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Aug 152017
 

Patient-Derived Mouse Models of Cancer: Patient-Derived Orthotopic Xenografts (PDOX) (Molecular and Translational Medicine)


This text highlights seminal discoveries and also provides comprehensive and state-of the-art approach to mouse models of human patient tumors. These areas include training, basic techniques, as well as general troubleshooting. Subsequent chapters focus on the different mouse models of patient tumors including the various strains of immunodeficient mice currently available and the transplantation techniques that can be used as well as state-of-the-art imaging techniques. Practical applications of the models from drug discovery, genome analysis to personalized treatment are also covered. Written by experts in that field, each of these sections address these critical issues. A brief review of the existing literature addressing the particular topic follows in each section.
Presently, there is no single source to provide information on technique and uses of mouse models of human patient tumors. Patient-Derived Mouse Models of Cancer will satisfy this need for cancer researchers, oncologists, pharmaceutical and biotechnology industry scientists as well as molecular biologists studying in vivo systems
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Aug 152017
 

Neurobiology and Treatment of Traumatic Dissociation: Towards an Embodied Self


Features: Neurobiology and Treatment of Traumatic Dissociation
By (author): Ulrich F. Lanius PhD, Sandra L. Paulsen PhD, Frank M. Corrigan MD

Encompassing the contributions of expert clinicians and researchers in the area of traumatic stress and dissociation, this volume is the first to integrate current neuroscience research regarding traumatic dissociation with several cutting-edge approaches to treatment, providing a comprehensive, neurobiologically based treatment approach.

The text discusses current neuroscientific research regarding traumatic stress and dissociation that includes attachment, affective neuroscience, polyvagal theory, structural dissociation, and information processing theory, yielding a comprehensive model that guides treatment and clinical interventions for traumatic dissociation. It then integrates this model with stage-oriented treatment and current therapeutic interventions, including EMDR, somatic and body psychotherapy approaches, Ego State Therapy, and adjunctive pharmacological interventions. Readers are given hands-on practical guidance regarding clinical decision making, enabling them to make sound choices about interventions that will facilitate optimal treatment outcomes.

Key Features:

  • Provides a broad-based treatment approach to traumatic stress syndromes and dissociation
  • Offers accessible current research in the basic neurosciences relevant to our understanding of attachment, traumatic stress, and dissociation
  • Includes practical suggestions for integrating EMDR, somatic, and body psychotherapy approaches with Ego State Therapy and adjunctive pharmacological interventions
  • Integrates concepts from the affective and cognitive neurosciences and the study of consciousness
  • Presents a comprehensive neurobiological model that accounts for the therapeutic effects of both somatic therapies and EMDR, as well as adjunctive pharmacological interventions
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Aug 152017
 

Phacoemulsification Cataract Surgery


By (author): Rajen Gupta

This book provides ophthalmic surgeons with a concise, clinical guide to performing the fundamentals steps in phacoemulsification cataract surgery. Clear diagrams and images are used throughout and the information can be adapted to a particular consultant’s own technique once the surgical principles are understood. The chapters serve as a modular framework that allows for safe, effective learning of skills and use as a clinical training resource.

Phacoemulsification Cataract Surgery serves as a helpful teaching aid for consultants, especially newly appointed, who have little experience in teaching. Basic fundamental rules are provided as a guide for training others to improve surgical techniques in clinical practice. Recently qualified and experienced consultants will find this book to be an indispensable resource for learning and teaching  in the area of phacoemulsification cataract surgery.

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Aug 152017
 

Mechanisms of Vascular Defects in Diabetes Mellitus (Advances in Biochemistry in Health and Disease)


