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Neurotoxin Modeling of Brain Disorders ― Life-long Outcomes in Behavioral Teratology

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Jul 142019
 

This book is authored by leading experts who made major discoveries in neuroteratology research focused on modeling human neural developmental disorders. Individual chapters address ADHD (attention-deficit hyperactivity disorder), Lesch-Nyhan disease, psychoses and schizophrenia, autism, and models of Parkinson’s Disease and tardive dyskinesia. The effects of perinatal stress and agonist insults on life-long outcomes are addressed, as well as the overall effects of perinatal neurotoxins on development of specific neural phenotypic systems. The book provides a unique compendium on how perinatal insults of various types can produce effects in brain that persist throughout the life span. Researchers can derive insight into experimental approaches in this research field; clinicians can develop insights into the influences of the many noxious and seemingly innocuous substances that might influence brain development in children.

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MicroRNAs and the Immune System: Methods and Protocols

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Jul 142019
 

In recent years, the critical role of microRNAs has been revealed within the biology of cells that constitute the immune system. In MicroRNAs and the Immune System: Methods and Protocols, expert researchers explore the latest techniques for studying miRNA expression, including the most up-to-date data on splinted ligation and qRT-PCR assays, as well as high-throughput profiling through cloning, deep sequencing, and microarrays. Chapters outline methods to study miRNA functions in various cell types from a single cell type level to entire model organisms, and present studies of miRNAs in the context of viruses and the immune response. Tools are also provided to help navigate bioinformatics databases on miRNAs and their targets. Composed in the highly successful Methods in Molecular Biology™ series format, each chapter contains a brief introduction, step-by-step methods, a list of necessary materials, and a Notes section which shares tips on troubleshooting and avoiding known pitfalls. Contemporary and innovative, MicroRNAs and the Immune System: Methods and Protocols is an essential handbook for immunologists, biochemists, and molecular biologists.
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Oxidative Stress in Aging: From Model Systems to Human Diseases

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Jul 142019
 

Oxidative Stress in Aging: From Model Systems to Human Diseases discusses the role of free radicals in aging in different animal models, as well as the relevance of free radicals on age-related diseases and pathological conditions in humans (following an introduction section of the basics and theory of free radicals). Human aging is a complex phenomenon – not everyone gets the same diseases and dies from the same cause. Accumulating reports implicate the connection between free radicals and various diseases and age-related pathological conditions. Although the causal relationships have not been established, it is necessary to discuss how free radicals are involved in each situation. In addition, the major interventions trials of antioxidant supplements in age-related disease, cancer and so forth are reviewed and discussed.
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Chromatin Protocols: Second Edition

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Jul 142019
 

Significant advancements have been made in the study of chromatin structure and function over the past fifty years but none as spectacular as those made in the last decade due to the development of novel techniques and the ability to sequence large stretches of DNA. In Chromatin Protocols, Second Edition, expert researchers delineate these cutting-edge techniques via step-by-step laboratory methods and protocols, which encompass a wide array of topics from the isolation of nucleosomes, assembly of nucleosomes and study of the basic chromatin structure to detailed analysis of histone modifications and chromatin function. Written in the highly successful Methods in Molecular Biology™ series style, chapters include brief introductions to the subjects, lists of the necessary materials and reagents, readily reproducible protocols, and Notes sections which highlight tips on troubleshooting and avoiding known pitfalls.Comprehensive and up-to-date, Chromatin Protocols, Second Edition is a valuable tool for scientists studying various aspects of chromatin function and an ideal guide to aid in the development of new techniques as well as new ideas in the field of chromatin biology.
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Textbook of Geriatric Dentistry

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Jul 142019
 

Textbook of Geriatric Dentistry, Third Edition provides a comprehensive review of the aging process and its relevance to oral health and dentistry. Now in full colour, this third edition has been fully revised and updated with new material encompassing recent research and clinical developments within geriatric dentistry. Written in a clear and accessible style, this is an essential guide to geriatric dental practice for undergraduate and postgraduate dentistry students and practicing clinicians alike. Key features include: * Contributions from an international group of expert authors * Comprehensive coverage of oral healthcare issues in the older adult, from demographics and physiology through to nutrition and pharmacology * Provides both foundational knowledge and a guide to clinical management * New chapters including material on orofacial pain, quality of life and treatment planning
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Challenging Cases in Neonatology: Cases from NeoReviews “Index of Suspicion in the Nursery” and “Visual Diagnosis” First Edition

