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Pediatric Surgery: Diagnosis and Treatment

 Pediatrics, Surgery  Comments Off on Pediatric Surgery: Diagnosis and Treatment
Oct 272018
 

Just as children are not little adults, the discipline of paediatric surgery is not equivalent to surgery for adults. Differences in anatomy, diseases affecting children and the appropriate therapies make the surgical care of children confusing and tense.

Even within paediatric care, the extensive changes children undergo as they develop from neonates to adolescents causes different care to be required at different stages. Full-size texts are available for comprehensive review of paediatric surgery when one has the luxury to sit and study at a desk, but no pocket-sized guide specific to paediatric surgery is available. This book will fulfil the need for rapid, clear, concise guidance in the immediate bedside evaluation and treatment of children suffering surgical disease.

It will provide assistance to surgical and paediatric providers alike; anyone who has a hand in the urgent care of children requiring a surgeon. The book is also a convenient focused board review guide for trainees and active practitioners taking board examinations. The editors are busy paediatric surgeons at a teaching hospital, performing operations on children every day, as well as training students and residents. The contributors are drawn from the broad spectrum of paediatric specialists encompassing the disciplines necessary to staff a tertiary children’s hospital.

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http://nitroflare.com/view/DC4ED4564B71131/3319043390.pdf

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From Gene to Therapy : Understanding Human Disease Through Genetics

 Genetics  Comments Off on From Gene to Therapy : Understanding Human Disease Through Genetics
Oct 272018
 

Lecture provides an overview of the progress made in molecular medicine applying genetics and genomics to the understanding, diagnosis, and treatment of human diseases. Specifically, the methods for identifying genes involved in human diseases are described. Examples from 10 genes and diseases will be provided, drawing on the author’s research. Topics include examples from simple Mendelian diseases, such as cystic fibrosis, inherited cancers, oncogenes activated by chromosomal translocations, host genes involved in infectious disease, genes identified via genomewide association studies, pathogens causing cancer, and gene families contributing to multiple diseases. For each example, historical details will be provided as background for readers to understand the context and process of the discoveries, technologies explained, and current understanding and treatment implications detailed.

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http://nitroflare.com/view/0F3E77427152802/From_Gene_to_Therapy.pdf

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Reproductive Medicine for Clinical Practice: Medical and Surgical Aspects

 Reproductive Health  Comments Off on Reproductive Medicine for Clinical Practice: Medical and Surgical Aspects
Oct 262018
 


This first volume of the series of the International Academy of Human Reproduction focuses on new aspects of reproductive medicine, from the professional responsibility model of ethics to the areas of high clinical involvement in human reproduction, such as endometriosis, polycystic ovary, family planning and post-coital contraception.
The book discusses fertility and assisted reproductive techniques in the context of genetics and epigenetics as well as psychosomatic and longevity aspects. In addition, it presents new technologies and therapeutic strategies to improve IVF results and prevent ovarian hyperstimulation syndrome, as well the new challenges and the future of imaging in reproduction. Menopause and the effects of estrogens on atero-prevention, mood, and more generally the reproductive hormones impact on dementia and healthy aging are also covered. Further, it includes a section devoted to innovative aspects of gynecological surgery, discussing the treatments of vaginal aplasia, reproductive microsurgery and technological breakthroughs in pelvic organ prolapse surgery. Last, but not least, it examines the syndromic aspects of preterm birth.
This volume is a useful and comprehensive tool for gynecologists, obstetricians, endocrinologists and all specialists who deal with women’s reproductive health.

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http://nitroflare.com/view/EE65F537644069F/3319780085.epub

http://nitroflare.com/view/B8EDC9C8D028076/3319780085.pdf

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Borderline Personality Disorder: A Case-Based Approach

 Miscellaneous  Comments Off on Borderline Personality Disorder: A Case-Based Approach
Oct 262018
 

This book brings together a series of experts and experienced clinicians to describe and discuss a series of BPD cases in a manner that emphasizes core descriptive and diagnostic features, generalizable principles and techniques, and key take-home messages for clinicians at all levels of experience. The book emphasizes consideration for the disorder from multiple perspectives to help identify effective responses to common clinical challenges and decision points.
To enhance interest, narrative, and readability, each chapter uses a consistent format to present a common clinical challenge along with an effective therapeutic response and discussion of relevant theoretical and empirically validated principles. Each chapter title contains a patient’s (fictionalized) name and a subheading identifying the clinical dilemma or approach to be illustrated. The text includes key points and chapter summaries to help pull together the most important takeaways as quick reference.
Borderline Personality Disorder is a vital resource for psychiatrists, psychologists, psychiatric nurses, general internists, social workers, and all medical professions working with patients suffering from Borderline Personality Disorder.

