Fast Facts: Immuno-Oncology

 Immunology, Oncology  Comments Off on Fast Facts: Immuno-Oncology
Jun 122018
 

The treatment of cancer is being revolutionized by drugs that modulate the immune system, offering the prospect of long-term response and extended survival for many patients with advanced incurable cancer. A plethora of new drugs are being incorporated into current standards of care but many questions remain unanswered and new ones emerge about how to use these exciting new drugs to best effect. A good understanding of immune-oncology is therefore becoming increasingly important to keep up to date with this rapidly changing field.

Fast Facts: Immuno-oncology takes you from the fundamentals of immunology through to the new concepts of immunoediting and immunotherapy and likely future directions. Whether you are a practicing oncologist, oncology health professional, medical student, cancer researcher or industry professional, this book provides all you need to know about immuno-oncology, concisely summarized.

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Immune Hematology: Diagnosis and Management of Autoimmune Cytopenias

 Hematology, Immunology  Comments Off on Immune Hematology: Diagnosis and Management of Autoimmune Cytopenias
May 272018
 

This text provides a concise yet comprehensive overview of the most common autoimmune cytopenias affecting adults and children. The book is divided into four sections, each of which focuses on a major autoimmune cytopenia. The first section features background, pathophysiology, presentation, evaluation, and treatment strategies for immune thrombocytopenia (ITP), the most common cause of antibody-mediated platelet destruction. The second section reviews common forms and treatment strategies for autoimmune hemolytic anemia (AIHA), including a chapter dedicated specifically to Evans Syndrome. The third section comprehensively reviews the pathophysiology, diagnosis and current management approaches to thrombotic thrombocytopenic purpura (TTP), a potentially life-threatening autoimmune syndrome. The book concludes with a final section on autoimmune neutropenia. Each section includes a review of common underlying systemic autoimmune conditions and immune deficiency syndromes that can accompany or cause autoimmune cytopenias.

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Psychoneuroimmunology: Methods and Protocols, Second Edition

 Immunology, Neurology/Neurosurgery, Psychiatry  Comments Off on Psychoneuroimmunology: Methods and Protocols, Second Edition
May 132018
 


This fully-updated book provides systems-based methodologies and innovative technologies that can be used for solving complicated problems of complex systems. A wide range of theoretical and experimental approaches are introduced for practical applications, as the content explores the basic and novel concepts in psychoneuroimmunology (PNI), especially the relationships among stress, inflammation, and psychophysiological disorders, as well as various cutting-edge technologies and methods for PNI studies, including the utilizations of mouse models and vaccine models.
In addition, this book focuses on translational medicine by applying PNI methods in clinical practice. As part of the Methods in Molecular Biology series, the chapters seek to provide a practical, state-of-the-art, and holistic view for the translation of PNI into better preventive and personalized medical practice.
Authoritative and hands-on, Psychoneuroimmunology: Methods and Protocols, Second Edition will be of use to biomedical students and professionals at all levels who are interested in integrative studies in psychology, psychiatry, neuroscience, immunology, molecular biology, genetics, bioengineering, physiology, pathology, microbiology, systems biology, and clinical medicine.

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Case Studies in Immunology: A Clinical Companion

 Immunology  Comments Off on Case Studies in Immunology: A Clinical Companion
May 072018
 

Case Studies in Immunology, Sixth Edition, presents major topics of immunology through a selection of clinical cases that reinforce and extend the basic science. The case histories illustrate essential points about the mechanisms of immunity and describe immunological problems seen in the clinic. This new edition vividly illustrates the importance of an understanding of immunology in diagnosis and therapy. Case Studies in Immunology highlights major common disorders of immunity, including hypersensitivity types I-IV, immune deficiencies, and autoimmune disorders. Each case history is preceded by basic scientific facts essential to understanding the immunology behind the specific disorders. An end-of-case summary, questions, and discussion points conclude each case.

Case Studies in Immunology can be used as a stand-alone book, or as a clinical companion alongside Janeway’s Immunobiology, Eighth Edition. A marginal icon in Janeway’s Immunobiology provides the reader with a link to the relevant Case Study, where the science is applied in a clinical setting.

The book includes a total of 53 cases. The Sixth Edition is extensively revised and updated and includes ten new cases:

– DiGeorge Syndrome

– Hemophagocytic Lymphohistiocytosis

– Chediak-Higashi Syndrome

– Hyper IgE Syndrome

– Ataxia Telangiectasia

– Warts, Hypogammaglobulinemia, Infections, and Myelokathexis (WHIM) Syndrome

– Severe Congenital Neutropenia

– Recurrent Herpes Simplex Encephalitis

– Systemic Onset Juvenile Idiopathic Arthritis

– Crohn’s Disease

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Crossroads between Innate and Adaptive Immunity

 Immunology  Comments Off on Crossroads between Innate and Adaptive Immunity
May 032018
 

This compilation presents mini-reviews derived from work presented at the Aegean Conference: “First Crossroads between Innate and Adaptive Immunity,” which occurred in October, 2005 at the Hilton Conference Center on the island of Rhodes, Greece. The conference included sessions dedicated to host recognition of and response to pathogens, innate immune networks, antigen presentation, and adaptive immune responses, each headlined by a leading scientist.

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Auto-Immunity Attacks the Body: Autoimmune Disease

 Immunology  Comments Off on Auto-Immunity Attacks the Body: Autoimmune Disease
May 022018
 

The human body is protected in critical ways as our immune system provides protection from a broad spectrum of infections and injuries. Unfortunately, in some individuals, their immune system targets components of their own bodies, causing autoimmune disease. Many different types of autoimmune diseases exist, each presenting unique symptoms depending on the body system that is damaged.

