Features: Used Book in Good Condition By (author): Joseph Kandel M.D., Christine Adamec
This encyclopedia serves as a comprehensive and objective guide for students and professionals alike. In more than 250 entries, the book relies on statistical information to paint a picture of aging and its key issues in the United States and around the globe.
JIMD Reports publishes case and short research reports in the area of inherited metabolic disorders. Case reports highlight some unusual or previously unrecorded feature relevant to the disorder, or serve as an important reminder of clinical or biochemical features of a Mendelian disorder.
By (author): Anver Kuliev, Svetlana Rechitsky, Oleg Verlinsky
Based on one leading center’s experience with over 100,000 cases, the new edition of this extensively illustrated atlas provides a detailed manual for procedures and techniques in preimplantation genetic diagnosis. New topics in this edition include de novo mutations, diseases with genetic predisposition, and HLA typing. The book provides insight from authors who are pioneers in some of the procedures described.
Reprogenetic technologies, which combine the power of reproductive techniques with the tools of genetic science and technology, promise prospective parents a remarkable degree of control to pick and choose the likely characteristics of their offspring. Not only can they select embryos with or without particular genetically-related diseases and disabilities but also choose embryos with non-disease related traits such as sex.
Prominent authors such as Agar, Buchanan, DeGrazia, Green, Harris, Robertson, Savulescu, and Silver have flocked to the banner of reprogenetics. For them, increased reproductive choice and reduced suffering through the elimination of genetic disease and disability are just the first step. They advocate use of these technologies to create beings who enjoy longer and healthier lives, possess greater intellectual capacities, and are capable of more refined emotional experiences. Indeed, Harris and Savulescu in particular take reprogenetic technologies to be so valuable to human beings that they have insisted that their use is not only morally permissible but morally required.
Rethinking Reprogenetics challenges this mainstream view with a contextualised, gender-attentive philosophical perspective. De Melo-Martín demonstrates that you do not have to be a Luddite, social conservative, or religious zealot to resist the siren song of reprogenetics. Pointing out the flawed nature of the arguments put forward by the technologies’ proponents, Rethinking Reprogenetics reveals the problematic nature of the assumptions underpinning current evaluations of these technologies and offers a framework for a more critical and sceptical assessment.
Molecular Medicine is the application of genetic or DNA-based knowledge to the modern practice of medicine. Molecular Medicine, 4e, provides contemporary insights into how the genetic revolution is influencing medical thinking and practice. The new edition includes recent changes in personalized medicine, new growth in omics and direct-to-consumer DNA testing, while focusing on advances in the Human Genome project and implications of the advances in clinical medicine. Graduate students, researchers, clinicians and allied health professionals will appreciate the background history and clinical application of up-to-date molecular advances.
Extensively revised to incorporate the results of the Human Genome Project, it provides the latest developments in molecular medicine
The only book in Molecular Medicine to reach its fourth edition
Identifies current practice as well as future developments
Presents extensive tables, well presented figures and resources for further understanding
In this fully updated and revised 2nd edition of Gene Therapy Protocols, leading experts from academic and industrial laboratories around the world detail their most effective viral and nonviral methods of gene transfer, as well as discuss their applications in different organ systems. These methods range from those in which new molecular conjugates show great promise for targeting gene transfer and regulating transgene expression, to those used in such exciting applications as the delivery of therapeutic proteins, vaccination, and tissue engineering. Up-to-date and highly practical, Gene Therapy Protocols, 2nd Edition, offers a rich compilation of the revolutionary advances that have recently occurred in gene transfer technology, with each article providing proven the step-by-step laboratory procedures that enable its successful therapeutic application.
Features: ISBN13: 9780387689890, Condition: New, Notes: 100% Satisfaction Guarantee. Tracking provided on most orders. Buy with Confidence! Millions of books sold! By (author): Spyros Papageorgiou
Hox Gene Expression starts with the amazing discovery of the homeobox twenty-three years ago and follows the exciting path thereafter of a series of breakthroughs in Genetics, Development and Evolution. It deals with homeotic genes, their evolution, structure, normal and abnormal function. Researchers and graduate students in biology and medicine will benefit from this integrated overview of Hox gene activities.
