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NEW – the leading book in its field now fully updated and revised!Click here to access two FREE sample chapters!An Essential resource for all hematologists, oncologists, pathologists, pediatricians, immunologists and all others interested in this dynamic area of medicine!Why you should buy this book….Extensive coverage of subject area – from the scientific basis to the view of the futureIncludes all experimental research and clinical applicationCombined the knowledge and expertise of over 170 international specialistsClear structure and layoutOver 500 illustrations, including a colour plate section Why buy the NEW edition……New and fully revised to reflect the latest developments in this fast moving field10 new chapters, covering some of the latest developments – see below for the complete tables of content Content: Chapter 1 A History of Bone Marrow Transplantation (pages 1–8): E. Donnall ThomasChapter 2 Uses and Growth of Hematopoietic Cell Transplantation (pages 9–15): Mary M. HorowitzChapter 3 Overview of Hematopoietic Cell Transplantation Immunology (pages 16–30): Paul J. MartinChapter 4 Histocompatibility (pages 31–42): Eric Mickelson and Effie W. PetersdorfChapter 5 Functional Evolution of the Major Histocompatibility Complex (pages 43–52): Lakshmi K. GaurChapter 6 The Hematopoietic Microenvironment (pages 53–61): Claudio Brunstein and Catherine M. VerfaillieChapter 7 Molecular Aspects of Stem Cell Renewal (pages 62–68): Peter M. LansdorpChapter 8 Biology of Hematopoietic Stem and Progenitor Cells (pages 69–95): Markus G. Manz, Koichi Akashi and Irving L. WeissmanChapter 9 Expansion of Hematopoietic Stem Cells (pages 96–106): Colleen Delaney, Robert Andrews and Irwin BernsteinChapter 10 Methods for Gene Transfer: Genetic Manipulation of Hematopoietic Stem Cells (pages 107–117): Thomas Moritz and David A. WilliamsChapter 11 Clinical Trials of Gene Marking and Gene Therapy Using Hematopoietic Stem Cells (pages 118–129): Donald B. Kohn and Gay M. CrooksChapter 12 Pharmacologic Basis for High?Dose Chemotherapy (pages 130–157): James H. Doroshow and Timothy SynoldChapter 13 Preparative Regimens and Modification of Regimen?Related Toxicities (pages 158–177): William I. Bensinger and Ricardo SpielbergerChapter 14 Radiotherapeutic Principles of Hematopoietic Cell Transplantation (pages 178–197): Brenda Shank and Richard T. HoppeChapter 15 Radioimmunotherapy and Hematopoietic Cell Transplantation (pages 198–208): Dana C. Matthews and Frederick R. AppelbaumChapter 16 Pharmacology and the Use of Immunosuppressive Agents After Hematopoietic Cell Transplantation (pages 209–220): Nelson J. ChaoChapter 17 T?Cell Depletion to Prevent Graft?vs.?Host Disease (pages 221–233): Robert J. SoifferChapter 18 Documentation of Engraftment and Characterization of Chimerism Following Hematopoietic Cell Transplantation (pages 234–243): Eileen Bryant and Paul J. MartinChapter 19 Antibody Mediated Purging (pages 244–253): John G. GribbenChapter 20 Pharmacologic Purging of Bone Marrow (pages 254–257): O. Michael ColvinChapter 21 Molecular Inhibition of Gene Expression in Hematopoietic Cells (pages 258–271): Joanna B. Opalinska and Alan M. GewirtzChapter 22 The Detection and Significance of Minimal Residual Disease (pages 272–285): Jerald P. Radich and Marilyn L. SlovakChapter 23 Pathology of Hematopoietic Cell Transplantation (pages 286–299): George E. Sale, Howard M. Shulman and Robert C. HackmanChapter 24 Mechanisms of Tolerance (pages 300–323): Megan SykesChapter 25 The Experimental Basis for Hematopoietic Cell Transplantation for Autoimmune Diseases (pages 324–343): Judith A. ShizuruChapter 26 Murine Models for Graft?Vs.?Host Disease (pages 344–352): Robert Korngold and Thea M. FriedmanChapter 27 The Pathophysiology of Graft?Vs.?Host Disease (pages 353–368): James L. M. Ferrara and Joseph AntinChapter 28 Graft?Vs.?Tumor Responses (pages 369–379): Alexander FeferChapter 29 Adoptive Immunotherapy With Antigen?Specific T Cells (pages 380–404): Stanley R. Riddell and Philip D. GreenbergChapter 30 Autologous Graft?vs.?Host Disease (pages 405–413): Allan D. Hess and Richard J. JonesChapter 31 Biostatistical Methods in Hematopoietic Cell Transplantation (pages 414–433): Joyce C. NilandChapter 32 Outcomes Research in Hematopoietic Cell Transplantation (pages 434–446): Stephanie J. LeeChapter 33 The Evaluation and Counseling of Candidates for Hematopoietic Cell Transplantation (pages 447–462): Karl G. Blume and Michael D. AmylonChapter 34 Clinical and Administrative Support for Hematopoietic Cell Transplant Programs (pages 463–468): Laura L. Adams and Angela A. JohnsChapter 35 Nursing Issues in Hematopoietic Cell Transplantation (pages 469–482): Rosemary C. Ford, Judy Campbell and Juanita MadisonChapter 36 The Patient’s Perspective (pages 483–487): Susan K. StewartChapter 37 Ethical Issues in Hematopoietic Cell Transplantation (pages 488–496): David S. SnyderChapter 38 Psychosocial Issues in Hematopoietic Cell Transplantation (pages 497–506): Michael A. Andrykowski and Richard P. McquellonChapter 39 Assessment of Quality of Life in Hematopoietic Cell Transplantation Recipients (pages 507–518): Karen SyrjalaChapter 40 Sexuality After Hematopoietic Cell Transplantation (pages 519–528): D. Kathryn TierneyChapter 41 Hematopoietic Cell Procurement, Processing and Transplantation: Regulation and Accreditation (pages 529–537): Phyllis I. Warkentin, Lewis Nick and Elizabeth J. ShpallChapter 42 Hematopoietic Cell Donors (pages 538–549): Dennis L. ConferChapter 43 Cord Blood Hematopoietic Cell Transplantation (pages 550–564): Hal E. Broxmeyer and Franklin O. SmithChapter 44 In Utero Transplantation (pages 565–575): Alan W. Flake and Esmail D. ZanjaniChapter 45 Mobilization of Autologous Peripheral Blood Hematopoietic Cells for Support of High?Dose Cancer Therapy (pages 576–587): Judith Ng?Cashin and Thomas SheaChapter 46 Peripheral Blood Hematopoietic Cells for Allogeneic Transplantation (pages 588–598): Norbert SchmitzChapter 47 Cryopreservation of Hematopoietic Cells (pages 599–612): Scott D. RowleyChapter 48 Recombinant Growth Factors After Hematopoietic Cell Transplantation (pages 613–623): JuRgen Finke and Roland MertelsmannChapter 49 Hematopoietic Cell Donor Registries (pages 624–631): Jeffrey W. ChellChapter 50 Graft?vs.?Host Disease (pages 633–664): Keith M. SullivanChapter 51 Bacterial Infections (pages 665–682): John R. Wingard and Helen L. LeatherChapter 52 Fungal Infections After Hematopoietic Cell Transplantation (pages 683–700): Janice (Wes) M. Y. BrownChapter 53 Cytomegalovirus Infection (pages 701–726): John A. ZaiaChapter 54 Herpes Simplex Virus Infections (pages 727–731): James I. ItoChapter 55 Varicella?Zoster Virus Infections (pages 732–748): Ann M. ArvinChapter 