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The Neurology of Neuroblastoma: Neuroblastoma as a Neurobiological Disease

 Neurology/Neurosurgery  Comments Off on The Neurology of Neuroblastoma: Neuroblastoma as a Neurobiological Disease
Jan 132019
 

Neuroblastoma is the single most common solid tumor of childhood. Although children with small primary neuroblastomas alone are almost always cured by surgery, 65% of children with neuroblastoma already have large bulky tumors or metastatic disease by the time of initial diagnosis. For these children, the 5-year survival rate is only somewhere between 5% and 20% with therapies including surgery, radiation, chemotherapy, and bone marrow transplantation. Dr Schor outlines a new approach to these tumors in order to make a difference for these children. There is much information to support the notion that neuroblastomas represent a developmental aberration of the nervous system, rather than a de novo abnormality in a previously normal cell. While the remote, paraneoplastic effects of neuroblastoma are often the purview of the child neurologist, the neoplasm itself has been viewed and approached therapeutically in much the same manner as all other solid tumors, as the purview of the pediatric oncologist. This work takes the view that approaching neuroblastoma rather as a disorder of nervous system development offers new therapeutic possibilities for this common tumor of childhood.
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Genetics and Genomics for the Cardiologist

 Cardiovascular, Genetics  Comments Off on Genetics and Genomics for the Cardiologist
Jan 132019
 

Genetics and Genomics for the Cardiologist is a concise, but comprehensive volume for the clinical cardiologist or medical student interested in learning how molecular genetics is now being applied to prevention and treatment of heart diseases, from DNA tests to pharmacogenomics and gene-based therapeutics. The volume, written in a plain language, contains detailed figures. A rich glossary, three appendices, many references and several URLs provide additional sources of information.
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Cardiac Positron Emission Tomography

 Cardiovascular  Comments Off on Cardiac Positron Emission Tomography
Jan 132019
 

It is the mark of an instructed mind to rest satisfied with the degree of precision which the nature of the subject admits, and not to seek exactness where only an approximation of the truth is possible. Aristotle With the development of imaging techniques, the in vivo study of human anatomy and physiology has become possible with increasing “approximation of the truth. ” Advances have been made not only in data acquisition, but also in processing as well as visualization of functional and morphological data. Following the successful application of planar two-dimensional imaging approaches, more recently three-dimensional data acquisition and correspond­ ing tomographic image reconstruction has become possible. With the rapid growth of computer support, advanced processing allows for user-friendly interaction with complex data sets. Classical x-ray imaging techniques have matured to excellent spatial resolution and contrast, which provide specific delineation of anatomical changes occurring in cardiovascular disease. In parallel, the use of tracer principles supported the successful introduction of nuclear medicine procedures for the functional characterization of physiology and pathophysiology. The application of such techniques were initially limited by relatively poor spatial resolution, but excelled in high sensitivity 30 years, scintigraphic imaging emerged from and specificity. In the last rectilinear scanning to planar gamma camera imaging and single-photon xvi Preface emISSIOn tomography (SPECT). Based on these advances and the experi­ mental success of autoradiography, the potential of scintigraphy as a clinical and research tool has been well appreciated.
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Practitioner’s Guide to Symptom Base Rates in Clinical Neuropsychology

 Neurology/Neurosurgery  Comments Off on Practitioner’s Guide to Symptom Base Rates in Clinical Neuropsychology
Jan 132019
 

This volume is intended to serve as an aid in the process of differential diagnosis which frequently confronts neuropsychologists. The guide is a compendium of information of the base rates of symptoms across a variety of disorders which neuropsychologists encounter. In addition to serving as a convenient source of information on symptom base rates, this volume also contains detailed cross referencing of symptoms across disorders.This book is intended for use by clinical neuropsychologists and psychologists.
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Concise Guide to Child and Adolescent Psychiatry, Fifth Edition

 Psychiatry  Comments Off on Concise Guide to Child and Adolescent Psychiatry, Fifth Edition
Jan 132019
 

