Nov 182016

Immunonutrition: Interactions of Diet, Genetics, and Inflammation

The interaction of immune function and nutrition underlies the low-grade chronic inflammation involved in the etiology of many common obesity-associated and age-related chronic disease conditions. This close interaction is the genesis of the term immunonutrition, which represents a new interdisciplinary field of nutritional and medical research. Immunonutrition: Interactions of Diet, Genetics, and Inflammation introduces the breadth of this field, which implicates nutrition in both immune function and in the etiology, prevention, and treatment of common diseases influenced by inflammation and immune imbalance, including obesity, diabetes, heart disease, asthma, autoimmune diseases, and common forms of cancer.

The book begins by reviewing the basic mechanisms of immunity and cellular mechanisms of cytokine activation. It discusses the effects of dietary fat intake and changes in Western diet and lifestyle linked to inflammation. It also describes the interaction of genetics and environment in the modulation of immune function and inflammation, and addresses exercise and skeletal muscle as an endocrine and immune organ. The book reviews the entire spectrum of inflammation and cancer from causation to its role in tumor therapy. It examines abdominal obesity and metabolic diseases, interactions between nutrition and autoimmunity in systemic lupus erythematosus and rheumatoid arthritis, and inflammation associated with type 2 diabetes, heart disease, kidney disease, Alzheimer’s disease, and asthma.

Considering potential nutrition-based treatments, the book explores approaches for reducing abdominal obesity, anti-inflammatory effects of phytochemicals, practical strategies for increasing fruit and vegetable intake, and anti-inflammatory properties of spice phytonutrients. In addition, it explores how uninformed food choices related to fats and oils create a balance of tissue-selective signals that produce harmful health outcomes and how to restore a healthy balance.

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Nov 122016

Genotyping: Methods and Protocols (Methods in Molecular Biology)

This volume explores a broad range of different genotyping techniques. Genotyping: Methods and Protocols consists of chapters that cover numerous topics such as: an overview of multiplexed microsatellite analysis; High Resolution Melt analysis and TaqMan-based assays; in situ analysis of variants in single RNA molecules; the MassARRAY system and Molecular Inversion Probes; Pulsed Field Gel Electrophoresis, Paralogue Ratio Test, and Multiplex Ligation-Dependent Probe Amplification; long-range PCR combined with PacBio sequencing; Targeted Locus Amplification; Multilocus Sequence Typing and rapid SNP detection with pyrosequencing; and genotyping-by-sequencing for plant analysis. Finally, the volume concludes with a summary of pertinent points to describe genetic variation. Written in the highly successful Methods in Molecular Biology series format, chapters include introductions to their respective topics, lists of the necessary materials and reagents, step-by-step, readily reproducible laboratory protocols, and tips on troubleshooting and avoiding known pitfalls.

Thorough and practical, Genotyping: Methods and Protocols is a valuable resource for anyone interested in learning more about the diverse field of genotyping.

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Nov 122016

The Encyclopedia of Elder Care (Facts on File Library of Health & Living)

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By (author): Joseph Kandel M.D., Christine Adamec

This encyclopedia serves as a comprehensive and objective guide for students and professionals alike. In more than 250 entries, the book relies on statistical information to paint a picture of aging and its key issues in the United States and around the globe.
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Nov 102016

JIMD Reports, Volume 30

JIMD Reports publishes case and short research reports in the area of inherited metabolic disorders. Case reports highlight some unusual or previously unrecorded feature relevant to the disorder, or serve as an important reminder of clinical or biochemical features of a Mendelian disorder.
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Nov 032016

Atlas of Preimplantation Genetic Diagnosis, Third Edition (Encyclopedia of Visual Medicine Series)

By (author): Anver Kuliev, Svetlana Rechitsky, Oleg Verlinsky

Based on one leading center’s experience with over 100,000 cases, the new edition of this extensively illustrated atlas provides a detailed manual for procedures and techniques in preimplantation genetic diagnosis. New topics in this edition include de novo mutations, diseases with genetic predisposition, and HLA typing. The book provides insight from authors who are pioneers in some of the procedures described.

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Nov 022016

Rethinking Reprogenetics: Enhancing Ethical Analyses of Reprogenetic Technologies

By (author): Inmaculada de Melo-Martin

Reprogenetic technologies, which combine the power of reproductive techniques with the tools of genetic science and technology, promise prospective parents a remarkable degree of control to pick and choose the likely characteristics of their offspring. Not only can they select embryos with or without particular genetically-related diseases and disabilities but also choose embryos with non-disease related traits such as sex.

Prominent authors such as Agar, Buchanan, DeGrazia, Green, Harris, Robertson, Savulescu, and Silver have flocked to the banner of reprogenetics. For them, increased reproductive choice and reduced suffering through the elimination of genetic disease and disability are just the first step. They advocate use of these technologies to create beings who enjoy longer and healthier lives, possess greater intellectual capacities, and are capable of more refined emotional experiences. Indeed, Harris and Savulescu in particular take reprogenetic technologies to be so valuable to human beings that they have insisted that their use is not only morally permissible but morally required.

