Pharmacology of Endogenous Neurotoxins: A Handbook

 Neurology/Neurosurgery, Pharmacology  Comments Off on Pharmacology of Endogenous Neurotoxins: A Handbook
Feb 112019
 

It is a great pleasure to write the foreword to this important volume for several reasons. First: As far as we know, already primitive societies had to cope with environmental toxins of many kinds and set up regulations to limit their effects on food and drug use. Modem science, synthesizing tens of millions of new compounds has incredibly magnified this challenge. Today, xenobiotic metabolism has become a crucial task for humans and many other species alike. Second: When reading this book, one is impressed by the extraordinary speed at which neurotoxicology has advanced. Obviously, processing (and endogenous formation) oftox­ ins has become an extremely relevant topic. When I had the chance, almost three decades ago, to work in chemical pharmacology with Bernard B. Brodie at NIH, the drug metabo­ lizing system of the liver had just been recognized and characterized. We had just started to work on the biogenic amines, newly discovered cyclic nucleotides in rat brain, human cere­ brospinal fluid, and on the effects of toxic drugs like amphetamines. Today, biochemical neuropharmacology is a mature field of neuroscience.
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Erythropoietin: Blood, Brain and Beyond

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Feb 082019
 

The use of Epo in medical practice is increasing constantly. It has revolutionized how we think of blood transfusion in medicine and surgery. Moreover, it has become widely known to scientists, physicians, biotech and pharmaceutical executives and the general public. Additionally, the past ten years have seen important advances in our knowledge and understanding of its action both within and outside of the hematopoietic system. Until now, there has been no single source that contains up-to-date information on Epo addressing the array of subjects that this book presents. The book covers all aspects from developmental biology to specific topics such as medical applications of recombinant Epo, receptor biology, mechanisms of Epo activity, structure/activity relationship, disease states and important actions on non-hematopoietic organs and tissues, including the central nervous system, heart, gastrointestinal tract, reproductive organs and endothelium.Content: Chapter 1 Introduction and History (pages 1–8): Chapter 2 Developmental Biology of Erythropoiesis and Erythropoietin Production (pages 9–23): Chapter 3 Regulation of the Erythropoietin Gene: A Paradigm for Hypoxia?dependent Genes (pages 25–41): Chapter 4 Physiology and Metabolism of Erythropoietin (pages 43–53): Chapter 5 Biochemistry and Protein Structure (pages 55–71): Chapter 6 Receptor Biology and Signal Transduction (pages 73–100): Chapter 7 Clinical Disorders of Erythropoietin and its Receptor (pages 101–115): Chapter 8 Recombinant Erythropoietin and the Treatment of Anemia (pages 117–154): Chapter 9 Functions of Erythropoietin Outside of Hematopoiesis (pages 155–182): Chapter 10 Erythropoietin and Sport (pages 183–197): Chapter 11 The Future of Erythropoietin (pages 199–215):
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Schizophrenia, Second Edition

