Nicotinic Acetylcholine Receptor Signaling in Neuroprotection

 Neurology/Neurosurgery  Comments Off on Nicotinic Acetylcholine Receptor Signaling in Neuroprotection
Apr 112018
 

This book presents the roles and mechanisms of signal transduction triggered by nicotinic acetylcholine receptors (nAChRs) stimulation in neuroprotection against toxic effects of risk factors of neurodegenerative diseases. Accumulating evidence suggests that nAChRs in the CNS play important roles not only in excitatory neurotransmission but also in neuronal survival and related functions. Neuroprotection mediated by nAChRs in neurodegenerative diseases such as Alzheimer’s disease is the major topic of this book. In response to rapidly evolving areas in clinical and laboratory neuropharmacology and neurochemistry, this volume provides in-depth coverage of neuroprotection in basic research and future developments in the clinical application of effective neuroprotective strategies in neurodegenerative diseases. This work appeals to both basic and clinical researchers in several fields, such as neuroscience, neurology, and pharmacology.

GET IT FREE HERE

http://nitroflare.com/view/86A74A3E7596CEB/9811084874.epub

http://nitroflare.com/view/F9B07463FFB9626/9811084874.pdf

Share Button

Intraoperative Ultrasound (IOUS) in Neurosurgery: From Standard B-mode to Elastosonography

 Neurology/Neurosurgery, Radiology  Comments Off on Intraoperative Ultrasound (IOUS) in Neurosurgery: From Standard B-mode to Elastosonography
Apr 102018
 

This book is intended as a practical manual on the use of intraoperative ultrasound (IOUS) as a tool for imaging guidance during cranial and spinal neurosurgical procedures. Full account is taken of the emergence of novel clinical applications and recent technical advances, with extensive coverage of the impact of developments such as improved probe technology, fusion imaging and virtual navigation, 3D ultrasound imaging, contrast-enhanced ultrasound, and elastosonography. Basic principles of ultrasound are elucidated in order to assist in the optimal use of IOUS and clear guidance is provided on the interpretation of imaging findings in various pathologies. Informative comparisons are also made of the use of techniques such as fusion imaging and contrast-enhanced ultrasound in general radiology and neurosurgery. The aim of the authors is to enhance the general knowledge regarding intra-operative ultrasound brain imaging, standardizing its use and exploring new techniques, leading in some way toward compensating the lack of specific training in the application of ultrasound among the neurosurgical community. IOUS is a sensitive tool that can improve surgical precision and help to reduce morbidity.
GET IT FREE HERE
Share Button

OCT in Central Nervous System Diseases: The Eye as a Window to the Brain

 Neurology/Neurosurgery  Comments Off on OCT in Central Nervous System Diseases: The Eye as a Window to the Brain
Apr 092018
 

This book reviews recent important advances in the use of optical coherence tomography (OCT) in order to analyze neurodegeneration within the retina through the quantification of axonal loss. Detailed information is provided on the role of OCT as a promising tool for the evaluation of disease progression in numerous neurodegenerative disorders and as a biological marker of neuroaxonal injury. The disorders considered include multiple sclerosis, Parkinson’s disease, Alzheimer’s disease, intracranial hypertension, Friedreich’s ataxia, schizophrenia, hereditary optic neuropathies, glaucoma, and amblyopia. Individual chapters are also devoted to OCT technique, new OCT technology in neuro-ophthalmology, OCT and pharmacological treatment, and the use of OCT in animal models. By documenting the ability of OCT to provide key information on CNS diseases, this book illustrates convincingly that the eye is indeed the “window to the brain”.
GET IT FREE HERE
Share Button

Alzheimer’s Turning Point: A Vascular Approach to Clinical Prevention

 Neurology/Neurosurgery  Comments Off on Alzheimer’s Turning Point: A Vascular Approach to Clinical Prevention
Apr 092018
 

