Category Archives: Genetics

Molecular Genetics of Mycobacteria Edition 2

A comprehensive collection of perspectives by experts in mycobacterial molecular biology
Mycobacterium tuberculosis causes one in four avoidable deaths in the developing world and kills more adults than malaria, AIDS, and all tropical diseases combined. Tuberculosis was named a global health emergency by the World Health Organization, a distinction no other disease has received. Although the study of mycobacterial genetics has expanded dramatically, with new investigations into mycobacterial growth, replication, metabolism, physiology, drug susceptibility, and virulence, most of the problems in tuberculosis control that existed in 2000 remain today.
Advances in our understanding of mycobacterial genetics have been reflected in exciting recent developments. New diagnostic approaches can identify drug resistance within a few hours, promising new drugs are progressing through the pipeline and into the clinic, and a range of newly developed vaccines are being evaluated. It is an exciting time as the fruits of 30 years of intensive genetic investigation are finally beginning to emerge.
Written by leading experts in the field, Molecular Genetics of Mycobacteria, Second Edition,
Discusses key areas of current research in mycobacterial genetics
Explains the genetics of the physiology, metabolism, and drug sensitivities of M. tuberculosis
Presents genetic approaches for manipulating M. tuberculosis
This book is an invaluable resource for anyone interested in the molecular genetics and molecular biology of mycobacteria.

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Peripheral Nerve Disorders: Pathology and Genetics

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Peripheral Nerve Disorders: Pathology and Genetics is a definitive, clinically-oriented guide to the pathology of peripheral nerve disorders.

These commonly seen neurological challenges have many causes and accurate diagnosis is often necessary via pathological analysis. New techniques exploiting molecular biological knowledge have opened up new vistas to understanding the pathogenesis of these disorders, and hence, their effective management.

This new title takes a disease-oriented approach to understanding the pathology of these conditions. It combines classical and contemporary techniques to enable practitioners in neurology and neuropathology to better understand the disease processes underlying patients’ presentations and to formulate appropriate management plans.

Peripheral Nerve Disorders: Pathology and Genetics is a valuable resource for neurologists, neuropathologists, pathologists, neurobiologists and geneticists.

Jean-Michel Vallat, Neurology Laboratory, National Referral Center for Rare Peripheral Neuropathies, University Hospital, Limoges, France

Joachim Weis, Director, Institute of Neuropathology, RWTH Aachen University Hospital, JARA Brain Translational Medicine, Aachen, Germany

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Moments of Truth in Genetic Medicine

Genetic research increasingly dominates medical thought and practice in the United States and in many other industrialized nations. Susan Lindee’s original study explores the institutions, disciplines, and ideas that initiated the reconfiguration of genetic medicine from a marginal field in the mid-1950s to a core research frontier of biomedicine. Tracing the work of geneticists and other experts in identifying and classifying disease during the explosive period between 1950 and 1980, Lindee identifies the individual “moments of truth” that moved the field away from its eugenic past to the center of a new world view in which nearly all disease is understood to be fundamentally genetic. She suggests that these moments of truth were experienced not only by scientists but also by those who had familial, intimate, emotional knowledge of hereditary disease: patients, family members, and research subjects. Focusing on benchmarks in the fieldÑsuch as the rise of neonatal testing in the 1960s, genetic studies of unique human populations such as the Amish, the development of human cytogenetics and human behavioral genetics, and the efforts to find genes for rare diseases such as familial dysautonomiaÑshe tracks the emergence of a biomedical consensus that nearly all disease is genetic disease. Using the success of this field as a point of entry, Lindee chronicles both the production of knowledge in biomedicine and changes in the cultural meaning of the body in the late twentieth century. She suggests that scientific knowledge is a community project that is shaped directly by people in many different social and professional locations. The power to experience and report scientific truth may be much more dispersed than it sometimes appears, because people know things about their own bodies, and their knowledge has often been incorporated into the technical infrastructure of genomic medicine. Lindee’s pathbreaking study shows

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Genetic Counseling and Preventive Medicine in Post-War Bosnia

Genetic Counseling and Preventive Medicine in Post-War Bosnia offers a unique new perspective to longstanding debates on healthcare reforms in Bosnia. In this penetrating analysis, Philip C. Aka argues that twenty-five years after the ethnic war that shook Bosnia and Herzegovina to its foundations, healthcare reforms are a function of preventive medicine, defined as genetic counselling, backed by tobacco and alcohol control. At its core, the book offers a fresh examination of healthcare reforms in Bosnia set in the multidisciplinary field of bioethics, supplemented by comparative health studies, and comparative human rights.
By offering an extensive list of electronically accessible literature on healthcare accessible in the public domain, Aka delivers an exemplar of research possibilities in the Information Age.

