Oligonucleotide-Based Drugs and Therapeutics: Preclinical and Clinical Considerations for Development

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Jul 082018

A comprehensive review of contemporary antisense oligonucleotides drugs and therapeutic principles, methods, applications, and research

Oligonucleotide–based drugs, in particular antisense oligonucleotides, are part of a growing number of pharmaceutical and biotech programs progressing to treat a wide range of indications including cancer, cardiovascular, neurodegenerative, neuromuscular, and respiratory diseases, as well as other severe and rare diseases. Reviewing fundamentals and offering guidelines for drug discovery and development, this book is a practical guide covering all key aspects of this increasingly popular area of pharmacology and biotech and pharma research, from the basic science behind antisense oligonucleotides chemistry, toxicology, manufacturing, to safety assessments, the design of therapeutic protocols, to clinical experience.

Antisense oligonucleotides are single strands of DNA or RNA that are complementary to a chosen sequence. While the idea of antisense oligonucleotides to target single genes dates back to the 1970′s, most advances have taken place in recent years. The increasing number of antisense oligonucleotide programs in clinical development is a testament to the progress and understanding of pharmacologic, pharmacokinetic, and toxicologic properties as well as improvement in the delivery of oligonucleotides. This valuable book reviews the fundamentals of oligonucleotides, with a focus on antisense oligonucleotide drugs, and reports on the latest research underway worldwide.

Helps readers understand antisense molecules and their targets, biochemistry, and toxicity mechanisms, roles in disease, and applications for safety and therapeutics

Examines the principles, practices, and tools for scientists in both pre–clinical and clinical settings and how to apply them to antisense oligonucleotides

Provides guidelines for scientists in drug design and discovery to help improve efficiency, assessment, and the success of drug candidates

Includes interdisciplinary perspectives, from academia, industry, regulatory and from the fields of pharmacology, toxicology, biology, and medicinal chemistry

Oligonucleotide–Based Drugs and Therapeutics belongs on the reference shelves of chemists, pharmaceutical scientists, chemical biologists, toxicologists and other scientists working in the pharmaceutical and biotechnology industries. It will also be a valuable resource for regulatory specialists and safety assessment professionals and an important reference for academic researchers and post–graduates interested in therapeutics, antisense therapy, and oligonucleotides.



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Special Type of Finger Replantation: Techniques and Cases

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Jul 082018

This book discusses the management of serious finger damage, which can have lifelong consequences for patients without timely and effective replantation treatment to restore the function of the hand. Featuring more than 30 cases and over 420 clinical surgical photographs, it combines systematic with thematic approaches, basic theory with clinical practice, and images with text descriptions.
The book is divided into nine main sections: overview of the development history of replantation of severed fingers; anatomy of the hand; common equipment and materials; commonly used drugs; the choice of anesthesia; routine replantation methods, etc. In addition, it includes typical images for 13 special types of amputated finger replantation, and introduces readers to the replantation concept, surgical approach, surgical technique, key points of operation and matters requiring attention for each type. As such, the book offers an invaluable reference guide for finger replantation and related surgeries.
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Color Atlas of Endo-Otoscopy : Examination-Diagnosis-Treatment

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Jul 082018

Despite the many advances in diagnostic technologies and imaging modalities in recent years, otoscopy remains the first diagnostic option in the diagnosis of otologic disease.

This is an easy-to-consult book for residents and specialists, featuring brilliant diagnostic images from the newest generation of endoscopic otoscopes. Written by a renowned team of experts with 30 years of experience, this book helps readers obtain proficiency in otoscopy and in the interpretation of findings. Readers will learn what clinical consequences the diagnoses may have through case examples and treatment suggestions.

Key Features:

– Richly illustrated with over 1000 mostly full-color photographs and many radiological studies
– Shows a vast range of common and rare pathologies that can be visualized and assessed via endo-otoscopy
– Juxtaposes, when appropriate, the clinical picture, radiological diagnosis, and intraoperative findings with the endo-otoscopic findings of the patient
– In each chapter, a surgical summary lists various approaches that may be used to optimally plan treatment of the patient
– A special final chapter covers the assessment of postsurgical findings as seen in otoscopy, so as to distinguish between normal healing and changes that may require further intervention

Color Atlas of Endo-Otoscopy, produced with the support of Mario Sanna Foundation, is certain to become a valuable tool for all physicians involved in the care of patients with ear ailments.