This compelling text provides an overview of the available technology for early detection and therapeutic management of vascular risk factors to Alzheimer’s before severe cognitive impairment symptoms appear. Chapters bring the reader from the trackless clinical research that has characterized Alzheimer’s progress for the last 20 years, to a nexus of new ideas and concepts that can change our outlook of this dementia. In-depth examinations of various hypotheses, preventive measures, current and prospective treatments are openly and clearly explored. The author discusses in depth his proposal of the vascular hypothesis of Alzheimer’s disease which has become a mother-lode for basic and clinical studies and a key approach to the prevention of this dementia.Alzheimer’s Turning Point offers professionals, students and those looking to learn more about this disorder a fresh clinical perspective of this devastating disease.
GET IT FREE HERE
Share Button

Psychoneuroimmunology: Systems Biology Approaches to Mind-Body Medicine

 Immunology, Neurology/Neurosurgery, Psychiatry  Comments Off on Psychoneuroimmunology: Systems Biology Approaches to Mind-Body Medicine
Apr 072018
 

This book provides a comprehensive overview of the cutting-edge discoveries and the systems approaches related to the multi-disciplinary field of psychoneuroimmunology (PNI), which may provide the scientific basis for mind-body relationships, and aid in the development of personalized medicine. Specifically, the book focuses on the systems biology studies of complex mechanisms, such as stress and inflammation. There is strong evidence supporting the close relationship between stress, inflammation, and disorders including obesity, cardiovascular disease, diabetes, skin diseases, and sleep disorders. As inflammation is a critical connection among different diseases, further elucidating this connection may contribute to the findings of systemic therapeutic targets. Translational medicine is also addressed, by applying PNI approaches in clinical practice. A major challenge in current bioscience is the translation of basic scientific discoveries into better clinical outcomes. With the understanding of the translational implications of PNI, integrative interventions can be applied to modulate stress responses and to promote healthier behaviors. As an important feature of this book, a broad overview of the PNI-associated integrative interventions is provided. These interventions include nutritional supplements, meditation, and other mind-body strategies. From basic concepts to systems methodologies, from theoretical sources to clinical applications, Psychoneuroimmunology contributes to the understanding and development of PNI toward the establishment of personalized and mind-body medicine.
GET IT FREE HERE
Share Button

Perioperative Considerations and Positioning for Neurosurgical Procedures: A Clinical Guide

 Neurology/Neurosurgery  Comments Off on Perioperative Considerations and Positioning for Neurosurgical Procedures: A Clinical Guide
Apr 042018
 


There are relationships that exist between neuroanesthesia, neurosurgical procedures, individual patient pathology and the positioning of a patient for said procedure. A comprehensive examination of these relationships, their association with patient morbidity/mortality and how to approach these issues in an evidence-based manner has yet to become available. Positioning related injuries have been documented as major contributors to neurosurgical/neuroanesthesiology liability.
This text examines these relationships. It provides considerations necessary to the correct positioning of a patient for a neurosurgical procedure for each individual patient and their individual pathology. In other words, this text will demonstrate how to construct the necessary surgical posture for the indicated neurosurgical procedure given the individual constraints of the patient within the environment of anesthesia and conforming to existing evidence-based practice guidelines. Sections will address physiological changes inherent in positioning in relation to anesthesia for neurosurgical procedures, assessment of patient for planned procedure, as well as considerations for managing problems associated with these relationships. Additional sections will examine the relationship between neurosurgical positioning and medical malpractice and the biomechanical science between positioning devices and neurosurgical procedures.
Neurosurgery and its patient population are in a constant state of change. Providing the necessary considerations for the neurosurgical procedure planned under the anesthesia conditions planned in the position planned, often in the absence of multicase study literary support, without incurring additional morbidity is the goal of this text.

