Oct 312016
 

Molecular Medicine: Genomics to Personalized Healthcare


By (author): R. J. Trent

Molecular Medicine is the application of genetic or DNA-based knowledge to the modern practice of medicine. Molecular Medicine, 4e, provides contemporary insights into how the genetic revolution is influencing medical thinking and practice. The new edition includes recent changes in personalized medicine, new growth in omics and direct-to-consumer DNA testing, while focusing on advances in the Human Genome project and implications of the advances in clinical medicine. Graduate students, researchers, clinicians and allied health professionals will appreciate the background history and clinical application of up-to-date molecular advances.

  • Extensively revised to incorporate the results of the Human Genome Project, it provides the latest developments in molecular medicine
  • The only book in Molecular Medicine to reach its fourth edition
  • Identifies current practice as well as future developments
  • Presents extensive tables, well presented figures and resources for further understanding
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Oct 252016
 

Gene Therapy Protocols (Methods in Molecular Medicine)


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In this fully updated and revised 2nd edition of Gene Therapy Protocols, leading experts from academic and industrial laboratories around the world detail their most effective viral and nonviral methods of gene transfer, as well as discuss their applications in different organ systems. These methods range from those in which new molecular conjugates show great promise for targeting gene transfer and regulating transgene expression, to those used in such exciting applications as the delivery of therapeutic proteins, vaccination, and tissue engineering. Up-to-date and highly practical, Gene Therapy Protocols, 2nd Edition, offers a rich compilation of the revolutionary advances that have recently occurred in gene transfer technology, with each article providing proven the step-by-step laboratory procedures that enable its successful therapeutic application.
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Oct 252016
 

HOX Gene Expression (Molecular Biology Intelligence Unit)


Features: ISBN13: 9780387689890, Condition: New, Notes: 100% Satisfaction Guarantee. Tracking provided on most orders. Buy with Confidence! Millions of books sold!
By (author): Spyros Papageorgiou

Hox Gene Expression starts with the amazing discovery of the homeobox twenty-three years ago and follows the exciting path thereafter of a series of breakthroughs in Genetics, Development and Evolution. It deals with homeotic genes, their evolution, structure, normal and abnormal function. Researchers and graduate students in biology and medicine will benefit from this integrated overview of Hox gene activities.

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Sep 272016
 

Functional Plasticity and Genetic Variation, Volume 91: Insights into the Neurobiology of Alcoholism (International Review of Neurobiology)


The brain, arguably the most complex organ of the body, plays a critical role in the predisposition, expression and maintenance of alcoholism.  This adds an unmatched degree of complexity in the search for the causes of alcoholism as compared to other illnesses with a genetic component such as type 2 diabetes.The brain orchestrates such processes as cognition, emotion, mood, learning and motivation through circuits in a network of different brain regions which communicate through synaptic connections.  Synaptic communication is spatially and temporally mediated by the cellular expression of genes, regulation of the expression of these genes and the functioning of the corresponding proteins.  However, how individual differences, influenced by genetic variation, affect synaptic communication and functional plasticity of alcohol-sensitive brain circuits is not well understood.  This is a burgeoning research area which holds promise for psychiatric research in general (Akil et al., 2010; Koob and Volkow, 2010). Over the last several decades a great deal of work has examined the consequences of alcohol exposure on the plasticity of the brain.  A parallel line of work has begun to uncover the genes and genetic variation that might contribute to or mediate alcohol-induced plasticity. This volume contains critical reviews of the current state of these research domains: Functional plasticity and genetic variation; which we hope will offer novel insights into the neurobiology of alcoholism.
The first chapter discusses the newly identified role of microRNAs in the neuronal mechanisms of alcohol tolerance and the potential involvement in other alcohol phenotypes.  The use of Drosophila in understanding the genetics of alcohol-related phenotypes is then reviewed followed by a chapter on neural plasticity, human genetics and risk for alcohol dependence.  In the next two chapters approaches to understanding alcoholism via examination of gene expression are reviewed.  The first of these (Farris et al.,) is a comprehensive review of the powerful use of expression genetics to study the neurobiology of alcoholism, while the second (Bjork et al.,) highlights the need to examine gene expression alterations in clinically relevant animal models of alcoholism. The final chapter in this section reviews progress in the identification of genes for alcohol phenotypes in mice.  The second half of the volume changes gears with chapters focusing on the cellular and synaptic consequences of alcohol-induced plasticity in specific brain regions.  The first of these reviews glutamate plasticity in the amygdala followed by a chapter on ethanol action on dopamine neurons of the ventral tegmental area.The prefrontal cortex and striatum are covered in the next two chapters. Finally, synaptic plasticity at Purkinje neurons in the cerebellum is reviewed.   
In summary, this volume has highlighted two important areas in alcohol research which have significantly increased our understanding and given us an appreciation for the complexity of alcoholism as a brain disease.We hope this volume will begin to stimulate some convergence between these areas.    
 
