Leading researchers are specially invited to provide a complete understanding of the key topics in these archetypal multidisciplinary fields. In a form immediately useful to scientists, this periodical aims to filter, highlight and review the latest developments in these rapidly advancing fields.
Medicinal chemistry is both science and art. The science of medicinal chemistry offers mankind one of its best hopes for improving the quality of life. The art of medicinal chemistry continues to challenge its practitioners with the need for both intuition and experience to discover new drugs. Hence sharing the experience of drug research is uniquely beneficial to the field of medicinal chemistry. Drug research requires interdisciplinary team-work at the interface between chemistry, biology and medicine. Therefore, the topic-related series Topics in Medicinal Chemistry covers all relevant aspects of drug research, e.g. pathobiochemistry of diseases, identification and validation of (emerging) drug targets, structural biology, drugability of targets, drug design approaches, chemogenomics, synthetic chemistry including combinatorial methods, bioorganic chemistry, natural compounds, high-throughput screening, pharmacological in vitro and in vivo investigations, drug-receptor interactions on the molecular level, structure-activity relationships, drug absorption, distribution, metabolism, elimination, toxicology and pharmacogenomics. In general, special volumes are edited by well known guest editors.
This new work is dedicated to glasses and their variants which can be used as biomaterials to repair diseased and damaged tissues. Bio-glasses are superior to other biomaterials in many applications, such as healing bone by signaling stem cells to become bone cells.
First book on biomaterials to focus on bio-glasses
Edited by a leading authority on bio-glasses trained by one of its inventors, Dr Larry Hench
Supported by the International Commission on Glass (ICG)
Authored by members of the ICG Biomedical Glass Committee, with the goal of creating a seamless textbook
Written in an accessible style to facilitate rapid absorption of information
Covers all types of glasses, their properties and applications, and demonstrates how glass is an attractive improvement to current procedures
Of interest to the biomedical as well as the materials science community.
The book covers all types of glasses: traditional glasses, bioactive glasses, sol-gel glasses, phosphate glasses, glass-ceramics, composites and hybrids. Alongside discussion on how bio-glasses are made, their properties, and the reasons for their use, the authors also cover their applications in dentistry, bone regeneration and tissue engineering and cancer treatment. Its solid guidance describes the steps needed to take a new material from concept to clinic, covering the essentials of patenting, scale-up, quality assurance and FDA approval.
This practical reference for medicinal and pharmaceutical chemists combines the theoretical background with modern methods as well as applications from recent lead finding and optimization projects. Divided into two parts on the thermodynamics and kinetics of drug-receptor interaction, the text provides the conceptual and methodological basis for characterizing binding mechanisms for drugs and other bioactive molecules. It covers all currently used methods, from experimental approaches, such as ITC or SPR, right up to the latest computational methods. Case studies of real-life lead or drug development projects are also included so readers can apply the methods learned to their own projects. Finally, the benefits of a thorough binding mode analysis for any drug development project are summarized in an outlook chapter written by the editors.
By (author): Stephanie R. De Vriese, Armond B. Christophe
Interest in lipid metabolism and polyunsaturated fatty acids in relation to sperm production has increased during the last decade. The motivation for the research described in this book originates from the discovery that sperm lipids contain extremely high proportions of long-chain polyunsaturated fatty acids, thus establishing a link between lipid biochemistry and male fertility. Moreover, the fact that polyunsaturated fatty acids must, in some form, be supplied in the diet suggests a relationship between fertility and nutrition and raises the possibility of improving male fertility by dietary means. This book gives the reader an up-to-date view of several aspects of male fertility in relation to lipid and fatty acid metabolism. Researchers in the domain of male fertility, fatty acid metabolism, and antioxidants; medical personnel involved in the treatment of male infertility; fat technologists; students in nutrition, dietetics, biochemistry, pharmacy, and medicine; and everybody interested in the field will find this book useful.
NEW FOR MCAT 2015! Get everything you need to ace the Biology and Biochemistry material on the new MCAT exam.
