Polycystic Kidney Disease: Translating Mechanisms into Therapy

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Jul 142018
 

This comprehensive guide to polycystic kidney disease captures the growing knowledge of this common, potentially-fatal and hereditary disease. The first two sections of the book provide an overview of PKD gene structures, mutations and pathophysiologic mechanisms. This is followed by chapters focused on PKD’s clinical features, including renal and extrarenal manifestations, and appropriate management of patients. The final section covers current clinical trials and emerging therapies in PKD. Authored by experts in the field, this book provides the clinician and researcher with critical information on basic and translational science and clinical approaches in one concise resource.
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Revival of Shelf Acetabuloplasty

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Jul 142018
 


This book provides an up-to-date overview of shelf acetabuloplasty, a traditional procedure for acetabular dysplasia.
Originally, shelf acetabuloplasty was mainly intended for the treatment of developmental dysplasia of the hip (DDH) in children and adolescents. However, secondary osteoarthritis of the hip due to DDH is more common than primary osteoarthritis, and shelf acetabuloplasty was subsequently applied to such cases in adults. Recently, periacetabular pelvic osteotomies, such as the rotational acetabular osteotomy have established themselves and are broadly indicated as joint-preserving operations for secondary hip osteoarthritis. With the increased interest in pelvic osteotomies, the role of shelf acetabuloplasty as a reliable and safe procedure now needs to be redefined.

Each chapter was prepared by an expert in his or her field. The authors highlight the essence of the indication, discuss advanced and cutting-edge techniques, and assess the outcomes of shelf acetabuloplasty. Taken together, they provide a valuable contribution to hip surgery.

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Cerebral Ischemic Reperfusion Injuries (CIRI): Bench Research and Clinical Implications

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Jul 142018
 

This volume is focused on subjects related to cerebral ischemia and reperfusion injuries after acute stroke. All chapters are selected from the Sixth Elite Stroke meeting named Pangu Stroke Conference and written by members of world leading laboratories of stroke studies. The contents cover both clinical and bench studies, from basic components of cerebral arterial system to clinical reperfusion injury cases, from reperfusion caused programmed cell death and astrocyte activation to oxidative stress and nitric oxide after reperfusion, from extracellular matrix and inflammation to a role of diabetes after reperfusion, from small artery disorders to collateral circulation and blood pressure control after reperfusion.
Wei-Jian Jiang, Chairman of New Era Stroke Care and Research Institute of PLA Rocket Force General Hospital, Beijing, China.

Wengui Yu, Professor and Director of Comprehensive Stroke & Cerebrovascular Center, University of California, Irvine

Yan Qu, Professor and Director of Neurosurgery at the Second Affiliated Hospital of Air Force Medical University, Xi’an, China.

Zhongsong Shi, Professor of Neurosurgery at Sun Yat-sen Memorial Hospital, Sun Yat-sen University, Guangzhou, China.

Ben-yan Luo, Professor and Chair of Neurology at the First Affiliated Hospital of Zhejiang University.

John H. Zhang, Professor of Anesthesiology and Physiology at Loma Linda University School of Medicine, Loma Linda, CA, USA.

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Philosophy of Molecular Medicine : Foundational Issues in Research and Practice

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Jul 132018
 

Philosophy of Molecular Medicine: Foundational Issues in Theory and Practice aims at a systematic investigation of a number of foundational issues in the field of molecular medicine. The volume is organized around four broad modules focusing, respectively, on the following key aspects: What are the nature, scope, and limits of molecular medicine? How does it provide explanations? How does it represent and model phenomena of interest? How does it infer new knowledge from data and experiments? The essays collected here, authored by prominent scientists and philosophers of science, focus on a handful of mainstream topics in the philosophical literature, such as causation, explanation, modeling, and scientific inference. These previously unpublished contributions shed new light on these traditional topics by integrating them with problems, methods, and results from three prominent areas of contemporary biomedical science: basic research, translational and clinical research, and clinical practice.

Giovanni Boniolo (degrees in Physics and in Philosophy) is Professor of Philosophy of Science and Medical Humanities at the Universita di Ferrara, and Anna Boyksen Fellow at the Institute for Advanced Study, Technische Universitat Munchen. He has published 13 books (plus 12 books edited) and about 200 research articles.

Marco J. Nathan is Assistant Professor of Philosophy at the University of Denver. His work has been published in various philosophical and scientific venues, including Nous, Philosophy of Science, British Journal for Philosophy of Science, Nephrology Dialysis and Transplantation, Biology and Philosophy, and Synthese.

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HSP70 in Human Diseases and Disorders

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Jul 122018
 

The book HSP70 in Human Diseases and Disorders provides the most comprehensive review on contemporary knowledge on the role of HSP70 family – one of the most studied HSP – in human diseases and disorders. Using an integrative approach to expand our current understanding of HSP70 functions, the contributors provide a synopsis of novel mechanisms by which HSP70 is involved in the regulation of human diseases and disorders.
Key basic and clinical research laboratories from major universities and academic medical hospitals around the world contribute chapters that review present research activity and importantly project the field into the future. The book is a must read for medical students and residents, clinical and basic science researchers, postdoctoral fellows and graduate students in the fields of Medicine, Physiology, Clinical Trials, Biotechnology, Molecular Medicine and Pathology.

