Clinical Neurology of the Older Adult

 Neurology/Neurosurgery  Comments Off on Clinical Neurology of the Older Adult
Sep 162019
 

Now in its Second Edition, this text is the most up-to-date reference on the evaluation and treatment of neurologic problems in older adults. The book is organized so that clinicians can quickly look up either a patient’s symptom(s) or a disease, and includes medication charts and diagnostic algorithms. Psychosocial issues such as driving and long-term care options are also addressed.
This edition has more information on EMG, evoked potentials, other clinical neurophysiologic procedures, brain imaging, PET scans for dementia screening, and functional imaging in patients with cognitive changes. Updated information on new antiparkinsonian agents and paraneoplastic syndromes is also included.

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Therapeutic Intranasal Delivery for Stroke and Neurological Disorders

 Neurology/Neurosurgery  Comments Off on Therapeutic Intranasal Delivery for Stroke and Neurological Disorders
Sep 112019
 

The blood-brain-barrier serves to encapsulate and protect the central nervous system, but it also presents a major barricade to therapeutic drug delivery. Poor penetration is the most common hurdle to translating a promising experimental therapy that uses invasive delivery methods to a clinically useful application. In the last 10 years, intranasal delivery of various therapeutic compounds including small chemicals, large proteins, and even stem cells has proven to be very effective in bypassing the blood-brain-barrier and has led to some important advances in translational research for stroke and other neurological diseases. The proposed book will bring together reports from various labs around the world who have had successes in pre-clinical studies of intranasal therapies for various diseases including adult and perinatal stroke, Alzheimer`s, Parkinson`s, and others.

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Neuroproteomics, Second Edition

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Sep 112019
 

This second edition volume expands on the previous edition with updates on the latest techniques used in the field of proteomics. Tissue and cellular proteins are now being analyzed at near proteome-wide levels and mass spectrometers are achieving higher sensitivity and speed, resolution, and accuracy.
The chapters in this book cover various new methods used in proteomic workflows such as laser microdissection for spatial proteomics of post-mortem brain tissue, sample preparation in single vessel with FASP and SP3 protocols, the crosslinking mass spectrometry, TMT-MS3 based proteomic with synchronous precursor selection, mass spectrometric data dependent acquisition (DDA) and data independent acquisition (DIA, SWATH) methods, 2D-DIGE, and MALDI Imaging Mass Spectrometry. In Neuromethods series style, chapters include the kind of detail and key advice from the specialists needed to get successful results in your laboratory.

Cutting-edge and comprehensive, Neuroproteomics, Second Edition is a valuable guide that help researchers obtain the finest results from current proteomics platforms.

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Neuroscience of Psychological Therapies

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Sep 092019
 

The Neuroscience of Psychological Therapies summarizes knowledge of brain function and brain behavior relationships within the context of psychotherapy implementation. It describes how specific locations in the brain carry out specific activities, how the different activities are combined to yield normal and pathological behavior, and how knowledge of brain activities can guide psychological assessment and intervention. Specific topics include the influence of neural networks on discovery and change, the therapist’s neuroscience, communicating with patients using the brain as reference, and using neuroscience concepts to compare and integrate traditional schools of psychotherapy. Applying a neuroscience framework to conceptualization and treatment of depression is offered as an example, and specific issues associated with trauma and false memories are discussed. The book is aimed at anyone working within a psychotherapy framework and who wishes to discover more about brain function and brain/behavior relationships.
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A Hole in the Head: More Tales in the History of Neuroscience

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Sep 092019
 

Essays on great figures and important issues, advances and blind alleys–from trepanation to the discovery of grandmother cells–in the history of brain sciences.
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Biomechanics of the Brain

 Neurology/Neurosurgery  Comments Off on Biomechanics of the Brain
Sep 082019
 

The mechanical properties of living tissues continue to be the major topic of biomechanical investigations. Most researchers have investigated load-bearing tissues, such as bones, ligaments, muscles and other components of the musculoskeletal system, blood vessels (and blood), lungs, skin and hair. Until recently, very soft tissues of organs whose role has little or nothing to do with transmitting mechanical loads have been outside the scope of the mainstream biomechanical research.
These “neglected” organs include the liver, kidneys, prostate and other abdominal organs, and especially the brain. Increased interest in the biomechanics of soft tissues, particularly the brain, as evidenced by the increased number of publications in this area, has motivated this effort to summarize recent developments. Biomechanics of the Brain will take the reader to the forefront of current research.