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Sep 262016
 

Opioid Research: Methods and Protocols (Methods in Molecular Medicine)


Opioid research is one of the multidisciplinary research areas that involve advanced techniques ranging from molecular genetics to neuropharmacology, and from behavioral neuroscience to clinical medicine. In current opioid research, it has become increasingly important to use multiple approaches at molecular, cellular, and system levels for investigations on a specific opio- related target system. That often requires understanding and applying cro- field techniques and methods for the success of one’s research projects. Through its broad spectrum of coverage, Opioid Research: Methods and Protocols provides a comprehensive collection of major laboratory methods and protocols in current opioid research, covering topics from molecular and genetic techniques to behavioral analyses of animal models, and then to clinical practice. It will serve as a convenient reference book from which those involved in opioid research will learn or perfect the necessary cross-field techniques. The detailed methods and protocols described in Opioid Research: Methods and Protocols have each been successfully applied in current opioid research. Part I provides molecular techniques for the cloning and expression of opioid receptors, and for the quantitative characterization of their signaling pathways. Part II includes primary techniques for mapping the distributions and detecting the expression levels of opioid receptors, opioid peptides, and their messages in brain tissues and in individual cells. Part III deals with methods for creating in vitro receptor models and in vivo animal models to study opioid functions. Part IV describes practical applications of opioids in clinical medicine for the treatment of pain and opioid addiction.
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Sep 082016
 

Genetic Analysis: An Integrated Approach (2nd Edition)


By (author): Mark F. Sanders, John L. Bowman

&>ALERT: Before you purchase, check with your instructor or review your course syllabus to ensure that you select the correct ISBN. Several versions of Pearson’s MyLab & Mastering products exist for each title, including customized versions for individual schools, and registrations are not transferable. In addition, you may need a CourseID, provided by your instructor, to register for and use Pearson’s MyLab & Mastering products.

 

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Informed by many years of genetics teaching and research expertise, authors Mark Sanders and John Bowman use an integrated approach that helps contextualize three core challenges of learning genetics: solving problems, understanding evolution, and understanding the connection between traditional genetics models and more modern approaches.

 

Genetic Analysis: An Integrated Approach, 2/e is extensively updated with relevant, cutting-edge coverage of modern genetics and is supported by MasteringGenetics, the most widely-used homework and assessment program in genetics. Featuring expanded assignment options, MasteringGenetics complements the book’s problem-solving approach, engages students, and improves results by helping them master concepts and problem-solving skills.

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Aug 312016
 

Pathology and Genetics: Tumours of Haematopoietic and Lymphoid Tissues (World Health Organization Classification of Tumours)


By (author): Elaine Sarkin Jaffe

“Pathology and Genetics of Tumours of the Haematopoietic and Lymphoid System” is the third volume in the WHO series on histological and genetic typing of human tumours. This authoritative, concise reference book provides an international standard for pathologists and oncologists and will serve as an indispensable guide for use in the design of studies monitoring response to therapy and clinical outcome.