GET IT FREE HERE

http://nitroflare.com/view/0105DD21151B729/3319726781.epub

http://nitroflare.com/view/0EA729F95BB4BC8/3319726781.pdf

Share Button

Neurodegenerative Diseases: Neurobiology, Pathogenesis and Therapeutics

 Neurology/Neurosurgery  Comments Off on Neurodegenerative Diseases: Neurobiology, Pathogenesis and Therapeutics
Mar 312018
 

Neurodegenerative diseases are major contributors to disability and disease, with Alzheimer’s and Parkinson’s diseases the most prevalent. This major reference reviews the rapidly advancing knowledge of pathogenesis and treatment of neurodegenerative diseases in the context of a comprehensive survey of each disease and its clinical features. The editors and contributors are among the leading experts in the field internationally. Covering basic science, diagnostic tools and therapeutic approaches, the book focuses on all aspects of neurodegenerative disease, including the normal aging process. The dementias, prion diseases, Parkinson’s disease and atypical parkinsonisms, neurodegenerative ataxias, motor neuron diseases, degenerative diseases with chorea, iron and copper disorders, and mitochondrial diseases, are all methodically presented and discussed, with extensive illustrations. In each case the underlying genetics, neuropathological and clinical issues are fully reviewed, making this the most complete as well as the most authoritative reference available to clinicians and neuroscientists.
GET IT FREE HERE
Share Button

The Genius Within: Smart Pills, Brain Hacks and Adventures in Intelligence

 Neurology/Neurosurgery  Comments Off on The Genius Within: Smart Pills, Brain Hacks and Adventures in Intelligence
Mar 312018
 

What if you have more intelligence than you realize? What if there is a genius inside you, just waiting to be released? And what if the route to better brain power is not hard work or thousands of hours of practice but to simply swallow a pill?

In The Genius Within, bestselling author David Adam explores the ground-breaking neuroscience of cognitive enhancement that is changing the way the brain and the mind works – to make it better, sharper, more focused and, yes, more intelligent. Sharing his own experiments with revolutionary smart drugs and electrical brain stimulation, he delves into the sinister history of intelligence tests, meets savants and brain hackers and reveals how he boosted his own IQ to cheat his way into Mensa.

Going to the heart of how we consider, measure and judge mental ability, The Genius Within asks difficult questions about the science that could rank and define us, and inevitably shape our future.

GET IT FREE HERE

http://nitroflare.com/view/DF6C3C370D7931F/The_Genius_Within_-_David_Adam.epub

Share Button

Brain Damage: Bridging Between Basic Research and Clinics

 Neurology/Neurosurgery  Comments Off on Brain Damage: Bridging Between Basic Research and Clinics
Mar 312018
 

This is a book that provides an insight into this very broad area of research, focusing on topics that deal with some of the main problems confronted by modern neurosciences, spanning through neurodevelopmental and neurodegenerative disorders, changes observed in drug addictions and sleep deprivation, as well as early assessment of brain injury for preventive strategies employing sensitive biomarkers.

GET IT FREE HERE

http://nitroflare.com/view/18B402646EE1093/BrainDamageITO.pdf

Share Button

Diagnostic and Therapeutic Neuroradiology: A Case-Based Guide to Good Practice

 Neurology/Neurosurgery  Comments Off on Diagnostic and Therapeutic Neuroradiology: A Case-Based Guide to Good Practice
Mar 282018
 

This book presents a wide-ranging series of illustrative clinical cases that cover the main pathologies and areas of interest in diagnostic and therapeutic neuroradiology. The aim is to enable the reader to learn important lessons from real cases that exemplify the caseload and capabilities of a large, modern neuroradiology department. The cases are presented in a quiz format. For each one, the first page documents clinical and imaging findings, followed by questions concerning these findings, differential diagnosis, and other aspects. On the second page, the answers are provided, with concise explanation and discussion. Attention is also drawn to the relevant available literature. Most of the cases derive from the Department of Neuroradiology at the University Hospital Center of Porto (Portugal), which is staffed by a large multidisciplinary team providing cutting-edge services. In addition, some cases from other centers have been included to ensure wider representation of experience. The book will be of particular value for residents and fellows in neuroradiology, radiology, neurology, and neurosurgery.
GET IT FREE HERE
Share Button