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Feb 022019
 

Schizophrenia is one of the most complex and puzzling diseases to affect mankind. It is the most common of the severe mental illnesses (psychoses) with an estimated prevalence of 0.5 – 1% in the general population and accounts for a very large portion of the day to day workload of the average psychiatrist. 50% of long-term psychiatric patients in mental hospitals are schizophrenic. There is a great deal of controversy about the causes, diagnosis and treatment of schizophrenia with the consequence that a huge amount of research is carried out in the field by psychiatrists, psychologists, neuroscientists and pharmacologists. For the average practising psychiatrist seeing schizophrenics on a regular basis, making sense of the vast body of information on the subject and filtering out what is of clinical relevance can be very difficult. There is a constant stream of new drugs emerging and the newer generation of drugs (the so-called atypicals) is very effective, but often expensive. The Editors (one American and one British) are both highly respected clinical psychiatrists who are probably the leading experts on schizophrenia from their respective countries and jointly have published almost 150 papers on the subject. They have brought together a strong group of contributors from the USA, UK and Europe to produce what will be an essential reference for the trainee and practising psychiatrist. The book consists of four sections; descriptive aspects, causative aspects, physical treatments and psychological/behavioural/social treatments. There will be discussion of the theoretical controversies over symptomatology, classification and aetiology, the relationship of schizophrenia to the other psychoses, the significance of positive and negative symptoms and pre-morbid personality. There will be chapters on organic models of schiziophrenia, neurodevelopmental, genetic and structural studies and the role of high-expressed emotion. The final section will cover social and environmental treatment, the role of the families of schizophrenics and the psychoanalytical therapies. There is a new chapter on the patient’s perspective written by a former patient. Content: Chapter 1 Concepts and Classification of Schizophrenia (pages 1–14): J.K. Wing and N. AgrawalChapter 2 Descriptive Psychopathology (pages 15–24): J. CuttingChapter 3 The Symptoms of Schizophrenia (pages 25–33): R.L.M. Fuller, S.K. Schultz and N.C. AndreasenChapter 4 Child and Adolescent Onset Schizophrenia (pages 34–53): C. HollisChapter 5 Atypical Psychotic Disorders (pages 54–67): C.B. Pull, J.M. Cloos and N.V. MurthyChapter 6 Late?Onset Schizophrenia (pages 68–79): R. Howard and D.V. JesteChapter 7 The Schizophrenia Spectrum Personality Disorders (pages 80–100): K. O’Flynn, J. Gruzelier, A. Bergman and L.J. SieverChapter 8 Course and Outcome of Schizophrenia (pages 101–141): H. Hafner and W. an der HeidenChapter 9 Depression and Schizophrenia (pages 142–167): S.G. Siris and C. BenchChapter 10 Neurocognitive Deficits in Schizophrenia (pages 168–184): T.E. Goldberg, A. David and J.M. GoldChapter 11 The Secondary Schizophrenias (pages 185–202): T.M. Hyde and S.W. LewisChapter 12 The Epidemiological Horizon (pages 203–231): A. JablenskyChapter 13 Risk Factors for Schizophrenia: From Conception to Birth (pages 232–250): J.J. McGrath and R. M. MurrayChapter 14 Genetics and Schizophrenia (pages 251–276): B. Riley, P.J. Asherson and P. McGuffinChapter 15 Intermediate Phenotypes in Genetic Studies of Schizophrenia (pages 277–297): M.F. Egan, M. Leboyer and D.R. WeinbergerChapter 16 Electrophysiology of Schizophrenia (pages 298–309): D.F. Salisbury, S. Krljes and R.W. McCarleyChapter 17 Neuropathology of Schizophrenia (pages 310–325): P.J. Harrison and D.A. LewisChapter 18 Schizophrenia as a Neurodevelopmental Disorder (pages 326–348): D.R. Weinberger and S. MarencoChapter 19 The Neurochemistry of Schizophrenia (pages 349–364): B. Moghaddam and J.H. KrystalChapter 20 Dopamine Transmission in the Schizophrenic Brain (pages 365–387): M. LaruelleChapter 21 Animal Models of Schizophrenia (pages 388–402): B.K. Lipska and D.R. WeinbergerChapter 22 Brain Imaging in Schizophrenia (pages 403–417): P. Liddle and C. PantelisChapter 23 The Neuroscience and Clinical Psychopharmacology of First? and Second?Generation Antipsychotic Drugs (pages 419–441): J.L. Waddington, S. Kapur and G.J. RemingtonChapter 24 Acute Pharmacological Treatment of Schizophrenia (pages 442–473): S. Miyamoto, T.S. Stroup, G.E. Duncan, A. Aoba and J.A. LiebermanChapter 25 Maintenance Treatment (pages 474–488): S.R. Marder and D.A. WirshingChapter 26 Treatment?Resistant Schizophrenia (pages 489–516): T.R.E. Barnes, P. Buckley and S.C. SchulzChapter 27 Electroconvulsive Therapy and Schizophrenia (pages 517–551): H.A. SackeimChapter 28 Neuroleptic?Induced Acute Extrapyramidal Syndromes and Tardive Dyskinesia (pages 552–572): V.S. Mattay and D.E. CaseyChapter 29 Non?Neurological Side?Effects of Antipsychotic Drugs (pages 573–588): D.C. Goff and R.I. ShaderChapter 30 Schizophrenia and Violence (pages 589–612): P.J. Taylor and S.E. EstroffChapter 31 Schizophrenia and Psychosocial Stresses (pages 613–636): P.E. Bebbington and E. KuipersChapter 32 Psychiatric Rehabilitation (pages 637–656): T.K.J. Craig, R.P. Liberman, M. Browne, M.J. Robertson and D. O’FlynnChapter 33 Psychological Treatments for Schizophrenia (pages 657–687): B.V. Martindale, K.T. Mueser, E. Kuipers, T. Sensky and L. GreenChapter 34 Mental Health Services (pages 688–700): M. Muijen, F. Holloway and H. GoldmanChapter 35 Psychosis and Recovery: Some Patients’ Perspectives (pages 701–712): Peter Chadwick, Robert Lundin, Grace Brown, Alison McPartlin, Claire Brookman and Janey AntoniouChapter 36 Economics of the Treatment of Schizophrenia (pages 713–723): S.M. Essock, L.K. Frisman and N.H. Covell
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Brain Facts: A Primer on the Brain and Nervous System