Much like the patients on which it focuses, the field of pediatric mental health continues to grow and develop. Among other advances, the body of clinical research and the number of empirically supported treatments have grown, evaluation practices have been refined, and awareness of emotional and behavioral problems in youth has increased. Stay up-to-date on significant DSM-5 changes to psychiatric nomenclature and criteria-and the developments that have spurred them-with the Concise Guide to Child and Adolescent Psychiatry.,br>This fifth edition prunes older content while distilling and incorporating clinically relevant findings, and features:Reorganized diagnostic chapters that reflect updates to DSM-5Tables of selected diagnostic criteria from DSM-5 for quick referenceRelevant treatment methods for each section on a specific disorder or clinical situationAn informative chapter dedicated to pharmacological treatments-from stimulant medications and antidepressants to antipsychotics and anticonvulsantsSuggested additional readings for those interested in learning more about particular topicsRecommended published and on-line information resources for parentsAn indispensable primer on child and adolescent psychiatry for medical and mental health students and clinical trainees, this guide also serves as an ideal, quick-reference update for practicing physicians, nurses, and advanced practice nurses.Complex theoretical notions, new research, and areas of controversy have been simplified in the interest of brevity and ease of reference, making this a useful resource for professionals in special education, child welfare, and juvenile justice, as well as parents

Review
Dulcans Concise Guide to Child and Adolescent Psychiatry is an excellent resource for child and adolescent psychiatry practitioners, and trainees. This text is well written and extremely well organized. A particular strength of this guide is its focus upon topics relevant to child psychiatrists; inclusion of the new DSM-5 criteria; and easy access to the core elements of assessment, diagnosis and treatment. The Concise Guide broadly and comprehensively covers important areas, while providing enough depth to make it a useful review for busy clinicians, for students, and for those preparing for psychiatry examinations. I buy this book with each new edition and recommend it for my faculty and trainees. –Tami D. Benton, M.D., FAAP, FAACAP, Psychiatrist-in-Chief and Chair, Department of Child and Adolescent Psychiatry and Behavioral Sciences, Childrens Hospital of Philadelphia

Dr. Dulcan and colleagues have done an outstanding job in summarizing the salient elements in a concise, digestible format. This guide will be helpful not only to trainees but to those preparing for MOC and more seasoned professionals looking for summaries on a variety of child mental health topics. This volume is a must for any mental health professionals bookshelf. –Oscar G. Bukstein, M.D., M.P.H., Associate Psychiatrist-in-Chief & Vice Chairman of Psychiatry, Training Director, Child & Adolescent Psychiatry Fellowship, Boston Childrens Hospital; Professor of Psychiatry, Harvard Medical School

The fifth edition of the Concise Guide to Child and Adolescent Psychiatry includes important DSM-5 updates and clearly defined reviews of new and changed diagnoses. The handy size, conciseness of chapters, and readability remain as hallmarks of this classic book. This edition will continue to be the favorite reference in our division for all medical students and residents because it is replete with highlights of all important areas of child and adolescent psychiatry. –Jeffrey Hunt, M.D., Professor and Program Director, Child and Adolescent Psychiatry Fellowship and Combined Program in Pediatrics, Psychiatry, and Child Psychiatry, Alpert Medical School of Brown University

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Orthopaedics for the Physical Therapist Assistant, Second Edition

 Orthopedics  Comments Off on Orthopaedics for the Physical Therapist Assistant, Second Edition
Jan 132019
 


Boasting a new full-color design, Orthopaedics for the Physical Therapist Assistant, Second Edition provides students with evidence-based guidelines for the assessment and rehabilitation of the orthopaedic patient. After considering the fundamental knowledge and skills needed by the PTA student, the text then explores therapeutic activities and the orthopaedic management of specific joints. These joint chapters follow a uniform structure that considers relevant anatomy and kinesiology, examination techniques, common pathologies, and the various strategies and techniques with which they can be addressed.

