Mar 182016
 

Advances in Cancer Biomarkers: From biochemistry to clinic for a critical revision (Advances in Experimental Medicine and Biology)


At present there are a growing number of biomolecules under investigation to understand their potential role as cancer biomarker for diagnostic, prognostic and therapeutic purposes.  Intriguingly, the state of art on cancer biomarkers research shows interesting and promising results together to clamorous failures. Also from a clinical point of view, there are contradictory results on routine clinical use of the present cancer biomarkers. Some patients may be simply  monitored in their course by a periodic blood sample, but sometimes this monitoring shows dramatic limits. A lot of patients show serious and extensive relapses without significant change in serum concentrations of biomarkers tested. Often the physician who should utilize these biomarker does not entirely  know their limits and the total potential applications as well and sometimes this knowledge is influenced by economical and marketing strategies. This limited and “polluted” knowledge may have dramatic consequences for patient.  The aim of this book is to diffuse all aspects of cancer biomarkers, from their biochemical peculiarities to all clinical implications by passing through their physiology and pathophysiology.

This critical approach towards old and new cancer biomarkers should foster a deepened and useful understanding of the diagnostic and prognostic index of these fundamental parameters of laboratory medicine and in the same time facilitating the research of new and more sensitive-specific signals of the cancer cell proliferation.

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Feb 262016
 

Biomolecular Interfaces: Interactions, Functions and Drug Design


By (author): Ariel Fernández Stigliano

The book focuses on the aqueous interface of biomolecules, a vital yet overlooked area of biophysical research. Most biological phenomena cannot be fully understood at the molecular level without considering interfacial behavior.

The author presents conceptual advances in molecular biophysics that herald the advent of a new discipline, epistructural biology, centered on the interactions of water and bio molecular structures across the interface. The author introduces powerful theoretical and computational resources in order to address fundamental topics such as protein folding, the physico-chemical basis of enzyme catalysis and protein associations. On the basis of this information, a multi-disciplinary approach is used to engineer therapeutic drugs and to allow substantive advances in targeted molecular medicine. This book will be of interest to scientists, students and practitioners in the fields of chemistry, biophysics and biomedical engineering.

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Feb 242016
 

Palmitic Acid: Occurrence, Biochemistry and Health Effects (Biochemistry Research Trends)


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Feb 192016
 

Clinical Biochemistry Made Ridiculously Simple (MedMaster Series, 2004 Edition)


Features: Used Book in Good Condition
By (author): Stephen Goldberg

University of Miami, FL. Focuses on the basic conceptual background of clinically relevant biochemistry for medical students and other health professionals. Line drawings and Biochemistryland Map in envelope inside back cover. Previous edition: c1993. Softcover.
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Feb 142016
 

Protein Folding and Metal Ions: Mechanisms, Biology and Disease


Features: Used Book in Good Condition

The role of metal ions in protein folding and structure is a critical topic to a range of scientists in numerous fields, particularly those working in structural biology and bioinorganic chemistry, those studying protein folding and disease, and those involved in the molecular and cellular aspects of metals in biological systems. Protein Folding and Metal Ions: Mechanisms, Biology and Disease presents the contributions of a cadre of international experts who offer a comprehensive exploration of this timely subject at the forefront of current research.

Divided into four sections, this volume:

  • Provides case study examples of protein folding and stability studies in particular systems or proteins that comprise different metal ions of co-factors
  • Reviews the proteins that shuttle metal ions in the cell to a particular target metalloprotein
  • Illustrates how metal binding can be connected to pathological protein conformations in unrelated diseases, from cancer to protein deposition disorders such as Parkinson’s disease
  • Addresses protein redesign of metal-containing proteins by computational methods, folding simulation studies, and work on model peptides ? dissecting the relative energetic contribution of metals sites to protein folding and stability

Together, the 13 chapters in this text cogently describe the state of the science today, illuminate current challenges, propose future possibilities, and encourage further study in this area that offers much promise especially with regard to novel approaches to the treatment of some of the most challenging  and tragic diseases.

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Jan 272016
 

Ligand Design in Medicinal Inorganic Chemistry


By (author): Tim Storr

Increasing the potency of therapeutic compounds, while limiting side-effects, is a common goal in medicinal chemistry. Ligands that effectively bind metal ions and also include specific features to enhance targeting, reporting, and overall efficacy are driving innovation in areas of disease diagnosis and therapy.

Ligand Design in Medicinal Inorganic Chemistry presents the state-of-the-art in ligand design for medicinal inorganic chemistry applications. Each individual chapter describes and explores the application of compounds that either target a disease site, or are activated by a disease-specific biological process.

