Immune Infertility

 Immunology  Comments Off on Immune Infertility
Feb 272018
 

Infertility is defned as the inability to conceive after having unprotected intercourse for a year. Infertility is increasing worldwide and has various causes both in the male and the female partner. Immune reactions to sperm can contribute up to 2-30% of infertility.

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http://nitroflare.com/view/009AEF2095D7853/3642013783.pdf

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Regulation of Cytokine Gene Expression in Immunity and Diseases

 Immunology  Comments Off on Regulation of Cytokine Gene Expression in Immunity and Diseases
Feb 142018
 

This book explores the major cytokines, such as IL-1 and IFN-γ, with respect to the regulation of their gene expression and protein production in specific immune cell types. It discusses both healthy physiological settings and in pathological situations in which the expression of some cytokines could be dysregulated, resulting in either immunodeficiency or exacerbated inflammatory sequelae in animal models as well as in human patients. Cytokines are important regulators of immune responses that require the highly coordinated participation and communication of multiple cell types. The expression of cytokines by various producer cell types is therefore carefully regulated in response to environmental cues at multiple levels: transcription, translation and posttranslational modification. Presenting cutting-edge advances in our understanding of the regulation of cytokine expression, this book is a valuable resource for anyone involved or interested in immune regulation.

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Transanal Endoscopic Microsurgery: Principles and Techniques

 Immunology  Comments Off on Transanal Endoscopic Microsurgery: Principles and Techniques
Feb 132018
 

 

Cancer of the rectum continues to be a significant health problem in industrialized co- tries around the world. Relative 5-year survival rates in the USA for cancer of the rectum from 1995 to 2001 improved to 65%, a 15% improvement over 20 years (American Cancer Society, 2007). The reasons for this dramatic improvement include more accurate pr- perative staging, aggressive neoadjuvant therapy and improved surgical technique as well as specialty-trained surgeons. Despite advances in nonoperative techniques of radiation therapy, chemotherapy and immunotherapy, surgical extirpation continues to be the cornerstone of curative treatment of this potentially lethal disease. Radical cancer excision with total mesorectal excision has become the preferred surgical procedure for even early-stage cancers of the rectum. Over the past decade the enthusiasm for local excision (and other local treatments) has given way to persuasive (predominantly retrospective) evidence that the incidence of locoregional recurrence due to unsuspected lymphatic metastases and positive lateral margins is un- ceptably high even for stage T tumors. Vigorous attempts to find characteristics of the 1 tumor that would allow successful local treatments are ongoing.

 

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http://nitroflare.com/view/2C4D6288A1686BE/Transanal_Endoscopic_Microsurgery.pdf

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Plasma Cell Neoplasms: A Morphologic, Cytogenetic and Immunophenotypic Approach

 Immunology  Comments Off on Plasma Cell Neoplasms: A Morphologic, Cytogenetic and Immunophenotypic Approach
Feb 132018
 

 

This textbook will provide a comprehensive, state-of-the art review the field of diagnostic hematopathology as it’s applied to patients with plasma cell neoplasms. Particular emphasis will be placed on immunophenotypic data – immunohistochemistry and flow cytometry – as well as cytogenetics. We will also discuss how these ancillary data can predict prognosis and chemotherapeutic response. Plasma Cell Neoplasms will serve as a very useful resource for physicians and researchers interested in the plasma cell myeloma diagnosis, therapy, and research. It will provide a concise yet comprehensive summary of the current status of the field that will help guide patient management and stimulate investigative efforts. All chapters will be written by experts in their fields and will include the most up to date scientific and clinical information.

 

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http://nitroflare.com/view/51DC400CC87BB11/3319109170.epub

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Policy Issues in the Clinical Development and Use of Immunotherapy for Cancer Treatment

 Immunology  Comments Off on Policy Issues in the Clinical Development and Use of Immunotherapy for Cancer Treatment
Feb 112018
 

 

Immunotherapy is a form of cancer therapy that harnesses the body’s immune system to destroy cancer cells. In recent years, immunotherapies have been developed for several cancers, including advanced melanoma, lung cancer, and kidney cancer. In some patients with metastatic cancers who have not responded well to other treatments, immunotherapy treatment has resulted in complete and durable responses. Given these promising findings, it is hoped that continued immunotherapy research and development will produce better cancer treatments that improve patient outcomes.

With this promise, however, there is also recognition that the clinical and biological landscape for immunotherapies is novel and not yet well understood. For example, adverse events with immunotherapy treatment are quite different from those experienced with other types of cancer therapy. Similarly, immunotherapy dosing, therapeutic responses, and response time lines are also markedly different from other cancer therapies. To examine these challenges and explore strategies to overcome them, the National Academies of Sciences, Engineering, and Medicine held a workshop in February and March of 2016. This report summarizes the presentations and discussions from the workshop.