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The Religion of Chiropractic : Populist Healing From the American Heartland

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Jul 082018

Chiropractic is by far the most common form of alternative medicine in the United States today, but its fascinating origins stretch back to the battles between science and religion in the nineteenth century. At the center of the story are chiropractic’s colorful founders, D. D. Palmer and his son, B. J. Palmer, of Davenport, Iowa, where in 1897 they established the Palmer College of Chiropractic. Holly Folk shows how the Palmers’ system depicted chiropractic as a conduit for both material and spiritualized versions of a ‘vital principle,’ reflecting popular contemporary therapies and nineteenth-century metaphysical beliefs, including the idea that the spine was home to occult forces.

The creation of chiropractic, and other Progressive-era versions of alternative medicine, happened at a time when the relationship between science and religion took on an urgent, increasingly competitive tinge. Many remarkable people, including the Palmers, undertook highly personal reinterpretations of their physical and spiritual worlds. In this context, Folk reframes alternative medicine and spirituality as a type of populist intellectual culture in which ideologies about the body comprise a highly appealing form of cultural resistance



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Ageless Brain: Think Faster, Remember More, and Stay Sharper by Lowering Your Brain Age

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Jul 072018

Breakthrough research has revealed that through living a brain-healthy lifestyle, we can reduce our “brain age” to improve memory, hone sharpness, and reduce health risks as we age.

It’s normal for the brain to short-circuit every now and then—you put your keys in the fridge, or can’t find the pair of glasses on top of your head. But what if there was a way to eat, exercise, and live that could eliminate these “senior moments?” Ageless Brain offers a plan to sharpen your memories and mind so that at 40, you have the quick, agile brain you had at 30. Based on groundbreaking scientific research, this plan is filled with brain-healthy foods, exercises, and little ways you can positively impact your most vital organ every day by de-stressing, adjusting your attitude, and constantly interacting with the world through play.

Scientists have discovered that the human brain continually generates new neurons—forging new pathways and connections in our minds—well into old age, as long as we pursue brain-healthy lifestyles from what we eat and how much we sleep, to how we exercise and handle stress. Exercising and nourishing our brains just like we do any other ailing organ encourages this growth—improving not only our mental fitness but also our physical fitness as a side effect.

With Ageless Brain, you will:
• Discover the 10 Commandments of an ageless brain
• Reduce key risk-factors for Alzheimer’s
• Identify and avoid brain poisons lurking in food, medicines, and home
• Learn to play and engage your brain more in everyday life
• Drop unsafe levels of blood pressure, cholesterol, and sugar—as well as belly fat
• Keep your brain nourished with 45 recipes



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Women’s Health: Medical Masterclass Questions and Explanatory Answers, Pt. 1: A Practical Guide for Health Professionals

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Jul 072018

This is a highly practical symptom-based manual of common women’s conditions. The patient-centred approach provides invaluable guidance on diagnosis, treatment and further investigation. Conditions are grouped as menstrual, hormonal, sexual, breast, urinary, pregnancy, or weight related, and within these areas each symptom is listed alphabetically for ease of reference. A helpful summary of each condition is included where possible to provide an overview, in non-technical language, for the patient. Concise and easy-to read, it is the ideal ready reference for any busy healthcare professional, especially doctors and nurses in primary care hospital emergency departments. ‘Despite brilliant advances in science, women’s health needs are still mainly focused around their unique reproductive role: contraception, unplanned pregnancy, pregnancy, infertility, the loss of fertility, body image and self esteem. I wanted to bring together information that could be used across these and other areas where women seek health advice: general practice, accident and emergency, etc. in a simple quick reference format.’ – Sarah Bekaert, in the Introduction.
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The Identity of the History of Science and Medicine (Variorum Collected Studies)

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Jul 052018

In these essays, Andrew Cunningham is concerned with issues of identity – what was the identity of topics, disciplines, arguments, diseases in the past, and whether they are identical with (more usually, how they are not identical with) topics, disciplines, arguments or diseases in the present. Historians usually tend to assume such continuous identities of present attitudes and activities with past ones, and rarely question them; the contention here is that this gives us a false image of the very things in the past that we went to look for.
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Colitis: A Practical Approach to Colon and Ileum Biopsy Interpretation, Second Edition

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Jul 042018

This revised and updated second edition explains how to analyze endoscopic mucosal biopsies of the ileum and colon. As in the first edition, the diagnosis and follow up of colitis in general and inflammatory bowel diseases in particular is covered and this edition also includes new chapters on ileitis and optimal biopsy procedures. The basic lesions are described using multiple drawings together with an explanatory text and endoscopic and histological photographs. A review of various differential diagnostic issues and types of colitis is also included.
Colitis: A Practical Approach to Colon and Ileum Biopsy Interpretation is aimed at general pathologists and pathologists in training and also gastroenterologists to help them understand how a precise diagnosis can be reached.




