Heart Replacement: Artificial Heart 5

 Cardiovascular  Comments Off on Heart Replacement: Artificial Heart 5
Jan 212019
 

The 5th International Symposium on Artificial Heart and Assist Devices was held in Tokyo on January 26 – 27, 1995, bringing together leading researchers and specialists from all over the world. The proceedings of the symposium presents the newest ideas and approaches in the field, and will be of special interest and relevance to all who are concerned with artificial organs, cardiovascular surgery, organ transplantation, biomaterials, and related disciplines. Reflecting the content of the symposium, the major topics in this volume include biocompatible material development, clinical use of assist devices, completely implantable devices, and heart transplantation. These are presented in the two main divisions of the book: The first consists of eight lectures by leading researchers, world-renowned in the field of the artificial heart. The second comprises more than 50 papers on such subjects as biomaterials, research and development of ventricular assist systems and the total artificial heart, and their use as a bridge to heart transplantation. An additional, special feature of the book is the inclusion of descriptions of exhibitions at the symposium, with photographs of all artificial heart devices and systems displayed by major laboratories and companies from around the world.
GET IT FREE HERE
ALTERNATIVE LINK
Share Button

Advances in Imaging Techniques in Ischemic Heart Disease

 Cardiovascular, Radiology  Comments Off on Advances in Imaging Techniques in Ischemic Heart Disease
Jan 182019
 

In recent years there have been tremendous advances in cardiac imaging techniques covering the complete spectrum from echocardiography, nuclear cardiology, magnetic resonance imaging to contrast angiography. With respect to these noninvasive and invasive cardiac imaging modalities, marked technological developments have allowed the cardiologist to visualize the myocardium in a far more refined manner than conventional imaging was capable of. Echocardiography has extended its domain with intravascular ultrasound, cardiovascular nuclear imaging has added positron emission tomography to its line of research, magnetic resonance imaging has been broadened with magnetic resonance angiography and spectroscopy, and finally contrast angiograp­ hy has widened its scope with excellent quantitation programs. For all these imaging modalities it is true that the application of dedicated quantitative analytic software packages enables the evaluation of the imaging studies in a more accurate, reliable, and reproducible manner. It goes without saying that these extensions and achievements have resulted in improved diagnostics and subsequently in improved patient care. Particularly in patients with ischemic heart disease, major progress has been made to detect coronary artery disease in an early phase of the disease process, to follow the atherosclerotic changes in the coronary arteries, to establish the functional and metabolic consequences of the luminal obstructions, and to accurately assess the results of interventional therapy.
GET IT FREE HERE
ALTERNATIVE LINK
Share Button

Excitation-Contraction Coupling and Cardiac Contractile Force

 Cardiovascular  Comments Off on Excitation-Contraction Coupling and Cardiac Contractile Force
Jan 162019
 

How is the heartbeat generated? What controls the strength of contraction of heart muscle? What are the links between cardiac structure and function? How does our understanding of skeletal and smooth muscle and non-muscle cells influence our thinking about force development in the heart? Are there important species differences in how contraction is regulated in the heart? How do the new molecular data fit together in understanding the heart beat? What goes wrong in ischemia, hypertrophy, and heart failure? This book paints a modern `portrait’ of how the heart works and in this picture the author shows a close-up of the structural, biochemical, and physiological links between excitation and contraction. The author takes the reader through a series of important, interrelated topics with great clarity and continuity and also includes many useful illustrations and tables. The book starts by considering the cellular structures involved in excitation-contraction coupling and then described the characteristics of the myofilaments as the end effector of excitation-contraction coupling. A general scheme of calcium regulation is described and the possible sources and sinks of calcium are discussed in simple, but quantitative terms. The cardiac action potential and its many underlying currents are reviewed. Then the characteristics of some key calcium transport systems (calcium channels, sodium/calcium exchange and SR calcium uptake and release) are discussed in detail. This is then built into a more integrated picture of calcium regulation in succeeding chapters by detailed discussions of excitation-calcium coupling mechanisms (in skeletal, cardiac, and smooth muscle), the interplay between calcium regulatory processes, and finally mechanisms of cardiac inotropy, calcium overload, and dysfunction (e.g., ischemia, hypertrophy, and heart failure). Excitation-Contraction Coupling and Cardiac Contractile Force&endash; Second Edition is an invaluable source of information for anyone who is interested in how the heart beat is controlled and especially suited for students of the cardiovascular system at all levels from medical/graduate students through senior investigators in related fields.
GET IT FREE HERE
ALTERNATIVE LINK
Share Button