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Feb 022019
 

This book provides a glimpse of what is known about the nervous system, the disorders of the brain, and some of the exciting avenues of research that promise new therapies for many neurological diseases.

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Neurodegeneration : metallostasis and proteostasis

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Jan 312019
 

This book covers the latest developments in the understanding the pathogenesis of neurodegenerative diseases. Content: Chemical evolution, brain and metallomics; Chemistry and biology of proteostasis; Environmental factors affecting cellular proteostasis; Neurodegeneration and cell membranes; The role of Metals in the intracellular clearance of amyloids; Speciation, coordination sites and metal binding affinities of proteins related to neurodegeneration; Copper, Zinc and trophic factors in neurodegeneration; Metals as catalysts of ROS production in neurodegeneration; Metal hypothesis of Alzheimer disease; Copper supply and metal homeostasis in AD; The role of iron in neurodegeneration; Aluminium in neurodegenerative diseases; Zinc trafficking in the AD brain; The role of metal ions in the pathogenesis of Parkinson’s disease; Metals in ALS pathology; Metals and prion diseases
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The Doctor of Nursing Practice Essentials : A New Model for Advanced Practice Nursing, Third Edition

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Jan 302019
 


The newly revised Third Edition of The Doctor of Nursing Practice Essentials: A New Model for Advanced Practice Nursing is the first text of its kind and is modeled after the eight DNP Essentials as outlined by the American Association of Colleges of Nursing (AACN). Each section discusses the materials relevant to an element of the Essentials document and advises on the steps necessary to fulfill the requirements of the degree. The text is written for current DNP students as well as those considering the degree program. It also serves as a fantastic reference for professionals and those who have already completed a DNP program.

Key revisions for the new third edition will include:

• Updated Chapters
• Expansion and emphasis on quality analysis and models, including statistical analysis methods and models
• Incorporation of adult learning theory
• Additional emphasis on the role of the nursing professional
• The addition of information literacy in the chapter on the DNP project needs assessment section
• Addition of the Squire Guidelines as they apply to dissemination, and the expansion of the section on dissemination
• Addition of information literacy as it relates to the DNP scholarly project
• Expansion of inter and intra professional collaboration as it relates to the project
• Information on the scholarly project committee

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Brain-Body-Mind in the Nebulous Cartesian System: A Holistic Approach by Oscillations

 Neurology/Neurosurgery  Comments Off on Brain-Body-Mind in the Nebulous Cartesian System: A Holistic Approach by Oscillations
Jan 302019
 