56 Epstein?Barr Virus Infection (pages 749–756): Richard F. AmbinderChapter 57 Other Viral Infections After Hematopoietic Cell Transplantation (pages 757–768): Michael BoeckhChapter 58 Gastrointestinal and Hepatic Complications (pages 769–810): Simone I. Strasser and George B. McdonaldChapter 59 Neurological Complications of Hematopoietic Cell Transplantation (pages 811–823): Harry OpenshawChapter 60 Blood Group Incompatibilities and Hemolytic Complications of Hematopoietic Cell Transplantation (pages 824–832): Margaret R. O’DonnellChapter 61 Principles of Transfusion Support Before and After Hematopoietic Cell Transplantation (pages 833–852): Jeffrey McculloughChapter 62 Immunological Reconstitution Following Hematopoietic Cell Transplantation (pages 853–861): Robertson Parkman and Kenneth I. WeinbergChapter 63 Vaccination of Hematopoietic Cell Transplant Recipients (pages 862–872): Clare A. DykewiczChapter 64 Pulmonary Complications After Hematopoietic Cell Transplantation (pages 873–882): David A. HorakChapter 65 Nutritional Support of Hematopoietic Cell Recipients (pages 883–893): Sally Weisdorf?Schindele and Sarah Jane SchwarzenbergChapter 66 Pain Management (pages 894–910): Jonathan R. Gavrin and F. Peter BuckleyChapter 67 Oral Complications (pages 911–928): Mark M. Schubert, Douglas E. Peterson and Michele E. LloidChapter 68 Growth and Development After Hematopoietic Cell Transplantation (pages 929–943): Jean E. SandersChapter 69 Delayed Complications After Hematopoietic Cell Transplantation (pages 944–961): Mary E. D. Flowers and H. Joachim DeegChapter 70 Secondary Malignancies After Hematopoietic Cell Transplantation (pages 962–977): Smita Bhatia and Ravi BhatiaChapter 71 Allogeneic Hematopoietic Cell Transplantation for Aplastic Anemia (pages 979–1001): George E. Georges and Rainer StorbChapter 72 Allogeneic Transplantation for Paroxysmal Nocturnal Hemoglobinuria (pages 1002–1006): Robert P. WitherspoonChapter 73 Allogeneic Transplantation for Chronic Myeloid Leukemia (pages 1007–1017): Frederick R. AppelbaumChapter 74 Hematopoietic Cell Transplantation for Juvenile Myelomonocytic Leukemia (pages 1018–1024): Robert A. KranceChapter 75 Allogeneic Hematopoietic Cell Transplantation for Adult Patients With Acute Myeloid Leukemia (pages 1025–1039): Keith E. Stockerl?Goldstein and Karl G. BlumeChapter 76 Allogeneic Transplantation for Acute Myeloid Leukemia in Children (pages 1040–1054): David A. Margolis and James T. CasperChapter 77 Allogeneic Hematopoietic Cell Transplantation for Acute Lymphoblastic Leukemia in Adults (pages 1055–1066): Stephen J. FormanChapter 78 Allogeneic Transplantation for Acute Lymphoblastic Leukemia in Children (pages 1067–1083): Stella M. Davies, Norma K. C. Ramsay and John H. KerseyChapter 79 Allogeneic Transplantation for Myelodysplastic and Myeloproliferative Disorders (pages 1084–1095): Jeanne E. AndersonChapter 80 Allogeneic Hematopoietic Cell Transplantation for Multiple Myeloma (pages 1096–1104): David G. Maloney and Gosta GahrtonChapter 81 Allogeneic Transplantation for Lymphoma and Chronic Lymphocytic Leukemia (pages 1105–1115): Issa Khouri and Richard ChamplinChapter 82 Hematopoietic Cell Transplantation from HLA Partially Matched Related Donors (pages 1116–1131): Claudio Anasetti and Andrea VelardiChapter 83 Hematopoietic Cell Transplantation from Unrelated Donors (pages 1132–1149): Effie