care, neonatal and pediatric care. In addition a series of chapters focused on management in particular disease settings are presented, including breast cancer, melanoma, cervical cancer, ovarian tumors, lymphoma, leukemia, and thoracic cancers.

The book reflects the major progress that has been achieved in the care of pregnant cancer patients in the recent years as important data have become available on patient management, and fetal safety in addition to valuable preclinical research on the impact of pregnancy on pharmacokinetics of anti-cancer agents. Edited and authored by worldwide leaders in the field, it will serve as a valuable resource not only for oncologists but also for obstetricians, gynecologists, neonatologists, and pediatricians caring for pregnant cancer patients and their newborns.

 

 

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Hepatobiliary and Pancreatic Cancer

 Oncology  Comments Off on Hepatobiliary and Pancreatic Cancer
Mar 272018
 

This book describes the pathways of dissemination of primary liver, biliary, and pancreatic neoplasms and proposes a practical and clinically driven approach to their imaging. The typical dissemination pathways for hepatocellular carcinoma, cholangiocarcinoma, exocrine pancreatic carcinoma, and neuroendocrine pancreatic tumors are systematically reviewed, and more unusual pathways are also documented.
The content is presented in an extremely schematic way, with numerous high-quality graphical illustrations and multimodality images (US, CT, MRI, and PET) that are accompanied by clear explanatory text. The clinical significance of findings and potential therapeutic options are explained whenever appropriate. In addition, relevant background information is provided on the role of morphopathological drivers of cancer spread and anatomy.

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Tumors and Tumor-Like Lesions of Bone: For Surgical Pathologists, Orthopedic Surgeons and Radiologists

 Oncology, Orthopedics, Surgery  Comments Off on Tumors and Tumor-Like Lesions of Bone: For Surgical Pathologists, Orthopedic Surgeons and Radiologists
Mar 272018
 

This book provides essential, internationally applicable information in the area of orthopedic pathology with emphasis on practical diagnostic aspects, including many illustrations: roentgenograms, CT-scans, MRI, scintigraphies, as well as pictures of gross surgical specimens and microphotographs, immunohistochemical reactions and genomics. Information on histopathological and molecular diagnosis, and basic therapeutic guidelines are provided.

This book offers generous coverage of epidemiology, clinical features, radiology, pathology, differential diagnosis and treatment, not only for common lesions, but also those less frequently encountered. Clues in the images and histopathology needed to arrive at a sharp differential diagnosis are discussed. The content is arranged based on the World Health Organization’s Consensus Classification, with the addition of other lesions not included therein.

Tumors and Tumor-Like Lesions of Bone is aimed at general and specialised surgical pathologists, radiologists, orthopedic surgeons, and oncologists, in practice and in training.

 

 

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Atlas of Operative Procedures in Surgical Oncology

 Medical Atlas, Oncology, Surgery  Comments Off on Atlas of Operative Procedures in Surgical Oncology
Mar 272018
 

This volume is the product of the author’s long experience with melanomas and sarcomas and to a lesser but significant degree with upper gastrointestinal cancers, colorectal and breast cancers. As such, it offers a “hands-on” practical guide to approaching complex soft-tissue tumors and for performing more extensive tumor resections based on over 40 years of surgical experience. It provides important details about the positioning of patients, incision types, and exposure which can be of paramount importance in the resection of certain tumors. The book contains important general surgical principles for approaching tumors in a variety of locations but also offers the detail necessary for the safe and oncologically sound resection of these malignancies. Moreover, this operative atlas contains specific information for procedures which are not as commonly encountered in surgical training, but can be invaluable in the management of patients with locally aggressive tumors, such as hemipelvectomy and its variants, sacral resections, and forequarter amputation.

Through the use of multiple detailed illustrations, Atlas of Operative Procedures in Surgical Oncology serves as a valuable resource to the general surgeon or surgical oncologist in the operative management of patients with cancer in the abdomen, retroperitoneum, pelvis or extremities.

 

 

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Multidisciplinary Treatment of Colorectal Cancer: Staging – Treatment – Pathology – Palliation

 Oncology  Comments Off on Multidisciplinary Treatment of Colorectal Cancer: Staging – Treatment – Pathology – Palliation
Mar 262018
 

This book is intended as the equivalent of the Swiss Army knife for all members of colorectal cancer (CRC) multidisciplinary teams and those training in the fields of CRC management. It describes how to organize the team and explains the basic principles within the different disciplines involved in the treatment and care of CRC patients.

Important, up-to-date knowledge is provided on visualization techniques, surgery, oncological treatment, palliation, and pathology, with special focus on controversies and aspects of interest to all team members. Care has been taken to ensure that each specialty-specific chapter will be approachable for team members from other specialties or professions, thereby facilitating an effective interdisciplinary approach to teamwork. The authors include leading European doctors and scientists who have influenced the development of the multidisciplinary team concept as well as other aspects of high-quality, individualized treatment of CRC patients.

 

 

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Rare Tumors and Tumor-like Conditions in Urological Pathology

 Oncology  Comments Off on Rare Tumors and Tumor-like Conditions in Urological Pathology
Mar 262018
 

This book is a comprehensive guide to rare tumors and tumor-like conditions of the urinary system and male genital organs. It comprises five chapters, devoted to the kidney, bladder, prostate, testes, and penis. Each chapter begins with a brief overview of “common” tumors and tumor-like conditions and with a section on the classification of both common and rare entities. The main clinical, pathological, immunohistochemical, and molecular findings for each rare tumor or tumor-like condition are then described and discussed. Significant characteristics are also documented by representative high-quality illustrations, with emphasis on those aspects of most relevance to differential diagnosis. In addition, prognostic features are fully covered. Urological Pathology: Rare Tumors and Tumor-Like Conditions will be ideal source of core information and practical guidance for residents, fellows, pathologists, urologists, and oncologists.

 

 

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Surgical Techniques for Kidney Cancer

 Oncology  Comments Off on Surgical Techniques for Kidney Cancer
Mar 252018
 

​Surgical Techniques for Kidney Cancer provides a comprehensive review and detailed description of surgical techniques for kidney and adrenal cancer. Through a step by step approach various surgical techniques are covered including radical nephrectomy, partial nephrectomy, and thermal ablation for renal cortical tumors. Each step by step approach is followed by the latest data on outcomes.
Furthermore, limitations as well as tips and tricks are detailed in addition to management of common complications. Kidney Surgery for Urologists will be a valuable resource for Urologists, Urological Surgeons, Fellows in Urologic Oncology and Minimally Invasive/Robotic Surgery as well as upper level residents training in Urology.​

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