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http://nitroflare.com/view/0E9D935E8C2C2FA/3319907425.pdf

http://nitroflare.com/view/E0F4FA8E2A11161/3319907425.epub

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Current Treatment of Retroperitoneal Sarcomas: A Joint Effort with the Italian Society of Surgical Oncology

 Oncology, Surgery  Comments Off on Current Treatment of Retroperitoneal Sarcomas: A Joint Effort with the Italian Society of Surgical Oncology
Oct 262018
 


This book provides a comprehensive overview of the approach to retroperitoneal sarcomas, rare and challenging tumors requiring highly specialized, multidisciplinary management. Based on an updated review of the literature and drawing on the expertise of respected authors, it analyzes key topics – such as pre-operative work-up and staging, multimodal therapy, multi-organ resection, surgical complications and management of local recurrence and advanced disease – as well as several other debated issues.
Presenting surgery as the cornerstone in the treatment of this disease, the book serves both as a guide for non-expert physicians wishing to understand the best management of RPS patients, including the need to refer them to specialized centers, and as a state-of-the-art overview for surgeons with interest in sarcoma surgery.

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http://nitroflare.com/view/F1090FCDB1D7E7C/8847039797.epub

http://nitroflare.com/view/A3C45409351A2BB/8847039797.pdf

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Ulcerative Colitis

 Surgery  Comments Off on Ulcerative Colitis
Oct 262018
 

This book reviews the latest advances in treating ulcerative colitis. Its structure is designed to reflect the natural presentation of the disease; accordingly, it starts with the symptoms and the clinical picture, before addressing the use of radiological and endoscopic studies that are performed to make a diagnosis, and the role of the pathological examination. The book also includes detailed information on the medical treatment of the disease, written by some of the most expert gastroenterologists in the field, while also paying considerable attention to the latest medical treatments and to expected future developments.
The book describes various surgical techniques for ulcerative colitis in detail, providing readers with concrete guidelines on which is the most appropriate operation to perform in any given case. It also presents extensive information on the most important operation, the formation of the IPAA (ileal pouch-anal anastomosis), together with helpful tips and tricks. A closing chapter addresses the long-term complications that can occur after a pouch formation, and what to do for each case. As such, the book offers a unique and comprehensive guide for surgeons, gastroenterologists, researchers and students alike.

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http://nitroflare.com/view/EF454ABD2FCF951/8847039762.epub

http://nitroflare.com/view/47A7CF2B8750E56/8847039762.pdf

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Rare Kidney Tumors: Comprehensive Multidisciplinary Management and Emerging Therapies

 Oncology  Comments Off on Rare Kidney Tumors: Comprehensive Multidisciplinary Management and Emerging Therapies
Oct 262018
 


This book provides clinicians with clear guidance on treatment decision-making in patients with rare kidney cancers. After a brief review on epidemiology, pathology, and biology, each chapter focuses on the multidisciplinary management of a particular tumor subtype using the full range of available cancer therapy modalities, including surgery, radiotherapy, chemotherapy, targeted therapies, and immunotherapy. Emerging therapies and future directions in the management of each cancer subtype are also discussed. The chapters are all written by multidisciplinary teams of international experts comprising at least a urologist, a medical oncologist, and a pathologist.
Rare kidney cancers represent 15% of renal cell carcinomas. In comparison with clear cell renal cell carcinomas, little is known about the biology of such cancers, and few trials have reported on the efficacy of targeted therapies in the metastatic setting. Optimal management thus poses significant challenges and often requires a multidisciplinary team. This book will be an ideal reference guide for all clinicians involved in the care of patients with these orphan tumors.