It is not clear what triggers the progression from normal immune reactivity to autoimmune disease, though both environmental and genetic factors are thought to contribute. This book focuses on three distinct examples of autoimmune disease or reactivity: multiple sclerosis, which involves an autoimmune response against structures that support neurons, rheumatoid arthritis, resulting from autoimmune-dependent damage to joints, and organ or graft rejection, which occurs when the immune system recognizes tissues from another individual as foreign. In each case, we consider current and future issues related to disease progression, diagnosis, and treatments.

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Apr 162018
 

This book addresses important issues regarding the interaction between the nervous system, the immune system, and the digestive system. Gut flora has a profound influence on the shaping of the immune response, not only in the gastrointestinal system but also in the nervous system. Fascinatingly, manipulation of intestinal immune responses can be used to modulate neurological disease. Conversely, the nervous system and the psyche have significant effects on the functioning of the gut and liver.
After introductory chapters on the neurology, the immunology and microbiology of the gut, the effects of the gut immune system and gut flora and its manipulation on neurological disease are discussed, followed by molecular mimicry and immune tolerance in neuroimmune diseases. Additionally, several chapters deal with gastrointestinal manifestations of neurological diseases.
Neuro-Immuno-Gastroenterology is aimed at neurologists, gastroenterologists, and immunologists.

 

 

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Psychoneuroimmunology: Systems Biology Approaches to Mind-Body Medicine

 Immunology, Neurology/Neurosurgery, Psychiatry  Comments Off on Psychoneuroimmunology: Systems Biology Approaches to Mind-Body Medicine
Apr 072018
 

This book provides a comprehensive overview of the cutting-edge discoveries and the systems approaches related to the multi-disciplinary field of psychoneuroimmunology (PNI), which may provide the scientific basis for mind-body relationships, and aid in the development of personalized medicine. Specifically, the book focuses on the systems biology studies of complex mechanisms, such as stress and inflammation. There is strong evidence supporting the close relationship between stress, inflammation, and disorders including obesity, cardiovascular disease, diabetes, skin diseases, and sleep disorders. As inflammation is a critical connection among different diseases, further elucidating this connection may contribute to the findings of systemic therapeutic targets. Translational medicine is also addressed, by applying PNI approaches in clinical practice. A major challenge in current bioscience is the translation of basic scientific discoveries into better clinical outcomes. With the understanding of the translational implications of PNI, integrative interventions can be applied to modulate stress responses and to promote healthier behaviors. As an important feature of this book, a broad overview of the PNI-associated integrative interventions is provided. These interventions include nutritional supplements, meditation, and other mind-body strategies. From basic concepts to systems methodologies, from theoretical sources to clinical applications, Psychoneuroimmunology contributes to the understanding and development of PNI toward the establishment of personalized and mind-body medicine.
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Skin Diseases in the Immunosuppressed

 Dermatology, Immunology  Comments Off on Skin Diseases in the Immunosuppressed
Apr 022018
 


In this book, expert dermatologists review state of the art knowledge concerning the clinical presentation and management of cutaneous diseases that develop in immunosuppressed individuals. A major aim is to enable dermatologists to identify the specific immunosuppressant responsible for a specific adverse effect in patients receiving a complex medication regimen in the setting of transplantation.
Further, the book will help the dermatologist to distinguish the cutaneous adverse effects of antiviral agents from effects arising directly from advancing HIV disease. Recognition of the cutaneous manifestations of often less common primary immunodeficiencies will also be emphasized. A final goal is to improve patient outcomes by identifying treatment strategies for skin disease arising in the immunosuppressed state. This book will be invaluable for a broad audience, from practicing dermatologists to medical and dermatology residents.​

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The Lyme Solution: A 5-Part Plan to Fight the Inflammatory Auto-Immune Response and Beat Lyme Disease

 Immunology  Comments Off on The Lyme Solution: A 5-Part Plan to Fight the Inflammatory Auto-Immune Response and Beat Lyme Disease
Apr 012018
 

A comprehensive, natural approach to treating acute and chronic Lyme disease, from a leading naturopathic physician who has managed his symptoms for more than fifteen years.

Lyme disease is one of the fastest-growing infectious diseases in the United States, and millions of people worldwide suffer from its shape-shifting symptoms. Now, in The Lyme Solution, Dr. Darin Ingels shares his revolutionary approach to treating and healing acute and chronic Lyme. Drawing on his experience as a naturopathic physician who has treated thousands of cases, and as a patient, Ingels reveals that Lyme is an autoimmune disease as much as it is an infection. Conventional treatments too often rely on toxic doses of antibiotics that weaken your body and worsen symptoms, instead of boosting your ability to fight for your health. Including the latest research about the diagnosis and treatment of Lyme, Ingels’s uniquely holistic approach provides a path to wellness by fortifying the microbiome, enhancing the immune system, and strengthening the body’s ability to heal from within. The Lyme Solution offers a simple, five-step plan, including:

• the most effective early treatment and prevention measures to avoid contracting the disease or stop it in its tracks;
• an Immune Boosting Diet and list of herbal supplements that will increase immunity and reduce inflammation;
• guidelines for when and how to use antibiotics as an effective part of your treatment plan;
• tools to identify and eliminate conditions that mimic Lyme disease or exacerbate your symptoms.

Whether you are facing acute or chronic Lyme, or undiagnosed autoimmune symptoms, the natural, whole-body approach of The Lyme Solution will help you permanently recover your health, and reclaim your life.

 

 

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