Disseminated intravascular coagulation is a devastating syndrome characterised by the systemic activation of widespread activation of the coagulation cascade and thrombosis, which may result in severe bleeding and may lead to organ failure. Recent studies have shown that the incidence of DIC is decreasing, especially in men. Despite the improvements in health care delivery, the morbidity and mortality due to DIC remains very high. This book provides an important timely update on the clinical manifestations, important risk factors, and treatment strategies for DIC, and provides in-depth information on pathophysiological aspects and various diagnostic scores used to diagnose DIC.
This book provides a unique frame work for examining acute lung syndromes that arise from hematologic disorders or is defined by a hematologic abnormality as a key feature. Acute lung processes arising from hematologic disorders can present as life-threatening conditions, and as such, the pulmonary physician or critical care physician are often directly involved in care or called upon to provide expertise. Chapters are organized into three sections, each with an emphasis on pathogenesis and current understanding of mechanisms. The text begins with the central theme of the lungs as the direct interface between the external environment and blood, description of individual components of the hematopoietic system, their function and relevance to the lungs. The second section outlines both benign and malignant primary hematologic disorders that can lead to acute pulmonary manifestations. The final section focuses on acute lung syndromes stemming from complications of transfusion and treatment. Chapters are presented in an easy-to-access format, providing information on diagnosis, management, and outcomes. This is a valuable resource for pulmonary fellows in training, pulmonologists, critical care physicians, and physicians involved in caring for patients in the ICU.
Features: Transfusion Medicine By (author): Jeffrey McCullough
Transfusion Medicine provides a concise, clinically focused and practical approach to the field of blood banking and transfusion therapy written by international expert, Jeffrey McCullough MD.
Concise, approachable, yet comprehensive approach to the field of transfusion medicine and blood banking
Offers extensive guidance on important topics such as; donor recruitment, blood collection and storage, donor testing and clinical uses of blood components, techniques of administration of blood components, complications of transfusion, transmissible diseases, the HLA system, and many more
Provides new content on patient blood management systems, the changing indications for red cell transfusion, new transmissible disease agents, management of massive blood loss, pathogen reduced blood components, therapeutic apheresis including photopheresis, management of massive transfusion and new cellular therapies.
Discusses global blood supply and US blood supply organizations and their consolidation and reorganization
Reviews other topics of current interest, such as mitigation strategies for TRALI prevention, effects of storage of blood on adverse effects, management of massive blood loss and massive transfusion protocols pathogen inactivation, and granulocyte transfusion
This volume highlights the molecular and cellular methods used in studying Chronic Myeloid Leukimia (CML) pathogenesis and stem cell biology. Written in the highly successful Methods in Molecular Biology series format, chapters include introductions to their respective topics, lists of the necessary materials and reagents, step-by-step, readily reproducible laboratory protocols, and tips on troubleshooting and avoiding known pitfalls.
Authoritative and cutting-edge, Chronic Myeloid Leukemia: Methods and Protocols aims to ensure successful results in the further study of this vital field.
In this volume, an international team of experts in chronic myeloid leukemia share their expertise. In particular, they contribute their insights on the latest advances in understanding this disease, and the implications those developments have for its management. They explore many topics, including a review of molecular and cellular biology, discussion of conventional chemotherapy and interferon therapy, and recent developments in allografting and autografting. The reader gains not only an incisive view of the biological structure of the disease, but applications of that biology to treatment modalities. Chronic Myeloid Leukemia is ideal for oncologists and other specialists in the field.
“Pathology and Genetics of Tumours of the Haematopoietic and Lymphoid System” is the third volume in the WHO series on histological and genetic typing of human tumours. This authoritative, concise reference book provides an international standard for pathologists and oncologists and will serve as an indispensable guide for use in the design of studies monitoring response to therapy and clinical outcome.
The volume covers chronic myeloproliferative diseases, myeloplastic / myeloproliferative diseases, myelodisplastic syndromes, acute myeloid leukaemia, precursor B- and T-cell neoplasms, mature B-cell, T-cell and NK-cell neoplasms, Hodgkin lymphoma, immunodeficiency-associated lymphoproliferative disorders, histiocytic and dendritic cell neoplasms, and mastocytosis. Diagnostic criteria, pathological features, associated genetic altertions and gene expression patterns are described in a strictly disease-oriented manner. Sections on all recognized neoplasms and their variants include new ICD-O codes, incidence, age and sex distribution, location, clinical signs and symptoms, pathology, genetics, and predictive factors.