Genetics and Genomics for the Cardiologist

 Cardiovascular, Genetics  Comments Off on Genetics and Genomics for the Cardiologist
Jan 132019
 

Genetics and Genomics for the Cardiologist is a concise, but comprehensive volume for the clinical cardiologist or medical student interested in learning how molecular genetics is now being applied to prevention and treatment of heart diseases, from DNA tests to pharmacogenomics and gene-based therapeutics. The volume, written in a plain language, contains detailed figures. A rich glossary, three appendices, many references and several URLs provide additional sources of information.
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Cardiac Positron Emission Tomography

 Cardiovascular  Comments Off on Cardiac Positron Emission Tomography
Jan 132019
 

It is the mark of an instructed mind to rest satisfied with the degree of precision which the nature of the subject admits, and not to seek exactness where only an approximation of the truth is possible. Aristotle With the development of imaging techniques, the in vivo study of human anatomy and physiology has become possible with increasing “approximation of the truth. ” Advances have been made not only in data acquisition, but also in processing as well as visualization of functional and morphological data. Following the successful application of planar two-dimensional imaging approaches, more recently three-dimensional data acquisition and correspond­ ing tomographic image reconstruction has become possible. With the rapid growth of computer support, advanced processing allows for user-friendly interaction with complex data sets. Classical x-ray imaging techniques have matured to excellent spatial resolution and contrast, which provide specific delineation of anatomical changes occurring in cardiovascular disease. In parallel, the use of tracer principles supported the successful introduction of nuclear medicine procedures for the functional characterization of physiology and pathophysiology. The application of such techniques were initially limited by relatively poor spatial resolution, but excelled in high sensitivity 30 years, scintigraphic imaging emerged from and specificity. In the last rectilinear scanning to planar gamma camera imaging and single-photon xvi Preface emISSIOn tomography (SPECT). Based on these advances and the experi­ mental success of autoradiography, the potential of scintigraphy as a clinical and research tool has been well appreciated.
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Pathophysiology of Heart Failure

 Cardiovascular, Pathology, Physiology  Comments Off on Pathophysiology of Heart Failure
Jan 132019
 

Pathophysiology of Heart Failure brings together leading basic scientists and clinicians, presenting new approaches to this complex problem, involving cardiomyopathic processes and ischemia perfusion injury. The result is a synthesis of state-of-the-art information on molecular biology, cellular physiology and structure-function relationships in the cardiovascular system. The role which excess intracellular calcium plays in the genesis of cardiac dysfunction is described as a fundamental mechanism underlying heart failure; one which may lead to improved prevention and treatment. Audience: Clinical and experimental cardiologists will find the book a helpful source of ideas and inspiration.
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Jan 122019
 

Diabetes is a major public health problem which is expected to affect 160 million people worldwide by the year 2000. Clearly an understanding of the effects of diabetes on the heart is an important step in the development of strategies to reduce the incidence of heart disease for diabetic patients, thus increasing their overall life-expectancy and quality of life. In this book, the editors bring together the different lines of evidence supportive of the idea of a diabetic cardiomyopathy. The first chapter provides an overview of the impact of cardiac dysfunction on the mortality and morbidity of the diabetic population in general, as well as a presentation of clinical aspects of heart disease in diabetes. This is followed by chapters concerned with the pathological and functional changes that occur in the heart as a result of diabetes and a description of the various therapeutic interventions that are available to reverse the effects of diabetes on the heart. Subsequent chapters focus on changes in protein synthesis, membrane function and intermediary metabolism that take place following the onset of diabetes. Since these alterations precede many of the functional and pathological changes, it may be that the processes responsible for the functional decline and tissue injury are initiated by diabetes-induced changes at the cellular and/or biochemical level.
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Stress Echocardiography: Its Role in the Diagnosis and Evaluation of Coronary Artery Disease

 Cardiovascular  Comments Off on Stress Echocardiography: Its Role in the Diagnosis and Evaluation of Coronary Artery Disease
Jan 122019
 

Stress Echocardiography – Its Role in the Diagnosis and Evaluation of Coronary Artery Disease – Second Edition by Thomas Marwick is a concise, practical guide for anyone new to the field of stress echocardiography or an excellent summary of the existing evidence base for the experienced user. Dr. W.F. Armstrong described the first edition of this book in his Foreword to the first edition as “a thorough, comprehensive review of the basic and advanced concepts of stress echocardiography. This text represents an excellent starting point for individuals wishing to gain initial familiarity with stress echocardiography and a superb reference source for more experienced investigators and clinicians finding a need to further develop their understanding of the technique and advance its clinical relevance in their laboratories.”
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Signal Transduction and Cardiac Hypertrophy

 Cardiovascular  Comments Off on Signal Transduction and Cardiac Hypertrophy
Jan 122019
 

