Hemostasis and Thrombosis: Basic Principles and Clinical Practice

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Feb 012019
 

Since publication of the First Edition in 1982, Hemostasis and Thrombosis has established itself as the pre-eminent book in the field of coagulation disorders. No other book is as inclusive in scope, with coverage of the field from the standpoint of both basic scientists and clinicians.

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Therapeutic Protein and Peptide Formulation and Delivery

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Feb 012019
 

Content: Developing pharmaceutical protein formulations : assumptions and analytical tools / Zahra Shahrokh — The pharmaceutical development of insulin : historical perspectives and future directions / Henry R. Costantino, Stanley Liauw, Samir Mitragotri, Robert Langer, Alexander M. Klibanov, and Victoria Sluzky — Stability of the dipeptide aspartame in solids and solutions / Leonard N. Bell — Mechanisms of methionine oxidation in peptides / Christian Schöneich, Fang Zhao, Jian Yang, and Brian L. Miller — A discussion of limitations on the use of polymers for stabilization of proteins during the freezing portion of lyophilization / David M. Barbieri, Martin C. Heller, Theodore W. Randolph, and John F. Carpenter — Phase separation and crystallization of components in frozen solutions : effect of molecular compatibility between solutes / Ken-ichi Izutsu, Sumie Yoshioka, and Shigeo Kojima — In situ formation of polymer matrices for localized drug delivery / Jennifer L. West — Transdermal delivery of macromolecules : recent advances by modification of skin’s barrier properties / Mark R. Prausnitz — Amino acid derived polymers for use in controlled delivery systems of peptides / S. Brocchini, D.M. Schachter, and J. Kohn — Analysis of the solution behavior of protein pharmaceuticals by laser light scattering photometry / Gay-May Wu, David Hummel, and Alan Herman — Applications of ultraviolet absorption spectroscopy to the analysis of biopharmaceuticals / Henryk Mach, Gautam Sanyal, David B. Volkin, and C. Russell Middaugh — Surfactant-stabilized protein formulations : a review of protein-surfactant interactions and novel analytical methodologies / LaToya S. Jones, Narendra B. Bam, and Theodore W. Randolph.
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Antinutrients and Phytochemicals in Food

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Feb 012019
 

Content: Beneficial health effects and drawbacks of antinutrients and phytochemicals in foods : an overview / Fereidoon Shahidi — Protease and [alpha]-amylase inhibitors of higher plants / John R. Whitaker — Plant lectins : properties, nutritional significance, and function / Irvin E. Liener — Antinutritional and allergenic proteins / H. Frøkiær, T.M.R. Jørgensen, A. Rosendal, M.C. Tonsgaard, and V. Barkholt — Potato polyphenols : role in the plant and in the diet / Mendel Friedman — Potato glycoalkaloids : chemical, analytical, and biochemical perspectives / S.J. Jadhav, S.E. Lutz, G. Mazza, and D.K. Salunkhe — Biological activities of potato glycoalkaloids / Leslie C. Plhak and Peter Sporns — [Alpha]-galactosides of sucrose in foods : composition, flatulence-causing effects, and removal / Marian Naczk, Ryszard Amarowicz, and Fereidoon Shahidi — Glucosinolates in Brassica oilseeds: processing effects and extraction / Fereidoon Shahidi, James K. Daun, and Douglas R. DeClercq — Cyanogenic glycosides of flaxseeds / Fereidoon Shahidi and P.K.J.P.D. Wanasundara — Nutritional implications of canola condensed tannins / Marian Naczk and Fereidoon Shahidi — Methods for determination of condensed and hydrolyzable tannins / Ann E. Hagerman, Yan Zhao, and Sarah Johnson — Lawsone : phenolic of henna and its potential use in protein-rich foods and staining / Rashda Ali and Syed Asad Sayeed — Anticarcinogenic activities of polyphenols in foods and herbs / Ken-ichi Miyamoto, Tsugiya Murayama, Takashi Yoshida, Tsutomu Hatano, and Takuo Okuda — Chemiluminescence of catechins and soybean saponins in the presence of active oxygen species / Kazuyoshi Okubo, Yumiko Yoshiki, Kiharu Igarashi, and Kazuhiko Yotsuhashi — Phytoestrogens and lignans: effects on reproduction and chronic disease / Sharon E. Rickard and Lilian U. Thompson — Interactions and biological effects of phytic acid / Sharon E. Rickard and Lilian U. Thompson — Anticarcinogenic effects of saponins and phytosterols / A.V. Rao and R. Koratkar.
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Rational Drug Design. Novel Methodology and Practical Applications