W. PetersdorfChapter 84 Management of Relapse After Allogeneic Transplantation (pages 1150–1163): Robert H. CollinsChapter 85 Nonmyeloablative Therapy and Hematopoietic Cell Transplantation for Hematologic Disorders (pages 1164–1176): Brenda M. Sandmaier and Rainer StorbChapter 86 Allogeneic Hematopoietic Cell Transplantation for Solid Tumors (pages 1177–1187): Richard W. Childs and Ramaprasad SrinivasanChapter 87 Autologous and Allogeneic Hematopoietic Cell Transplantation for Hodgkin’s Disease (pages 1189–1206): Philip J. Bierman and Auayporn NademaneeChapter 88 Autologous Hematopoietic Cell Transplantation for Non?Hodgkin’s Lymphoma (pages 1207–1220): Sandra J. Horning and James O. ArmitageChapter 89 Autologous Hematopoietic Cell Transplantation for Acute Myeloid Leukemia (pages 1221–1237): Anthony S. Stein and Stephen J. FormanChapter 90 Autologous Hematopoietic Cell Transplantation for Acute Lymphoblastic Leukemia (pages 1238–1249): Charles A. LinkerChapter 91 Autologous Hematopoietic Cell Transplantation for Chronic Myeloid Leukemia (pages 1250–1261): Ravi Bhatia and Philip B. McglaveChapter 92 Autologous Hematopoietic Cell Transplantation for Multiple Myeloma (pages 1262–1282): Laurence Catley and Kenneth AndersonChapter 93 Autologous Hematopoietic Cell Transplantation for AL Amyloidosis (pages 1283–1297): Raymond L. Comenzo and Morie A. GertzChapter 94 Hematopoietic Cell Transplantation for Breast Cancer (pages 1298–1307): Karen H. AntmanChapter 95 Hematopoietic Cell Transplantation in Germ Cell Tumors (pages 1308–1319): Brandon Hayes?Lattin and Craig R. NicholsChapter 96 Hematopoietic Cell Transplantation in Ovarian Carcinoma (pages 1320–1332): Patrick J. StiffChapter 97 Hematopoietic Cell Transplantation for Neuroblastoma (pages 1333–1344): Katherine K. MatthayChapter 98 Hematopoietic Cell Transplantation for Brain Tumors (pages 1345–1353): Ira J. Dunkel and Jonathan L. FinlayChapter 99 Hematopoietic Cell Transplantation for Pediatric Patients With Solid Tumors (pages 1354–1368): Allen R. Chen and Curt I. CivinChapter 100 AIDS and Hematopoietic Transplantation: HIV Infection, AIDS, Lymphoma and Gene Therapy (pages 1369–1384): John A. Zaia, J. Scott Cairns and John J. RossiChapter 101 Hematopoietic Stem Cell Transplantation for Autoimmune Diseases (pages 1385–1393): Alan Tyndall and Alois GratwohlChapter 102 Prevention and Therapy of Relapse Following Autologous Hematopoietic Cell Transplantation (pages 1394–1405): Robert S. NegrinChapter 103 Marrow Transplantation in Thalassemia (pages 1407–1416): Guido Lucarelli and Reginald A. CliftChapter 104 Hematopoietic Cell Transplantation for Sickle Cell Disease (pages 1417–1429): Mark C. WaltersChapter 105 Hematopoietic Cell Transplantation for Immunodeficiency Diseases (pages 1430–1442): Trudy N. Small, Wilhelm Friedrich and Richard J. O’ReillyChapter 106 Hematopoietic Cell Transplantation for Osteopetrosis (pages 1443–1454): Peter F. CocciaChapter 107 Hematopoietic Cell Transplantation for Storage Diseases (pages 1455–1470): Charles PetersChapter 108 Hematopoietic Cell Transplantation for Macrophage and Granulocyte Disorders (pages 1471–1482): Rajni AgarwalChapter 109 Hematopoietic Cell Transplantation for Fanconi Anemia (pages 1483–1504): John E. Wagner, Margaret L. Macmillan and Arleen D. AuerbachChapter 110 Hematopoietic Cell Transplantation in the 21st Century (pages 1505–1510): Ernest Beutler