Covering topics from brain anatomy and imaging to sophisticated methods of modeling brain injury and neurosurgery, to the cutting edge methods in analyzing cerebrospinal fluid and blood flow, this book is the first comprehensive reference in the field of biomechanics of the brain. Experienced biomechanics researchers as well as those new to the field will find parts of this book useful.

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Re-Visioning Psychiatry: Cultural Phenomenology, Critical Neuroscience, and Global Mental Health

 Neurology/Neurosurgery, Psychiatry  Comments Off on Re-Visioning Psychiatry: Cultural Phenomenology, Critical Neuroscience, and Global Mental Health
Sep 082019
 

Revisioning Psychiatry explores new theories and models from cultural psychiatry and psychology, philosophy, neuroscience, and anthropology that clarify how mental health problems emerge in specific contexts and points toward future integration of these perspectives. Taken together, the contributions point to the need for fundamental shifts in psychiatric theory and practice: • Restoring phenomenology to its rightful place in research and practice; • Advancing the social and cultural neuroscience of brain-person-environment systems over time and across social contexts; • Understanding how self-awareness, interpersonal interactions, and larger social processes give rise to vicious circles that constitute mental health problems; • Locating efforts to help and heal within the local and global social, economic, and political contexts that influence how we frame problems and imagine solutions. In advancing ecosystemic models of mental disorders, contributors challenge reductionistic models and culture-bound perspectives and highlight possibilities for a more transdisciplinary, integrated approach to research, mental health policy, and clinical practice.

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The brain-shaped mind: what the brain can tell us about the mind

 Neurology/Neurosurgery  Comments Off on The brain-shaped mind: what the brain can tell us about the mind
Sep 062019
 

In the same way atomic structures explain the physical properties of an object, neuroscientists are now learning about the human mind by examining how the neurons in the brain are connected to one another and their surrounding environments. Will brain scientists ever be capable of reading minds? Why are certain things harder to remember than others? The Brain-Shaped Mind addresses these and other questions to provide a clear account of how the structure of the brain influences the workings of the mind. Naomi Goldblum is a lecturer in psychology at Bar-Ilan University in Ramat Gan, Israel. She has studied neuropsychology with a particular emphasis on cognitive psychology.
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Sidman’s Neuroanatomy: A Programmed Learning Tool

 Anatomy, Neurology/Neurosurgery  Comments Off on Sidman’s Neuroanatomy: A Programmed Learning Tool
Sep 062019
 

Sidman’s Neuroanatomy: A Programmed Learning Tool, Second Edition is an innovative combined neuroanatomy text and review that covers the structure of the entire nervous system. Its unique programmed learning approach allows students to easily retain information and learn at their own pace by slowly building on previously learned concepts throughout each chapter.
The programmed learning approach introduces new information and reviews previously learned information by presenting it in new contexts, calling attention to important details and illustrating steps in a reasoning process. This learning method adds to and reinforces the student’s understanding and retention of neuroanatomical knowledge.
This edition features updated illustrations, a systems-based organization, and new concepts on the cerebellum, extrapyramidal pathways, special sensory pathways, diencephalon, ventricular system, and vascular anatomy. Terminology has been updated to conform to Terminologia Anatomica .

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Neuronal mechanisms of memory formation

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Sep 042019
 

Long-term potentiation (LTP) is the most dominant model for neuronal changes that might encode memory. LTP is an elegant concept that meets many criteria set up by theoreticians long before the model’s discovery, and also fits the anatomical data of learning-dependent synapse changes. Since the discovery of LTP, the question has remained regarding how closely LTP produced in vitro by artificial stimulation of neurons actually models putative learning-induced synaptic changes. A number of recent investigations have tried to correlate synaptic changes observed after learning with changes produced by artificial stimulation of neurons. Some of these studies have failed to find a correlation between the two forms of synaptic plasticity, signalling a need to discuss the concept of LTP and possible alternate processes that could fit the available data. This book presents a selection of ideas that range from supporters of the LTP theory to different novel concepts that have yet to be investigated. This volume will prepare the ground for research in this area in the new millennium.
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