Orthopaedics for the Physical Therapist Assistant utilizes a range of pedagogical features to improve learning and retention. These include Chapter Objectives that assist students in identifying key learning outcomes; Key Point boxes that emphasize important concepts, and Case Studies that allow students to apply their knowledge. Each chapter ends with Review Questions that test retention of key concepts

About the Author
Allegheny General Hospital, Pittsburgh, Pennsylvania

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Infectious Complications of Cancer

 Infectious Diseases, Oncology  Comments Off on Infectious Complications of Cancer
Jan 132019
 

Despite the major developments in the therapeutic armamentarium for the treatment of infection, the morbidity and mortality of this complication remains very high in patients with compromised defences. Cancer and its treatment represents a major predisposing condition to a variety of infections. These adverse events are still with us, in spite of much progress in the therapy of infectious disease, since cancer therapy is becoming more aggressive, yet further lowering the host’s capacity to cope with infections. Moreover, the pathogens adapt effectively to drugs, and at a pace that might outrun industry’s capability to produce new agents. Finally, new pathogens are appearing as a consequence of both selection and severe immunosuppression. Infection is so common among cancer patients that its diagnosis and management represent a daily challenge to all oncologists, who must continually strive to keep abreast of developments in the area. The present comprehensive review of the most crucial and challenging aspects of the infectious complications in cancer patients will help them to do just that.
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Mammary Tumor Cell Cycle, Differentiation, and Metastasis: Advances in Cellular and Molecular Biology of Breast Cancer

 Oncology  Comments Off on Mammary Tumor Cell Cycle, Differentiation, and Metastasis: Advances in Cellular and Molecular Biology of Breast Cancer
Jan 132019
 

Mammary Tumor Cell Cycle, Differentiation and Metastasis is the fifth volume since 1988 in a series designed to broadly examine current advances in the cellular and molecular biology of breast cancer. As in previous volumes, the editors have invited recognized experts in cutting-edge topics to provide a chapter focused on their area of research. The editors have turned to the researchers who study rodent models of the disease and to those who study the cellular and molecular basis of human breast cancer. The first section of the book is devoted to new mouse models of mammary development and tumorigenesis. The second section moves to studies of human breast cancer and focuses on receptors, signalling, and the cell cycle. The final section deals with defective tissue interactions in human breast cancer. We are now in a period of extremely rapid accumulation of data on the molecular and cellular biology of breast cancer. These findings are highlighted in chapters from Mammary Tumor Cell Cycle, Differentiationand Metastasis: Advances in Cellular and Molecular Biology of BreastCancer.
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Pathophysiology of Heart Failure

 Cardiovascular, Pathology, Physiology  Comments Off on Pathophysiology of Heart Failure
Jan 132019
 

Pathophysiology of Heart Failure brings together leading basic scientists and clinicians, presenting new approaches to this complex problem, involving cardiomyopathic processes and ischemia perfusion injury. The result is a synthesis of state-of-the-art information on molecular biology, cellular physiology and structure-function relationships in the cardiovascular system. The role which excess intracellular calcium plays in the genesis of cardiac dysfunction is described as a fundamental mechanism underlying heart failure; one which may lead to improved prevention and treatment. Audience: Clinical and experimental cardiologists will find the book a helpful source of ideas and inspiration.
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Advances in Cancer Screening

 Oncology  Comments Off on Advances in Cancer Screening
Jan 122019
 

Screening for cancer is an important focus of cancer control. Yet screening, as it involves administering a test to large segments of the population deemed to be at risk for the disease of interest, is potentially a major consumer of scarce health care resources. In addition, the benefits sought from cancer screening, particularly reduction in mortality from the disease, are not always realized, either for biological or organizational reasons. Thus, the paradigm that `early detection must always be beneficial’, taught to health care professionals, and publicized widely through the media to the public, has been challenged in the last two decades for a number of cancer sites. It is the purpose of Advances in Cancer Screening to determine the extent to which the requirements for the introduction of population-based screening programs have been met, as a result of extensive research on screening during the last two decades, with a major concentration on findings from the recent decade.
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