The Heterogeneity of Cancer Metabolism

 Endocrinology/Metabolism/Diabetes Mellitus, Oncology  Comments Off on The Heterogeneity of Cancer Metabolism
Jul 122018
 

Genetic alterations in cancer, in addition to being the fundamental drivers of tumorigenesis, can give rise to a variety of metabolic adaptations that allow cancer cells to survive and proliferate in diverse tumor microenvironments. This metabolic flexibility is different from normal cellular metabolic processes and leads to heterogeneity in cancer metabolism within the same cancer type or even within the same tumor.
In this book, we delve into the complexity and diversity of cancer metabolism, and highlight how understanding the heterogeneity of cancer metabolism is fundamental to the development of effective metabolism-based therapeutic strategies. Deciphering how cancer cells utilize various nutrient resources will enable clinicians and researchers to pair specific chemotherapeutic agents with patients who are most likely to respond with positive outcomes, allowing for more cost-effective and personalized cancer therapeutic strategies.

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Jul 122018
 

Diabetes Epidemic & You is not a cliché! It is a mandate for the awakening of the “silent” millions worldwide with “normal” fasting blood sugars and undiagnosed diabetes. If you have a “normal” fasting blood sugar, You may be one of the undiagnosed millions. Yes, I do mean You.

Since Hippocrates’ time, earliest diagnosis provided the greatest opportunity for treatment and cure. This book highlights the earliest identification of type 2 diabetes by utilizing the insulin assay with the oral glucose tolerance.

My cumulative experience of 14,384 oral glucose tolerances with insulin assays established the earliest diagnosis of prediabetes and diabetes when the blood sugars were normal. Prediabetes is type 2 diabetes. The tolerances were separated according to age groups, from 3 – ­13 years to 81 – ­90+ years. Each group was further divided into normal glucose tolerances, impaired glucose tolerances, and diabetes mellitus glucose tolerances. You, upon testing by oral glucose tolerance, will be in one of these categories.

This resource of oral glucose tolerance with insulin assay is unequaled in world medical literature. The importance of early diagnosis is that the clinical pathology of diabetes mainly heart disease, high blood pressure, stroke, cataracts, erectile dysfunction, and other metabolic disorders occurs not only in those with advanced diabetes, but also in those with “normal” blood sugars.

Yes, this could happen to You! When early diagnosis is coupled with specific therapy, the Diabetes Epidemic will be arrested and then reversed. Early diagnosis is the goal of this book beginning with You.

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Jul 022018
 

The indispensable guide to all aspects of clinical care, the Oxford Handbook of Endocrinology and Diabetes has been fully revised for its third edition. Concise, practical, and packed with vital information and invaluable hands-on advice, this is the must have resource for all those managing patients with endocrine and diabetic disorders.

This unique pocket guide has been updated with new dedicated chapters on endocrine surgery, endocrinology and ageing, and obesity, as well as new topics, including intrinsic imperfections of endocrine replacement therapy, transition to adult care, and survivors of childhood cancer. Written in conjunction with the Oxford Textbook of Endocrinology and Diabetes, it covers clinical investigation and management of both common and rare conditions. Following the latest protocols and clinical guidelines it ensures readers are up-to-date with the latest clinical care and practice. Clear, concise, and easy-to-use, this handbook will ensure readers have all the information they need at their fingertips.

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Pediatric Endocrinology and Inborn Errors of Metabolism, Second Edition

 Endocrinology/Metabolism/Diabetes Mellitus, Pediatrics  Comments Off on Pediatric Endocrinology and Inborn Errors of Metabolism, Second Edition
Jul 022018
 

The acclaimed clinical guide to managing both pediatric endocrine disorders and inborn errors of metabolism

No other text so skillfully blends the disciplines of endocrinology and inborn metabolic disorders into one clinically focused, highly visual resource as Pediatric Endocrinology and Inborn Errors of Metabolism, Second Edition.

In this practical, user-friendly tutorial, a team of international contributors delivers the latest information and clinical insights clinicians need to confidently diagnose and manage pediatric patients. This full-color resource guides you through the etiology, pathophysiology, presenting signs and symptoms, diagnostic laboratory examinations, and treatments regimens of each disorder. Pediatric Endocrinology and Inborn Errors of Metabolism, Second Edition successfully balances authority and comprehensiveness with a strong clinical, practical approach that delivers an unmatched integrated discussion of the fields.