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Retinal Dystrophy Gene Atlas

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Jul 122018
 

Classically, photo atlases of retinal dystrophies have been divided into sections that describe and depict a particular retinal finding or disease, after which a differential diagnosis of potential diseases or mutated genes is provided. However, given the rapid improvement in molecular diagnostics, and the exponential increase in our understanding of the phenotypes caused by each mutated gene, the paradigm has changed. Physicians are now more interested in the variable expressivity associated with mutations in each individual gene.
Therefore, Retinal Dystrophy Gene Atlas catalogs the different phenotypes that have been reported with each mutated gene. Each section describes a gene and its known clinical phenotypes and features of disease, along with retinal photos of affected patients. Written by prominent retinal dystrophy specialists from the largest dystrophy centers worldwide, Retinal Dystrophy Gene Atlas contains more than 80 chapters, each of which describes the clinical and photographic manifestations of a specific gene. The chapters include stunning clinical color photographs of the retina, autofluorescence imaging, electrophysiologic findings, and cross-sectional imaging. Retinal Dystrophy Gene Atlas serves as a resource to aid genetic diagnosis in patients with retinal dystrophies.

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Professional Guide to Signs and Symptoms (Professional Guide Series)

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Jul 122018
 

Publisher’s Note: Products purchased from 3rd Party sellers are not guaranteed by the Publisher for quality, authenticity, or access to any online entitlements included with the product. Thoroughly updated and now in full color, the Sixth Edition of this comprehensive manual covers over 550 signs and symptoms. More than 300 of the most important signs and symptoms are organized alphabetically; each entry includes a description, emergency interventions (where appropriate), history and physical examination, causes, associated signs and symptoms, special considerations, pediatric pointers, geriatric pointers, and patient counseling. Over 500 illustrations, tables, and flowcharts are included. Appendices describe 250 less familiar signs and symptoms and provide English/Spanish translations of common signs and symptoms. This edition includes signs and symptoms of important emerging diseases.

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Clinical Breast Tomosynthesis : A Case-Based Approach

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Jul 112018
 

Digital breast tomosynthesis (DBT), popularly called ‘3D mammography’ is a state-of-the-art breast imaging technology that provides the ability to view inside the breast, layer by layer. Advantages of DBT include elimination of superimposed tissue, improved detection of otherwise hidden lesions, and significantly higher cancer detection rates compared to conventional mammography.

Although it is increasingly being implemented in imaging centers, hands-on clinical learning tools have been lacking – until now. Written by renowned breast imaging specialists, this multimedia textbook is the most definitive DBT reference available. The first section is dedicated to DBT fundamentals, including physics, reconstruction methods, acquisition parameters, and patient dose and data size considerations. The next two sections are case-based clinical practice presentations, organized by DBT screening and diagnostic components.

Key Features

– The use of 3D breast imaging to detect and differentiate malignancies from normal and benign findings
– 100 case studies include pertinent clinical information, introductory images, and findings labeled on subsequent images with BI-RADS terminology
– Full field digital mammography and/or synthetic 2D mammogram images included in all case studies mirror what is typically encountered in DBT breast-imaging programs
– Clinical pearls on navigating the technology, interpreting images, making diagnoses, and decisions regarding follow-up studies
– Accompanying online videos further elucidate the still images

This remarkable, interactive reference is a must-have for trainee and practicing radiologists and will also benefit mammography technicians. The detailed case studies and videos demonstrate the full utility of DBT as a screening and diagnostic technology in context with mammography, ultrasound, and MRI of the breast.

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Therapeutic Use of Medicinal Plants and their Extracts: Volume 2: Phytochemistry and Bioactive Compounds

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Jul 112018
 

This book starts with a general introduction to phytochemistry, followed by chapters on plant constituents, their origins and chemistry, but also discussing animal-, microorganism- and mineral-based drugs. Further chapters cover vitamins, food additives and excipients as well as xenobiotics and poisons. The book also explores the herbal approach to disease management and molecular pharmacognosy and introduces methods of qualitative and quantitative analysis of plant constituents.
Phytochemicals are classified as primary (e.g. carbohydrates, lipids, amino acid derivations, etc.) or secondary (e.g. alkaloids, terpenes and terpenoids, phenolic compounds, glycosides, etc.) metabolites according to their metabolic route of origin, chemical structure and function. A wide variety of primary and secondary phytochemicals are present in medicinal plants, some of which are active phytomedicines and some of which are pharmaceutical excipients.

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Practical Biostatistics in Translational Healthcare

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Jul 112018
 

There is an ever-increasing emphasis on evidence-based medicine that is distinguished by systematic crafting of the patient-centered research question, detailed literature searches, and careful appraisal of the resulting evidence. The consensus that ultimately emerges must then be applied in specific clinical settings, and it is to this process that translational effectiveness analysis refers. This portable and easy-to-use handbook is intended as a practical teaching guide on translational effectiveness for students and clinicians.
Specifically, it will serve as a primer on patient-centered outcomes research methodology in the health sciences and explain how to acquire and understand the fundamental data that determine which reports are valued as the “best available” evidence. It presents an accessible and readily intelligible set of principles which doctors, dentists, nurses, and insurance carriers will be able to use in the process of health care-related decision-making.

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