This book intends to bring together, a panel of renowned experts in the field of vascular biology and diabetology, to integrate the current understanding of the pathogenesis and pathophysiology of vascular diseases in diabetes mellitus. This attempt is significant given the increasing interest in this area as the prevalence of vascular diseases continues to escalate globally. Patients with diabetes are at a higher risk of structural and functional changes in all vessel walls of the human body. Vascular complications of diabetes are leading causes for both morbidity and mortality.
In recent years, several articles have focused on advancing our knowledge on the profound effect of hyperglycemia and insulin resistance on building up vascular wall inflammation leading to endothelial dysfunction in patients with diabetes mellitus  Other reports have elaborated on the various disorders, hyperglycemia can lead to, their therapies, adverse effects and complications. There are also studies that highlight the role of factors that induce vascular wall alterations in hyperglycemia. 
In this book, we attempt to discuss vascular disease progression in diabetes with a unique approach. We attempt to provide a complete perspective of the pathophysiology of vascular complications and then dissect each of the factors that play a key role in accelerating vascular wall alterations in diabetes. Each of these factors has been adversely implicated in the initiation and progression of disease to a large extent. In this collection for the first time all these factors would be described under a common canopy. Further, the text would emphasize on pathogenesis of micro vascular complications of diabetes, such as retinopathy, neuropathy and nephropathy. Pharmacological therapies for treating vascular dysfunction in diabetes mellitus would also be reviewed. This compendium hopefully would be an invaluable replacement to scores of literature on diabetic vascular disease and would be of great interest to clinicians, academicians, medical students and researchers.
The book will be divided into seven sections, each emphasizing a common incentive to development of vascular disease in diabetes. Section I deals with pathophysiology of diabetic vascular disease, beginning with an update on the global burden of diabetes mellitus and its vascular complications. The pathophysiology and pathogenesis of diabetes associated macrovasculopathy, how hyperglycemia functions as an atherogenic factor, effects of hyperglycemia on smooth muscle accumulation in vascular lesions and genetic susceptibility for increased risk of vascular disease in diabetes will be discussed in the following chapters of this section.
The next section (Section II) surveys the process of endothelial dysfunction under hyperglycaemia and hyperinsulinemia and their effects on angiogenesis, vascular remodeling and wound healing. A chapter is also dedicated to the endothelial progenitor cell population and its dysfunction during development of vascular complications in diabetes.
Section III will highlight the molecular mechanisms underlying endothelial dysfunction, various pathways such as nitric oxide synthase pathway, oxidative stress pathway, renin – angiotensin system and increased vascular superoxide production in the initiation and progression of vascular disease in diabetes. This section also covers role of endothelin, monocyte derived cytokines, peroxynitrate and adipokines in macrovascular complications of diabetes.
Metabolic factors such as advanced glycation end products, atherogenic dyslipoproteinaemia, and homocysteine will be reviewed in Section IV, whereas an overview of the hemostatic factors such as platelet dysfunction, hyperglycaemia induced thrombin formation and aberrant clot lysis will be dwelled upon in Section V.

Section VI includes chapters on microvascular complications of diabetes which encompasses long term complications of diabetes affecting small blood vessels of the eye, kidneys and nervous system. The pathogenesis and mechanisms of these complications would be detailed here.

The final section (Section VII) of the book will consider mechanism of action of drugs for treating endothelial dysfunction in diabetes mellitus which would elaborate on lipid regulating therapies such as statins, as well as other therapies such as ACE inhibitors, Angiotensin II receptors, insulin, metformin and their effects on enhancing vascular function in diabetes.
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We intend to invite authors who symbolize a multidisciplinary approach to this complicated disease. The proposed authors include clinicians who understand the trend of vascular complications in their long term clientele, epidemiologists with a holistic view, basic and experimental researchers with years of experience in dissecting the factors leading to endothelial dysfunction and clinical researchers with the skill of translating bench work to the bedside. We expect this book will be of significant value and interest to the same group of clinicians, researchers, post doctoral fellows and medical and non medical graduate students. The novel assimilated insights could stimulate development of mechanism based prevention and therapeutic strategies providing a promising option to limit cardiovascular complications in diabetes mellitus.

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Aug 152017
 

Biomarkers of the Tumor Microenvironment: Basic Studies and Practical Applications


This book reviews different aspects of the cancer microenvironment, and its regulation and importance for tumor progression. Practical applications, in terms of how biomarkers are increasingly included in therapy protocols, will also be discussed. 

Biomarkers of the Tumour Microenvironment: Basic Studies and Practical Applications is aimed at research pathologists in the cancer field, and also cancer researchers from other backgrounds, especially those using morphology techniques and models focusing on cross-talk between different cell types in tumors.
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Aug 152017
 

Consent in Pediatric Urology (Handbook Series of Consent in Pediatric Surgical Subspecialities)


This comprehensive handbook of consent in surgical subspecialities is dedicated to the risks and complications that a child needs to be consented for in the vast majority of pediatric surgical procedures with evidence base and outcomes.

The chapters address common and rare complications encountered in pediatric subspeciality practice which clinicians need to be aware of to allow them to take fully informed consent. The contributors are renowned for their expertise in pediatric urology and provide evidence and outcome based areas for consent in the first book of the series: ‘Consent in Pediatric Urology’.  

