This book offers a collection of articles on binomial chitin/chitinase from authors who have all personally contributed to the development and increased acknowledgement of this topic. The book will represents a milestone for future researchers by taking into account the known archaic function of chitinases and the new description of chitin and chitinases roles in innate immunity. This recently discovered role has likely been vital in the process of genetic selection.
Features: Used Book in Good Condition By (author): Encyclopedia Britannica
From Gregor Mendel’s first experiments with peas during the eighteenth century to the announcement of the Human Genome Project in 1998, genetics have become the key to cracking many of the scientific ideas of our age. How much do our genes determine our personalities? What makes us different from other species? What is revealed behind the controversy of genetically modified food or stem cell research? This volume is the ideal companion for students or general popular science readers who wish to know the facts behind the latest research and discoveries.
This comprehensive volume explores human genetic engineering its pre-clinical and clinical applications, current developments, and as treatment for hereditary diseases. It presents and evaluates the most recent advances in the understanding of mammalian host DNA repair mechanisms, such as double-strand break induced gene targeting and mutagenesis, the development of zinc-finger nucleases, genome editing for neuromuscular diseases, phase integrases, triplex forming oligonucleotides and peptide nucleic acids, aptamer-guided gene targeting, AAV gene editing via DSB repair, engineered nucleases and trinucleotide repeat diseases, and creation of HIV-resistant cells. The expertly authored chapters contextualize current developments within the history of genome editing while also discussing the current and potential safety concerns of this rapidly growing field.
Genome Editing: The Next Step in Gene Therapy, the latest volume in the American Society of Gene and Cell Therapy series, deftly illuminates the potential of genetic engineering technology to eradicate today’s deadliest and most prolific diseases. It is ideal reading for clinicians and researchers in genetics and immunology.
By (author): Petr Berka, Jan Rauch, Djamel Abdelkader Zighed
The healthcare industry produces a constant flow of data, creating a need for deep analysis of databases through data mining tools and techniques resulting in expanded medical research, diagnosis, and treatment.
Data Mining and Medical Knowledge Management: Cases and Applications presents case studies on applications of various modern data mining methods in several important areas of medicine, covering classical data mining methods, elaborated approaches related to mining in electroencephalogram and electrocardiogram data, and methods related to mining in genetic data. A premier resource for those involved in data mining and medical knowledge management, this book tackles ethical issues related to cost-sensitive learning in medicine and produces theoretical contributions concerning general problems of data, information, knowledge, and ontologies.
Written by a team of international experts, this book provides an authoritative overview and practical guide to the molecular biology and genetic basis of haematologic cancers including leukemia. Focusing on the importance of cytogenetics and related assays, both as diagnostic tools and as a basis for translational research, this is an invaluable guide for basic and clinical researchers with an interest in medical genetics and haemato-oncology.
The Genetic Basis of HaematologicalCancers reviews the etiology and significance of genetic and epigenetic defects that occur in malignancies of the haematopoietic system. Some of these chromosomal and molecular aberrations are well established and already embedded in clinical management, while many others have only recently come to light as a result of advances in genomic technology and functional investigation. The book includes seven chapters written by clinical and academic leaders in the field, organised according to haematological malignancy sub-type. Each chapter includes a background on disease pathology and the genetic abnormalities most commonly associated with the condition. Authors present in-depth discussions outlining the biological significance of these lesions in pathogenesis and progression, and their use in diagnosis and monitoring response to therapy. The current or potential role of specific abnormalities as novel therapeutic targets is also discussed. There is also a full colour section containing original FISH, microarrays and immunostaining images.
Written by global experts, this book provides a modern comprehensive insight into the pharmacogenetics of treatment of major psychoses: schizophrenia, bipolar disorder and depression. The pharmacogenomics of three categories of the most important psychiatric drugs, antipsychotics, antidepressants and mood stabilizers, has been updated and reviewed.
Some promising directions and perspectives for future research in pharmacogenetics in major psychoses are indicated. They are, among others, connected with the development of new methods in molecular genetics and with linking pharmacogenetics assessment with biomarkers, including neuroimaging ones. Finally, the attempts to use pharmacogenetics of antipsychotic, antidepressant and mood-stabilizing drugs in practice are presented. New pharmacogenetic tools may greatly contribute to introducing personalized medicine into psychiatric clinical practice.
Features: Used Book in Good Condition By (author): Anja J. Karnein
In light of new biomedical technologies, such as artificial reproduction, stem cell research, genetic selection and design, the question of what we owe to future persons-and unborn life more generally-is as contested as ever. In A Theory of Unborn Life: From Abortion to Genetic Manipulation, author Anja J. Karnein provides a novel theory that shows how our commitments to persons can help us make sense of our obligations to unborn life. We should treat embryos that will develop into persons in anticipation of these persons. But how viable is this theory? Moreover, what does it mean to treat embryos in anticipation of the future persons they will develop into?
Exploring the attractiveness of this approach for Germany and the U.S. – two countries with very different legal approaches to valuing unborn life-Karnein comes to startling conclusions to some of today’s greatest ethical and legal debates. Under Karnein’s theory, abortion and stem cell research are legitimate, since embryos that do not have mothers willing to continue to assist their growth have no way of developing into persons. However, Karnein also contends that where the health of embryos is threatened by third parties or even by the women carrying them, embryos need to be treated with the same care due to the children that emerge from them. In the case of genetic manipulation, it is important to respect future persons like our contemporaries, respecting their independence as individuals as well as the way they enter this world without modification. Genetic interventions are therefore only legitimate for insuring that future persons have the necessary physical and mental endowment to lead independent lives so as to be protected from being dominated by their contemporaries. Evincing polarization and dogma, Karnein’s clean, philosophically-driven analysis provides a sound ethical foundation for the interpretation of any variety of legal dilemmas surrounding unborn life.
This superbly structured text is designed for practical ease of use. Quick and easy to read, it bridges the gap between primary literature and daily practice in this specialized field. Neuro-ophthalmology encompasses lesions of both the afferent and efferent pathways, which can result from various etiologies, including tumoral, paraneoplastic, vascular, inflammatory, infectious, or hereditary – just to name a few. This volume of Essentials in Ophthalmology is dedicated to the review of new developments in neuro-ophthalmology. It has been written by an array of authors with real expertise in the subject. The text includes all the latest developments, including those in diagnosis, physiology, investigations, and in therapeutic options.