Novel Therapeutic Targets for Antiarrhythmic Drugs

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Oct 232018
 

Profiles potential treatment approaches for cardiac arrhythmias
Cardiac arrhythmias of ventricular origin are responsible for the deaths of nearly half a million Americans each year while atrial fibrillation accounts for about 2.3 million cases per year, a rate that is projected to increase 2.5 fold over the next half century.

Effectively managing these cardiac rhythm disorders remains a major challenge for both caregivers and the pharmaceutical industry. Filling a gap in the current literature, Novel Therapeutic Targets for Antiarrhythmic Drugs presents the latest treatments for cardiac arrhythmias alongside comprehensive presentations of basic cardiac physiology and pharmacology.

Written by leading experts in their research areas, this invaluable resource offers both practitioners and researchers a one-stop guide that brings together previously dispersed information. The text consists of four sections:

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Section One comprehensively reviews basic cardiac electrophysiology, the mechanisms responsible for arrhythmias in the setting of ischemia, and basic pharmacology of antiarrhythmic drugs.
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Section Two addresses safety pharmacology, including the concept of “repolarization reserve,” safety challenges, and regulatory issues for the development of novel antiarrhythmic drugs.
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Section Three describes several novel pharmacological targets for antiarrhythmic drugs, including both ion channel and non-ion channel targets.
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Section Four describes promising non-pharmacological antiarrhythmic interventions including selective cardiac neural disruption or nerve stimulation, aerobic exercise training, and diet (omega-3 fatty acids).

Offering an unparalleled look at the current state and future direction of cardiac arrhythmia treatment, Novel Therapeutic Targets for Antiarrhythmic Drugs provides an important resource to advanced students, working researchers, and busy professionals alike.

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Cosmeceutical Science in Clinical Practice

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Oct 222018
 

Cosmeceuticals are skin-care products that fall between a cosmetic and a pharmaceutical; that is, they have active ingredients that counter skin ageing and promote skin rejuvenation. As such, they are an invaluable adjunct to the cosmetic dermatologist or plastic surgeon performing minimally invasive aesthetic procedures.

Many of these products have been developed in Europe and are only now being introduced to the USA, so this guide from expert practitioners explains how best to integrate the potential of cosmeceutical products into the best international clinical practice.

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Foot and Ankle Disorders: Tricks of the Trade

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Oct 182018
 

In this quick, easy-to-access reference, a top team of orthopedic surgeons share their tricks and techniques for performing a wide range of foot and ankle surgeries. This concise book discusses 35 different procedures for the foot and ankle, covering everything from hind foot alignment and hallux varus to metatarsal phalangeal fusion and adult flatfoot syndrome. For each operation, you’ll find notes, clear and simplified drawings, tips, and pitfalls, all designed to make even the most challenging surgery seem easy.

Special benefits:

Simplifies all concepts with succinct, to-the-point text
Annotated drawings allow you to grasp the procedure at a glance
Pitfalls describe typical problems and strategies for avoiding them
Guidelines help explain procedures to patients and obtain informed consent

Here is the valuable text all orthopedists, podiatrists, and residents who perform foot and ankle procedures need to expand their surgical armamentarium.

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The Routledge Handbook of the Computational Mind

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Oct 142018
 

Computational approaches dominate contemporary cognitive science, promising a unified, scientific explanation of how the mind works. However, computational approaches raise major philosophical and scientific questions. In what sense is the mind computational? How do computational approaches explain perception, learning, and decision making? What kinds of challenges should computational approaches overcome to advance our understanding of mind, brain, and behaviour?

The Routledge Handbook of the Computational Mind is an outstanding overview and exploration of these issues and the first philosophical collection of its kind. Comprising thirty-five chapters by an international team of contributors from different disciplines, the Handbook is organised into four parts:

History and future prospects of computational approaches
Types of computational approach
Foundations and challenges of computational approaches
Applications to specific parts of psychology.

Essential reading for students and researchers in philosophy of mind, philosophy of psychology, and philosophy of science, The Routledge Handbook of the Computational Mind will also be of interest to those studying computational models in related subjects such as psychology, neuroscience, and computer science.