Rethinking Reprogenetics challenges this mainstream view with a contextualised, gender-attentive philosophical perspective. De Melo-Martín demonstrates that you do not have to be a Luddite, social conservative, or religious zealot to resist the siren song of reprogenetics. Pointing out the flawed nature of the arguments put forward by the technologies’ proponents, Rethinking Reprogenetics reveals the problematic nature of the assumptions underpinning current evaluations of these technologies and offers a framework for a more critical and sceptical assessment.

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Oct 312016

Molecular Medicine: Genomics to Personalized Healthcare

By (author): R. J. Trent

Molecular Medicine is the application of genetic or DNA-based knowledge to the modern practice of medicine. Molecular Medicine, 4e, provides contemporary insights into how the genetic revolution is influencing medical thinking and practice. The new edition includes recent changes in personalized medicine, new growth in omics and direct-to-consumer DNA testing, while focusing on advances in the Human Genome project and implications of the advances in clinical medicine. Graduate students, researchers, clinicians and allied health professionals will appreciate the background history and clinical application of up-to-date molecular advances.

  • Extensively revised to incorporate the results of the Human Genome Project, it provides the latest developments in molecular medicine
  • The only book in Molecular Medicine to reach its fourth edition
  • Identifies current practice as well as future developments
  • Presents extensive tables, well presented figures and resources for further understanding
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Oct 252016

Gene Therapy Protocols (Methods in Molecular Medicine)

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In this fully updated and revised 2nd edition of Gene Therapy Protocols, leading experts from academic and industrial laboratories around the world detail their most effective viral and nonviral methods of gene transfer, as well as discuss their applications in different organ systems. These methods range from those in which new molecular conjugates show great promise for targeting gene transfer and regulating transgene expression, to those used in such exciting applications as the delivery of therapeutic proteins, vaccination, and tissue engineering. Up-to-date and highly practical, Gene Therapy Protocols, 2nd Edition, offers a rich compilation of the revolutionary advances that have recently occurred in gene transfer technology, with each article providing proven the step-by-step laboratory procedures that enable its successful therapeutic application.
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Oct 252016

HOX Gene Expression (Molecular Biology Intelligence Unit)

Features: ISBN13: 9780387689890, Condition: New, Notes: 100% Satisfaction Guarantee. Tracking provided on most orders. Buy with Confidence! Millions of books sold!
By (author): Spyros Papageorgiou

Hox Gene Expression starts with the amazing discovery of the homeobox twenty-three years ago and follows the exciting path thereafter of a series of breakthroughs in Genetics, Development and Evolution. It deals with homeotic genes, their evolution, structure, normal and abnormal function. Researchers and graduate students in biology and medicine will benefit from this integrated overview of Hox gene activities.

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Sep 272016

Functional Plasticity and Genetic Variation, Volume 91: Insights into the Neurobiology of Alcoholism (International Review of Neurobiology)

The brain, arguably the most complex organ of the body, plays a critical role in the predisposition, expression and maintenance of alcoholism.  This adds an unmatched degree of complexity in the search for the causes of alcoholism as compared to other illnesses with a genetic component such as type 2 diabetes.The brain orchestrates such processes as cognition, emotion, mood, learning and motivation through circuits in a network of different brain regions which communicate through synaptic connections.  Synaptic communication is spatially and temporally mediated by the cellular expression of genes, regulation of the expression of these genes and the functioning of the corresponding proteins.  However, how individual differences, influenced by genetic variation, affect synaptic communication and functional plasticity of alcohol-sensitive brain circuits is not well understood.  This is a burgeoning research area which holds promise for psychiatric research in general (Akil et al., 2010; Koob and Volkow, 2010). Over the last several decades a great deal of work has examined the consequences of alcohol exposure on the plasticity of the brain.  A parallel line of work has begun to uncover the genes and genetic variation that might contribute to or mediate alcohol-induced plasticity. This volume contains critical reviews of the current state of these research domains: Functional plasticity and genetic variation; which we hope will offer novel insights into the neurobiology of alcoholism.
The first chapter discusses the newly identified role of microRNAs in the neuronal mechanisms of alcohol tolerance and the potential involvement in other alcohol phenotypes.  The use of Drosophila in understanding the genetics of alcohol-related phenotypes is then reviewed followed by a chapter on neural plasticity, human genetics and risk for alcohol dependence.  In the next two chapters approaches to understanding alcoholism via examination of gene expression are reviewed.  The first of these (Farris et al.,) is a comprehensive review of the powerful use of expression genetics to study the neurobiology of alcoholism, while the second (Bjork et al.,) highlights the need to examine gene expression alterations in clinically relevant animal models of alcoholism. The final chapter in this section reviews progress in the identification of genes for alcohol phenotypes in mice.  The second half of the volume changes gears with chapters focusing on the cellular and synaptic consequences of alcohol-induced plasticity in specific brain regions.  The first of these reviews glutamate plasticity in the amygdala followed by a chapter on ethanol action on dopamine neurons of the ventral tegmental area.The prefrontal cortex and striatum are covered in the next two chapters. Finally, synaptic plasticity at Purkinje neurons in the cerebellum is reviewed.   
In summary, this volume has highlighted two important areas in alcohol research which have significantly increased our understanding and given us an appreciation for the complexity of alcoholism as a brain disease.We hope this volume will begin to stimulate some convergence between these areas.    
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