Inhaled sedation in the intensive care unit: A new option and its technical prerequisites

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Aug 292019
 


Andreas Meiser summarizes the current literature on inhalation sedation of critically ill patients. To meet clinical demands, he describes the development of new devices to administer volatile anesthetics together with common ICU ventilators. Their basic principle is called anesthetic reflection. The author discusses advantages and drawbacks of these devices in line with clinical studies demonstrating advantages of inhaled versus intravenous ICU sedation.
About the Author:
Dr. med. Andreas Meiser is working as a consultant anesthesiologist on the interdisciplinary operative ICU of the Saarland University Medical Center. He has been a pioneer in the field of inhalation ICU sedation. He has been treating patients using the AnaConDa administration devices since 2004, and has published many original articles in scientific journals on the subject.

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Seiki Jutsu: The Practice of Non-Subtle Energy Medicine

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Aug 292019
 

A guide to the ancient Japanese art of working with concentrated life-force energy, seiki, for self-healing, revitalization, and creativity

• Explains how to awaken seiki, guiding you through the stages of seiki development

• Details how to develop your own daily practice for self-healing and renewal as well as providing exercises to infuse your everyday activities with seiki

• Includes many inspiring stories from the authors’ decades of healing work

Seiki jutsu is the ancient Japanese shamanic art of working with seiki, concentrated life-force energy, for self-healing, revitalization, creativity, and inspiration. Known in Tantra as kundalini and to the Kalahari Bushmen as n/om, seiki has been called “activated and strengthened chi” and is often described as a “non-subtle” energy because it is strongly felt when awakened. Centering on spontaneity of movement to gather and transmit seiki, the practice of seiki jutsu does not require years of training or endless memorization of forms. Once you have received seiki, your daily practice will teach you to activate the flow of this powerful energy to recharge your body, mind, and spirit and empower you to find your unique destiny.

Renowned seiki jutsu masters Bradford and Hillary Keeney detail the history and lineage of seiki jutsu beginning in 8th-century Japan and reveal how this ancient practice was used by the samurai. The authors show how seiki underlies the “flow experience” sought after by artists, musicians, athletes, and performers of all types. They explain how to recognize the awakening of seiki, guiding you through the stages of seiki development with stories of healings they have participated in or witnessed. They reveal how to develop your own daily practice for self-healing and renewal as well as provide active exercises to discover your life’s purpose, infuse your everyday activities with seiki, and motivate yourself to create a fulfilling life. They show that no method of performance, spiritual practice, or philosophy of life can fully awaken unless you are instilled with sufficient seiki. Regarded in Japan as “the fountain of youth,” seiki jutsu provides a way to bring maximum vitality into every aspect of life.

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Coenzyme Q: Molecular mechanisms in health and disease

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Aug 292019
 

Since its discovery in 1957, Coenzyme Q has piqued the interest of scientists from a wide range of disciplines because of its bioenergetics, vitamin-like behavior, and interactions with antioxidant vitamins E and C. Coenzyme Q: Molecular Mechanisms in Health and Disease is a comprehensive treatise on this often-studied coenzyme. International experts cover the research that led to its emergence as an exciting, new dietary supplement.The present volume summarizes the latest developments in various areas of CoQ research. New concepts on extramitochondrial functions of CoQ are discussed in two chapters, while recent discoveries in biosynthetic pathways for CoQ based on molecular genetic approaches are presented in another chapter.Further chapters explore the role of CoQ as an antioxidant, revealing the need for additional research in this exciting area. This book will be of extreme interest to biochemists, biophysicists, molecular and cell biologists, as well as nutritionists and biomedical health workers.
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Pollen Allergy in a Changing World: A Guide to Scientific Understanding and Clinical Practice

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Aug 292019
 

This book presents the latest scientific knowledge on the role of pollens in triggering respiratory allergies and offers up-to-date guidance on the diagnosis, treatment, and prevention of pollen allergy. Detailed information is supplied on allergenic plants and on the complex associations between pollen allergy and local weather conditions, air pollution, and climate change.
Readers will learn how climate change in particular is impacting on pollen concentrations, pollen allergenicity, the pollen season, and plant and pollen distribution. A further important feature is the presentation of a forecasting system for allergenic pollens that takes into account a variety of meteorological factors and is designed to be of benefit to allergy patients. This up-to-date scientific knowledge is complemented by clear guidance on all aspects of the management of pollen allergy. The closing chapters address global trends in allergy research and future prospects for pollen allergy. The book will appeal both to researchers seeking state of the art information on the topic and to clinicians wishing to optimize patient care.

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https://nitroflare.com/view/77B2C8998E5DE43/9811054983.epub

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Early Life Origins of Ageing and Longevity

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Aug 272019
 

This book provides a comprehensive overview of the field of developmental programming of ageing phenotypes. Although gerontological research has traditionally focused on later stages of the life cycle, growing evidence indicates that both the rate of ageing-associated functional declines, and the risks of later-life chronic pathological conditions, can be traced to origins early in life.
While other books in the field concentrate on the developmental origin of particular disorders, this volume offers a detailed guide to all important aspects of the role of early-life conditions in programming both chronic pathological conditions and the ageing process.

Interest in the study of ageing and longevity had its beginnings in research on the fetal origins of adult disease. This has evolved into a hypothesis on the Developmental Origins of Adult Health and Disease (DOHaD), which postulates that adverse environmental exposures during critical in-utero and early postnatal stages of development may permanently change physiological responses and cause functional impairments and disorders in adult life.