Features:

• Full-color presentation with numerous photos, illustrations, diagnostic algorithms, tables, and text boxes that summarize key concepts and assist in the decision-making process
• At-a-Glance feature beginning each disease-based chapter summarizes all the clinical information you need to differentiate between disorder sub-types in one easy-to-find place
• All-inclusive coverage encompasses the full spectrum of critical topics
• Emergency assessment and treatment chapter gives you fast, clear guidance on acute presentations of endocrine and metabolic disorders
• Chapter on newborn screening walks you through an abnormal screening result to follow-up diagnostic testing
• Complete and detailed information on all laboratory and radiographic testing used to diagnose disorders in both disciplines

If you’re in need of a clinically focused learning tool that bridges the gap between endocrinology and inborn metabolic disorders, your search ends here.

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Gastrointestinal Complications of Diabetes: A Comprehensive Guide

 Endocrinology/Metabolism/Diabetes Mellitus, Gastroenterology/Hepatology  Comments Off on Gastrointestinal Complications of Diabetes: A Comprehensive Guide
Jun 302018
 

This text provides a state-of-the art review of the gastrointestinal complications of diabetes, their pathophysiology, clinical manifestations, diagnostic evaluation and management. Divided into six sections, the volume shows how diabetes affects the entire GI tract, from the oral cavity and esophagus to the large bowel and anorectal region. By offering a detailed diagnostic approach and featuring therapeutic algorithms at the end of each chapter, the text is a useful guideline and reference point for every day practice, specifically in recognizing and diagnosing patients with gastrointestinal complications of diabetes in a timely fashion.
Written by experts in the field, Gastrointestinal Complications of Diabetes: A Comprehensive Guide is a valuable resource for physicians dealing with diabetes mellitus or gastrointestinal disorders, and researchers interested in this multidisciplinary problem.

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http://nitroflare.com/view/F75E780D0561997/3319758551.pdf

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Yen & Jaffe’s Reproductive Endocrinology: Physiology, Pathophysiology, and Clinical Management, 8th Edition (March 2018 Release)

 Endocrinology/Metabolism/Diabetes Mellitus  Comments Off on Yen & Jaffe’s Reproductive Endocrinology: Physiology, Pathophysiology, and Clinical Management, 8th Edition (March 2018 Release)
Jun 192018
 

Now celebrating its 40th anniversary, Yen & Jaffe’s Reproductive Endocrinology, 8th Edition, by Drs. Jerome F. Strauss III, Robert L. Barbieri, and Antonio R. Gargiulo, keeps you up to date with the latest information on the diagnosis and management of the full range of female and male reproductive disorders. This cornerstone text thoroughly covers both basic science and clinical practice, making it a one-stop reference for all reproductive issues, including impaired fertility, infertility, recurrent pregnancy loss, problems of sexual development, menstrual disturbances, fibroids, endometriosis, female and male reproductive aging, fertility preservation, assisted reproduction technologies including ovarian stimulation and ovulation induction, transgender hormonal treatment, and contraception. Every chapter has been completely revised and updated to reflect important changes in this fast-moving field.

  • Covers key topics such as the role of genetics in reproductive endocrinology, environmental factors in reproductive endocrinology, and recent advances in surgical procedures.
  • Features full-color, high-quality illustrations that clearly depict basic anatomic structures, endocrine processes, and cell function and dysfunction.
    • Provides the knowledge and expertise of global experts who draw on the latest developments in the field to keep you abreast of current science and practice in endocrinology. Coverage includes molecular, cellular, and genetic concepts and their relevance to pathophysiology, diagnosis, and therapy.
    • Features new bulleted lists under major headings in each chapter for quick, at-a-glance summaries of every section.
    • Includes a new online video library that highlights surgical procedures, diagnostic imaging, and functional ultrasound imaging. Videos cover Disorders of Sex Development, Endometriosis, Benign Uterine Disorders, Gamete and Embryo Manipulation, and Fertility Preservation.

  • Expert Consult™ eBook version included with purchase. This enhanced eBook experience allows you to search all of the text, figures, and references from the book on a variety of devices.