The volume covers chronic myeloproliferative diseases, myeloplastic / myeloproliferative diseases, myelodisplastic syndromes, acute myeloid leukaemia, precursor B- and T-cell neoplasms, mature B-cell, T-cell and NK-cell neoplasms, Hodgkin lymphoma, immunodeficiency-associated lymphoproliferative disorders, histiocytic and dendritic cell neoplasms, and mastocytosis. Diagnostic criteria, pathological features, associated genetic altertions and gene expression patterns are described in a strictly disease-oriented manner. Sections on all recognized neoplasms and their variants include new ICD-O codes, incidence, age and sex distribution, location, clinical signs and symptoms, pathology, genetics, and predictive factors.

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Aug 312016
 

Pathology and Genetics of Tumours of Endocrine Organs (IARC WHO Classification of Tumours)


By (author): The International Agency for Research on Cancer

This volume covers tumors of the pituary, the thyroid and parathyroid, the adrenal gland, the endocrine pancreas, and inherited tumor syndromes. Each entity is extensively discussed with information on clinicopathological, epidemiological, immunophenotypic and genetic aspects of these diseases. The book is an authoritative, concise reference, prepared by 150 authors from 20 countries. It contains more than 500 color photographs, numerous, MRIs, ultrasound images, CT scans, charts and more than 2900 references.

This book is in the series commonly referred to as the “Blue Book” series.
Pathology and Genetics of Tumors of Endocrine Organs