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Complementary and Alternative Medicine Information for Teens, Third Edition

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Jul 042018

Complementary And Alternative Medicine Information For Teens, Third Edition provides updated information about complementary and alternative medicine (CAM) systems, therapies, and practices, including various whole medical systems, manipulative practices, and movement therapies. Mind- body medicine, biologically based practices, energy medicine, and creative arts therapies are also discussed. A special section describes CAM therapies intended to help patients with specific diseases and conditions, such as cancer, diabetes, asthma, irritable bowel syndrome, and attention deficit hyperactivity disorder (ADHD). The book concludes with information about CAM clinical trials, suggestions for further reading, and a directory of CAM resources.

This book is divided into parts and chapters. Parts focus on broad areas of interest; chapters are devoted to single topics within a part.

Part One: Introduction To Complementary And Alternative Medicine defines CAM, provides statistics on CAM use in the United States, and describes how to evaluate web-based CAM information. It includes suggestions for selecting a CAM practitioner and offers tips for talking with a conventional health care provider about the possibility of pursuing CAM therapies.

Part Two: Whole Medical Systems explains systems of medicine that were built upon theories and practices that developed separately, and often independently, from the standard approach to medicine used among physicians in Western nations. These include traditional Chinese medicine, Ayurvedic medicine, homeopathy, and others.

Part Three: Manipulative Practices And Movement Therapies describes procedures based on the theory that different types of body repositioning can have an effect on health and well-being. Chiropractic medicine, kinesiology, massage therapy, Rolfing structural integration, and Feldenkrais method are among the techniques explained.

Part Four: Mind-Body Medicine discusses therapies that rely on focus and relaxation. These include biofeedback, meditation, hypnotherapy, aromatherapy, and guided imagery. Qigong, tai chi, and yoga are also included, and spirituality as a form of CAM therapy is addressed.

Part Five: Biologically Based Practices provides facts about nutrition and health, dietary and antioxidant supplements, herbal medicine, and botanical products—including one of the most controversial: marijuana. It also explains biologically based practices, such as oral probiotics, apitherapy, Gonzalez Regimen, and the Gerson therapy. In addition, specialized diets (such as raw food, macrobiotic, and detox diets) are discussed.

Part Six: Energy Medicine describes practices purported to induce healing by manipulating the body’s life force. These include acupuncture, which has been studied extensively related to its role in pain management and nausea relief, and others about which less is known, such as magnet therapy, therapeutic touch, reiki, and crystal therapies.

Part Seven: Creative Arts Therapies discusses how art, color, and music therapies can affect health in a positive way.

Part Eight: CAM Treatments For Cancer And Other Diseases And Conditions offers information about the types of complementary health therapies that are used most frequently for cancer, pain management, asthma, diabetes, irritable bowel syndrome, attention deficit hyperactivity disorder (ADHD), posttraumatic stress disorder (PTSD) and other health concerns.

Part Nine: If You Need More Information includes facts about finding CAM clinical trials. It also provides suggestions for additional reading and a directory of organizations able to provide further materials about CAM therapies and practices.



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The Doctor’s Handbook: Part 2

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Jul 042018

Many doctors do not receive training early in their careers on the broad range of non-clinical aspects of their work, and confront day-to-day issues for which initial medical education has failed to prepare them. Experienced doctors and consultants can also experience a similar lack of accessible reference material on these aspects of their role and for the non-clinical training of their juniors. This book and its companion volume The Doctor’s Handbook Part 1: managing your role beyond clinical medicine, have been written to address these and other needs. Previously published as The Specialist Registrar and New Consultant Handbook, these completely revised and reconfigured volumes reflect the changing everyday work of specialist trainees, registrars and consultants.
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