Philip C. Aka is professor and former Dean of the Faculty of Law at the International University of Sarajevo. In spring 2020, Aka was a visiting professor at the Southern Illinois University School of Law, USA. He is the author of the award-winning book Human Rights in Nigeria’s External Relations: Building the Record of a Moral Superpower (Lexington Books, 2017).

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https://nitroflare.com/view/89B7B061945857C/9811579865.epub

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Metallochemistry of Neurodegeneration: Biological, Chemical and Genetic Aspects

Bioinorganic chemistry has a cross disciplinary approach, applying the principles of chemistry to biological systems. Metallochemistry of Neurodegeneration: Biological, Chemical and Genetic Aspects discusses the rapidly developing area of metals in the nervous system and their role in neurodegenerative disease, such as Alzheimer’s, Parkinson’s and prion diseases. Written by leading experts in their fields, each chapter combines elements of genetics, biochemistry and biological inorganic chemistry in its discussion. The book highlights the differences in pathologies of neurodegenerative diseases but also discusses the mechanistic similarities. Sections include: metal ions and prion diseases; metal ions and Alzheimer disease; manganese in brain functioning; metal involvement in Parkinson disease; Cu-Zn superoxide dismutase and familial amyotrophic lateral sclerosis. This book will appeal to both chemists and biologists at the post graduate and research level.

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Molecular Genetics of Hypertension (Human Molecular Genetics)

Molecular Genetics of Hypertension is one of the first books to consolidate the current knowledge of this expanding research area. The book considers the study and applications of molecular genetic approaches to this important disease, providing a comprehMolecular Genetics of Hypertension is one of the first books to consolidate the current knowledge of this expanding research area.

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Type 1 Diabetes Pathogenesis Genetics and Immunotherapy

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Gestational Trophoblastic Disease: Diagnostic and Molecular Genetic Pathology

In this volume Dr Hui has brought together a comprehensive overview of gestational trophoblastic disease that includes all the currently recognized entities: complete and partial hydatidiform moles, placental site trophoblastic tumor, epithelioid trophoblastic tumor, gestational choriocarcinoma, persistent gestational trophoblastic neoplasia, placental site nodule and exaggerated placental site reaction. Each entity is reviewed in detail, with emphasis on genetic background, clinical presentation, pathologic findings and ancillary studies, differential diagnosis and clinicopathological correlations.Descriptions of the pathology are supported by numerous excellent photomicrographs. Recent advances in our understanding of the genetics of gestational trophoblastic diseases are stressed. Introductory chapters cover the developmental biology of the placenta and the genetic basis of gestational trophoblastic disease, and one chapter is devoted to the molecular diagnosis of gestational trophoblastic disease. This chapter includes a review of the use of short tandem repeat (STR) genotyping which is of particular value in the diagnosis of hydatidiform moles. The final chapter covers clinical aspects of gestational trophoblastic disease, including treatment. The text throughout is current and thoroughly referenced. This book will be of great value to pathologists, community gynecologists, gynecological pathologists and medical students.

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Preimplantation Genetic Testing: Recent Advances in Reproductive Medicine

Preimplantation genetic testing (PGT) is now well established as a valuable treatment option for patients wishing to start or continue a family, for a range of indications from advanced maternal age to high risk of transmitting inherited disease. This text brings together contemporary thinking from international opinion leaders and will be an invaluable guide for practitioners in Reproductive Medicine wishing to keep pace with the latest developments and clinical data.

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Neurogenetics: A Guide for Clinicians

Progress in genetic knowledge is profoundly affecting medical practice, and no clinical specialty has more diseases associated with genetic mutations than neurology. As a more complete picture of the genes which give rise to neurological disease is obtained, trainee and practising neurologists need a guide to basic principles and the more important clinical entities with a genetic component. It is against this background that Neurogenetics: A Guide for Clinicians has been written. The book opens with coverage of genetic testing and counselling. Subsequent chapters discuss genetic factors for all the major neurological diseases, including epilepsy, Alzheimer’s disease, Parkinsonism and muscular dystrophies. No book in this field can hope to be fully up to date with the latest research; rather this work provides a framework on which to add new genetic discoveries. Neurogenetics: A Guide for Clinicians provides a synoptic overview for neurologists, medical geneticists and scientists working in the field.

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