Serotoninergic Neurons and 5-HT Receptors in the CNS

 Neurology/Neurosurgery  Comments Off on Serotoninergic Neurons and 5-HT Receptors in the CNS
Jan 022019
 

This volume provides an up-to-date and comprehensive overview of the anatomy, physiology, and basic and applied pharmacology of CNS serotonin neurons and serotonin receptor subtypes required for understanding the role(s) of serotonin in brain function and in behavior. The book comprises 28 chapters on various aspects of CNS serotonin neurons, such as their development, plasticity and transduction mechanisms, their structural and functional components involved in synaptic transmission, their physiological properties, their role in behavior, their putative involvement in neuropsychiatric diseases, and their role as targets of drugs used in the treatment of CNS disorders.
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Immunoneurology

 Immunology, Neurology/Neurosurgery  Comments Off on Immunoneurology
Jan 022019
 

A considerable amount of information has been gathered in the field of immunoneurology over recent years. This knowledge about modifications in the pathways of neuroimmune diseases has enabled the development of new therapies.In this volume leading experts present the state of the art in the field, covering all aspects from basic science to the development of better therapies.
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How Brain Arousal Mechanisms Work: Volume 1: Paths Toward Consciousness

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Jan 022019
 


What are the physical paths towards consciousness? How do humans transition out of deep anesthesia, deep sleep, or traumatic brain injury? This book presents a new argument that expands past theories centered on the cerebral cortex, and instead emphasizes the longitudinally-integrated brainstem systems that are essential to the mechanism of consciousness. The workings of these vertical pathways that ‘wake up the brain’ are examined in neurobiological and molecular detail. Mirroring the evolution of this system from fish to humans, chapters in the book move from hindbrain to forebrain and from animal brain to human brain, developing the unified approach involved in the brain arousal mechanism. Considering consciousness through an array of neuronal structures, this book provides a new physical explanation of the phenomenon. Written for neurologists, neuroscientists, psychologists and psychiatrists, the book’s succinct and readable tone means it is also suitable for readers interested in the workings of the brain

About the Author
Donald Pfaff is Professor of Neurobiology and Behavior at the Rockefeller University, New York. With over fifty years of experience in the field, he has authored or edited more than thirty books and is active on six journal editorial boards in topics of neuroscience. His study of generalized arousal led to the first operational definition of the term, enabling scientists to measure arousal quantitatively in laboratory animals and humans.

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Traumatic Subarachnoid Haemorrhage

 Neurology/Neurosurgery  Comments Off on Traumatic Subarachnoid Haemorrhage
Jan 022019
 

This monograph highlights the clinical significance of traumatic subarachnoid haemorrhage on CT scan after head injury, a subject which has received little attention until recently. The diagnosis, clinical aspects, prognosis, and therapy are discussed for patients with traumatic subarachnoid haemorrhage.
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Proceedings of the XV Symposium Neuroradiologicum: Kumamoto, 25 September – 1 October 1994

 Neurology/Neurosurgery, Radiology  Comments Off on Proceedings of the XV Symposium Neuroradiologicum: Kumamoto, 25 September – 1 October 1994
Dec 312018
 

Since 1939, the Symposium Neuroradiologicum has been held every 4 years in various cities throughout the world. Great neuroradiologists such as Taveras, Du Boulay, Greitz, Lindgren, and DiChiro have been among the presidents of the previous symposia. The XV Symposium Neuroradiologicum was held in Kumamoto from 25 September through 1 October 1994. More than 1,200 participants gathered to discuss the most recent developments, including interventional neuroradiology, functional imaging, MRI contrast media, new techniques in MRI, iodinated contrast media and other advances. The communications are presented in this book. Special lectures held by Drs. Dillon, Harwood-Nash, and Picard are included. This book covers the most recent advances in neuroradiology.
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Early CT Diagnosis of Hemispheric Brain Infarction

 Neurology/Neurosurgery  Comments Off on Early CT Diagnosis of Hemispheric Brain Infarction
Dec 302018
 

CT signs of early cerebral infarction are subtle within the first 6 hours after symptom onset, but important to recognize. The CT reading panel of ECASS wants to share its experience by publishing this series of early CT scans from study patients in order to improve early recognition of ischemic infarction by CT and thus to improve patient care, and to provide material for practice. In this book each CT scan can be read with and without neuroradiological description. Follow-up scans of each case confirm early findings.
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Practitioner’s Guide to Evaluating Change with Neuropsychological Assessment Instruments