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The Therapeutic Use of N-Acetylcysteine (NAC) in Medicine

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Oct 122018
 

Focusing on the practical use of N-Acetyl-Cysteine (NAC) in medicine, this book provides a comprehensive review of the basic biological and clinical studies documenting its benefits in treating medical disease. NAC is perhaps best known as an antidote for acetaminophen, but its therapeutic effect in a wide range of medical diseases has recently been realized. In addition to its well recognized use in radiological contrast prophylaxis for renal disease and pulmonary disorders, studies have suggested significant promise in psychiatric and neurological disorders such as addiction, Alzheimer’s disease, ataxia, autism, bipolar disorder, depression, epilepsy, neuropathy, obsessive-compulsive disorder, schizophrenia, traumatic brain injury and trichotillomania in addition to promising studies in audiology, cardiology, exercise physiology, gastroenterology, hematology, infectious disease, infertility and ophthalmology. Given the promising studies for a wide range of medical conditions, coupled with a excellent safety profile, the potential for NAC in the treatment of human disease appears considerable.Dr Leonore A Herzenberg from Stanford University, a pioneer of redox physiology and the use of NAC, provides a succinct history of the development of the therapeutic use of NAC for medical disease. This is followed by a series of basic science chapters outlining the role of NAC in important physiological processes, including modulation of dopamine and glutamate neurotransmitter systems, redox and mitochondrial metabolism, apoptosis and inflammation.

The last section of the book is dedicated to clinically oriented chapters that comprehensively review the literature on medical disorders in which NAC has been found to be effective, including toxicity and cardiovascular, gastrointestinal, neurological, psychiatric, pulmonary and renal disorders. Each chapter reviews the theoretical biological mechanisms of NAC for the specific diseases reviewed, rates the clinical studies using a standardized criteria in order to provide an objective level of evidence and grade of recommendation for the use of NAC for specific medical conditions and outlines the ongoing clinical trials examining NAC for the treatment of specific diseases. Final chapters review the clinical evidence verifying that specific theoretical biological mechanisms are actually being targeted by NAC in medical disease. Studies on the pharmacology, formulation and potential adverse effects of NAC are also reviewed. A final chapter synthesizes the clinical studies to suggest that the effectiveness of NAC may signal a new basic physiological disorder, glutathione deficiency, which may be an important pathophysiological mechanism of many diseases.

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Studies on Retinal and Choroidal Disorders

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Oct 122018
 

Studies on Retinal and Choroidal Disorders examines the role that oxidative and nitrosative stress plays in the complex physiology and pathophysiology of the retina and choroid. Both the basic science researcher and the clinical practitioner can use this book as a guide to the current understanding of retinal and choroidal cellular mechanisms involved in aging and disease.

Beginning with a review of oxidative stress and inflammation in the pathoetiology of AMD and a review of the complement system in the retina, the book then takes a detailed look at oxidative stress in lipid metabolism and oxidized lipoproteins in the retina. It examines the anti-apoptotic activity of α-crystallins in the presence of glutathione, oxidative stress in the mitochondria and endoplasmic reticulum, the role of iron in retinal disease, the mechanisms of pathological VEGF expression, NAPDH oxidase mechanisms, and Hepatocyte Growth Factor in oxidative stress in the retina.

A detailed look at the Ccl2-/-/Cx3cr1-/- mouse model of AMD follows. Then a detailed examination of the systemic changes in AMD is followed by a discussion of cerium oxide nanoparticle reduction of oxidative stress. Two chapters discuss progenitor cells in the cause and treatment of retinal diseases including AMD and diabetic retinopathy. Natural compounds in the prevention and treatment of retinal diseases are exhaustively presented, followed by a chapter on serotonin 5-HT1A receptor agonists in oxidative stress of the retina. The current anti-VEGF treatment strategies of neovascular AMD are then given. The volume continues with a detailed look at nitric oxide and inducible nitric oxide synthase in retinal vascular disease, an explanation of an in vivo technique of studying the effect of lipid hydroperoxides on circulating leucocytes in the retina, an excellent review of oxidative stress in retinopathy of prematurity, and a look at VEGF induced oxidative stress in the retinal ganglion cell. The book ends with a detail examination of the role of carotenoids in retinal health and disease. These 31 chapters summarize what is known about oxidative stress in retinal and choroidal disorders. All those involved with degenerative diseases of the eye will find Studies on Retinal and Choroidal Disorders to be illuminating and comprehensive.