Cellular signaling in cardiac muscle refers to the myriad of stimuli and responses that direct and control the physiological operation of this organ. Our understand­ ing of these complex signaling cascades has increased dramatically over the past few decades with the advent of molecular tools for their dissection. Moreover, this infor­ mation is beginning to provide tangible targets towards manipulating cardiac func­ tion in the setting of cardiovascular disease. The mechanisms and factors that regulate cardiac cell growth are of particular interest as both adaptive and maladaptive responses can occur during cardiac hypertrophy. Cardiac hypertrophy describes the increase in individual cardiac myocyte size that is accomplished through the series and/or parallel addition of sarcomeres. The ability of cardiac muscle to increase in size through hyperplasia becomes highly restricted or negligible shortly after birth. Consequently, the increase in heart size associated with development and growth of an individual occurs through hypertrophy. In response to a chronic increase in workload, cardiac muscle cells can dramatically increase in size to face their increasing contractile demands. While this plasticity is clearly a ben­ eficial response under many conditions, it can be highly deleterious and inappropri­ ate under others. For example, cardiac hypertrophy associated with endurance exercise clearly enhances athletic performance. In contrast, the hypertrophy associated with chronic hypertension, stenotic or regurgitant heart valves, or following a myocardial infarction often continues far beyond the period where this adaptive response is ben­ eficial.

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Protocols for Cardiac MR and CT: A Guide to Study Planning and Image Interpretation

 Cardiovascular  Comments Off on Protocols for Cardiac MR and CT: A Guide to Study Planning and Image Interpretation
Jan 082019
 

This practically oriented book opens by describing the basic Cardiac MR (CMR) sequences and Cardiac CT (CCT) acquisition techniques, offering step-by-step guidelines on acquiring CMR and CCT studies and analyzing images. The main body of the book provides a comprehensive description of the study protocols most suitable for particular diseases and discusses their respective rationales. In addition, it highlights key findings for every pathological condition, complemented by extensive illustrations.

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Biomarkers in Heart Disease

 Cardiovascular  Comments Off on Biomarkers in Heart Disease
Jan 062019
 

Biomarkers in Heart Disease is the first title in the AHA Clinical Series and is aimed at meeting the needs of clinicians, providing cardiologists, internists, emergency physicians, laboratorians, and other healthcare providers with a clear understanding of the role of biomarkers in contemporary cardiovascular medicine.

information on the most promising biomarkers that are likely to impact practice in the next few years. It is divided into four parts, organized around clinical scenarios rather than individual biomarkers.

This book will help the practicing physician decide which biomarkers to measure, when to measure them, how to interpret the results and how to make decisions based on the test result.

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Cardiovascular Surgery: A Clinical Casebook

 Cardiovascular, Surgery  Comments Off on Cardiovascular Surgery: A Clinical Casebook
Jan 052019
 

This clinical case book is comprised of surgical cases involving the most important cardiovascular diseases in a concise, easy-to-ready format (5×8 in trim size, like other titles in this burgeoning, informal product line in the Springer clinical medicine program).
Each chapter is a case that opens with a unique clinical presentation, followed by a description of the diagnosis, assessment and management techniques used to treat it, as well as questions and answers (between 8 and 10) about relevant aspects related to the diagnosis and treatment of the addressed disease. The Q&A section will broaden discussion and increase the title’s pedagogical value.

The casebook features 40 surgical cases in the following thematic areas: Aortic Disease, Arrhythmias, Cardiac Tumors, Coronary Insufficiency, Congenital Heart Disease, Endovascular Therapies, Heart Failure, Heart Transplantation, Mechanical Circulatory Support, Pericardial Disease, Pulmonary Embolism and Valvular Heart Disease.

This book will be prepared by the Brazilian Department for Academic Leagues of Cardiovascular Surgery, within the Brazilian Society of Cardiovascular Surgery (BSCVS). This department is the section within BSCVS that consists of the academic leagues of cardiovascular surgery from each university throughout the country. In Brazil, medical academic leagues are organizations that gathers students, interns and residents to discuss a certain topic and promote research and teaching-oriented extra-class activities, supervised by a group of professors. Thus trainees will have involvement in writing the chapters and the senior professor supervisors will edit and finalize the work. Basically, each chapter is written by an intern or resident and, ultimately, his/her supervisor. As the books volume editors, doctors Almeida and Jatene will have final responsibility for the cases and overall manuscript.

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Applied Cardiovascular Physiology

 Cardiovascular, Physiology  Comments Off on Applied Cardiovascular Physiology
Jan 012019
 

This book represents the collective efforts of several excellent,clini­ cian-scientists who have devoted many years of their lives and many hours in each day to the application of physiological principles to the bedside care of critically ill patients. The universal challenge of car­ diovascular instability confronts all health care providers who treat patients in an acute care setting. Whether that be in the field or Emergency Department, general ward, operating suite or intensive care unit, all patients carry a common theme of potential life-taking processes which must to identified and treated in a timely fashion or severe morbidity and death rapidly follow. Since the cardiovascular system subserves the body in maintain­ ing metabolic stability through global and regional blood flow at an adequate pressure to insure appropriate autoregulation of blood flow distribution, it would be difficult to describe the mechanisms of cardiovascular instability their diagnosis and treatment without placing them within the context of overall metabolism and tissue vi­ ability. Accordingly, this book has been grouped into four arbitrary subsets. First, we address issues of basic cardiovascular physiology. Classic developments of ventricular pump function and arterial re­ sistance are balanced with newer applications of ventriculo-arterial coupling, right ventricular function, and tissue oxygen delivery.

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