Immunopathogenesis of HIV Infection

 Immunology, Infectious Diseases, Pathology  Comments Off on Immunopathogenesis of HIV Infection
Jan 022019
 

During the last 5 years, major advances have been made in our understanding of the pathogenesis of human immunodeficiency virus (HIV) disease and in the development of new potent antiviral agents. With regard to HIV pathogenesis, several recent observations have not only changed our perspectives of HIV disease, but have been critical for the design of therapeutic strategies. These oberservations include: 1. The delineation of the virologic and immunologic events associated with primary HIV infection. 2. The development of highly sensitive molecular techniques including polymerase chain reaction (PCR) assays for the determination of HIV RNA in plasma, together with the identification of lymphoid tissue as the primary anatomic site for HIV replication and spreading. 3. The characterization of the dynamics of HIV infection. 4. The identification of chemokines with suppressor activity on HIV replication and the discovery of co-receptor molecules for HIV entry.
GET IT FREE HERE
ALTERNATIVE LINK
Share Button

Immunoneurology

 Immunology, Neurology/Neurosurgery  Comments Off on Immunoneurology
Jan 022019
 

A considerable amount of information has been gathered in the field of immunoneurology over recent years. This knowledge about modifications in the pathways of neuroimmune diseases has enabled the development of new therapies.In this volume leading experts present the state of the art in the field, covering all aspects from basic science to the development of better therapies.
\
GET IT FREE HERE
ALTERNATIVE LINK
Share Button

Reproductive Immunology

 Immunology  Comments Off on Reproductive Immunology
Jan 012019
 

Discrimination of self from nonself is the major function of the immune system and understanding the mechanism(s) involved a main employer of immunologists. Hence, the age-old puzzle of why a fetus that contains a panel of major histocompatibility (MHC) antigens derived from its mother and its father is not rejected (spontaneously aborted) by lymphocytes from its mother who should theoretically recognize foreign MHC molecules from the father has remained of great interest. This dilemma has enticed immunologists and developmental biologists for many years. This volume was created to present the information currently on hand in this subject to the scientific public. The guest editor, Professor Lars Olding, has a long and distinguished history of contributions in this field, having been one of the main propo­ nents of the argument that lymphocytes from the fetus play an active role in this process by suppressing lymphocytes from the mother from proliferating and thereby acting as killer cells. His work has defined the phenomenon and identified suppressor molecules (factors) involved in the process. In a different but related chapter, Margareta Unander extends such observations to the clinical study of women with repeated “habitual” mIS­ carriages.

GET IT FREE HERE

http://nitroflare.com/view/B645970445CB391/3642644759_Reproductive.pdf

ALTERNATIVE LINK

https://filejoker.net/2hwgwfg7gdh2

Share Button

Symposium in Immunology IV: Allergic Diseases

 Immunology  Comments Off on Symposium in Immunology IV: Allergic Diseases
Dec 312018
 

This is the fourth of a series of Symposia in Immunology which were organized to bring important new information on the expanding field of immunology to practicing physicians interested in the field. Highly renowned basic scientists share their results with physicians conducting clinical research and those experienced in the treatment of the respective diseases. This series of symposia is planned to cover different areas of immunology and will help to close the gap between special achievements of scientists and practicing physicians.
GET IT FREE HERE
ALTERNATIVE LINK
Share Button

Dendritic Cells in Fundamental and Clinical Immunology: Volume 3

 Immunology  Comments Off on Dendritic Cells in Fundamental and Clinical Immunology: Volume 3
Dec 302018
 
These proceedings contain selected contributions from the participants to the Fourth International Symposium on Dendritic cells that was held in Venice (Lido) Italy, from Oc­ tober 5 to 10, 1996. The symposium was attended by more than 500 scientists coming from 24 different countries. Studies on dendritic cells (DC) have been greatly hampered by the difficulties in preparing sufficient cell numbers and in a reasonable pure form. At this meeting it has been shown that large quantities of DC can be generated from precursors in both mice and humans, and this possibility has enormously encouraged studies aimed to characterize DC physiology and DC-specific genes, and to employ DC therapeutically as adjuvants for im­ munization. The possibility of generating large numbers of autologous DC that can be used in the manipulation of the immune response against cancer and infectious diseases has tremendously boosted dendritic cell research and the role of DC in a number of medi­ cal areas has been heatedly discussed.
GET IT FREE HERE
ALTERNATIVE LINK
Share Button

