Phospholipid Metabolism in Apoptosis

 Endocrinology/Metabolism/Diabetes Mellitus  Comments Off on Phospholipid Metabolism in Apoptosis
Feb 122019
 

The last few years have witnessed an explosion of both interest and knowledge about apoptosis, the process by which a cell actively commits suicide. The number of publications on the topic has increased from nothing in the early 1980s to more than 10,000 papers annually today. It is now well recognized that apoptosis is essential in many aspects of normal development and is required for maintaining tissue homeostasis. The idea that life requires death seems somewhat paradoxical, but cell suicide is essential for an animal to survive. For example, without selective destruction of “non-self” T cells, an animal would lack immunity. Similarly, meaningful neural connections in the brain are whittled from a mass of cells. Further, developmental cell remodeling during tissue maturation involves programmed cell death as the major mechanism for functional and structural safe transition of undifferentiated cells to more specialized counterparts. Apoptosis research, with roots in biochemistry, developmental and cell biology, genetics, and immunology, embraces this long-ignored natural law. Failure to properly regulate apoptosis can have catastrophic consequences. Cancer and many diseases (AIDS, Alzheimer’s disease, Parkinson’s disease, heart attack, stroke, etc. ) are thought to arise from deregulation of apoptosis. As apoptosis emerges as a key biological regulatory mechanism, it has become harder and harder to keep up with new developments in this field.
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Diabetic Foot Care: Case Studies in Clinical Management

 Endocrinology/Metabolism/Diabetes Mellitus  Comments Off on Diabetic Foot Care: Case Studies in Clinical Management
Feb 112019
 

Diabetic Foot Care: Case Studies in Clinical Management uses a 100% illustrated patient case study format to demonstrate the multidisciplinary care and clinical management of patients with feet and lower limb problems as a result of diabetes. Every case has colour illustrations highlighting both the initial presentation of the foot, right through to treatment and long term follow-up care. Of particular focus are the management problems, barriers to effective care, preventable mistakes, unnecessary delays in presentations, challenging situations, conflicts, dilemmas and solutions that podiatrists and diabetic specialists face. Sections in the book include: Neuropathic and neuroischaemic foot, neuropathic ulcers, ischaemic ulcers, infections, gangrene, traumatic injuries, Charcot’s osteoarthropathy, dermatological problems associated with diabetes, painful neuropathy, diabetic foot emergencies, angiology and foot surgery/amputation. With key points and summaries at the beginning and end of each section, this book is clear and easy to navigate, making it an ideal tool for diabetes specialists, diabetes nurses and podiatrists.Content: Chapter 1 Neuropathic Case Studies (pages 1–82): Chapter 2 Ischaemic Case Studies (pages 83–155): Chapter 3 Charcot Case Studies (pages 157–215): Chapter 4 Renal Case Studies (pages 217–260):
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Doves, Diplomats, and Diabetes: A Darwinian Interpretation of Type 2 Diabetes and Related Disorders

 Endocrinology/Metabolism/Diabetes Mellitus  Comments Off on Doves, Diplomats, and Diabetes: A Darwinian Interpretation of Type 2 Diabetes and Related Disorders
Feb 112019
 

Darwinian medicine looks at the ecological and evolutionary roots of disease. A disease is an interaction between a genome and its biotic or abiotic environment and therefore a disease is essentially an ecological process. Good understanding of ecology and a Darwinian way of thinking can give us novel and useful perspectives on health and disease. If we understand the disease process better, we can certainly prevent, control as well as treat diseases in a better way. Although the thought that the origins of obesity and type 2 diabetes (T2D) might lie in our hunter gatherer adaptations is not new, research over the last decade makes us rethink many of the classical concepts. Brain and behavior is increasingly being recognized as central to all the endocrine, metabolic and immunological changes that earmark type 2 diabetes and other metabolic syndrome disorders. A major change in paradigm appears to be on the horizon and the proposed book intends to speed up the paradigm shift by raising important questions, pointing out flaws and inadequacies in the prevalent paradigm and stimulating radical rethinking which would redirect and refine the line of research as well as bring some fundamental changes in drug discovery and clinical practice. ​
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Handbook of Clinical Pediatric Endocrinology