Contributors::Dr. Susan L. Abbondanzo, Dr. GoranAkerstrom, Dr. Lars Andreas Akslen, Dr. Jorgo Albores-Saavedra, Dr. Micheala A. Aldred, Dr. Katsuyki Aozasa, Dr. Andrew Arnold, Dr. Sylvia L. Asa, Dr. Zubair W. Baloch, Dr. Ariel L. Barkan, Dr. Bora E. Baysal, Dr. Gazanfer Belge, Dr. Xavier Bertagna, Dr. Wojciech Biernat, Dr. John P. Bilezikian, Dr. Scott Boerner, Dr. Tom Bohling, Dr. Lennart Bondeson, Dr. Ceasare Bordi, Dr. Gianni Bussolati, Dr. Blake Cady, Dr. Alain Calender, Dr. Jose Cameselle-Teijeiro, Dr. Carlo Capella, Dr. Maria Luise Carcanciu, Dr. J. Aiden Carney, Dr. Paul Caruso, Dr. Barbara Centeno, Dr. John K. C. Chan, Dr. Liang Cheng, Dr. Runjan Chetty, Dr. Wah Cheuk, Dr. George P. Chrousos, Dr. Orlo H. Clark, Dr. Randall D. Craver, Dr. Yogeshwar Dayal, Dr. Ronald R. De Krijger, Dr. Ronald A. Delellis, Dr. Kari-Michael Derwahl, Dr. David M. Dorfman, Carrlo Melvin Drovdlic, Dr. Damian E. Dupuy, Dr. Charles Eng, Dr. Vincenzo Eusebi, Dr. Harry L. Evans, Dr. D. Gareth Evans, Dr. Sheroon Ezzat, Dr. James A. Fagin, Dr. William Clay Faquin, Dr. Nadir R. Farid, Dr. P. Farid, Dr. William E. Farrell, Dr. William Foulkes, Dr. Kaarle O. Franssila, Dr. Robert F. Gagel, Dr. Kim R. Geisinger, Dr. Ronald A. Ghossein, Dr. Oliver Gimm, Dr. Thomas J. Giordano, Dr. Dario Guiffrida, Dr. Lara Grimelius, Dr. Gerardo Esteban Guiter, Dr. Philip I. Haigh, Dr. Hector Ruben Harach, Dr. Ian D. Hay, Dr. Philipp U. Heitz, Dr. Geoffrey N. Hendy, Dr. Mitsauyoshi Hirokawa, Dr. Eva Horvath, Dr. Leonard B. Kahn, Dr. Klaus Kaserer, Dr. Akiro Kawashima, Dr. Noriko Kimura, Dr. Yutaka Kitamura, Dr. Paul Kleihues, Dr. David S. Klimstra, Dr. Richard T. Kloos, Dr. Gunter Kloppel, Dr. Christian A. Koch, Dr. Paul Komminoth, Dr. George Kontogeorgos, Dr. Kalman Kovacs, Dr. Todd Gerard Kroll, Dr. Alfred King Yin Lam, Dr. Catherine Larsson, Dr. Juen Lechago, Dr. E. Paul Lindell, Dr. Virginia Livolsi, Dr. Ricardo V. Lloyd, Dr. M. Beatriz S. Lopes, Dr. Eamonn R. Maher, Dr. Xavier Matias-Guiu, Dr. Ernest L. Mazzaferri, Dr. Anne Marie McNicol, Dr. L. Jeffrey Medeiros, Dr. Maria J. Merino, Dr. Jeffrey F. Moley, Dr. Carl D. Morrison, Dr. Lois Mulligan, Dr. Katherine L. Nathanson, Dr. Hartmut P. Neumann, Dr. Yuri E. Nikiforov, Dr. Shiro Noguchi, Dr. Vania Nose, Professor Kjell Oberg, Dr. Nelson G. Ordonez, Dr. Josep Oriola, Dr. Robert Yoshiyuki Osamura, Dr. Mauro Papotti, Dr. Ralf Paschke, Dr. Juha Peltonen, Dr. Aurel Perren, Dr. Silvana Pilotti, Dr. Karl H. Plate, Dr. Hartmut M. Rabes, Dr. Guido Rindi, Dr. Fedorico Roncaroli, Dr. Sergio Vidal Ruibal, Dr. Wolfgang Saeger, Dr. Atsuhiko Sakamoto, Dr. Toshiaki Sano, Dr. Massimo Santoro, Dr. Hironobu Sasano, Dr. Bernd W. Scheithauer, Dr. Katherine A. Schneider, Dr. Arthur B. Schneider, Dr. Jean Yves Scoazec, Dr. Elizabeth Shane, Dr. Leslie H. Sobin, Dr. Manual Sobrinho-Simoes, Dr. Ernst J. M. Speel, Dr. Constantine A. Stratakis, Dr. Hugo Studer, Dr. Iwao Sugitani, Dr. Saul Suster, Mr. Kevin M. Sweet, Dr. Giovanni Tallini, Dr. Bin Tean The, Dr. Lester D.R. Thompson, Dr. Arthur S. Tischler, Dr. Jacqueline Trouillas, Dr. Thomas M. Ulbright, Dr. M. Volante, Dr. Petri.E. Voutilainen, Dr. Robert Watson, Dr. A. L. Weber, Dr. Loe S. Weinstein, Dr. Lawrence M. Weiss, Dr. Bruce M. Wenig, Dr. E. Dilwyn Williams, Dr. Shozo Yamada, Dr. William F. Young JR, Dr. Mauren Zakowski

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Aug 312016
 

Pathology and Genetics of Tumours of the Lung, Pleura, Thymus and Heart (IARC WHO Classification of Tumours)


Features: Used Book in Good Condition
By (author): The International Agency for Research on Cancer

This book is an authoritative, concise reference on the histological and genetic typing of tumors of the lung, pleura, thymus and heart. Prepared by 200 authors from 25 countries, it contains more than 670 color photographs, numerous MRIs, ultrasound images, CT scans, charts and approximately 2200 references. Diagnostic criteria, pathological features and associated genetic alterations are described in a strictly disease-oriented manner. Sections on all recognized neoplasms and their variants include new ICD-O codes, incidence, age and sex distribution, location, clinical signs and symptoms, pathology, genetics and predictive factors.