Immunotherapy of Sarcoma

 Immunology  Comments Off on Immunotherapy of Sarcoma
Dec 272018
 

This book describes recent progress in the development of immunotherapies for advanced sarcoma, paying special attention to the potential role of manipulations of the sarcoma tumor immune microenvironment in achieving durable remissions. Readers will find a thorough overview of the state of the art in tumor immunology and immunotherapy as they relate to sarcoma. Among the topics addressed are advances in vaccine therapy; the value of adoptive transfer of cytokine-induced natural killer cells; the development of adoptive T cell strategies; and the scope for use of checkpoint inhibitors in patients with sarcoma, mirroring the tremendous breakthroughs made in other malignancies. Detailed information is provided on laboratory and clinical research, with analysis of outcomes of recent trials and identification of key challenges. There is every reason to believe that more effective and less toxic therapies for metastatic sarcoma can be attained by deepening our understanding of cancer immunology and building on the advances in immunotherapy for other solid tumors. In this context, Immunotherapy of Sarcoma will be of high interest for all medical oncologists responsible for the treatment of sarcoma patients.
GET IT FREE HERE
ALTERNATIVE LINK
Share Button

Rare Rheumatic Diseases of Immunologic Dysregulation

 Immunology, Rheumatology  Comments Off on Rare Rheumatic Diseases of Immunologic Dysregulation
Nov 162018
 

This book is a practical, user-friendly guide for diagnosing and treating patients with rare rheumatic diseases of immunologic dysregulation. Covering uncommon diseases such as IgG4-Related Disease, Castleman’s Disease, and Felty Syndrome, chapters aggregate information from case reports and anecdotal literature to create a single, comprehensive handbook for treating patients.
Each chapter provides historical perspective and epidemiology; a literature review (including research trials, translational research, historical and current case reports, and case series); pathogenesis; clinical presentation; laboratory evaluation; imaging; histopathology; treatment; and outcomes. Rare Rheumatic Diseases of Immunologic Dysregulation is an invaluable resource for rheumatologists, rheumatology fellows, and clinical immunologists to better diagnose and treat patients with rare rheumatic diseases.

GET IT FREE HERE

http://nitroflare.com/view/DF0AC3D35D5ACD2/3319991388.epub

http://nitroflare.com/view/A539F1C35E62827/3319991388.pdf

ALTERNATIVE LINK

https://filejoker.net/qwu9lrdgt2zy

https://filejoker.net/zy0zh7kprk87

Share Button

Liver Immunology: Principles and Practice

 Immunology  Comments Off on Liver Immunology: Principles and Practice
Nov 102018
 

Liver Immunology: Principles and Practice, Second Edition begins with important information about the epidemiology and mortality of liver disease worldwide. This information is followed by chapters related to basic immunology, application of liver immunology for diagnosis, and several excellent chapters that provide a solid foundation for understanding immune-mediated liver disease, including those associated with the biliary tree. A chapter on non-hepatic manifestations of immune mediated liver disease helps provide context for how these diseases affect the patient overall.  In addition, chapters discuss various discrete immunologically-mediated infectious liver disorders including those related to bacteria, parasites, and all of the classic viruses. Chapters on the traditional autoimmune liver diseases –  primary biliary cirrhosis, autoimmune hepatitis, primary sclerosing cholangitis as well as overlap syndrome – are also included. The breadth of this comprehensive second edition is highlighted by chapters on alcoholic liver disease, non-alcoholic fatty liver disease, and drug-induced liver disease, among others.  This invaluable new edition ends with a forward-looking view of future directions and how the field might meet the challenge of refractory patients.  Developed by a renowned group of authors, Liver Immunology: Principles and Practice, Second Edition will again serve as a comprehensive textbook by providing an excellent overview for this rapidly evolving field. It greatly adds to the understanding of the pathogenesis of these diseases, while also providing novel insights that can be harnessed into helping improve the care of patients afflicted with various immune-mediated diseases.  This volume will again be a must-read for clinicians at all levels, investigators and students.