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Aug 152017
 

Diagnostic Principles and Applications: Avoiding Medical Errors, Passing Board Exams, and Providing Informed Patient Care


Features: Used Book in Good Condition
By (author): Robert B. Taylor

This book fills the need for a resource presenting important diagnostic facts that clinicians should have learned during their classroom lectures and subsequent clinical training, but often didn’t. The content will be literature-based information that can help the clinician avoid diagnostic errors. Most other diagnosis books on the market are either ‘physical diagnosis’ texts targeting student readers or ‘differential diagnosis books intended for use by practicing physicians, though both types of books aim to be comprehensive. What sets this book apart from other diagnosis books is that it is a curated collection of facts, tailored specifically to address common gaps in clinical knowledge and describe less-traveled pathways to important diagnostic destinations. This book focuses on high-impact techniques. Essential Diagnostic Facts Every Clinician Should Know contains: – Classical diagnostic pearls clinicians should have learned in physical diagnosis courses. For example, a patient with acute pericarditis may find that leaning forward relieves the pain. – Red flag symptoms of serious disease. For example, an infant that tastes salty when kissed might be the first clue to a diagnosis of cystic fibrosis. – Pathognomonic signs allowing an occasional early diagnosis: For example, Koplik spots in a febrile child are found only with measles. – Plastic pearls exposed: For example, contrary to clinical lore, back pain at night has not been found to be a useful indicator for serious spinal pathology. – Counterintuitive clinical manifestations: For example, the patient with gout may have a normal or even low serum uric acid level during an acute attack. – Clinical manifestations that may point to uncommon diagnoses: For example, nocturnal bone pain, sometimes dramatically relieved by aspirin, characterizes osteoid osteoma.
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Aug 152017
 

Handbook of Early Intervention for Autism Spectrum Disorders: Research, Policy, and Practice (Autism and Child Psychopathology Series)


Current rates of autism diagnoses have been cause for concern and research as well as rumor and misinformation. Important questions surround the condition: how early can an accurate diagnosis be made? At what age should intervention start? How can parents recognize warning signs? And what causes autism in the first place?

There are no easy answers, but the Handbook of Early Intervention for Autism Spectrum Disorders gives researchers, practitioners, and academics the science and guidance to better understand and intervene. Background chapters survey the history of professional understanding of the disorders and the ongoing debate over autism as a single entity or a continuum. Chapters on best methods in screening, assessment, and diagnosis reflect the transition between the DSM-V and older diagnostic criteria. And at the heart of the book, the intervention section ranges from evidence-based strategies for developing core skills to ethical concerns, cultural considerations, and controversial treatments.

Included in the Handbook‘s broad-based coverage:

  • Designing curriculum programs for children with autism spectrum disorders (ASD).
  • Mainstream education for children with ASD.
  • Teaching independent living skills to children with ASD.
  • Social skills and play.
  • Behavioral and mental health disorders in children with ASD.
  • Training and supporting caregivers in evidence-based practices.
  • Teaching cognitive skills to children with ASD.

The Handbook of Early Intervention for Autism Spectrum Disorders is a comprehensive reference for researchers, professors, and graduate students as well as clinicians and other scientist-practitioners in clinical child and school psychology, child and adolescent psychiatry, social work, rehabilitation, special education, and pediatric medicine.

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Aug 152017
 

Gout: Basic Science and Clinical Practice


Features: Used Book in Good Condition
By (author): David S. Newcombe

Gout: Basic Science and Clinical Practice is a thoroughly researched comprehensive text which covers all important aspects of gout, including its genetics, pathophysiology, diagnosis, and management.

 

Gout is probably the most common rheumatic disease after osteoarthritis and is becoming more common with the prevalence of the metabolic syndrome in the US, and in many other countries.  Only about 10% of patients with gout are treated by rheumatologists and this often leads to inadequate diagnosis and treatment in general medical practice. 

 

Written by an expert in the field this book is valuable reference for rheumatologists and others in the medical profession who are interested in understanding and managing this important disease.

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Aug 152017
 

Advancements in Clinical Research (Advances in Experimental Medicine and Biology)


The book presents current progress in clinical practice and research, particularly involving pulmonary diseases. Chapters tackle a variety of topics including a search for potential biomarkers of lung tumors, sleep disordered breathing, neurogenic lung dysfunction, community acquired and nosocomial respiratory infections developing in the chronically ill, mechanisms of hypoxia sensing, and the reasons for frequent visits to primary care facilities causing an ever increasing costs for caregivers and society. Identifying molecular markers expressed in tumors, rather than histological stratification of cancer type, forms a rapidly evolving basis of precision medicine, with the hope of a future development of targeted treatment. Creative ideas drive basic research that spurs innovations that, in turn, when translated into clinical applications, lay the foundation of breakthroughs, hopefully leading to increased longevity and better quality of life. This book is intended for healthcare professionals, particularly pulmonologists, primary care physicians, and other specialists involved in the management of patients.
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