This book is in the series commonly referred to as the “Blue Book” series.
Pathology and Genetics of Tumors of the Lung, Pleura, Thymus and Heart

Contributors:Dr. Seena Aisner, Dr. Philip A. Araoz,
Dr. Hisao Asamura, Dr. Marie-Christine Aubry, Dr. P.M. Banks, Dr. Mattia Barbareschi, Dr. Helmut Bartsch, Dr. Craig T. Basson, Dr. Audrey S. Baur, Dr. Mary Beth Beasley, Dr. Paolo Boffetta, Dr. Carsten Bokemeyer, Dr. Félix Bonilla, Dr. Michael Borowitz, Dr. Christian Brambilla, Dr. Elizabeth Brambilla, Dr. Allen Burke, Dr. Louise M. Burke, Dr. Jagdish W. Butany, Dr. Philip T. Cagle, Dr. Federico Caligaris-Cappio, Dr. Vera Luiza Capelozzi, Dr. Neil Caporaso, Dr. Frédérique Capron, Dr. J.A. Carney, Dr. Lina Carvalho, Dr. Alexander C.L. Chan, Dr. John K.C. Chan, Dr. Gang Chen, Dr. Roberto Chiarle, Dr. Prem Chopra, Dr. Andrew Churg, Dr. Thomas V. Colby, Dr. Bryan Corrin, Dr. David H. Dail, Dr. Daphne De Jong, Dr. Vincent T. De Montpreville, Dr. Louis P. Dehner, Dr. Mojgan, Devouassouxshisheboran, Dr. T. Dijkhuizen, Dr. Elizabeth Dulmet, Dr. Alberto Edwards, Dr. Tadaaki Eimoto, Dr. Dina El-Demellawy, Dr. Peter Engel, Dr. Emilio Alvarez Fernandez, Dr. Sydney D. Finkelstein, Dr. Jonathan A. Fletcher, Dr. Douglas B. Flieder, Dr. Armando E. Fraire, Dr. Wilbur A. Franklin, Dr. Teri J. Franks, Dr. Christopher A. French, Dr. Takeshi Fujii, Dr. Masashi Fukayama, Dr. Anthony Gal, Dr. Françoise Galateau-Salle, Dr. Jeffrey Galvin, Dr. Philippe Gaulard, Dr. Adi F. Gazdar, Dr. Kim Geisinger, Dr. Tal Geva, Dr. Allen R. Gibbs, Dr. Ulrich Göbel, Dr. José Javier Gomez-Roman, Dr. John R. Gosney, Dr. Daniel Grandmougin, Dr. Thomas Grogan, Dr. Donald G. Guinee, Dr. Pierre Hainaut, Dr. Samuel P. Hammar, Dr. Samir M. Hanash, Dr. Curtis C. Harris, Dr. Nancy Lee Harris, Dr. J.T. Hartmann, Dr. Philip S. Hasleton, Dr. Aage Haugen, Dr. Douglas W. Henderson, Dr. Kristin Henry, Dr. Claudia I. Henschke, Dr. Elizabeth P. Henske, Dr. Hiroaki Hiraga, Dr. Fred R. Hirsch, Dr. Tsunekazu Hishima, Dr. Masashi Horimoto, Dr. Hiroshi Inagaki, Dr. Kouki Inai, Dr. Masayoshi Inoue, Dr. Elaine S. Jaffe, Dr. Nirmala A. Jambhekar, Dr. Jin Jen, Dr. S.X. Jiang, Dr. Hiroyuki Kamiya, Dr. Toshiaki Kawai, Dr. Keith M. Kerr, Dr. Andras Khoor, Dr. Hitoshi Kitamura, Dr. Paul Kleihues, Dr. Michael N. Koss, Dr. Tseng-Tong Kuo, Dr. Michael O. Kurrer, Dr. R. Hubert Laeng, Dr. Stephen Lam, Dr. Sylvie Lantuejoul, Dr. Kevin Leslie, Dr. Emilio Maiers, Dr. Toshiaki Manabe, Dr. Alberto M. Marchevsky, Dr. Mirella Marino, Dr. Alexander Marx, Dr. Yoshihiro Matsuno, Dr. Frank Mayer, Dr. Fabio Menestrina, Dr. Matthew Meyerson, Dr. Markku Miettinen, Dr. Thierry J. Molina, Dr. Peter Möller, Dr. Cesar Moran, Dr. Kiyoshi Mukai, Dr. Klaus-Michael Müller, Dr. H. Konrad Müller-Hermelink, Dr. Shigeo Nakamura, Dr. Yukio Nakatani, Dr. Oscar Nappi, Dr. Andrew