 

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http://nitroflare.com/view/637EC280F8619A2/Policy_Issues_in_the_Clinical_Development_and_Use_of_Immunothera.pdf

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Immunology at a Glance, 10th Edition

 Immunology  Comments Off on Immunology at a Glance, 10th Edition
Feb 102018
 

Immunology at a Glance provides a user–friendly overview of the body’s defence mechanisms. Ideal from day one of a medical, biomedical or life science course, the text begins with a basic overview of both adaptive and innate immunity, before progressing to applied immunological concepts, which look at what happens when things go wrong, and how, in clinical medicine, each body system can be affected by immunity. Each double–page spread corresponds to a typical lecture and diagrammatically summarises core concepts in immunology, through accessible schematic diagrams on left–hand pages, with key points concisely summarised on the right–hand page. There are also self–assessment essay questions so you can test your knowledge. New for this 10th edition: Thoroughly updated and reorganised chapters offer greater clarity and easier understanding for those new to the subject New chapters on cytokine receptors and ‘Immunology in the Laboratory’ A completely re–written section on autoimmunity A brand new companion website featuring self–assessment questions and PowerPoint slides of images from the book, ideal for teaching and revision at www.ataglanceseries.com/immunologyImmunology at a Glance is the ideal companion for anyone about to start a new course in immunology and will appeal to medical and biomedical science students. Perfect for exam preparation, it provides the concepts and frameworks you need to succeed in your exam.

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http://nitroflare.com/view/1C17A78E47886B0/0470673036.pdf

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Essentials of Clinical Immunology

 Immunology  Comments Off on Essentials of Clinical Immunology
Feb 082018
 

 

Essential Clinical Immunology is aimed at clinical medical students and trainee doctors, although it will also appeal to medical professionals seeking a refresher in clinical immunology.

 

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http://nitroflare.com/view/BF2F440677B4A5B/1405127619.pdf

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DNA Methylation

 Immunology, Microbiology, Statistics  Comments Off on DNA Methylation
Feb 022018
 

The structural and functional importance of the correct patterns of DNA methylation in all parts of a mammalian genome is, unfortunately, not well understood. The stability, inheritability, and developmental flexibility of these patterns all point to a major role that these patterns appear to play in determining structure and function of the genome.

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http://nitroflare.com/view/F57C8C76DFBCEF9/3540291148.pdf

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Astrovirus Research: Essential Ideas, Everyday Impacts, Future Directions

 Immunology  Comments Off on Astrovirus Research: Essential Ideas, Everyday Impacts, Future Directions
Feb 012018
 

 

Astroviruses were first identified in the feces of children in 1975. Since then, they have been found in ~ 3 to 20% of children with diarrhea. Given that serological studies have demonstrated that up to 90% of children have been exposed to at least one strain of astrovirus by age 9, the prevalence of infection may be much higher. Supporting this are studies demonstrating that astroviruses can also be isolated in a subset of asymptomatic individuals, suggesting that a proportion of infected individuals shed the virus asymptomatically or for some time after the resolution of other symptoms of infection. Asymptomatic carriers may be a major reservoir for astroviruses in the environment and could contribute to dissemination of the virus. Astroviruses are extremely stable in the environment and can be transmitted nosocomially, directly from infected individuals and potentially animals, and through contaminated food and water. Although typically an acute disease, astrovirus infection in premature infants may be associated with the development of necrotizing enterocolitis and in new-onset celiac disease in children. Immunocompromised children are even more susceptible often developing persistent infections that lead to wasting or even systemic infections associated with fatal encephalitis. In spite of its importance, little is known about astrovirus pathogenesis, molecular biology, epidemiology, or cell biology. The goal of this book is to provide the latest and most up-to-date information on this medically important and rapidly evolving group of viruses. It will include sections on the history of astroviruses and their disease in humans; information on viral replication and immune responses; new information on how astroviruses induce disease including the expression of a viral enterotoxin regulating intestinal epithelial cell tight junctions, the isolation and identification of new astrovirus genotypes in mammals including humans, and astroviruses of veterinary importance. Finally, the book will also introduce the complexity of astrovirus epidemiology and potential as an important new zoonotic disease, and its role in food-borne disease. This will be the first book of its kind and will be of great interest to microbiologists, virologists, infectious disease specialists, immunologists, pediatricians, public health and food safety experts, veterinarians, poultry industry specialists, and researchers and clinicians interested in enteritis.

 

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http://nitroflare.com/view/A7EAF96C868DB44/1461447348_Astrovirus1bst.pdf

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Immune Modulation and Anti-Inflammatory Therapy in Ocular Disorders: IOIS Guidelines

 Immunology  Comments Off on Immune Modulation and Anti-Inflammatory Therapy in Ocular Disorders: IOIS Guidelines
Jan 292018
 

 

These guidelines, compiled by a panel of clinicians and scientists with a high level of expertise, aim to provide readers with the most up-to-date and comprehensive instructions on the treatment and prevention of ocular inflammation. All of the recommendations are explicitly linked to supporting evidence and graded according to the strength of that evidence and the editors have made every effort to ensure that chapters are of a consistently high methodological quality. The guidelines for each treatment include dose and the frequency and mode of delivery. Significant side-effects of treatment are identified and distinguished from those of the disease in question. Suggestions are presented for the prevention both of the disease itself and of the treatment-related complications. In addition, likely future directions in treatment and prevention are identified. These guidelines will be of great practical value for all clinicians and clinical scientists with an interest in the subject.
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