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Frontiers in Clinical Drug Research-HIV: Volume 1

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Oct 112018
 

Frontiers in Clinical Drug Research – HIV is an eBook series that brings updated reviews to readers interested in learning about advances in the development of pharmaceutical agents for the treatment of acquired immune deficiency syndrome (AIDS) and other disorders associated with human immunodeficiency virus (HIV) infection. The scope of the eBook series covers a range of topics including the medicinal chemistry and pharmacology of natural and synthetic drugs employed in the treatment of AIDS (including HAART) and resulting complications, and the virology and immunological study of HIV and related viruses. Frontiers in Clinical Drug Research – HIV is a valuable resource for pharmaceutical scientists, clinicians and postgraduate students seeking updated and critically important information for developing clinical trials and devising research plans in HIV/AIDS research. The first volume of this series features 7 chapters that cover a variety of topics including: -Antiretroviral drug development -HIV-1 genomics -HIV drug targets such as ribosomes and HIV Integrase -HAART associated nephrotoxicity

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Measurement of Antioxidant Activity and Capacity

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Oct 092018
 

A comprehensive reference for assessing the antioxidant potential of foods and essential techniques for developing healthy food products

Measurement of Antioxidant Activity & Capacity offers a much-needed resource for assessing the antioxidant potential of food and includes proven approaches for creating healthy food products. With contributions from world-class experts in the field, the text presents the general mechanisms underlying the various assessments, the types of molecules detected, and the key advantages and disadvantages of each method. Both thermodynamic (i.e. efficiency of scavenging reactive species) and kinetic (i.e. rates of hydrogen atom or electron transfer reactions) aspects of available methods are discussed in detail.

A thorough description of all available methods provides a basis and rationale for developing standardized antioxidant capacity/activity methods for food and nutraceutical sciences and industries. This text also contains data on new antioxidant measurement techniques including nanotechnological methods in spectroscopy and electrochemistry, as well as on innovative assays combining several principles. Therefore, the comparison of conventional methods versus novel approaches is made possible. This important resource:

Offers suggestions for assessing the antioxidant potential of foods and their components
Includes strategies for the development of healthy functional food products
Contains information for identifying antioxidant activity in the body
Presents the pros and cons of the available antioxidant determination methods, and helps in the selection of the most appropriate method

Written for researchers and professionals in the nutraceutical and functional food industries, academia and government laboratories, this text includes the most current knowledge in order to form a common language between research groups and to contribute to the solution of critical problems existing for all researchers working in this field.

About the Author
Resat Apak is Professor of Analytical Chemistry Division, Department of Chemistry, Faculty of Engineering, Istanbul University, Turkey.

Esra Capanoglu is Associate Professor at the Food Engineering Department, Faculty of Chemical and Metallurgical Engineering, Istanbul Technical University, Turkey.

Fereidoon Shahidi is a University Research Professor at the Department of Biochemistry, Memorial University of Newfoundland, St. John’s, Canada

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Digital Forensics

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Oct 092018
 

The definitive text for students of digital forensics, as well as professionals looking to deepen their understanding of an increasingly critical field

Written by faculty members and associates of the world-renowned Norwegian Information Security Laboratory (NisLab) at the Norwegian University of Science and Technology (NTNU), this textbook takes a scientific approach to digital forensics ideally suited for university courses in digital forensics and information security. Each chapter was written by an accomplished expert in his or her field, many of them with extensive experience in law enforcement and industry. The author team comprises experts in digital forensics, cybercrime law, information security and related areas.