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Feb 012019
 

Content: Overview of rational drug design / M. Rami Reddy and Abby L. Parrill — Conformational and energetic aspects of receptor-ligand recognition / J.D. Hirst, B. Dominy, Z. Guo, M. Vieth, and C.L. Brooks — New free energy calculation methods for structure-based drug design and prediction of protein stability / Lu Wang, Mats A.L. Eriksson, Jed Pitera, and Peter A. Kollman — Binding evaluation using the finite difference solution to the linearized Poisson-Boltzmann equation and solvation entropy correction / Jian Shen — SmoG, a ligand design method based on knowledge-based parametrization of a solvent reorganization model / Robert S. DeWitte and Eugene I. Shakhnovich — The evaluation of multi-body dynamics for studying ligand-protein interactions : using MBO(N)D to probe the unbinding pathways of Cbz-Val-Phe-Phe-Val-Cbz from the active site of HIV-1 protease / Donovan Chin, David N. Haney, Katya Delak, Hon M. Chun, and Carlos E. Padilla — Calculation of relative hydration free energy differences for heteroaromatic compounds : use in the design of AMP deaminase inhibitors / Mark D. Erion and M. Rami Reddy — New tools for rational drug design / Gregory D. Hawkins, Jiabo Li, Tianhai (Tony) Zhu, Candee C. Chambers, David J. Giesen, Daniel A. Liotard, Christopher J. Cramer, and Donald G. Truhlar — Rational Approaches to inhibition of human osteoclast cathepsin K and treatment of osteoporosis / Sherin S. Abdel-Meguid, Baoguang Zhao, Ward W. Smith, Cheryl A. Hanson, Judith LaLonde, Thomas Carr, Karla D’Alessio, Michael S. McQueney, H.-J. Oh, Scott K. Thompson, Daniel F. Veber, and Dennis S. Yamashita — Building a hypothesis for nucleotide transport inhibitors / K. Raghavan, Scott D. Kahn, and John K. Buolamwini — Unified pharmacophoric model for cannabinoids and aminoalkylindoles derived from molecular superimposition of CB₁ cannabinoid receptor agonists CP55244 and WIN55212-2 / Joong-Youn Shim, Elizabeth R. Collantes, William J. Welsh, and Allyn C. Howlett — Structure-based design of novel conformationally restricted HIV protease inhibitors / B.G. Rao, C.T. Baker, J.T. Court, D.D. Deininger, J.P. Griffith, E.E. Kim, J.L. Kim, B. Li, S. Pazhanisamy, F.G. Salituro, W.C. Schairer, and R.D. Tung — “New tricks for an old dog” : development and application of novel QSAR methods for rational design of combinatorial chemical libraries and database mining / A. Tropsha, S.J. Cho, and W. Zheng — Molecular hologram QSAR / Trevor W. Heritage and David R. Lowis — Adapting structure-based drug design in the paradigm of combinatorial chemistry and high-throughput screening : an overview and new examples with important caveats for newcomers to combinatorial library design using pharmacophore models or multiple copy simultaneous search fragments / Arup K. Ghose, Veharkad N. Viswanadhan, and John J. Wendoloski — The basic shape topology of protein interfaces / John Lawton, Melanie Tudor, and W. Todd Wipke — Evolutionary algorithms in computer-aided molecular design : a review of current applications and a look to the future / David E. Clark — Further development of a genetic algorithm for ligand docking and its application to screening combinatorial libraries / Gareth Jones, Peter Willett, Robert C. Glen, Andrew R. Leach, and Robin Taylor — Reduced dimensionality in ligand-protein structure prediction : covalent inhibitors of serine proteases and design of site-directed combinatorial libraries / Daniel K. Gehlhaar, Djamal Bouzida, and Paul A. Rejto — Development and validation of the EVA descriptor for QSAR studies / David B. Turner, Peter Willett, Allan M. Ferguson, and Trevor W. Heritage — PRO_ANALOG, automated analog building according to principles of medicinal chemistry / Richard G.A. Bone, Michael A. Firth, Richard A. Sykes, Christopher W. Murray, and Jin Li — Is rational design good for anything? / Donald B. Boyd.
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Anthracycline Antibiotics. New Analogues, Methods of Delivery, and Mechanisms of Action