The MCAT is being entirely overhauled in 2015—and students planning on taking the test after January 2015 will need to prepare for a longer, tougher exam. The Princeton Review’s MCAT BIOLOGY AND BIOCHEMISTRY REVIEWis designed specifically for those test-takers. It features:
Everything You Need to Know For a High Score: · Access to our online Student Tools portal for up-to-the-moment information on late-breaking AAMC changes to the exam · In-depth coverage of the challenging biology and biochemistry topics on this important test · Bulleted chapter summaries for quick review · Full-color illustrations, diagrams, and tables · An extensive glossary for handy reference · Strategic guidance and effective test-taking techniques
More Practice Than Ever: · 3 full-length practice tests online · End-of-chapter practice questions · MCAT-style practice passages · Detailed answer explanations for every practice question
In MCAT BIOLOGY AND BIOCHEMISTRY REVIEW, you’ll gain mastery of topics like: · MCAT 2015 Basics · Biology Strategy for the MCAT · Biologically Important Molecules · Biochemistry · Molecular Biology · Microbiology · Eukaryotic Cells · Genetics and Evolution · The Nervous and Endocrine Systems · The Circulatory, Lymphatic, and Immune Systems · The Excretory and Digestive Systems · The Muscular and Skeletal Systems · The Respiratory System and the Skin · The Reproductive Systems And more!
The state of the art in Biopharmaceutics, Pharmacokinetics, and Pharmacodynamics Modeling is presented in this new second edition book. It shows how advanced physical and mathematical methods can expand classical models in order to cover heterogeneous drug-biological processes and therapeutic effects in the body.
The book is divided into four parts; the first deals with the fundamental principles of fractals, diffusion and nonlinear dynamics; the second with drug dissolution, release, and absorption; the third with epirical, compartmental, and stochastic pharmacokinetic models, with two new chapters, one on fractional pharmacokinetics and one on bioequivalence; and the fourth mainly with classical and nonclassical aspects of pharmacodynamics. The classical models that have relevance and application to these sciences are also considered throughout. This second edition has new information on reaction limited models of dissolution, non binary biopharmaceutic classification system, time varying models, and interface models. Many examples are used to illustrate the intrinsic complexity of drug administration related phenomena in the human, justifying the use of advanced modeling methods.
This book will appeal to graduate students and researchers in pharmacology, pharmaceutical sciences, bioengineering, and physiology.
Reviews of the first edition:
“This book presents a novel modelling approach to biopharmaceutics, pharmacokinetics and pharmacodynamic phenomena. This state-of-the-art volume will be helpful to students and researchers in pharmacology, bioengineering, and physiology. This book is a must for pharmaceutical researchers to keep up with recent developments in this field.” (P. R. Parthasarathy, Zentralblatt MATH, Vol. 1103 (5), 2007)
“These authors are the unique (or sole) contributors in this area that are working on these questions and bring a special expertise to the field that is now being recognized as essential to understanding biological system and kinetic/dynamic characteristics in drug development…This text is an essential primer for those who would envision the incorporation of heterogeneous approaches to systems where homogeneous approaches are not sufficient to describe the system.” (Robert R. Bies, Journal of Clinical Pharmacology, Vol. 46, 2006)
This book summarizes recent advances in understanding the functions of plant and algal lipids in photosynthesis, in development and signaling, and in industrial applications. As readers will discover, biochemistry, enzymology and analytical chemistry, as well as gene knock-out studies have all contributed to our rapidly increasing understanding of the functions of lipids. In the past few decades, distinct physical and biochemical properties of specific lipid classes were revealed in plant and algal lipids and the functional aspects of lipids in modulating critical biological processes have been uncovered.
These chapters from international authors across relevant research fields highlight the underlying evolutionary context of lipid function in photosynthetic unicellular and multicellular organisms. The book goes on to encompass what lipids can do for industrial applications at a time of fascination with plants and algae in carbon fixation and as sources for production of food, energy and novel chemicals. The developmental context is a part of the fresh and engaging perspective that is presented in this work which graduate students and scientists will find both illuminating and useful.
By (author): Arpan Bhagat, Giorgia Caruso, Maria Micali, Salvatore Parisi
This Brief discusses aspects of the increasingly complex production of legal and reliable food products of non-animal origin. It introduces to the Food Safety Modernization Act (FSMA) in the USA (from January 2011), which requires the food industry to follow risk-based approaches with stronger self-regulation of food safety through measures such as the foreign supplier verification programs (FSVPs). The Brief addresses important chemical hazards of vegetable products: their peculiar microbial ecology, that can become responsible for the occurrence of specific foodborne disease outbreaks, and the chemistry of the involved neurotoxins and other dangerous molecules, that can potentially lead to lethal pathological reactions. Finally, the Brief also critically discusses the technology of ready-to-eat vegetable products and chemical and physical modifications used for packed products (respiration of vegetables, colorimetric modifications, etc.).
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