WHO Classification of Tumours of the Urinary System and Male Genital Organs

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Sep 042018
 

WHO Classification of Tumours of the Urinary System and Male Genital Organs is the eighth volume in the 4th Edition of the WHO series on histological and genetic typing of human tumours. This authoritative, concise reference book provides an international standard for oncologists and pathologists and will serve as an indispensable guide for use in the design of studies monitoring response to therapy and clinical outcome.Diagnostic criteria, pathological features, and associated genetic alterations are described in a strictly disease-oriented manner. Sections on all recognized neoplasms and their variants include new ICD-O codes, epidemiology, clinical features, macroscopy, pathology, genetics, and prognosis and predictive factors. It contains numerous color photographs, MRIs, ultrasound images, CT scans, charts and references.This book is in the series commonly referred to as the “Blue Book” series.
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Collagenase in Dupuytren Disease

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Sep 032018
 

This book offers detailed guidance on the use of collagenase, or enzymatic fasciotomy, as a nonsurgical treatment for Dupuytren’s contracture and explains its role in relation to the other forms of treatment, including open fasciectomy, needle aponeurotomy, and lipofilling. Clear guidance is provided on technique, current indications, and off-label usage. With the help of tips and tricks from leading experts, the reader will learn how to personalize the procedure to meet the needs of individual patients. Advice is also provided on all aspects of rehabilitation, which is a key determinant of treatment outcome. Collagenase treatment of Dupuytren’s disease has the benefits of low invasiveness and rapid patient recovery and achieves reasonable recurrence-free periods. It is especially valuable in patients with rapid recurrence following surgery. In documenting and appraising every aspect of its use, this book will be of value for all who treat patients with Dupuytren’s disease, including hand surgeons, orthopedists, plastic surgeons, physiatrists, and physiotherapists.

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Specialist Outreach Clinics in General Practice

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Sep 032018
 

Other titles in the National Primary Care Research and Development Centre series: NPCRDC:What is the Future for a Primary Care-led NHS? NPCRDC: Primary Care: Understanding Health Need and Demand NPCRDC: Better Building for Better Services NPCRDC: Primary Care and Social Services: developing new partnerships for older people NPCRDC: Primary Health Care and the Private Sector
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Improving Quality of Care in Family Planning: A Research and Advocacy Agenda for India

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Sep 022018
 

In this book the authors review initiatives in improving the quality of care for family planning in India and bring them to the broader forum of policy-level discussions. ​The global Family Planning 2020 (FP2020) framework argues for voluntary rights-based family planning programmes. The rights-based approach builds on the bedrock of quality of care, which means listening to what women want, treating individuals with dignity and respect and ensuring that everyone has access to full information and high quality care. Improving the quality of care in family planning services in a country like India is crucial from individual, national and global considerations.
This book critically discusses and evaluates the various interventions undertaken so far and the reasons for success and failure. It also synthesizes current research studies in India, identifies gaps and presents a research agenda to bridge this gap and accelerate progress towards improving quality of care in family planning. It presents a comprehensive framework that underscores the importance of health systems and community environments in creating enabling, motivating and empowering roles for providers and clients. The examples and perspectives presented in this book make a strong case for adoption into policy frameworks and scaling up of quality of care efforts, and identifying research priorities for strengthening the response to family planning. This book greatly contributes towards enhancing the quality of family planning care at the grass-roots level in low resource settings and is of interest to researchers and practitioners of public health, particularly community health, maternal and child health, and social work.

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Body, Mind, and Sport: The Mind-Body Guide to Lifelong Health, Fitness, and Your Personal Best

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Sep 022018
 

Until recently, the effortless “Zone” of peak performance was only within the reach of serious athletes. Now, with Body, Mind, and Sport, anyone can reach the Zone, regardless of fitness level.

Designed to accommodate a variety of individual fitness needs, the Body, Mind, and Sport program is split into two levels. Level 1 is for non-athletes who want to improve overall fitness; Level 2 is for those who want to train for competitive or recreational purposes. Your own unique mind-body type is taken into account to guide you in achieving your personal best without stress or strain. In this revised and updated edition of Body, Mind, and Sport, fitness expert and trainer John Douillard outlines a program in which your individual seasonal constitution-Winter, Spring, or Summer-determines what exercises or sports are best suited to your mind-body type and what foods you should eat for optimum results.

Using the Body, Mind, and Sport approach you can decrease heart and breath rates while improving both fitness and performance. Dozens of world-class athletes, including Martina Navratilova and Billie Jean King, have used John Douillard’s expert breathing techniques, dietary recommendations, and seasonally balanced workouts. Now you can, too!