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Jan 312019
 

Content: Unresolved structure-activity relationships in anthracycline analogue development / Edward M. Acton — Non-cross-resistant anthracyclines with reduced basicity and increased stability of the glycosidic bond / Waldemar Priebe, Piotr Skibicki, Oscar Varela, Nouri Neamati, Marcos Sznaidman, Krzysztof Dziewiszek, Grzegorz Grynkiewicz, Derek Horton, Yiyu Zou, Yi-He Ling, and Roman Perez-Soler — Fluorinated anthracyclinones and their glycosylated products / Antonio Guidi, Franca Canfarini, Alessandro Giolitti, Franco Pasqui, Vittorio Pestellini, and Federico Arcamone — Semisynthetic rhodomycins and anthracycline prodrugs / Cenek Kolar, Klaus Bosslet, Jörg Czech, Manfred Gerken, Peter Hermentin, Dieter Hoffmann, and Hans-Harold Sedlacek — Synthetic options for reversal of anthracycline resistance and cardiotoxicity / Claude Monneret, Jean-Claude Florent, Jean-Pierre Gesson, Jean-Claude Jacquesy, François Tillequin, and Michel Koch — Synthesis and biological activities of fluorinated daunorubicin and doxorubicin analogues / Tsutomu Tsuchiya and Yasushi Takagi — Redox chemistry of anthracyclines and use of oxomorpholinyl radicals / Tad H. Koch and Giorgio Gaudiano — Synthesis of anthraquinone analogues of linked anthracycline / Ping Ge and Richard A. Russell — Synthesis and study of structure-activity relationships of new classes of anthracyclines / Antonino Suarato, Francesco Angelucci, Alberto Bargiotti, Michele Caruso, Daniela Faiardi, Laura Capolongo, Cristina Geroni, Marina Ripamonti, and Maria Grandi — Molecular recognition of DNA by daunorubicin / Jonathan B. Chaires — Adducts of DNA and anthracycline antibiotics : structures, interactions, and activities / Jasmine Y.-T. Wang, Mark Chao, and Andrew H.-J. Wang — DNA topoisomerases and their inhibition by anthracyclines / Yves Pommier — Anthracycline antihelicase action : new mechanism with implications for guanosine-cytidine intercalation specificity / Nicholas R. Bachur, Robin Johnson, Fang Yu, Robert Hickey, and Linda Malkas — Membrane biophysical parameters influencing anthracycline action / Ratna Mehta and Thomas G. Burke — Signal transduction systems in doxorubicin hydrochloride mechanism of action / Paul Vichi, James Song, Jean Hess, and Thomas R. Tritton — Analysis of multidrug transporter in living cells : application to uptake and release of anthracycline derivatives by drug-resistant K562 cells / Arlette Garnier-Suillerot, Frédéric Frézard, Marie-Nicole Borrel, Elene Pereira, Jolanta Tarasiuk, and Marina Fiallo — Role of reactive-oxygen metabolism in cardiac toxicity of anthracycline antibiotics / James H. Doroshow — Amelioration of anthracycline-induced cardiotoxicity by organic chemicals / Donald T. Witiak and Eugene H. Herman — Use of drug carriers to ameliorate the therapeutic index of anthracycline antibiotics / Roman Perez-Soler, Steven Sugarman, Yiyu Zou, and Waldemar Priebe.
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Silver in healthcare : its antimicrobial efficacy and safety in use

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Jan 312019
 

A comprehensive account of the history of silver in medicine, its clinical benefits and advantages as a broad spectrum antimicrobial agent. Content: Foreword; Introduction; Silver: chemistry and biological interactions; Uptake and metabolism of silver in the human body; Silver as an antibiotic; Silver in healthcare: clinical benefits vs safety in use; Clinical use of silver in human medicine; Discussion and conclusions; Acknowledgements; References
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Structure-based Drug Discovery

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Jan 312019
 

” … In this volume a leading group of inrternational authorities consider the issues surrounding the legitimation of force from several distinct disciplinary perspectives, including political science, law, history and philosophy. In particular, they examine the underlying question of wether and how international society’s traditional norms of sovereignty and non-intervention can coexist both with the new norm of humanitarian intervention and with the new norm of humanitarian intervention and with an increasingly hegemonial (‘if not imperial’) role played by the United States. From the bookjacket.
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Structural Virology

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Jan 312019
 

“Structural Virology covers a wide range of topics and is split into three sections. The first discusses the vast biophysical methodologies used in structural virology, including sample production and purification, confocal microscopy, mass spectrometry, negative-stain and cryo-electron microscopy, X-ray crystallography and nuclear magnetic resonance spectroscopy. The second discusses the role of virus capsid protein structures in determining the functional roles required for receptor recognition, cellular entry, capsid assembly, genome packaging and mechanisms of host immune system evasion. The last section discusses therapeutic strategies based on virus protein structures, including the design of antiviral drugs and the development of viral capsids as vehicles for foreign gene delivery”–From publisher’s description.
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New frontiers in chemical biology : enabling drug discovery

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Jan 312019
 

Annotation Content: Chemical Proteomics; Chemical Genetics; Chemical Biology of Post-Translational; Modifications; Chemical Biology of Epigenetics; RNA Interference; Proteolysis Targeting; himeric Molecules (PROTACS); Antibody-Drug Conjugates; Chemologics: New Therapeutics at the Interface of Chemistry and Biology;
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Hypertension Therapy Annual 2002

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Jan 262019
 

The latest in this series of current topics in hypertension focuses on subjects which are either contentious, confusing or difficult to treat. Taking into account evidence-based data from both published clinical trials and those in progress, the contributors provide detailed yet concise chapters, with comprehensive referencing in this annual publication.
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