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Dec 292018
 

The impetus for this volume began with our research in the 1980’s involving serial neuropsychological evaluation with various patient populations. At that time, reports on the practice effects associated with routinely utilized clinical neuropsychological instruments were sparse. While test-retest data were available for almost all assessment instruments, this was usually in the form of correlation coefficients and not changes in mean performance between or across assessment periods (see McCaffrey & Westervelt, 1995 for a detailed discussion of these and related issues). Clinical neuropsychological practitioners had few guidelines to assist them in determining if a change in a patient’s performance across assessments was due to an intervention, maturation, practice effects, or a combination of factors. This volume represents our efforts at reviewing the literature between 1970 and 1998 and extracting the reported information on practice effects. The tables include the assessment instrument used, information on the subject/patient groups, the sample size (n}, gender, age, intervention, interval between the assessments, scores at both assessment points, and the citation. Those studies that reported data on more than two assessment points are indicated by a notation~ however, any data beyond the second assessment are not reported and the interested reader should refer to the original article. The tables are arranged alphabetically for the most widely used assessment instruments. Those instruments for which there was limited data on practice effects are grouped by “domain” (e. g.
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Cell Adhesion Molecules: Implications in Neurological Diseases

 Neurology/Neurosurgery  Comments Off on Cell Adhesion Molecules: Implications in Neurological Diseases
Dec 292018
 

Cell Adhesion Molecules: Implications in Neurological Diseases contains review articles on recent developments in the field of neural cell adhesion molecules (CAMs). The main focus is on the role of cell adhesion molecules in various neurological and neurodegenerative diseases. This perspective has been essentially overlooked in recently published books on neural CAMs. In addition, the contributors cover many newly identified cell adhesion molecules and some that have not received much attention in recent years. This books fills an important gap in the currently available literature. ​
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Fundamentals of Pharmaceutical Nanoscience

 Neurology/Neurosurgery, Pharmacology  Comments Off on Fundamentals of Pharmaceutical Nanoscience
Dec 292018
 

Nanoscience or the science of the very small offers the pharmaceutical scientist a wealth of opportunities. By fabricating at the nanoscale, it is possible to exert unprecedented control on drug activity. This textbook will showcase a variety of nanosystems working from their design and construction to their application in the field of drug delivery. The book is intended for graduate students in drug delivery, physical and polymer chemistry, and applied pharmaceutical sciences courses that involve fundamental nanoscience.The purpose of the text is to present physicochemical and biomedical properties of synthetic polymers with an emphasis on their application in polymer therapeutics i.e., pharmaceutical nanosystems, drug delivery and biological performance. There are two main objectives of this text. The first is to provide advanced graduate students with knowledge of the principles of nanosystems and polymer science including synthesis, structure, and characterization of solution and solid state properties. The second is to describe the fundamentals of therapeutic applications of polymers in drug delivery, targeting, response modifiers as well as regulatory issues.The courses, often listed as Advanced Drug Delivery and Applied Pharmaceutics; Polymer Therapeutics; or Nanomedicine, are designed as an overview of the field specifically for graduate students in the Department of Pharmaceutical Sciences Graduate Programs. However, the course content may also be of interest for graduate students in related biomedical research programs.These courses generally include a discussion of the major principles of polymer science and fundamental concepts of application of polymers as modern therapeutics. All courses are moving away from the above mentioned course names and going by ‘pharmaceutical nanoscience or nanosystems’. This area of research and technology development has attracted tremendous attention during the last two decades and it is expected that it will continue to grow in importance. However, the area is just emerging and courses are limited but they are offered.
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Acquired Brain Injury in the Fetus and Newborn

 Neurology/Neurosurgery  Comments Off on Acquired Brain Injury in the Fetus and Newborn
Dec 282018
 

Given the tremendous recent advances in the understanding of acquired neonatal brain injury and in the care of affected newborn infants, this book provides a timely review for the practising neurologist, neonatologist and pediatrician. The editors take a pragmatic approach, focusing on specific populations encountered regularly by the clinician. They begin by addressing aspects of fetal neurology and the interpretation of fetal imaging studies. They then follow a “bench to bedside” approach to acquired brain injury in the preterm and term newborn infant in the next chapters. The contributors, all internationally recognized clinician scientists, provide the clinician reader with a state-of-the art review in their area of expertise. The final section of the book address special populations and concerns, areas that are largely overlooked in existing neurology textbooks. Each of these areas has seen considerable advances in the last five years and is of increasing relevance to the neurologist and neonatologist clinician. The comprehensive nature of each section (from basic science to acute clinical care to outcomes) should appeal broadly to scientists and allied health professionals working in neonatal neurology

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