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Jul 132019
 

This valuable reference and learning tool showcases 50 unique, real-life cases from NeoReviews popular “Index of Suspicion in the Nursery” and “Visual Diagnosis”.  These 50 cases cover rare conditions or unusual clinical manifestations of common conditions that medical professionals see every day.

Topic areas include cardiology, dermatology, endocrinology, fluids and electrolytes, gastroenterology, genetics, hematology and oncology, inborn errors of metabolism, maternal-fetal medicine, neurology, ophthalmology, orthopedics, otolaryngology, and pulmonology. More than 100 images provide assistance for visual learning

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Principles of Pediatric Nursing: Caring for Children (7th Edition)

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Jul 132019
 

Help readers learn to think like nurses and visualize how to care for children

To prepare today’s students to begin thinking and acting like nurses, Principles of Pediatric Nursing, Seventh Edition presents a foundation of core pediatric nursing principles with an emphasis on growth and development, family-centered care, and health promotion and maintenance. Nursing students often bring an Adult Health mindset to Pediatric Nursing, which can obscure the special considerations needed to effectively care for children. Principles of Pediatric Nursing helps students visualize how to care for children and understand the ways caring for pediatric patients is similar to, and different from, adult patients.

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Design of Efficient and Safe Neural Stimulators: A Multidisciplinary Approach

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Jul 132019
 

This book discusses the design of neural stimulator systems which are used for the treatment of a wide variety of brain disorders such as Parkinson’s, depression and tinnitus. Whereas many existing books treating neural stimulation focus on one particular design aspect, such as the electrical design of the stimulator, this book uses a multidisciplinary approach: by combining the fields of neuroscience, electrophysiology and electrical engineering a thorough understanding of the complete neural stimulation chain is created (from the stimulation IC down to the neural cell). This multidisciplinary approach enables readers to gain new insights into stimulator design, while context is provided by presenting innovative design examples.

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High-Throughput Next Generation Sequencing: Methods and Applications

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Jul 132019
 

Due to their novel concepts and extraordinary high-throughput sequencing capacity, the “next generation sequencing” methods allow scientists to grasp system-wide landscapes of the complex molecular events taking place in various biological systems, including microorganisms and microbial communities. These methods are now being recognized as essential tools for a more comprehensive and deeper understanding of the mechanisms underlying many biological processes. In High-Throughput Next Generation Sequencing: Methods and Applications, experts in the field explore the most recent advances in the applications of next generation sequencing technologies with an emphasis on microorganisms and their communities; however, the methods described in this book will also offer general applications relevant to the study of any living organisms. Written in the highly successful Methods in Molecular Biology™ series format, chapters include introductions to their respective topics, lists of the necessary materials and reagents, step-by-step, readily reproducible laboratory protocols, and key tips on troubleshooting and avoiding known pitfalls.Comprehensive and cutting-edge, High-Throughput Next Generation Sequencing: Methods and Applications is an excellent collection of chapters to aid all scientists who wish to apply these innovative research tools to enhance their own pursuits in microbiology and also biology in general.
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The Difficult Airway: An Atlas of Tools and Techniques for Clinical Management

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Jul 132019
 

The Difficult Airway provides a comprehensive textual and visual coverage of how to deal with patients who have expected or unexpected difficult airways. The text begins with a description of the incidence and importance of the difficult airway and then describes the ASA Difficult Airway Algorithm created to facilitate the management of “difficult airways.” The majority of the book features a comprehensive step-by-step approach to the rescue techniques listed as part of the ASA Algorithm. Noted experts in each of the techniques have been recruited by the book editors to present the information. Figures throughout the book illustrate important points and procedures. This is a wonderful resource for professionals in the health care field including anesthesiologists, intensive care physicians, emergency room physicians, nurses, and out-of-hospital first responders.

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