Digital forensics is a key competency in meeting the growing risks of cybercrime, as well as for criminal investigation generally. Considering the astonishing pace at which new information technology – and new ways of exploiting information technology – is brought on line, researchers and practitioners regularly face new technical challenges, forcing them to continuously upgrade their investigatory skills. Designed to prepare the next generation to rise to those challenges, the material contained in Digital Forensics has been tested and refined by use in both graduate and undergraduate programs and subjected to formal evaluations for more than ten years.

Encompasses all aspects of the field, including methodological, scientific, technical and legal matters
Based on the latest research, it provides novel insights for students, including an informed look at the future of digital forensics
Includes test questions from actual exam sets, multiple choice questions suitable for online use and numerous visuals, illustrations and case example images
Features real-word examples and scenarios, including court cases and technical problems, as well as a rich library of academic references and references to online media
Digital Forensics is an excellent introductory text for programs in computer science and computer engineering and for master degree programs in military and police education. It is also a valuable reference for legal practitioners, police officers, investigators, and forensic practitioners seeking to gain a deeper understanding of digital forensics and cybercrime.

About the Author
ANDRÉ ÅRNES, PhD is Senior Vice President and Chief Security Office of Telenor Group and an Associate Professor on the faculty of the Norwegian Information Security Laboratory (NisLab) at the Norwegian University of Technology and Science (NTNU). An experienced cyber security expert,Dr. Årnes has extensive experience both as a security leader in a global corporation and as a computer crime special investigator in law enforcement

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Research Methods in Biomechanics, 2 edition

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Oct 062018
 

Research Methods in Biomechanics, Second Edition, demonstrates the range of available research techniques and how to best apply this knowledge to ensure valid data collection. In the highly technical field of biomechanics, research methods are frequently upgraded as the speed and sophistication of software and hardware technologies increase. With this in mind, the second edition includes up-to-date research methods and presents new information detailing advanced analytical tools for investigating human movement.

Expanded into 14 chapters and reorganized into four parts, the improved second edition features more than 100 new pieces of art and illustrations and new chapters introducing the latest techniques and up-and-coming areas of research. Also included is access to biomechanics research software designed by C-Motion, Visual3D Educational Edition, which allows users to explore the full range of modeling capabilities of the professional Visual3D software in sample data files as well as display visualizations for other data sets. Additional enhancements in this edition include the following:

– Special features called From the Scientific Literature highlight the ways in which biomechanical research techniques have been used in both classic and cutting-edge studies.

– An overview, summary, and list of suggested readings in each chapter guide students and researchers through the content and on to further study.

– Sample problems appear in select chapters, and answers are provided at the end of the text.

– Appendixes contain mathematical and technical references and additional examples.

– A glossary provides a reference for terminology associated with human movement studies.

Research Methods in Biomechanics, Second Edition, assists readers in developing a comprehensive understanding of methods for quantifying human movement. Parts I and II of the text examine planar and three-dimensional kinematics and kinetics in research, issues of body segment parameters and forces, and energy, work, and power as they relate to analysis of two- and three-dimensional inverse dynamics. Two of the chapters have been extensively revised to reflect current research practices in biomechanics, in particular the widespread use of Visual3D software. Calculations from these two chapters are now located online with the supplemental software resource, making it easier for readers to grasp the progression of steps in the analysis.

In part III, readers can explore the use of musculoskeletal models in analyzing human movement. This part also discusses electromyography, computer simulation, muscle modeling, and musculoskeletal modeling; it presents new information on MRI and ultrasound use in calculating muscle parameters. Part IV offers a revised chapter on additional analytical procedures, including signal processing techniques. Also included is a new chapter on movement analysis and dynamical systems, which focuses on how to assess and measure coordination and stability in changing movement patterns and the role of movement variability in health and disease. In addition, readers will find discussion of statistical tools useful for identifying the essential characteristics of any human movement.

The second edition of Research Methods in Biomechanics explains the mathematics and data collection systems behind both simple and sophisticated biomechanics. Integrating software and text, Research Methods in Biomechanics, Second Edition, assists both beginning and experienced researchers in developing their methods for analyzing and quantifying human movement.

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