The brain, arguably the most complex organ of the body, plays a critical role in the predisposition, expression and maintenance of alcoholism.This adds an unmatched degree of complexity in the search for the causes of alcoholism as compared to other illnesses with a genetic component such as type 2 diabetes.The brain orchestrates such processes as cognition, emotion, mood, learning and motivation through circuits in a network of different brain regions which communicate through synaptic connections.Synaptic communication is spatially and temporally mediated by the cellular expression of genes, regulation of the expression of these genes and the functioning of the corresponding proteins.However, how individual differences, influenced by genetic variation, affect synaptic communication and functional plasticity of alcohol-sensitive brain circuits is not well understood.This is a burgeoning research area which holds promise for psychiatric research in general (Akil et al., 2010; Koob and Volkow, 2010). Over the last several decades a great deal of work has examined the consequences of alcohol exposure on the plasticity of the brain.A parallel line of work has begun to uncover the genes and genetic variation that might contribute to or mediate alcohol-induced plasticity. This volume contains critical reviews of the current state of these research domains: Functional plasticity and genetic variation; which we hope will offer novel insights into the neurobiology of alcoholism. The first chapter discusses the newly identified role of microRNAs in the neuronal mechanisms of alcohol tolerance and the potential involvement in other alcohol phenotypes.The use of Drosophila in understanding the genetics of alcohol-related phenotypes is then reviewed followed by a chapter on neural plasticity, human genetics and risk for alcohol dependence.In the next two chapters approaches to understanding alcoholism via examination of gene expression are reviewed.The first of these (Farris et al.,) is a comprehensive review of the powerful use of expression genetics to study the neurobiology of alcoholism, while the second (Bjork et al.,) highlights the need to examine gene expression alterations in clinically relevant animal models of alcoholism. The final chapter in this section reviews progress in the identification of genes for alcohol phenotypes in mice.The second half of the volume changes gears with chapters focusing on the cellular and synaptic consequences of alcohol-induced plasticity in specific brain regions.The first of these reviews glutamate plasticity in the amygdala followed by a chapter on ethanol action on dopamine neurons of the ventral tegmental area.The prefrontal cortex and striatum are covered in the next two chapters. Finally, synaptic plasticity at Purkinje neurons in the cerebellum is reviewed. In summary, this volume has highlighted two important areas in alcohol research which have significantly increased our understanding and given us an appreciation for the complexity of alcoholism as a brain disease.We hope this volume will begin to stimulate some convergence between these areas.
Opioid research is one of the multidisciplinary research areas that involve advanced techniques ranging from molecular genetics to neuropharmacology, and from behavioral neuroscience to clinical medicine. In current opioid research, it has become increasingly important to use multiple approaches at molecular, cellular, and system levels for investigations on a specific opio- related target system. That often requires understanding and applying cro- field techniques and methods for the success of one’s research projects. Through its broad spectrum of coverage, Opioid Research: Methods and Protocols provides a comprehensive collection of major laboratory methods and protocols in current opioid research, covering topics from molecular and genetic techniques to behavioral analyses of animal models, and then to clinical practice. It will serve as a convenient reference book from which those involved in opioid research will learn or perfect the necessary cross-field techniques. The detailed methods and protocols described in Opioid Research: Methods and Protocols have each been successfully applied in current opioid research. Part I provides molecular techniques for the cloning and expression of opioid receptors, and for the quantitative characterization of their signaling pathways. Part II includes primary techniques for mapping the distributions and detecting the expression levels of opioid receptors, opioid peptides, and their messages in brain tissues and in individual cells. Part III deals with methods for creating in vitro receptor models and in vivo animal models to study opioid functions. Part IV describes practical applications of opioids in clinical medicine for the treatment of pain and opioid addiction.
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Informed by many years of genetics teaching and research expertise, authors Mark Sanders and John Bowman use an integrated approach that helps contextualize three core challenges of learning genetics: solving problems, understanding evolution, and understanding the connection between traditional genetics models and more modern approaches.
Genetic Analysis: An Integrated Approach, 2/e is extensively updated with relevant, cutting-edge coverage of modern genetics and is supported by MasteringGenetics, the most widely-used homework and assessment program in genetics. Featuring expanded assignment options, MasteringGenetics complements the book’s problem-solving approach, engages students, and improves results by helping them master concepts and problem-solving skills.