Ligand design is discussed in the following areas:

  • Platinum, Ruthenium, and Gold-containing anticancer agents
  • Emissive metal-based optical probes
  • Metal-based antimalarial agents
  • Metal overload disorders
  • Modulation of metal-protein interactions in neurodegenerative diseases
  • Photoactivatable metal complexes and their use in biology and medicine
  • Radiodiagnostic agents and Magnetic Resonance Imaging (MRI) agents
  • Carbohydrate-containing ligands and Schiff-base ligands in Medicinal Inorganic Chemistry
  • Metalloprotein inhibitors

Ligand Design in Medicinal Inorganic Chemistry provides graduate students, industrial chemists and academic researchers with a launching pad for new research in medicinal chemistry.

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Jan 202016
 

Privileged Scaffolds in Medicinal Chemistry: Design, Synthesis, Evaluation (Drug Discovery)


One strategy to expedite the discovery of new drugs, a process that is somewhat slow and serendipitous, is the identification and use of privileged scaffolds. This book covers the history of the discovery and use of privileged scaffolds and addresses the various classes of these important molecular fragments.
The first of the benzodiazepines, a class of drugs that is powerful for treating anxiety, may not have been discovered had it not been for a chance experiment on the contents of a discarded flask found during a lab clean-up. Some years later, scientists discovered that benzodiazepine derivatives were also effective in treating other diseases. This class of molecules was the first to be described as privileged in the sense that it is especially effective at altering the course of disease. Other privileged molecular structures have since been discovered, and since these compounds are so effective at interacting with numerous classes of proteins, they may be an effective starting point to look for new drugs against the supposedly “undruggable” proteins.
Following introductory chapters presenting an overview, a historical perspective and the theoretical background and findings, main chapters describe the structure of privileged structures in turn and discuss major drug classes associated with them and their syntheses. This book provides comprehensive coverage of the subject through chapters contributed by expert authors from both academia and industry and will be an excellent reference source for medicinal chemists of a range of disciplines and experiences.
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Dec 282015
 

USMLE Step 1 Lecture Notes 2016: Biochemistry and Medical Genetics (Kaplan Test Prep)


By (author): Kaplan

The only official Kaplan Lecture Notes for USMLE Step 1 available for sale!

Get the comprehensive information you need to ace USMLE Step 1 and match into the residency of your choice.

* Up-to-date: Updated annually by Kaplan’s all-star faculty
* Integrated: Packed with clinical correlations and bridges between disciplines
* Learner-efficient: Organized in outline format with high-yield summary boxes
* Trusted: Used by thousands of students each year to succeed on USMLE Step 1
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Dec 162015
 

Circulating microRNAs in Disease Diagnostics and their Potential Biological Relevance (Experientia Supplementum)


MicroRNAs as the endogenous mediators of RNA interference have experienced an unprecedented career in recent years, highlighting their pathogenic, diagnostic and potential therapeutic relevance. Beside tissue microRNAs, they are also found in body fluids, most notably in blood. Significant differences of circulating microRNA levels have been found in various diseases, making them candidates for minimally invasive markers of disease, for example tumor malignancy. The book focuses on the potential diagnostic applicability of circulating microRNAs in various diseases and their potential biological significance.
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Dec 162015
 

Reviews of Physiology, Biochemistry and Pharmacology


Protein transport events occurring at the endoplasmic reticulum (ER) of eukaryotic cells and the cytoplasmic membrane of prokaryotic organisms share many similarities. Resident proteins of both membranes span the lipid bilayer once or several times by a-helical stretches and their integration is usually mediated by uncleaved signal-anchor sequences. Proteins that are translocated across either membrane, collectively also termed secretory proteins, harbour cleavable N-terminal signal sequences. Prokaryotic and eukaryotic signal sequences have the same modular structure and are functionally exchangeable. Integration of membrane proteins and translocation of secretory proteins basically occur at the same sites (pores) within each membrane. In both types of membranes, these pores are c- posed of homologous components forming the Sec translocons. Parts of the Sec trans- cons are found populated by ribosomes, the membrane-bound ribosomes. Bacterial m- brane and eukaryotic secretory proteins are targeted to the Sec translocons by the same molecular mechanism involving signal recognition particle (SRP) and its receptor (SRP – ceptor, SR). Structure and assembly of the SRP The functional core of SRP The functional core of this ribonucleoprotein complex consists of the signal sequence binding subunit (SRP54 in eukaryotes and Ffh in prokaryotes) and the SRP RNA molecule (see Fig. 1). This core is conserved in all organisms, with the intriguing exception of chloroplasts, where the SRP lacks the RNA subunit.
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