 Endocrinology/Metabolism/Diabetes Mellitus, Pediatrics  Comments Off on Handbook of Clinical Pediatric Endocrinology
Feb 102019
 

Commended in the Endocrinology category of the 2008 BMA Medical Book CompetitionThe Handbook of Clinical Pediatric Endocrinology provides an up-to-date clinical guide presenting best (and, where possible, evidence-based) practice in the diagnosis, treatment and management of pediatric endocrine disorders.It is a companion title to Brook’s Clinical Pediatric Endocrinology, which is well established as the leading international work of reference in the field of pediatric endocrinology, covering endocrine disorders, their diagnosis and treatment. Content: Chapter 1 The Application of Science to Clinical Practice (pages 1–13): Chapter 2 The Endocrine Problems of Infancy (pages 14–32): Chapter 3 Problems of Growth in Childhood (pages 33–58): Chapter 4 Problems of Puberty and Adolescence (pages 59–83): Chapter 5 The Thyroid Gland (pages 84–98): Chapter 6 The Adrenal Gland (pages 99–122): Chapter 7 Disorders of Calcium and Bone Metabolism (pages 123–145): Chapter 8 Water Balance (pages 146–163): Chapter 9 Polyglandular Syndromes (pages 164–171): Chapter 10 Hypoglycemia (pages 172–178): Chapter 11 Obesity and Type 2 Diabetes Mellitus (pages 179–188): Chapter 12 Type 1 Diabetes Mellitus (pages 189–213): Chapter 13 Tests and Normal Values in Pediatric Endocrinology (pages 214–237):
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Metabolomics by In Vivo NMR

 Endocrinology/Metabolism/Diabetes Mellitus  Comments Off on Metabolomics by In Vivo NMR
Feb 082019
 

Metabolism By In Vivo NMR reviews and extends the experimental and theoretical reports concerning in vivo NMR, a pioneering approach that offers versatile new ways of studying metabolic pathways. Perfectly timed to coincide with recent findings that demonstrate the novelty and strength of this approach, the book covers recent applications in biochemistry, medicine, and psychology; in vivo NMR techniques; MCA; glucose metabolism focusing on glycogen; the value of muscle glycogen measurements in exercise; and much more. This book is unique in linking in vivo 13C NMR measurements of neuronal activity and energetics with applications to functional imaging and certain disease states Provides a fundamental neurochemical explanation of brain activity applicable to functional imaging, theories of neuronal activity and disease states, e.g. epilepsy, psychiatric diseases and developmental disorders Novel and potentially controversial Will inspire future research directions. Content: Chapter 1 Introduction (pages 1–5): Robert G. ShulmanChapter 2 In Vivo NMR Spectroscopy – Techniques; Direct Detection; MRS; Kinetics and Labels; Fluxes; Concentrations (pages 7–29): Robin de GraafChapter 3 Metabolic Control Analysis for the NMR Spectroscopist (pages 31–44): David A. FellChapter 4 MRS Studies of the Role of the Muscle Glycogen Synthesis Pathway in the Pathophysiology of Type 2 Diabetes (pages 45–57): Gerald I. Shulman and Douglas L. RothmanChapter 5 Phosphorylation of Allosteric Enzymes Can Serve Homeostasis rather than Control Flux: The Example of Glycogen Synthase (pages 59–71): James R.A. Schafer, David A. Fell, Douglas L. Rothman and Robert G. ShulmanChapter 6 Regulation of Glycogen Metabolism in Muscle during Exercise (pages 73–86): Thomas B. PriceChapter 7 13C NMR Studies of Heart Glycogen Metabolism (pages 87–102): Maren R. Laughlin, Douglas L. Rothman and Robert G. ShulmanChapter 8 Bioenergetics Implication of Metabolic Fluctuation during Muscle Contraction (pages 103–123): Thomas JueChapter 9 Lactate, Glycogen and Fatigue (pages 125–135): Robert G. Shulman and Douglas L. RothmanChapter 10 Futile Cycling in Yeast: How to Control Gluttony in the Midst of Plenty (pages 137–148): Jan den Hollander and Robert G. ShulmanChapter 11 Trehalose Energetics in Yeast Spores (pages 149–158): Robert G. Shulman and Jan den HollanderChapter 12 Metabolic Networks in the Liver by 2H and 13C NMR (pages 159–174): A. Dean Sherry and Craig R. MalloyChapter 13 Summarized Reflections on Metabolism (pages 175–184): Robert G. Shulman, Douglas L. Rothman and James R. A. Schafer
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Fatty Acids and Lipotoxicity in Obesity and Diabetes: Novartis Foundation Symposium 286