Cardiac Positron Emission Tomography: Viability, Perfusion, Receptors and Cardiomyopathy

 Cardiovascular  Comments Off on Cardiac Positron Emission Tomography: Viability, Perfusion, Receptors and Cardiomyopathy
Jan 162019
 

Myocardial viability has become one of the most important issues in clinical cardiology. In particular, absence or presence of viability may be decisive in patient management, and the decision to perform angioplasty (PTCA) or bypass surgery (CABG) is frequently based on the accurate assessment of viability. Although echocardiography and conventional nuclear medicine techniques may provide valuable information on viability, positron emission tomography (PET) is currently considered to be the gold standard for the assessment of myocardial viability. The simultaneous evaluation of myocardial metabolism and perfusion allows precise delineation and accurate quantification of residual myocardial viability in affected regions. In addition, accurate quantification of myocardial perfusion alone may provide insight into the basic mechanisms of syndrome X and may assist in the appropriate clarification of this clinically complicated, but frequently occurring phenomenon. Besides that, cardiac PET may deepen our insight into metabolism and perfusion of cardiac muscle disease, particularly in hypertrophic cardiomyopathy. Furthermore, receptor imaging studies with PET will become important as the study of cardiac neurohumoral regulation in heart failure has gained in interest. Cardiac Positron Emission Tomography: Viability, Perfusion,Receptors and Cardiomyopathy describes the most recent developments in cardiac PET as these are related to myocardial viability and myocardial perfusion studies of syndrome X. The value of PET for receptor imaging and cardiac muscle disease is also discussed. For cardiologists, nuclear medicine physicians, radiochemists, physiologists, technicians and basic researchers interested in understanding the most recent achievements in cardiovascular PET.
GET IT FREE HERE
ALTERNATIVE LINK
Share Button

Cardiac Arrhythmias, Pacing & Electrophysiology: The Expert View

 Cardiovascular, Physiology  Comments Off on Cardiac Arrhythmias, Pacing & Electrophysiology: The Expert View
Jan 152019
 

Europace ’97 was held in Athens, Greece, on 8-11 June Leads were, as usual, an important topic, with the earl­ 1997 in the city of classical civilisation and learning. iest mention of the then-new polyurethane leads. Future Though now held in modem surroundings and meeting conferences elaborated on these basic topics while pro­ facilities, the influence of the ancient city-state was un­ gressively adding sensors and sensor function, dual­ mistakable, with the architecture and learning of antiquity chamber pacing, and recognising the development of looming over the city, by its influence over the intellectual clinical cardiac electrophysiology. activities of the symposium. The ancient magnificence of Clinical cardiac electrophysiology and compre­ the site was matched by the novelty of modem art and hension of arrhythmias has been largely a development science, Europace is a European symposium, begun in of the twentieth century. With the description and 1979, and has occurred every second year since. Con­ recording of the bundle of His depolarisation, by direct sistent with its importance and continental reach the actual access and by catheter, modem clinical investigation of symposium has moved to different cities throughout arrhythmias and cardiac electrophysiology began. The Western Europe. The first symposium was held in London disciplines of cardiac stimulation and of investigation of and subsequent symposia have been held in Torremolinos, arrhythmias, impulse formation and A V conduction Ostend, Florence, Istanbul and other cities. Because of the were essentially separate for many years.
GET IT FREE HERE
ALTERNATIVE LINK
Share Button