G. Nicholson, Dr. Siobhan Nicholson, Dr. Seiji Niho, Dr. Masayuki Noguchi, Dr. N. Paul Ohori, Dr. Attilio Orazi, Dr.Nelson G. Ordonez, Dr. Giorgio Palestro, Dr. D. Maxwell Parkin, Dr. Chandrakant R. Patel, Dr. Elizabeth J. Perlman, Dr. Iver Petersen, Dr. Nicolai Petrovitchev, Dr. Stefano A. Pileri, Dr. Helmut Popper, Dr. Marlene Praet, Dr. Robert Pugatch, Dr. D.J. Radford, Dr. Ramón Rami-Porta, Dr. Angela Risch, Dr. Victor Roggli, Dr. Giovanni Rolla, Dr. Juan Rosai, Dr. Andreas Rosenwald, Dr. Giulio Rossi, Dr. Thomas Rüdiger, Dr. Valerie Rusch, Dr. Jonathan M. Samet, Dr. Rodolfo Saracci, Dr. Dominik T. Schneider, Dr Shehata, Dr. Mary N. Sheppard, Dr. Peter G. Shields, Dr. Yukio Shimosato, Dr. Ivy Sng, Dr. Leslie H. Sobin, Dr. Gabriella Sozzi, Dr. Philipp Ströbel, Dr. Saul Suster, Dr. Takashi Takahashi Dr. Hisashi Tateyama, Dr. Henry Tazelaar, Dr. Joseph R. Testa, Dr. Françoise Thivolet-Bejui, Dr. F.B. Thunnissen, Dr. Joseph F. Tomashefski, Jr., Dr. Marketa Tomsova, Dr. G. Tornambene, Dr. William D. Travis, Dr. S. Tsukamoto, Dr. Jerzy E. Tyczynski, Dr. James W. Vardiman, Dr. Madeline F. Vazquez, Dr. John P. Veinot, Dr. Jean-Michel Vignaud, Dr. Paolo Vineis, Dr. Renu Virmani, Dr. Peter Vogt, Dr. Paul Walter, Dr. R.A. Warnke, Dr. Go Watanabe, Dr. Hans Weill, Dr. William H. Westra, Dr. Mark R. Wick, Dr. Ignacio I. Wistuba, Dr. Eunhee S. Yi, Dr. Tomoyuki Yokose, Dr. Satoshi Yoneda, Dr. Samuel A. Yousem, Dr. Andreas Zettl, Dr. Paul J. Zhang, Dr. Robert Loire, Dr. Akira Masaoka.

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Aug 192016
 

GMO Sapiens: The Life-Changing Science of Designer Babies


By (author): Paul Knoepfler

Genetically modified organisms (GMOs) including plants and foods are a hot topic of debate today, but soon related technology could go much further and literally change what it means to be human. Scientists are on the verge of being able to create people who are GMOs.
Should they do it? Could we become a healthier and ‘better’ species or might eugenics go viral leading to a real, new world of genetic dystopia? GMO Sapiens tackles such questions by taking a fresh look at the cutting-edge biotech discoveries that have made genetically modified people possible.
Bioengineering, genomics, synthetic biology, and stem cells are changing sci-fi into reality before our eyes. This book will capture your imagination with its clear, approachable writing style. It will draw you into the fascinating discussion of the life-changing science of human genetic modification.
Readership: Undergraduate biology majors, graduate biology majors, non-experts interested in GMOs, biologists and teenagers interested in cloning and human genetic modification.

***2015 Indiefab Science Book of the Year Bronze Winner***
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