 Endocrinology/Metabolism/Diabetes Mellitus  Comments Off on Fatty Acids and Lipotoxicity in Obesity and Diabetes: Novartis Foundation Symposium 286
Feb 052019
 

The potential lipotoxic effect of accumulation of fatty acids in non-adipose tissues is thought to be a major component in the development of insulin resistance. Chronic exposure to high concentrations of free fatty acids in the blood affects pancreatic ? cell function, insulin secretion and lipid synthesis in the liver, and storage in adipose tissue. Maintaining the normal levels of fatty acids requires coordinated regulation between the liver, adipose tissue and skeletal muscle. This book deals with the molecular aspects of fatty acid action in obesity and insulin resistance. The topics include lipid metabolism and adipose tissue biology, and ? cell function and insulin resistance. Chapters deal with the molecular genetics and molecular physiology of energy homeostasis.Content:
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Staged Diabetes Management: A Systematic Approach, Second Edition

 Endocrinology/Metabolism/Diabetes Mellitus  Comments Off on Staged Diabetes Management: A Systematic Approach, Second Edition
Feb 022019
 

Using evidence-based medicine, this title addresses the prominent issues of primary care diabetes management. It provides practical solutions to the detection and treatment of diabetes, its complications and such new areas as metabolic syndrome, pre-diabetes and diabetes in children. The text reviews the fundamental basis of diabetes management and then addresses treatment of each type of diabetes and the major micro- and macrovascular complications. This Revised Second Edition uniquely focuses on advanced technologies and advanced therapeutics. Key changes include: Integration of incretin hormones in the basic pathophysiology of type 2 diabetes; Incretin mimetics and potentiators; Revised clinical decision paths with new medications and advanced insulin algorithms; New section on continuous glucose monitoring. Staged Diabetes Management: A Systematic Approach, Second Edition, Revised presents a clear set of clinical algorithms consistent with the EASD/ADA recommended algorithms. It provides a means of applying the principles using a proven methodology and one that has been applied internationally. Based on the highly successful diabetes programmes for primary care developed by the world-renowned International Diabetes Center in Minneapolis, USA Features Decision Paths and Practice Guidelines to facilitate clinical decision making Clearly written and illustrated: each chapter may be read alone but complements the others to give a broad view of diabetes care This title is an invaluable guide for healthcare professionals, particularly primary care physicians, diabetes specialist nurses, and for all those with an interest in diabetes. It is also useful for all Diabetes educators and medical students.Content: Chapter 1 Introduction to Staged Diabetes Management (pages 1–25): Chapter 2 The Implementation of Staged Diabetes Management (pages 27–48): Chapter 3 Therapeutic Principles for the Treatment of Diabetes (pages 49–75): Chapter 4 Type 2 Diabetes (pages 77–154): Chapter 5 Type 2 Diabetes and Metabolic Syndrome in Children and Adolescents (pages 155–216): Chapter 6 Type 1 Diabetes (pages 217–256): Chapter 7 Pregestational and Gestational Diabetes (pages 257–292): Chapter 8 Macrovascular Disease (pages 295–317): Chapter 9 Microvascular Complications (pages 319–367): Chapter 10 Hospitalization (pages 369–384):
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Endocrine Disorders in Thalassemia: Physiopathological and Therapeutical Aspects