Brain-Body-Mind in the Nebulous Cartesian System: A Holistic Approach by Oscillations is a research monograph, with didactical features, on the mechanisms of the mind, encompassing a wide spectrum of results and analyses. The book should appeal to scientists and graduate students in the fields of neuroscience, neurology, psychiatry, physiology, psychology, physics and philosophy. Its goals are the development of an empirical-analytical construct, denoted as “Reasonings to Approach the Mind”, and the comprehension of 20 principles for understanding the mind. This book amalgamates results from work on the brain, vegetative system, brains in the evolution of species, the maturing brain, dynamic memory, emotional processes, and cognitive impairment in neuro-psychiatric disorders (Alzheimer, Schizophrenia, Bipolar disorders). The findings are comparatively evaluated within the framework of brain oscillations and neurotransmitters. Further, a holistic approach links the brain to the cardiovascular system and overall myogenic coordination of the vegetative system. The results emphasize that EEG oscillations, ultraslow oscillations, and neurotransmitters are quasi-invariant building blocks in brain-body-mind function and also during the evolution of species: The temporal domain is where the importance of research on neural oscillators is indispensable. The core, holistic concept that emerges is that the brain, spinal cord, overall myogenic system, brain-body-oscillations, and neurotransmitters form a functional syncytium. Accordingly, the concept of “Syncytium Brain-Body-Mind” replaces the concept of “Mind”. About the Author: Erol Başar, currently Professor of Physiology and Biophysics at The Kultur University Istanbul, is a pioneer in the field of Brain Dynamics and Oscillations. He has published seven monographs, edited 10 books, and authored or co-authored 250 papers in neuroscience and cardiovascular research. Başar’s monograph, EEG-Brain Dynamics (1980) introduced the functional importance of brain oscillations and the quantum concept; it is considered a milestone in neuroscience literature. The author was educated in high-energy physics and in physiology at the Universities of Munich, Hamburg and Hanover. He taught physiology at the Medical University, Lübeck between 1980 and 2000. He was also involved in research and teaching in New York, San Diego, Ankara and Izmir. Başar’s route to multidisciplinary research was directly influenced, during the 1960s, by the advice of Werner Heisenberg and the renowned natural philosopher, Carl Friedrich von Weizsäcker. The Darwinian view discussed by Başar is the result of a longstanding collaboration with Theodore Holmes Bullock, in California.
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Neurology and Psychiatry: 1000 Questions to Help You Pass the Boards

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Jan 292019
 

This book is an excellent review for neurology residents and practicing neurologists studying for the American Board of Psychiatry and Neurology certification and recertification exams. The book has 1,000 multiple-choice questions that mimic the Boards, along with answers and explanations. The Neurology and Psychiatry sections consist of chapters on specific topics that are emphasized in the Board exams. Neurology High Yield Points, Psychiatry High Yield Points, and Psychiatry Factoids chapters list the most important points for quick review just prior to the exam.

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Developmental Neurobiology

 Neurology/Neurosurgery  Comments Off on Developmental Neurobiology
Jan 272019
 

Developmental Neurobiology tells the extraordinary process of neural development by showing how the scientific discoveries were made and how the hypotheses evolved over time. Each chapter explores the specific mechanisms of development while highlighting the key experiments and methods used to make those discoveries―including descriptions of, and experiments utilizing, both invertebrate and vertebrate animal models. This distinctive approach provides the essential facts while strengthening the reader’s appreciation of the scientific method. Discussions of neurodevelopmental disorders and therapeutic approaches to them will captivate those interested in the more clinical aspects of the field. With its clear illustrations and easy-to-follow writing style, Developmental Neurobiology presents an accessible approach to neural development for undergraduate students.

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Neurology, 4th edition

 Neurology/Neurosurgery  Comments Off on Neurology, 4th edition
Jan 272019
 

Aiming to present the basic knowledge required for the practice of neurology, this book has become a major textbook and reference work for students and trainees the world over. Yet the comprehensiveness of the information will also appeal to specialists in neurology and neurosurgery who need a rapid reference on less familiar clinical problems.

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