GET IT FREE HERE

http://nitroflare.com/view/EF730A841D6E08E/Liver_Immunology_Principles_and_Practice.pdf

ALTERNATIVE LINK

https://filejoker.net/h2orxxgddq0j

Share Button

Human Immunodeficiency Virus Reverse Transcriptase

 Immunology  Comments Off on Human Immunodeficiency Virus Reverse Transcriptase
Oct 252018
 

The Reverse Transcriptase (RT) of Human Immunodeficiency Virus Type 1 (HIV-1) arguably ranks amongst one of the most extensively studied retroviral enzymes.

Heterologous expression and purification of HIV-1 RT in the early eighties, approval of the first nucleoside analogue RT inhibitor (NRTI) in 1987, discovery of resistance to RT inhibitors, approval of the first non-nucleoside analogue RT inhibitor (NNRTI) in 1996 and the various crystal structures of RT with and without bound substrate(s) and/or inhibitors represent only a few of the important milestones that describe the a bench-to-bedside success in the continuing effort to combat HIV-1 infection and its consequences. Nucleoside and nonnucleoside RT inhibitors remain important components in frequently used drug regimens to treat the infection. RT inhibitors also play important roles in recently validated strategies to prevent transmission of the virus.

The relevance of HIV-1 RT as a drug target has simultaneously triggered interest in basic research studies aimed at providing a more detailed understanding of interactions between proteins, nucleic acids, and small molecule ligands in general terms. In light of the ever-growing knowledge on structure and function of HIV-1 RT, this enzyme serves as a valuable “model system” in efforts to develop novel experimental tools and to explain biochemical processes. This monograph is designed to provide an overview of important aspects in past and current HIV-1 RT research, with focus on mechanistic aspects and translation of knowledge into drug discovery and development. The first section includes chapters with emphasis placed on the coordination of the RT-associated DNA polymerase and ribonuclease H (RNase H) activities. The second covers mechanisms of action and future perspectives associated with NRTIs and NNRTIs, while the third section includes chapters focusing on novel strategies to target the RT enzyme. Chapters of the final part are intended to discuss mechanisms involved in HIV variability and the development of drug resistance. We hope that these contributions will stimulate interest, and encourage research aimed at the development of novel RT inhibitors. The lack of bona fide RNase H inhibitors with potent antiviral activity provides an example for challenges and opportunities in the field.

GET IT FREE HERE

http://nitroflare.com/view/4F4DBBB570931D2/1461472903.pdf

ALTERNATIVE LINK

https://filejoker.net/5xo3nscuuqb5

Share Button

Primary Immunodeficiency Diseases: A Molecular & Cellular Approach, 2 edition

 Genetics, Immunology  Comments Off on Primary Immunodeficiency Diseases: A Molecular & Cellular Approach, 2 edition
Oct 232018
 

The second edition of Primary Immunodeficiency Diseases presents discussions of gene identification, mutation detection, and clinical and research applications for over 100 genetic immune disorders–disorders featuring an increased susceptibility to infections and, in certain conditions, an icreased rate of malignancies and autoimmune disorders.

Since the publication of the first edition, a flurry of new disease entities has been defined and new treatment regimens have been introduced, the most spectacular being successful treatment by gene therapy for two genotypes of combined immunodeficiency.

The first edition marked a historic turning point in the field of immunodeficiencies, demonstrating that many of the disorders of the immune systam could be understood at a molecular level. This new edition can proudly document the tremendous pace of progress in dissecting the complex immunologic networks responsible for protecting individuals from these disorders.

GET IT FREE HERE

http://nitroflare.com/view/B53F307206A8670/019514774X.pdf

ALTERNATIVE LINK

https://filejoker.net/x2w9f7rgnq7m

Share Button