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http://nitroflare.com/view/B44B757EC7AA536/3319969889.epub

http://nitroflare.com/view/B9E0522BFE02630/3319969889.pdf

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Molecular Basis of Resilience: Adapting to a Changing Environment

 Miscellaneous  Comments Off on Molecular Basis of Resilience: Adapting to a Changing Environment
Oct 262018
 

This book illuminates mechanisms of resilience. Threats and defense systems lead to adaptive changes in gene expression. Environmental conditions may dampen adaptive responses at the level of RNA expression. The first seven chapters elaborate threats to human health. Human populations spontaneously invade niche boundaries exposing us to threats that drive the resilience process.
Emerging RNA viruses are a significant threat to human health. Antiviral drugs are reviewed and how viral genomes respond to the environment driving genome sequence plasticity. Limitations in predicting the human outcome are described in “nonlinear anomalies.” An example includes medical countermeasures for Ebola and Marburg viruses under the “Animal Rule.” Bacterial infections and a review of antibacterial drugs and bacterial resilience mediated by horizontal gene transfer follow. Chapter 6 shifts focus to cancer and discovery of novel therapeutics for leukemia. The spontaneous resolution of AML in children with Down syndrome highlights human resilience. Chapter 7 explores chemicals in the environment. Examples of chemical carcinogenesis illustrate how chemicals disrupt genomes. Historic research ignored RNA damage from chemically induced nucleic acid damage. The emergence of important forms of RNA and their possible role in resilience is proposed.

Chapters 8-10 discuss threat recognition and defense systems responding to improve resilience. Chapter 8 describes the immune response as a threat recognition system and response via diverse RNA expression. Oligonucleotides designed to suppress specific RNA to manipulate the immune response including exon-skipping strategies are described. Threat recognition and response by the cytochrome P450 enzymes parallels immune responses. The author proposes metabolic clearance of small molecules is a companion to the immune system. Chapter 10 highlights RNA diversity expressed from a single gene. Molecular Resilience lists paths to RNA transcriptome plasticity forms the molecular basis for resilience.

Chapter 11 is an account of ExonDys 51, an approved drug for the treatment of Duchenne muscular dystrophy. Chapter 12 addresses the question “what informs molecular mechanisms of resilience?” that drives the limits to adaptation and boundaries for molecular resilience. He speculates that radical oxygen, epigenetic modifications, and ligands to nuclear hormone receptors play critical roles in regulating molecular resilience.

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http://nitroflare.com/view/E2A037E13C29205/3319981633.epub

http://nitroflare.com/view/CB536F8B3564502/3319981633.pdf

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Recent Advancements in Biofuels and Bioenergy Utilization

 Miscellaneous  Comments Off on Recent Advancements in Biofuels and Bioenergy Utilization
Oct 262018
 

The concerns relating to global warming, climate change, and increasing energy demands have led to significant research towards the development of alternative energy to substitute the fossil energy sources. Biomass-based energy or biofuels are highly promising due to many perceptible environmental and socio-economic advantages. Cutting-edge academic research and advanced industrial product development have created tremendous scope for the implementation of biofuels at a global scale to reduce the greenhouse gas emissions and supplement the escalating energy demands. The prime focus of this book is to provide an overview of the different technologies utilized to harness the chemical energy from plant-based non-edible biomass and other organic wastes in the form of solid, liquid, and gaseous biofuels.
The opportunities and challenges of different biomass conversion technologies, especially biomass-to-liquid, biomass-to-gas and gas-to-liquid routes, as well as biomass pretreatments, densification, anaerobic digestion, reforming, transesterification, supercritical fluid extraction, microalgal carbon sequestration, life-cycle assessment and techno-economic analysis have been comprehensively discussed in this book. This book is an amalgamation of fifteen different chapters each with distinctive investigations and a collective focus relating to the transition from fossil fuels towards carbon-neutral biofuels. This book serves as a benchmark for academic and industrial researchers involved in exploring the true potentials of plant residues and waste organic matter to produce alternative renewable fuels. To realize the real promises of bioenergy, this book attempts to assess the biorefining approaches, biofuel production and application, and environmental sustainability.

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http://nitroflare.com/view/C38A052670A95F8/9811313067.epub

http://nitroflare.com/view/431B8C1DF969688/9811313067.pdf

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Trends in the Management of Cerebrovascular Diseases

 Miscellaneous  Comments Off on Trends in the Management of Cerebrovascular Diseases
Oct 262018
 

This is a proceeding book of 8th European-Japanese Cerebrovascular Congress (held in Zurich in 2016).
Since many experts from Europe and Japan had very important and fruitful discussion on the management of cerebrovascular diseases, the proceeding book will be very attractive for the physicians and scientists of the area.

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http://nitroflare.com/view/AAF1062252A7F25/3319737384.epub

http://nitroflare.com/view/EAAC6D5A2ADDFCA/3319737384.pdf

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