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Thyroid Diseases: Pathogenesis, Diagnosis, and Treatment

 Endocrinology/Metabolism/Diabetes Mellitus  Comments Off on Thyroid Diseases: Pathogenesis, Diagnosis, and Treatment
Jun 132018
 

This book presents the latest advances in knowledge of the pathogenesis of thyroid diseases and describes the state of the art in their diagnosis and treatment, including newly emerging management approaches. After an opening section that addresses thyroid physiology and laboratory evaluation, each of the major thyroid diseases and their subtypes is discussed, covering goiter and thyroid nodule, thyroiditis, hypothyroidism, hyperthyroidism and thyrotoxicosis, and thyroid carcinoma. Other conditions that affect thyroid function or induce thyroid dysfunction are also considered, e.g., pregnancy, non-thyroidal disorders, and medication use. The book is designed to assist practitioners to achieve optimal outcomes in clinical routine by providing clear guidance on clinical examination, the use of diagnostic tests, first- and second-line therapies, and follow-up. Chapter have been written by recognized experts in the field.

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Pediatric Endocrinology: A Clinical Handbook

 Endocrinology/Metabolism/Diabetes Mellitus, Pediatrics  Comments Off on Pediatric Endocrinology: A Clinical Handbook
Jun 132018
 

Practical in design with easy to read, disease-specific chapters
Offers a primary care focus – helps the reader manage the major endocrine disorders encountered in primary care pediatric practice
Includes abundant algorithms and tables, providing quick access to essential information such as calculation of target height for children, clinical phases of insulin-dependent diabetes, insulin treatment regimens, features of carbohydrates metabolism and more

This text provides a concise, straightforward and clearly written approach for the evaluation of common topics in pediatric endocrinology. Pediatricians, family physicians, residents, fellows and medical students will benefit from the discussion of endocrine physiology and its application to common clinical practice. The text presents the major signs and symptoms and the diagnosis and management of pediatric endocrine disorders. The information presented can prepare a provider for communication with parents of a child with an endocrine condition and may allow the practitioner to avoid an unnecessary consultation. The concepts covered in the text are designed to address the first 10 headings in the content outline of the Sub-board of Pediatric Endocrinology of The American Board of Pediatrics with varying degrees of specificity. The Suggested Reading sections at the conclusion of each chapter direct the reader to outstanding larger and more detailed texts, manuscripts and websites which offer increased detail.

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Managing the Diabetic Foot, 3rd Edition

 Endocrinology/Metabolism/Diabetes Mellitus  Comments Off on Managing the Diabetic Foot, 3rd Edition
Jun 072018
 

Foot problems in diabetic patients are some of the most challenging complications to treat, due to an often quite late presentation of symptoms from the patient. Therefore visual recognition of presenting clinical signs is absolutely key for a successful diagnosis and subsequently, the right management programme.

The 3rd edition of Managing the Diabetic Foot once again provides a practical, handy and accessible pocket guide to the clinical management of patients with severe feet problems associated with diabetes, such as ulcers, infections and necrosis. By focusing on the need for a speedy response to the clinical signs, it will enable doctors make rapid, effective management decisions in order to help prevent deterioration and avoid the need for evental foot amputation.

Each chapter focuses specifically on the different stages of foot disease and the clinical management required at that particular stage, ie, the normal foot; high-risk foot, ulcerated foot, infected foot, necrotic foot and unsalvageable foot.

Full colour throughout, it will feature over 150 clinical photos, numerous hints and tips to aid rapid-reference, as well as the latest national and international guidelines on diabetic foot management.

Managing the Diabetic Foot, 3E, is the ideal go-to clinical tool for all diabetes professionals, specialist diabetes nurses and podiatrists managing patients with diabetic foot problems.

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Diabetes Mellitus : A Medical History Journey

 Endocrinology/Metabolism/Diabetes Mellitus  Comments Off on Diabetes Mellitus : A Medical History Journey
May 302018
 

The United States CDC (Center for Disese Control and Prevention) estimated that 86 million adult Americans have prediabetes and therefore risk of developing T2DM, and 1 in 10 are unaware of their condition. About 29 million people have actual diabetes with most T2DM. With about 9% of the population having diabetes, we are talking about a public health issue of proportion.

Contents:

Introduction
Chapter 1 Trends in child and youth diabetes

Section One: Diabetes mellitus history
Chapter 2 A historical journey of diabetes mellitus

Section Two: Acknowledgments
Chapter 3 About the authors
Chapter 4 About the Department of Pediatric and Adolescent Medicine, Western Michigan University Homer Stryker MD School of Medicine (WMED), Kalamazoo, Michigan, USA
Chapter 5 About the National Institute of Child Health and Human Development in Israel
Chapter 6 About the book series “Public health: Practices, methods and policies”

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