Delayed Preconditioning and Adaptive Cardioprotection

 Cardiovascular  Comments Off on Delayed Preconditioning and Adaptive Cardioprotection
Jan 152019
 

Interest in the ability of myocardium to adapt to ischaemic stress has continued to grow since the discovery of ischaemic preconditioning in 1986. In 1993, two reports heralded the recognition of a delayed preconditioning response in the heart, now commonly known as the `second window’ of protection. Since then, a number of studies have described the ability of delayed preconditioning and related adaptive phenomena to protect against a variety of pathologies in the ischaemic and reperfused myocardium. Our understanding of the cellular mechanisms of sub-acute adaptive cardioprotection has advanced considerably during this period. This compilation of state-of-the-art reviews by those who have made significant contributions to this field provides detailed and critical analysis of this research, from molecular basis to potential clinical relevance. The book aims to provide an authoritative, comprehensive and thoroughly up-to-date overview for scientists and clinicians engaged in, or observing, this rapidly-developing area of heart research. It will also be of interest to those engaged in research on other tissues where ischaemia-reperfusion pathology is of major concern.
GET IT FREE HERE
ALTERNATIVE LINK
Share Button

Multiple Risk Factors in Cardiovascular Disease: Strategies of Prevention of Coronary Heart Disease, Cardiac Failure, and Strok

 Cardiovascular  Comments Off on Multiple Risk Factors in Cardiovascular Disease: Strategies of Prevention of Coronary Heart Disease, Cardiac Failure, and Strok
Jan 152019
 

This volume is a collection of the most significant contributions to the 4th International Symposium on MULTIPLE RISK FACTORS IN CARDIOVASCULAR DISEASE: STRATEGIES OF PREVENTION OF CORONARY HEART DISEASE, CARDIAC F AlLURE, AND STROKE held in Washington, D. C. in April 1997. The meeting focused on the risk factors for cardiovascular disease and their interactions. The need for this symposium is based on the epidemiological, clinical, and biological evidence that individuals from industrialized countries often possess two or more risk factors which synergistically increase the global risk profile. This has become more evident in recent years with the increase in life expectancy of populations in the industrialized countries. The evidence that a combination of risk factors confers a very high risk of developing cardiovascular diseases, is of pivotal interest in the process of detection of patients who will benefit the most from pharmacological treatment. Many recent epidemiological data identifying the intrinsic and environmental factors contributing to the development of atherosclerosis are discussed. These results, in parallel with basic and clinical research, underline atherosclerosis as a complex and multifactorial process involving the influences of lipids, including lipoprotein subfractions, blood pressure rheologic forces, carbohydrate tolerance, and thrombogenic factors, including fibrinogen, tissue factor, PAl-I, and homocysteine. Furthennore, the risk associated with anyone of these risk factors varies widely depending on the level of the associated atherogenic risk factors. Hyper­ cholesterolemia and hypertriglyceridemia, for instance, are more common than would be expected by chance among hypertensive patients.
GET IT FREE HERE
ALTERNATIVE LINK
Share Button

Atlas of Practical Cardiac Applications of MRI

 Cardiovascular  Comments Off on Atlas of Practical Cardiac Applications of MRI
Jan 142019
 