In this book, the contributing authors and leading experts from around the world, describe research on mechanisms underlying the developmental programming phenomenon, as well as interventional strategies aimed at restoring developmentally disrupted epigenetic patterns.

Early Life Origins of Ageing and Longevity benefits a wide audience of working scientists, clinicians, and advanced students, and will also interest scientifically curious general readers who wish to know more about current research in this rapidly evolving field.

https://nitroflare.com/view/C84A85AEE13DDFA/3030249573.epub

https://nitroflare.com/view/EC539D2A8B2C7A9/3030249573.pdf

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Atlas of Mandibular and Maxillary Reconstruction with the Fibula Flap: A step-by-step approach

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Aug 272019
 

This atlas deals with the standard technique used for reconstructing the mandible and the maxilla – the fibula flap. The reader will find useful information on all issues that are important in the surgical procedure, including the use of CAD-CAM technology (Computer Assisted Technology), bone synthesis and flap modelling. The editors draw on their 30 years of experience to provide a step-by-step description of this surgical procedure. With the help of numerous illustrations, the reader will learn the technical, functional and aesthetic developments since 1989 when this technique was first described.Plastic surgeons, otorhinolaryngologists and oral- and maxillofacial surgeons will find this book a valuable guide to the sophisticated principles of jaw reconstruction and how to apply them in their everyday practice.

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Amyotrophic Lateral Sclerosis and the Frontotemporal Dementias

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Aug 262019
 

Over the past ten years, there has been an increasing recognition that syndromes of frontotemporal dysfunction (FTD) are a common occurrence in patients with amyotrophic lateral sclerosis (ALS). Such syndromes may be present in as many as 60% of patients with ALS. Conversely, the occurrence of motor neuron dysfunction in patients with clinically pure frontotemporal dementia is increasingly recognized. This suggests that to some extent there are overlapping syndromes in which both ALS and FTD occur within the same individual.

This volume summarizes the advances in our understanding of these two disorders, as well as the potential relationship between the two. Key topics include advances in our ability to clinically describe the frontotemporal syndromes, preclinical detection, neuroimaging, and genetics. The exploding field of new markers in neuropathology is examined, as is the role of new genetic mutations in DNA/RNA transport systems. This book is the essential reference text for this topic, and will be of interest to neurologists and neurological trainees with a clinical or research interest in the FTDs or ALS, neuropsychologists, neuropathologists, and researchers.

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Weight-of-Evidence for Forensic DNA Profiles Edition 2

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Aug 262019
 

DNA evidence is widely used in the modern justice system. Statistical methodology plays a key role in ensuring that this evidence is collected, interpreted, analysed and presented correctly. This book is a guide to assessing DNA evidence and presenting that evidence in a courtroom setting. It offers practical guidance to forensic scientists with little dependence on mathematical ability, and provides the scientist with the understanding they require to apply the methods in their work. Since the publication of the first edition of this book in 2005 there have been many incremental changes, and one dramatic change which is the emergence of low template DNA (LTDNA) profiles. This second edition is edited and expanded to cover the basics of LTDNA technology. The author’s own open-source R code likeLTD is described and used for worked examples in the book. Commercial and free software are also covered.
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Retinoid and Rexinoid Signaling: Methods and Protocols

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Aug 252019
 

This volume explores the latest synthetic procedures for producing receptor-specific retinoids and rexinoids, molecular biology methods, and new technologies to demonstrate the therapeutic activities of molecules.
The chapters in this book cover topics such as lentiviral delivery of shRNA constructs into acute promyelocytic leukemia cells for ATRA induced differentiation and autophagy; methods to analyze RAR signaling in colorectal cancer cells; differentiation of primary myoblasts by using RXR agonist; methodology for analyzing effects of retinoid treatment on nervous system development and larval swimming behavior; and protocols for assessment of autophagic flux in ATRA treated 2D and 3D breast cancer cultures. Written in the highly successful Methods in Molecular Biology series format, chapters include introductions to their respective topics, lists of the necessary materials and reagents, step-by-step, readily reproducible laboratory protocols, and tips on troubleshooting and avoiding known pitfalls.

Cutting-edge and comprehensive, Retinoid and Rexinoid Signaling: Methods and Protocols is a valuable resources for graduate students, postdoctoral fellows, and principal investigators who are interested in further exploring the signaling mechanisms of these molecules in their specific preclinical models.

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Viruses and Nanotechnology

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Aug 252019
 


Nanobiotechnology involves the exploitation of biomaterials, devices or methodologies at the nanoscale. Virus particles are natural nanomaterials and have received particular attention as novel building blocks for materials design and fabrication. In this volume, leaders in the field of viral nanobiotechnology address the fundamental means for generating virus-based nanoparticles by performing chemistry on virion substrates, multilayered arrays and hybrid virus networks incorporating materials such as quantum dots and carbon nanotubes.
The use of virus-like protein cages to generate novel materials that can be used for biomedical applications such as biomedical imaging and vaccine purposes is discussed. Finally, the novel tumor-targeting properties of certain viruses are harnessed to achieve specificity in vivo. This volume describes the unprecedented opportunities to capitalize on the vast knowledge of virus particles and their physical and material properties.

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