 Endocrinology/Metabolism/Diabetes Mellitus  Comments Off on Endocrine Disorders in Thalassemia: Physiopathological and Therapeutical Aspects
Jan 192019
 

Endocrine glands may be involved in patients with thalassemia major. In the last 20 years, new therapies have significantly improved life expectancy, while several endocrine abnormalities have been described in children, adolescents, and young adults suffering from thalassemia major. The practical objective of this book is to establish guidelines for the management of endocrine disorders underlying the various phases of thalassemic life. Internationally acknowledged experts give a state-of-the-art account of physiopathological and therapeutical approaches to endocrine disorders in thalassemia and focus on such topics as growth hormones, thyroid diseases, puberty, hypogonadism, diabetes, and bone metabolism.
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Diabetic Renal-Retinal Syndrome: 21st Century Management Now

 Endocrinology/Metabolism/Diabetes Mellitus  Comments Off on Diabetic Renal-Retinal Syndrome: 21st Century Management Now
Jan 152019
 

After a decade or longer, approximately one-third of individuals with either type 1 or type 2 diabetes commence a downhill course in which decreasing renal function and failing vision define a Renal-Retinal Syndrome, dominating all aspects of life and presaging early death. Only a generation ago, survival after onset of end-stage renal disease (ESRD) in diabetes was limited because rehabilitation was preempted by blindness, limb amputation, stroke, and heart disease. By 1998, however, team management has improved the outlook, with preserved sight and return to work and home responsibilities, usually for a decade or longer, following kidney transplantation and laser photocoagulation. Recognition of the critical requirement for blood pressure regulation and metabolic control are central themes in management. In this unique book, the accomplishments of ophthalmologists, nephrologists, diabetologists, transplant surgeons, and basic scientists are blended into a strategic approach that may be readily applied by all those caring for diabetic patients. Each of twenty-one presentations suitable for primary care physicians, as well as for subspecialists concerned with macrovascular and microvascular complications of diabetes, is placed in perspective by an introductory editorial analysis. Promising near-term innovative therapies, including insertion of genetically engineered beta cells or polymer-coated islets of Langerhans, interdiction of kinins that promote retinal angiogenesis, and prevention of synthesis of advanced glycosylated endproducts (AGEs), are presented in detail. While comprehensive care of diabetic patients reflects multiple incremental advances that in sum afford major benefit, this text envisions further remarkable changes likely to suppress and possibly entirely prevent the Diabetic Renal-Retinal Syndrome.
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Jan 122019
 

Diabetes is a major public health problem which is expected to affect 160 million people worldwide by the year 2000. Clearly an understanding of the effects of diabetes on the heart is an important step in the development of strategies to reduce the incidence of heart disease for diabetic patients, thus increasing their overall life-expectancy and quality of life. In this book, the editors bring together the different lines of evidence supportive of the idea of a diabetic cardiomyopathy. The first chapter provides an overview of the impact of cardiac dysfunction on the mortality and morbidity of the diabetic population in general, as well as a presentation of clinical aspects of heart disease in diabetes. This is followed by chapters concerned with the pathological and functional changes that occur in the heart as a result of diabetes and a description of the various therapeutic interventions that are available to reverse the effects of diabetes on the heart. Subsequent chapters focus on changes in protein synthesis, membrane function and intermediary metabolism that take place following the onset of diabetes. Since these alterations precede many of the functional and pathological changes, it may be that the processes responsible for the functional decline and tissue injury are initiated by diabetes-induced changes at the cellular and/or biochemical level.
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