Glossary 4 Chapter 1: Basics of Cardiac Magnetic Resonance and 6 Normal Views 1. 1 Definition and Physical Basics 6 a. Definition and historical background 6 b. Physical basics 6 1. 2 Technical Modalities 10 a. Spin echo 12 b. Gradient echo 12 c. Fast gradient echo 13 d. Specialized techniques 13 e. Techniques under clinical investigation 13 1. 3 Study Methodology: Normal Anatomy 13 a. Technical equipment 13 b. Medical personnel 13 c. Preparation of the patient 13 d. Normal MRI anatomy 17 References 17 Chapter 2: Ventricular Morphology and Function: Study of 26 Cardiomyopathies 2. 1 Morphological Study of Heart Chambers 26 a. Left ventricle 26 b. Right ventricle 31 2. 2 Ventricular Function 31 a. Left ventricular function 31 b. Right ventricular function 33 2. 3 Cardiomyopathies 33 a. Dilated cardiomyopathy 33 b. Hypertrophic cardiomyopathy 33 c. Restrictive cardiomyopathy 35 d. Arrhythmogenic dysplasia of the right ventricle 35 References 35 (f) Chapter 3: Acquired Diseases of the Aorta 38 I c 3. 1 Technical Aspects of the Aortic Study by MRI: Imaging the Normal Aorta 38 3. 2 Aortic Aneurysm 43 3. 3 Aortic Dissection and Related Entities OJ 43 a. Strategy for the study of aortic dissection by MRI 43 I b. Differential diagnosis of aortic dissection by MRI 47 References 49 c o U . ;jj Chapter 4: Study of Valvular Heart Disease 54 4. 1 Introduction 54 4. 2 Velocity Calculation and Flow Quantitation 54 4.
GET IT FREE HERE
ALTERNATIVE LINK
Share Button

Fundamental Approaches to the Management of Cardiac Arrhythmias

 Cardiovascular  Comments Off on Fundamental Approaches to the Management of Cardiac Arrhythmias
Jan 142019
 

This new edition provides up-to-date comprehensive coverage of the rapidly evolving field of clinical cardiac electrophysiology. It is designed for physicians, cardiologists, cardiac electrophysiologists, and allied professionals practising or learning the speciality of clinical cardiac electrophysiology. This textbook – written entirely by two practising authorities in the field – offers a cohesive and comprehensive summary of the principles and practice of clinical cardiac electrophysiology. The authors emphasize the clinical approach to the patient and provide a fundamental, yet thorough, discussion of the primary therapeutic modalities used today in a state-of-the-art electrophysiology laboratory, including the latest pharmacotherapy options, catheter ablation treatment, and the newest implantable devices. The authors provide the reader with a concise, organized discussion of the management of patients with benign to life-threatening arrhythmias using the newest concepts, equipment, and techniques of diagnostic and therapeutic electrophysiology.
GET IT FREE HERE
ALTERNATIVE LINK
Share Button

Cardiovascular Genomics: New Pathophysiological Concepts: Proceedings of the 2001 European Science Foundation Workshop in Maast

 Cardiovascular  Comments Off on Cardiovascular Genomics: New Pathophysiological Concepts: Proceedings of the 2001 European Science Foundation Workshop in Maast
Jan 132019
 

Four years ago-in December 1997-the first European Science Foundation Workshop on Cardiovascular Specific Gene Expression was held in Maastricht. It was hardly possible to imagine the progress in the field in those four years. In 1997, gene expression was still an art focused on individual genes; in 200 I, many labs have access to micro-array facilities to determine the expression of thousands of genes simultaneously. In 1997, gene expression was an area of fundamental research in basis molecular biology laboratories; in 200 I, clinical cardiovascular research has incorporated gene expression approaches. In 1997, the interpretation of a gene expression experiment was usually straightforward; in 200 I, advanced bioinformatics tools are needed to approach the extreme complexities of genetic control of cell and tissue function. The second symposium in this series is focused on Cardiovascular Genomics. New Pathophysiological Concepts. The organizing committee chose to invite a group of renown scientists and young investigators around four topics of eminent importance in cardiovascular research. These topics reflect the major present-day clinical cardiovascular problems: atherosclerosis, hypertension, arrhythmias and heart failure. In addition to these four disease-driven topics, the workshop has sessions on gene expression methodologies and cellular transplant approaches to cardiovascular disease.
GET IT FREE HERE
ALTERNATIVE LINK
Share Button