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Modeling Methods for Medical Systems Biology: Regulatory Dynamics Underlying the Emergence of Disease Processes

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Sep 022018
 

This book contributes to better understand how lifestyle modulations can effectively halt the emergence and progression of human diseases. The book will allow the reader to gain a better understanding of the mechanisms by which the environment interferes with the bio-molecular regulatory processes underlying the emergence and progression of complex diseases, such as cancer. Focusing on key and early cellular bio-molecular events giving rise to the emergence of degenerative chronic disease, it builds on previous experience on the development of multi-cellular organisms, to propose a mathematical and computer based framework that allows the reader to analyze the complex interplay between bio-molecular processes and the (micro)-environment from an integrative, mechanistic, quantitative and dynamical perspective. Taking the wealth of empirical evidence that exists it will show how to build and analyze models of core regulatory networks involved in the emergence and progression of chronic degenerative diseases, using a bottom-up approach.

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Activating Agents and Protecting Groups: Activating and Protecting Agents v. 4 (Handbook of Reagents for Organic Synthesis)

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Aug 222018
 

Recognising the need for a cost effective reference work that deals not only with the most popular reagents in synthesis but also reaches the widest possible audience of practising organic chemists, the editors of ′The Encyclopedia of Reagents for Organic Synthesis′ (EROS) have developed a list of the most important and useful reagents employed in the field, conveniently presented in four separate volumes.

The reagents included in this volume reflect the fact that protecting groups and activation procedures are often used in combination. There are many instances in the synthesis of natural and unnatural products, pharmaceuticals, oligosaccharides, and oligonucleotides, etc., where similar tactics must be employed to prevent undesired activation or reaction of functionality. Accordingly, the most important reagents used to protect amines, alcohols, carboxyl, carbonyl and other reactive functional groups are included in this volume. The list of activating agents includes well known reagents that activate functional groups for substitution or elimination reactions, as well as less traditional examples, e.g. HMPA used to “activate” enolates and alkyllithium reagents to increase the nucleophilicity.

Each article contains all of the information found in EROS as well as expanded related reagents listings and additional references to enable the reader to quickly access a broad range of information that is beyond the scope of the reagent entries themselves. This text will prove an invaluable resource.

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he Hormone Survival Guide for Perimenopause: Balance Your Hormones Naturally

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Aug 202018
 

Explaining why women between the ages of 35 and 50 often experience significant changes in mood, weight, sex drive, and general well-being due to hormonal imbalances, this guide shows women how to regain control of their hormones—and their lives—and feel good again through natural means. Women who have had long-standing physical and emotional complaints written off by doctors as normal or genetic are provided with step-by-step solutions to such hormone-related problems as weight gain, fibroids, sex-drive doldrums, adult acne, depression, anxiety, irritability, chronic fatigue, and facial hair. Perimenopausal women will be able to regain control of their health by putting together a game plan for renewal—including hormone balancing and weight management plans that will help them feel better—with dramatic, life-changing results.

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Developmental Origins of Health and Disease (DOHaD)

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Aug 192018
 

This book addresses the developmental origins of health and disease (DOHaD), a new medical concept that demonstrates that various adult diseases start in the fetal period. It discusses our current understanding of the molecular mechanisms of DOHaD, including gene body epigenetics and non-coding RNA, and comprehensively examines diseases such type 2 diabetes, a well known as standard DOHaD-associated disease, as well as non-alcoholic fatty liver disease, hypertension and neurodevelopmental disorders. It argues that most adult diseases start at a very early stage, such as in the fetal and neonatal periods, and that earlier prevention and intervention would result in better outcomes for adult diseases such as type 2 diabetes and cardiac disorders, which are increasing in both developed and developing countries. The book appeals to obstetricians and pediatricians, as well as physicians who treat adult patients, wanting to understand the origins of diseases.

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Superoxide Dismutase (SOD) : Sources, Therapeutic Uses and Health Benefits

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Aug 172018
 

Superoxide dismutase (SOD) is an antioxidant enzyme that scavenges superoxide radicals, and are found in all living cells. SODs have been studied as a therapeutic tool for very diverse pathological situations for more than 30 years and, in many animal models and a few clinical trials, their use has shown positive outcomes. In this book, Chapter One begins with an overview of the association between manganese superoxide dismutase and cardiovascular disease. Chapter Two examines the indispensable roles of superoxide dismutation in mammalian erythrocytes. Chapter Three discusses the structure, catalysis and therapeutic uses of the Fe/Mn SOD family. Chapter Four reviews several strategies of nanomedicines development that have been used to prolong the circulation time and improve the therapeutic action of SODs. Chapter Five studies the emerging role of SOD3 in controlling skin inflammation and immune responses.

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